{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:51:26Z","timestamp":1790952686948,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772373"],"award-info":[{"award-number":["81772373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572167"],"award-info":[{"award-number":["81572167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772387"],"award-info":[{"award-number":["81772387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472064"],"award-info":[{"award-number":["81472064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2018YFC1105200"],"award-info":[{"award-number":["2018YFC1105200"]}]},{"name":"Key Research and Development Plan in Zhejiang province","award":["2018C03060"],"award-info":[{"award-number":["2018C03060"]}]},{"name":"Health Department of Zhejiang Province","award":["2017KY024"],"award-info":[{"award-number":["2017KY024"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bbadis.2018.10.026","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T17:20:03Z","timestamp":1540747203000},"page":"115-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis"],"prefix":"10.1016","volume":"1865","author":[{"given":"Zhiwei","family":"Jie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangde","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunwu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2018.10.026_bb0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10555-007-9109-4","article-title":"The bone microenvironment in metastasis; what is special about bone?","volume":"27","author":"Bussard","year":"2008","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.critrevonc.2017.09.003","article-title":"Evaluation and management of skeletal disease in cancer care","volume":"120","author":"Kommalapati","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0015","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0020","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/j.bbamem.2015.02.004","article-title":"Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain","volume":"1848","author":"Yoneda","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/path.4882","article-title":"The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone","volume":"242","author":"Bellanger","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10585-013-9624-3","article-title":"RANK expression on breast cancer cells promotes skeletal metastasis","volume":"31","author":"Blake","year":"2014","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0035","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0040","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2015.11.017","article-title":"Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer","volume":"99 (","author":"Futakuchi","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1124\/mi.10.3.5","article-title":"Bisphosphonate therapeutics in bone disease: the hard and soft data on osteoclast inhibition","volume":"10","author":"Drake","year":"2010","journal-title":"Mol. Interv."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SPC.0b013e328349731c","article-title":"Denosumab: benefits of RANK ligand inhibition in cancer patients","volume":"5","author":"Lipton","year":"2011","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/jcb.25266","article-title":"Risks and benefits of bisphosphonate therapies","volume":"117","author":"Reyes","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0060","doi-asserted-by":"crossref","first-page":"706","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0065","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/path.5001","article-title":"C\/ebpalpha controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1","volume":"244","author":"Chen","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0075","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0080","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0085","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/jbmr.2229","article-title":"Identification of novel transcription factors in osteoclast differentiation using genome-wide analysis of open chromatin determined by DNase-seq","volume":"29","author":"Inoue","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0090","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.bbadis.2015.08.018","article-title":"Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation","volume":"1852","author":"Inoue","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0095","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/1535-7163.MCT-13-0797","article-title":"Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling","volume":"13","author":"Li","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41588-017-0027-2","article-title":"An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer","volume":"50","author":"Chen","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0105","doi-asserted-by":"crossref","first-page":"17001","DOI":"10.1074\/jbc.C116.737346","article-title":"Fatostatin inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division","volume":"291","author":"Gholkar","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0110","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jbmr.3334","article-title":"A novel diterpenoid suppresses osteoclastogenesis and promotes osteogenesis by inhibiting Ifrd1-mediated and IkappaBalpha-mediated p65 nuclear translocation","volume":"33","author":"Xie","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0115","article-title":"Glabridin inhibits osteosarcoma migration and invasion via blocking the p38- and JNK-mediated CREB-AP1 complexes formation","author":"Jie","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0120","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41419-018-0417-0","article-title":"Raddeanin A suppresses breast cancer-associated osteolysis through inhibiting osteoclasts and breast cancer cells","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0125","doi-asserted-by":"crossref","first-page":"e2094","DOI":"10.1038\/cddis.2016.11","article-title":"Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK\/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model","volume":"7","author":"Qiao","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0130","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"van't Veer","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0135","first-page":"716","article-title":"Bone metastases - pathophysiology, diagnostic testing and therapy (part 1)","volume":"155","author":"Koob","year":"2017","journal-title":"Z. Orthop. Unfall"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10070218","article-title":"The osteoclast in bone metastasis: player and target","volume":"10","author":"Maurizi","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","article-title":"Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis","volume":"52","author":"Musso","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0150","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bone.2011.10.028","article-title":"Receptor activator of NF-kappaB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein","volume":"50","author":"Hada","year":"2012","journal-title":"Bone"},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2018.10.026_bb0155","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1038\/sj.cdd.4401399","article-title":"Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol\/lipoproteins","volume":"11","author":"Luegmayr","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0160","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm1515","article-title":"Regulation of osteoclast differentiation and function by the CaMK-CREB pathway","volume":"12","author":"Sato","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0165","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35085068","article-title":"Transcriptional regulation by the phosphorylation-dependent factor CREB","volume":"2","author":"Mayr","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0170","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.29206","article-title":"A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0175","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1172\/JCI94606","article-title":"The many ways of osteoclast activation","volume":"127","author":"Lorenzo","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0185","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0190","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.celrep.2017.02.006","article-title":"Extracellular acidic pH activates the sterol regulatory element-binding protein 2 to promote tumor progression","volume":"18","author":"Kondo","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0195","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1038\/sj.onc.1208802","article-title":"PKB\/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP","volume":"24","author":"Porstmann","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0200","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1200\/JCO.2016.70.3116","article-title":"Cholesterol, cholesterol-lowering medication use, and breast cancer outcome in the BIG 1-98 study","volume":"35","author":"Borgquist","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0205","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrc884","article-title":"Strategies for MMP inhibition in cancer: innovations for the post-trial era","volume":"2","author":"Overall","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2018.10.026_bb0210","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/jnci\/85.21.1758","article-title":"Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production","volume":"85","author":"Azzam","year":"1993","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0215","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.canlet.2017.10.027","article-title":"Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion","volume":"412","author":"Bai","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0220","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/14737159.2018.1439382","article-title":"The breast tumor microenvironment: role in cancer development, progression and response to therapy","volume":"18","author":"Mittal","year":"2018","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0225","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2018.10.026_bb0230","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc865","article-title":"Dissemination and growth of cancer cells in metastatic sites","volume":"2","author":"Chambers","year":"2002","journal-title":"Nat. Rev. Cancer"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918304290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443918304290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:44:31Z","timestamp":1760417071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443918304290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0925443918304290"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.10.026","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2018.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}