{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:47:18Z","timestamp":1781545638150,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21AR067473"],"award-info":[{"award-number":["R21AR067473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbadis.2018.07.034","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T12:36:27Z","timestamp":1533126987000},"page":"3449-3458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pigment epithelium derived factor regulates human Sost\/Sclerostin and other osteocyte gene expression via the receptor and induction of Erk\/GSK-3beta\/beta-catenin signaling"],"prefix":"10.1016","volume":"1864","author":[{"given":"Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarret D.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Tombran-Tink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Niyibizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.07.034_bb0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-4835(91)90248-D","article-title":"PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity","volume":"53","author":"Tombran-Tink","year":"1991","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0015","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1073\/pnas.90.4.1526","article-title":"Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family","volume":"90","author":"Steele","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0020","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2353\/ajpath.2010.091085","article-title":"Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells","volume":"177","author":"Ho","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00223-004-0068-2","article-title":"Localization of pigment epithelium-derived factor in growing mouse bone","volume":"76","author":"Quan","year":"2005","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0030","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2004.02.076","article-title":"Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone","volume":"316","author":"Tombran-Tink","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbrc.2004.11.041","article-title":"Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF","volume":"326","author":"Aparicio","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0040","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1167\/iovs.04-0172","article-title":"Stimulation of neovascularization by the anti-angiogenic factor PEDF","volume":"45","author":"Apte","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0045","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1089\/jop.2012.0225","article-title":"Antiangiogenesis effects of endostatin in retinal neovascularization","volume":"29","author":"Bai","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nrc3484","article-title":"The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential","volume":"13","author":"Becerra","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0055","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ajhg.2011.01.015","article-title":"Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta","volume":"88","author":"Becker","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0060","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1002\/jbmr.487","article-title":"Mutations in SERPINF1 cause osteogenesis imperfecta type VI","volume":"26","author":"Homan","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0065","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/jbmr.1480","article-title":"Lack of expression of SERPINF1, the gene coding for pigment epithelium-derived factor, causes progressively deforming osteogenesis imperfecta with normal type I collagen","volume":"27","author":"Venturi","year":"2012","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0070","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/stem.1505","article-title":"Pigment epithelium-derived factor enhances differentiation and mineral deposition of human mesenchymal stem cells","volume":"31","author":"Li","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0075","first-page":"4384","article-title":"Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content","volume":"27","author":"Gattu","year":"2013","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Experiment. Biol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0080","first-page":"2837","article-title":"Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade","volume":"30","author":"Belinsky","year":"2016","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Experiment. Biol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0085","first-page":"1651","article-title":"Pigment epithelium derived factor suppresses expression of Sost\/sclerostin by osteocytes: Implication for its role in bone matrix mineralization","volume":"24","author":"Li","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0090","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2119\/molmed.2012.00008","article-title":"Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice","volume":"18","author":"Liu","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0095","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/jbmr.345","article-title":"Sclerostin is a locally acting regulator of late-osteoblast\/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism","volume":"26","author":"Atkins","year":"2011","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0100","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1359\/jbmr.080601","article-title":"MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM","volume":"23","author":"Addison","year":"2008","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0105","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1210\/en.2007-1205","article-title":"Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP","volume":"149","author":"Martin","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0110","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1210\/en.2009-0216","article-title":"Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator","volume":"150","author":"David","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0115","doi-asserted-by":"crossref","first-page":"E1378","DOI":"10.1152\/ajpendo.00252.2009","article-title":"Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK\/ERK pathway in 3T3-L1 preadipocytes","volume":"297","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0120","first-page":"1114","article-title":"Pigment epithelium-derived factor (PEDF) peptide promotes the expansion of hepatic stem\/progenitor cells via ERK and STAT3-dependent signaling","volume":"9","author":"Shih","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2011.09.003","article-title":"Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1\/2 and induction of