{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:00:35Z","timestamp":1789614035620,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"US Public Health Service Grant RO1","award":["DK062092"],"award-info":[{"award-number":["DK062092"]}]},{"name":"US Public Health Service Grant RO1","award":["DK111678"],"award-info":[{"award-number":["DK111678"]}]},{"name":"US Public Health Service Grant RO1","award":["DK113147"],"award-info":[{"award-number":["DK113147"]}]},{"name":"NIH","award":["K01DK110264"],"award-info":[{"award-number":["K01DK110264"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F31AA024960"],"award-info":[{"award-number":["F31AA024960"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbadis.2018.08.012","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T16:15:30Z","timestamp":1533744930000},"page":"3537-3545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN\/AKT pathway"],"prefix":"10.1016","volume":"1864","author":[{"given":"Pradeep","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reben","family":"Raeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Chopyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tekla","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Anania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.08.012_bb0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.05.016","article-title":"Pathophysiology of liver fibrosis and the methodological barriers to the development of anti-fibrogenic agents","volume":"121","author":"Bottcher","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0025","doi-asserted-by":"crossref","first-page":"8323747","DOI":"10.1155\/2016\/8323747","article-title":"Regulation of hepatic stellate cells and fibrogenesis by fibroblast growth factors","volume":"2016","author":"Schumacher","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0030","article-title":"Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice","volume":"5","author":"Jenke","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0035","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1096\/fj.14-253229","article-title":"Adiponectin modulates focal adhesion disassembly in activated hepatic stellate cells: implication for reversing hepatic fibrosis","volume":"28","author":"Kumar","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0040","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/BJ20102148","article-title":"Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis","volume":"440","author":"Handy","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40139-015-0094-y","article-title":"Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver","volume":"3","author":"Park","year":"2015","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0050","doi-asserted-by":"crossref","first-page":"62780","DOI":"10.18632\/oncotarget.19376","article-title":"AMPK: a novel target for treating hepatic fibrosis","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0055","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbadis.2017.12.012","article-title":"The role of AdipoR1 and AdipoR2 in liver fibrosis","volume":"1864","author":"Alzahrani","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","article-title":"A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity","volume":"503","author":"Okada-Iwabu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0065","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1007\/s00018-017-2500-6","article-title":"PTEN proteoforms in biology and disease","volume":"74","author":"Malaney","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0070","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2017.05.007","article-title":"LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN\/MMP-2 signaling pathway","volume":"386","author":"Tao","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0075","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/CS20150427","article-title":"miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7","volume":"129","author":"McClelland","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0080","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/jid.2011.156","article-title":"Loss of PTEN expression by dermal fibroblasts causes skin fibrosis","volume":"131","author":"Parapuram","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0085","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1080\/10715762.2016.1189078","article-title":"Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung","volume":"50","author":"Zhang","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0090","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3892\/ijmm.2012.1151","article-title":"Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal","volume":"30","author":"Zheng","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13069-016-0045-1","article-title":"Activation of hepatic stellate cell in Pten null liver injury model","volume":"9","author":"He","year":"2016","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-014-2199-8","article-title":"Hepatic stellate cell is activated by microRNA-181b via PTEN\/Akt pathway","volume":"398","author":"Zheng","year":"2015","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0105","doi-asserted-by":"crossref","first-page":"9856538","DOI":"10.1155\/2016\/9856538","article-title":"Identification of a novel lincRNA-p21-miR-181b-PTEN signaling cascade in liver fibrosis","volume":"2016","author":"Yu","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0110","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.biopha.2013.03.014","article-title":"MicroRNA-21 activates hepatic stellate cells via PTEN\/Akt signaling","volume":"67","author":"Wei","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.taap.2012.06.022","article-title":"DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats","volume":"264","author":"Bian","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.addr.2017.10.011","article-title":"Epigenetic reprogramming in liver fibrosis and cancer","volume":"121","author":"Wilson","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcmgh.2017.04.007","article-title":"Epigenetics and liver fibrosis","volume":"4","author":"Moran-Salvador","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0130","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40291-016-0253-9","article-title":"MicroRNA-29: a crucial player in fibrotic disease","volume":"21","author":"Deng","year":"2017","journal-title":"Mol. Diagn. Ther."