{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:43:18Z","timestamp":1771472598945,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33670564"],"award-info":[{"award-number":["17POST33670564"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570274"],"award-info":[{"award-number":["81570274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","award":["2016_BSTDJJ-19"],"award-info":[{"award-number":["2016_BSTDJJ-19"]}],"id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL080472"],"award-info":[{"award-number":["HL080472"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL123568"],"award-info":[{"award-number":["HL123568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL60942"],"award-info":[{"award-number":["HL60942"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RRM Charitable Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbadis.2019.01.011","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T09:07:57Z","timestamp":1547197677000},"page":"1170-1181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction"],"prefix":"10.1016","volume":"1865","author":[{"given":"Yunzhe","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongzhe","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina K.","family":"Sukhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Gurish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Libby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Ping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.01.011_bb0005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrcardio.2015.117","article-title":"Mast cells in human and experimental cardiometabolic diseases","volume":"12","author":"Shi","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0010","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1182\/blood-2010-01-257287","article-title":"Mast cell proteases: multifaceted regulators of inflammatory disease","volume":"115","author":"Pejler","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(07)95006-3","article-title":"Mast cell proteases","volume":"95","author":"Pejler","year":"2007","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0020","doi-asserted-by":"crossref","first-page":"H3032","DOI":"10.1152\/ajpheart.01210.2006","article-title":"Angiotensin II mediates postischemic leukocyte-endothelial interactions: role of calcitonin gene-related peptide","volume":"292","author":"Yusof","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0025","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/ATVBAHA.115.306827","article-title":"Carboxyl-terminal cleavage of apolipoprotein A-I by human mast cell chymase impairs its anti-inflammatory properties","volume":"36","author":"Nguyen","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2019.01.011_bb0030","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1038\/sj.jhh.1000745","article-title":"Effect of an angiotensin II receptor antagonist, candesartan cilexetil, on canine intima hyperplasia after balloon injury","volume":"13","author":"Miyazaki","year":"1999","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.pharmthera.2006.05.008","article-title":"Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models","volume":"112","author":"Miyazaki","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0040","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.CIR.101.12.1372","article-title":"Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability","volume":"101","author":"Schieffer","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0045","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI114344","article-title":"Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation","volume":"84","author":"Gruber","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0050","doi-asserted-by":"crossref","first-page":"18134","DOI":"10.1016\/S0021-9258(17)32427-4","article-title":"Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase","volume":"269","author":"Saarinen","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0055","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1074\/jbc.270.9.4689","article-title":"Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells","volume":"270","author":"Taipale","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0060","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1124\/jpet.102.045179","article-title":"A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidin e-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters","volume":"305","author":"Takai","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000047325","article-title":"High cardiac angiotensin-II-forming activity in infarcted and non-infarcted human myocardium","volume":"94","author":"Ihara","year":"2000","journal-title":"Cardiology"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0014-5793(97)00295-0","article-title":"Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension","volume":"406","author":"Shiota","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.atherosclerosis.2008.09.032","article-title":"Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice","volume":"204","author":"Inoue","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0080","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI39345","article-title":"Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents","volume":"120","author":"Wei","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2019.01.011_bb0085","first-page":"S11","article-title":"Chymase inhibitor improves survival in hamsters with myocardial infarction","volume":"41","author":"Hoshino","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0090","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0024-3205(02)01689-2","article-title":"Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction","volume":"71","author":"Jin","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0095","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0008-6363(03)00535-2","article-title":"Impact of chymase inhibitor on cardiac function and survival after myocardial infarction","volume":"60","author":"Jin","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1291\/hypres.29.57","article-title":"Chymase inhibition prevents cardiac fibrosis and dysfunction after myocardial infarction in rats","volume":"29","author":"Kanemitsu","year":"2006","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0105","article-title":"Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia\/reperfusion in the dog","volume":"9","author":"Zheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0110","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.109.849679","article-title":"Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation","volume":"120","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0115","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.1073\/pnas.1603127113","article-title":"IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction","volume":"113","author":"Tejada","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0120","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/CIRCINTERVENTIONS.111.964049","article-title":"Cardioprotection of insulin-like growth factor-1 during reperfusion therapy: what is the underlying mechanism or mechanisms?","volume":"4","author":"Dai","year":"2011","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/cvr\/cvt158","article-title":"Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction","volume":"100","author":"Chen","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0130","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm1601","article-title":"Mast cells promote atherosclerosis by releasing proinflammatory cytokines","volume":"13","author":"Sun","year":"2007","journal-title":"Nat. Med."