Bcl-2","volume":"72","author":"Sanchez","year":"2012","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0130","doi-asserted-by":"crossref","first-page":"31605","DOI":"10.1074\/jbc.274.44.31605","article-title":"Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor","volume":"274","author":"Alberdi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0135","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1074\/jbc.M809259200","article-title":"Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor","volume":"284","author":"Bernard","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0140","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05401","article-title":"Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF","volume":"3","author":"Cheng","year":"2014","journal-title":"elife"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0145","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.bone.2008.12.021","article-title":"Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells","volume":"44","author":"Brounais","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0150","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00198-008-0728-6","article-title":"Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response","volume":"20","author":"Atkins","year":"2009","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0155","doi-asserted-by":"crossref","first-page":"23771","DOI":"10.1074\/jbc.M111.251116","article-title":"An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts","volume":"286","author":"Rybchyn","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0160","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbmr.465","article-title":"Cell line IDG-SW3 replicates osteoblast-to-late-osteocyte differentiation in vitro and accelerates bone formation in vivo","volume":"26","author":"Woo","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-1-61779-367-7_22","article-title":"Isolation and culture of human osteoblasts","volume":"806","author":"Gartland","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015056","article-title":"Codon preference optimization increases heterologous PEDF expression","volume":"5","author":"Gvritishvili","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0175","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2005.06.009","article-title":"Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin","volume":"19","author":"Ding","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yexcr.2003.09.029","article-title":"Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing","volume":"293","author":"Cheon","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0185","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.onc.1204064","article-title":"Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation","volume":"20","author":"Desbois-Mouthon","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0190","doi-asserted-by":"crossref","first-page":"45847","DOI":"10.1074\/jbc.M209354200","article-title":"Fibroblast growth factor-2 induces Lef\/Tcf-dependent transcription in human endothelial cells","volume":"277","author":"Holnthoner","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0195","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1006\/bbrc.1998.8888","article-title":"WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells","volume":"247","author":"Papkoff","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0200","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"Winkler","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0205","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/jbmr.161","article-title":"Sclerostin: a gem from the genome leads to bone-building antibodies","volume":"25","author":"Paszty","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0210","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/beta-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bone.2010.09.009","article-title":"Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model","volume":"48","author":"Tian","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0220","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/MCB.01211-10","article-title":"Identification of a novel inhibitor of the canonical Wnt pathway","volume":"31","author":"Park","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0225","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jcmgh.2015.06.006","article-title":"Pigment epithelium-derived factor (PEDF) inhibits Wnt\/-catenin signaling in the liver","volume":"1","author":"Protiva","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0230","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.str.2011.07.005","article-title":"Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5\/6","volume":"19","author":"Bourhis","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0235","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ajhg.2013.02.010","article-title":"Mutations in WNT1 cause different forms of bone fragility","volume":"92","author":"Keupp","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0240","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajhg.2013.02.009","article-title":"WNT1 mutations in families affected by moderately severe and progressive recessive osteogenesis imperfecta","volume":"92","author":"Pyott","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0245","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/jbmr.304","article-title":"PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling","volume":"26","author":"Rhee","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0250","first-page":"358","article-title":"Downregulation of SOST\/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes","volume":"6","author":"Bellido","year":"2006","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/JOE-10-0308","article-title":"Targeted ablation of the PTH\/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses","volume":"209","author":"Powell","year":"2011","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0260","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/jbmr.3011","article-title":"Control of bone anabolism in response to mechanical loading and PTH by distinct mechanisms downstream of the PTH receptor","volume":"32","author":"Delgado-Calle","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4419-1399-9_4","article-title":"Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity","volume":"664","author":"Subramanian","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0270","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"Notari","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0275","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2007.10.012","article-title":"Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)","volume":"48","author":"Chung","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2018.07.034_bb0280","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/CS20140631","article-title":"Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis","volume":"129","author":"He","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbadis.2018.07.034_bb0285","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ccr.2010.11.001","article-title":"Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization","volume":"18","author":"Tvorogov","year":"2010","journal-title":"Cancer Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T23:15:00Z","timestamp":1569885300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918302837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0925443918302837"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.034","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pigment epithelium derived factor regulates human Sost\/Sclerostin and other osteocyte gene expression via the receptor and induction of Erk\/GSK-3beta\/beta-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}