{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:55:35Z","timestamp":1789793735649,"version":"4.0.1"},"reference-count":87,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"MIUR","doi-asserted-by":"publisher","award":["RBSI144MT"],"award-info":[{"award-number":["RBSI144MT"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondi di Ateneo Progetti Grandi","award":["RG116154C9214D1A"],"award-info":[{"award-number":["RG116154C9214D1A"]}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union's Seventh Framework Programme","award":["624341"],"award-info":[{"award-number":["624341"]}]},{"DOI":"10.13039\/501100003770","name":"Banca d'Italia","doi-asserted-by":"crossref","award":["12868\/17"],"award-info":[{"award-number":["12868\/17"]}],"id":[{"id":"10.13039\/501100003770","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"crossref","award":["C26H15JT9X"],"award-info":[{"award-number":["C26H15JT9X"]}],"id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbadis.2018.07.017","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T23:14:01Z","timestamp":1532042041000},"page":"3309-3321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease"],"prefix":"10.1016","volume":"1864","author":[{"given":"Antonella","family":"Tramutola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lanzillotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Iavarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Vincenzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Castagnola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Allan","family":"Butterfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Gaetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Perluigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Di Domenico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.07.017_bb0005","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1093\/brain\/awp099","article-title":"Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease","volume":"132","author":"Liu","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0010","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.bbadis.2014.05.014","article-title":"Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain","volume":"1842","author":"Forster","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2004.02.049","article-title":"Glucose metabolism and insulin receptor signal transduction in Alzheimer disease","volume":"490","author":"Hoyer","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0020","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1001\/archneur.1992.00530350056020","article-title":"Topography of cross-sectional and longitudinal glucose metabolic deficits in Alzheimer's disease. Pathophysiologic implications","volume":"49","author":"Smith","year":"1992","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0025","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jalz.2016.02.011","article-title":"O-GlcNAcylation: a regulator of tau pathology and neurodegeneration","volume":"12","author":"Gong","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00702-014-1294-z","article-title":"Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3\u00d7Tg-AD mice","volume":"122","author":"Yu","year":"2015","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0035","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/prca.201300001","article-title":"O-GlcNAcomics\u2013revealing roles of O-GlcNAcylation in disease mechanisms and development of potential diagnostics","volume":"7","author":"Copeland","year":"2013","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0040","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.biocel.2009.03.008","article-title":"O-GlcNAc cycling: implications for neurodegenerative disorders","volume":"41","author":"Lazarus","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0045","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/10409238.2014.884535","article-title":"Functional O-GlcNAc modifications: implications in molecular regulation and pathophysiology","volume":"49","author":"Vaidyanathan","year":"2014","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0050","article-title":"Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0055","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1096\/fj.07-8309com","article-title":"Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease","volume":"22","author":"Deng","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0060","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1111\/j.1460-9568.2006.04735.x","article-title":"Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting","volume":"23","author":"Li","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0065","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1074\/mcp.O112.018366","article-title":"Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse","volume":"11","author":"Trinidad","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1242\/jcs.053678","article-title":"The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways","volume":"123","author":"Zeidan","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0075","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1039\/b704905f","article-title":"O-GlcNAc modification in diabetes and Alzheimer's disease","volume":"3","author":"Dias","year":"2007","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1471-4159.2009.06320.x","article-title":"Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease","volume":"111","author":"Liu","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/01616412.2015.1133485","article-title":"Roles of O-GlcNAcylation on amyloid-beta precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease","volume":"38","author":"Zheng","year":"2016","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0090","doi-asserted-by":"crossref","first-page":"34472","DOI":"10.1074\/jbc.R114.601351","article-title":"The emerging link between O-GlcNAc and Alzheimer disease","volume":"289","author":"Zhu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.phrs.2016.01.006","article-title":"Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease","volume":"105","author":"Gatta","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0100","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.jmb.2014.01.004","article-title":"O-GlcNAc modification of tau directly inhibits its aggregation without perturbing the conformational properties of tau monomers","volume":"426","author":"Yuzwa","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0105","doi-asserted-by":"crossref","first-page":"10804","DOI":"10.1073\/pnas.0400348101","article-title":"O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease","volume":"101","author":"Liu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1601576","article-title":"Interplay between protein glycosylation pathways in Alzheimer's disease","volume":"3","author":"Frenkel-Pinter","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0115","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1006\/bbrc.1995.2149","article-title":"O-linked N-acetylglucosamine is upregulated in Alzheimer brains","volume":"213","author":"Griffith","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrneurol.2015.225","article-title":"Tau and neurodegenerative disease: the story so far","volume":"12","author":"Iqbal","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0125","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bbrc.2017.06.067","article-title":"O-GlcNAcylation of amyloid-beta precursor protein at threonine 576 residue regulates trafficking and