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0135","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Ha","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0140","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4254\/wjh.v9.i12.586","article-title":"Role of circulating microRNAs in liver diseases","volume":"9","author":"Loosen","year":"2017","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0145","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/jcb.25116","article-title":"MicroRNA-19b reduces hepatic stellate cell proliferation by targeting GRB2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol","volume":"116","author":"Ge","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0150","doi-asserted-by":"crossref","first-page":"11336","DOI":"10.1074\/jbc.M116.773291","article-title":"The let-7\/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury","volume":"292","author":"McDaniel","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0155","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ymthe.2016.10.015","article-title":"HOTAIR epigenetically modulates PTEN expression via MicroRNA-29b: a novel mechanism in regulation of liver fibrosis","volume":"25","author":"Yu","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0160","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cellsig.2013.09.018","article-title":"Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells","volume":"26","author":"Li","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0165","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbagrm.2015.05.005","article-title":"Epigenetic control of EMT\/MET dynamics: HNF4alpha impacts DNMT3s through miRs-29","volume":"1849","author":"Cicchini","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0170","article-title":"Dysregulation of junctional adhesion molecule-A contributes to ethanol-induced barrier disruption in intestinal epithelial cell monolayers","volume":"5","author":"Chopyk","year":"2017","journal-title":"Phys. Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2018.08.012_bb0175","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jgh.12023","article-title":"Hepatic stellate cells, liver innate immunity, and hepatitis C virus","volume":"28","author":"Wang","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0180","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/egh.11.92","article-title":"Update on hepatic stellate cells: pathogenic role in liver fibrosis and novel isolation techniques","volume":"6","author":"Tacke","year":"2012","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0185","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s10620-017-4470-9","article-title":"Activation of insulin-PI3K\/Akt-p70S6K pathway in hepatic stellate cells contributes to fibrosis in nonalcoholic steatohepatitis","volume":"62","author":"Cai","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.lfs.2017.07.004","article-title":"Lipopolysaccharides induce Smad2 phosphorylation through PI3K\/Akt and MAPK cascades in HSC-T6 hepatic stellate cells","volume":"184","author":"Kao","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0195","doi-asserted-by":"crossref","first-page":"13817","DOI":"10.1038\/ncomms13817","article-title":"Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt","volume":"7","author":"Han","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0200","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.3390\/md13106099","article-title":"Fucoidan elevates MicroRNA-29b to regulate DNMT3B-MTSS1 Axis and inhibit EMT in human hepatocellular carcinoma cells","volume":"13","author":"Yan","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbadis.2018.08.012_bb0205","first-page":"557","article-title":"Micro-ribonucleic acid 29b inhibits cell proliferation and invasion and enhances cell apoptosis and chemotherapy effects of cisplatin via targeting of DNMT3b and AKT3 in prostate cancer","volume":"8","author":"Yan","year":"2015","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0210","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1074\/jbc.M114.598011","article-title":"Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion","volume":"290","author":"Ramezani-Moghadam","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0215","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1038\/s41598-017-04162-1","article-title":"Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target","volume":"7","author":"Marangoni","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0220","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/1873-3468.12309","article-title":"miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis","volume":"590","author":"Niu","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0225","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s10620-015-3976-2","article-title":"Regulatory effects and mechanism of adenovirus-mediated PTEN gene on hepatic stellate cells","volume":"61","author":"An","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0230","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/sigtrans.2017.38","article-title":"Phosphatase and tensin homologue: a therapeutic target for SMA","volume":"2","author":"Godena","year":"2017","journal-title":"Signal Transduction Targeted Ther."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0235","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.3748\/wjg.v23.i32.5904","article-title":"Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis","volume":"23","author":"Xie","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0240","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.bbrc.2016.12.076","article-title":"Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells","volume":"483","author":"Liu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0245","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/acer.12641","article-title":"The adiponectin-SIRT1-AMPK pathway in alcoholic fatty liver disease in the rat","volume":"39","author":"Jiang","year":"2015","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbrc.2017.06.009","article-title":"Adiponectin regulates AQP3 via PPARalpha in human hepatic stellate cells","volume":"490","author":"Tardelli","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2018.08.012_bb0255","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41419-018-0605-y","article-title":"MicroRNA-29b\/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-gamma gene","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918302977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T12:46:25Z","timestamp":1604753185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918302977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0925443918302977"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.08.012","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}