},{"issue":"21","key":"10.1016\/j.bbadis.2019.01.011_bb0135","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1161\/CIRCULATIONAHA.105.541714","article-title":"Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution","volume":"112","author":"Sales","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1074-7613(00)80020-5","article-title":"Cathepsin S required for normal MHC class II peptide loading and germinal center development","volume":"10","author":"Shi","year":"1999","journal-title":"Immunity"},{"issue":"87","key":"10.1016\/j.bbadis.2019.01.011_bb0145","doi-asserted-by":"crossref","DOI":"10.3791\/51357-v","article-title":"Isolation and culture of adult mouse cardiomyocytes for cell signaling and in vitro cardiac hypertrophy","author":"Li","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13578-015-0053-7","article-title":"Ouabain prevents pathological cardiac hypertrophy and heart failure through activation of phosphoinositide 3-kinase alpha in mouse","volume":"5","author":"Wu","year":"2015","journal-title":"Cell Biosci."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0155","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI118583","article-title":"Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase","volume":"97","author":"Fang","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0160","doi-asserted-by":"crossref","first-page":"11530","DOI":"10.1016\/S0021-9258(19)78156-3","article-title":"Human cathepsin S: chromosomal localization, gene structure, and tissue distribution","volume":"269","author":"Shi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0165","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/HJH.0000000000000231","article-title":"Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats","volume":"32","author":"Takai","year":"2014","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0170","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1161\/01.CIR.100.13.1443","article-title":"Mast cells cause apoptosis of cardiomyocytes and proliferation of other intramyocardial cells in vitro","volume":"100","author":"Hara","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0175","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13104-015-1284-8","article-title":"Matrix-metalloproteinase-9 is cleaved and activated by cathepsin K","volume":"8","author":"Christensen","year":"2015","journal-title":"BMC. Res. Notes"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41569-018-0002-3","article-title":"Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials","volume":"15","author":"Liu","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0185","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1091\/mbc.12.4.1079","article-title":"Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner","volume":"12","author":"Kurisaki","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.devcel.2009.01.022","article-title":"Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling","volume":"16","author":"Dai","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2019.01.011_bb0195","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cardiores.2005.04.012","article-title":"Myocyte apoptosis in heart failure","volume":"67","author":"van Empel","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0200","doi-asserted-by":"crossref","first-page":"19140","DOI":"10.1074\/jbc.M802513200","article-title":"Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues","volume":"283","author":"Droga-Mazovec","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0205","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1189\/jlb.0506359","article-title":"Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization","volume":"81","author":"Blomgran","year":"2007","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0210","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1183\/09031936.00018215","article-title":"Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis","volume":"46","author":"Kosanovic","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1124\/jpet.112.202275","article-title":"Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1","volume":"346","author":"Houde","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0220","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1161\/ATVBAHA.111.230201","article-title":"Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice","volume":"31","author":"Sun","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0225","doi-asserted-by":"crossref","first-page":"18551","DOI":"10.1074\/jbc.M100223200","article-title":"Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice","volume":"276","author":"Wolters","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0230","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/hr.2017.73","article-title":"Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia","volume":"40","author":"Gu","year":"2017","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0235","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-beta signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"Koitabashi","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0240","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz Jel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0245","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/CIRCRESAHA.114.302653","article-title":"Cardiomyocyte-specific transforming growth factor beta suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction","volume":"114","author":"Rainer","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0250","first-page":"3088","article-title":"MiR-24 alleviates cardiomyocyte apoptosis after myocardial infarction via targeting BIM","volume":"21","author":"Pan","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0255","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1172\/JCI32490","article-title":"Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice","volume":"117","author":"Diwan","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0260","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.RES.83.5.516","article-title":"Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I","volume":"83","author":"Wang","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0265","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.bbrc.2005.08.245","article-title":"IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB","volume":"336","author":"Maldonado","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0270","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/jcp.22619","article-title":"TGFbeta receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release","volume":"226","author":"Heger","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0275","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005357","article-title":"Transforming growth factor-beta receptor III is a potential regulator of ischemia-induced cardiomyocyte apoptosis","volume":"6","author":"Sun","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0280","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cardiores.2005.02.021","article-title":"SMAD proteins are involved in apoptosis induction in ventricular cardiomyocytes","volume":"67","author":"Schneiders","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0285","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCRESAHA.116.304599","article-title":"Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening","volume":"116","author":"Van Aelst","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2019.01.011_bb0290","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/cvr\/cvq149","article-title":"Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11betaHSD1-deficient mice post-MI","volume":"88","author":"McSweeney","year":"2010","journal-title":"Cardiovasc. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919300110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919300110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:51:09Z","timestamp":1760417469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919300110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0925443919300110"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.01.011","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}