processing","volume":"490","author":"Chun","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0130","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-140096","article-title":"O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-beta protein precursor via inhibition of endocytosis from the plasma membrane","volume":"44","author":"Chun","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0135","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bbrc.2010.12.080","article-title":"O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-beta precursor protein (APP)","volume":"404","author":"Jacobsen","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0140","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neurobiolaging.2012.03.001","article-title":"O-linked beta-N-acetylglucosaminidase inhibitor attenuates beta-amyloid plaque and rescues memory impairment","volume":"34","author":"Kim","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0145","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2005.07.021","article-title":"Nicastrin: gatekeeper of the gamma-secretase complex","volume":"122","author":"De Strooper","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0150","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nchembio.797","article-title":"Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation","volume":"8","author":"Yuzwa","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1326-9-42","article-title":"Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau\/APP mutant mice","volume":"9","author":"Yuzwa","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0160","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1021\/pr1011153","article-title":"A novel post-translational modification in nerve terminals: O-linked N-acetylglucosamine phosphorylation","volume":"10","author":"Graham","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0165","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1021\/acschemneuro.8b00015","article-title":"Pharmacological inhibition of O-GlcNAcase enhances autophagy in brain through an mTOR-independent pathway","volume":"9","author":"Zhu","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.freeradbiomed.2015.12.012","article-title":"Impairment of biliverdin reductase-a promotes brain insulin resistance in Alzheimer disease: a new paradigm","volume":"91","author":"Barone","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0175","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1002\/jnr.22528","article-title":"The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: implications for disease pathogenesis and progression","volume":"88","author":"Di Domenico","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/pr800667a","article-title":"Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD","volume":"8","author":"Owen","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0185","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0190","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbr.2011.06.029","article-title":"Olfactory memory is impaired in a triple transgenic model of Alzheimer disease","volume":"224","author":"Cassano","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0195","article-title":"Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease","volume":"18","author":"Romano","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0200","first-page":"16","article-title":"Detection and analysis of proteins modified by O-linked N-acetylglucosamine, Curr Protoc Mol Biol, Chapter 17","volume":"17","author":"Zachara","year":"2011","journal-title":"Unitas"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079977","article-title":"Early decline in glucose transport and metabolism precedes shift to ketogenic system in female aging and Alzheimer's mouse brain: implication for bioenergetic intervention","volume":"8","author":"Ding","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0210","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.brainres.2010.05.084","article-title":"Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models","volume":"1347","author":"Nicholson","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0215","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cmet.2012.12.017","article-title":"Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock","volume":"17","author":"Kaasik","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0220","doi-asserted-by":"crossref","first-page":"10592","DOI":"10.1074\/jbc.M113.523068","article-title":"Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK)","volume":"289","author":"Bullen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/srep34614","article-title":"Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation","volume":"6","author":"Seo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0230","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0235","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1073\/pnas.072072399","article-title":"Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes","volume":"99","author":"Vosseller","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0240","doi-asserted-by":"crossref","first-page":"29179","DOI":"10.1074\/jbc.R000010200","article-title":"O-glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate","volume":"275","author":"Comer","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0245","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jbior.2013.09.007","article-title":"O-GlcNAcylation in cellular functions and human diseases","volume":"54","author":"Yang","year":"2014","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0250","doi-asserted-by":"crossref","first-page":"32015","DOI":"10.1074\/jbc.274.45.32015","article-title":"Regulation of a cytosolic and nuclear O-GlcNAc transferase. Role of the tetratricopeptide repeats","volume":"274","author":"Kreppel","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0255","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/324753","article-title":"Alternate phosphorylation\/O-GlcNAc modification on human insulin IRSs: a road towards impaired insulin signaling in Alzheimer and diabetes","volume":"2014","author":"Jahangir","year":"2014","journal-title":"Adv. Bioinforma."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0260","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-2010-1375","article-title":"Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration","volume":"20","author":"Butterfield","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0265","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1021\/pr700657y","article-title":"Strategy for comprehensive identification of post-translational modifications in cellular proteins, including low abundant modifications: application to glyceraldehyde-3-phosphate dehydrogenase","volume":"7","author":"Seo","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0270","first-page":"711","article-title":"Interaction of purified protein kinase C with key proteins of energy metabolism and cellular motility","volume":"38","author":"Reiss","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0275","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1042\/bj2390691","article-title":"Five enzymes of the glycolytic pathway serve as substrates for purified epidermal-growth-factor-receptor kinase","volume":"239","author":"Reiss","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0280","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jprot.2013.11.014","article-title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome","volume":"96","author":"Bian","year":"2014","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0285","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1021\/pr300630k","article-title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome","volume":"12","author":"Zhou","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0290","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00726-010-0645-9","article-title":"Human Alzheimer's disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry","volume":"40","author":"Skorobogatko","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0295","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jprot.2011.03.033","article-title":"Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects","volume":"74","author":"Di Domenico","year":"2011","journal-title":"J. Proteome"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0300","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1016\/j.bbadis.2016.07.005","article-title":"Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways","volume":"1862","author":"Perluigi","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0305","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1471-4159.2012.07737.x","article-title":"Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer's disease patients","volume":"121","author":"Zahid","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0310","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/mas.21374","article-title":"Mass spectrometry and redox proteomics: applications in disease","volume":"33","author":"Butterfield","year":"2014","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0315","doi-asserted-by":"crossref","first-page":"6492","DOI":"10.1093\/hmg\/ddv358","article-title":"Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease","volume":"24","author":"Cha","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0320","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnins.2015.00204","article-title":"Aberrant insulin signaling in Alzheimer's disease: current knowledge","volume":"9","author":"Bedse","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0325","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.psyneuen.2017.05.004","article-title":"Insulin signaling: an opportunistic target to minify the risk of Alzheimer's disease","volume":"83","author":"Pardeshi","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0330","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1074\/jbc.M109.077818","article-title":"Regulation of insulin receptor substrate 1 (IRS-1)\/AKT kinase-mediated insulin signaling by O-linked beta-N-acetylglucosamine in 3T3-L1 adipocytes","volume":"285","author":"Whelan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0335","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.289.5487.2122","article-title":"Role of brain insulin receptor in control of body weight and reproduction","volume":"289","author":"Bruning","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0340","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.diabet.2010.09.001","article-title":"O-GlcNAc modification, insulin signaling and diabetic complications","volume":"36 (","author":"Issad","year":"2010","journal-title":"Diabete Metab."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/srep43842","article-title":"High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation","volume":"7","author":"Phoomak","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0350","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1074\/mcp.M500314-MCP200","article-title":"Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1","volume":"5","author":"Ball","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0355","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1038\/srep14500","article-title":"O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling","volume":"5","author":"Shi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0360","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.febslet.2012.05.063","article-title":"Diverse regulation of AKT and GSK-3beta by O-GlcNAcylation in various types of cells","volume":"586","author":"Shi","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0365","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40035-015-0030-4","article-title":"Posttranslational modifications of alpha-tubulin in alzheimer disease","volume":"4","author":"Zhang","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0370","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tcb.2014.10.004","article-title":"Post-translational modifications of tubulin: pathways to functional diversity of microtubules","volume":"25","author":"Song","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0375","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1242\/jcs.063727","article-title":"Post-translational modifications of microtubules","volume":"123","author":"Wloga","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0380","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1046\/j.1471-4159.2001.00655.x","article-title":"Cytosolic O-glycosylation is abundant in nerve terminals","volume":"79","author":"Cole","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0385","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-150417","article-title":"Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease","volume":"49","author":"Triplett","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0390","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/awm260","article-title":"The beta-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism","volume":"131","author":"Petratos","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0395","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","article-title":"GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity","volume":"120","author":"Yoshimura","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2018.07.017_bb0400","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/14737175.2017.1244482","article-title":"Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies","volume":"17","author":"Tramutola","year":"2017","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0405","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/ars.2016.6759","article-title":"The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics","volume":"26","author":"Di Domenico","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0410","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2017.10.001","article-title":"Dysfunction of autophagy and endosomal-lysosomal pathways: roles in pathogenesis of down syndrome and Alzheimer's disease","volume":"114","author":"Colacurcio","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0415","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nbd.2015.03.014","article-title":"mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy","volume":"84","author":"Perluigi","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0420","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/labinvest.2014.131","article-title":"Regulation of autophagy by protein post-translational modification","volume":"95","author":"Wani","year":"2015","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0425","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/jnc.13037","article-title":"Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD","volume":"133","author":"Tramutola","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0430","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2018.07.017_bb0435","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8-a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:42:02Z","timestamp":1760416922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918302606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0925443918302606"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.017","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}