{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:05:10Z","timestamp":1783357510497,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870234"],"award-info":[{"award-number":["81870234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770854"],"award-info":[{"award-number":["81770854"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571378"],"award-info":[{"award-number":["81571378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571290"],"award-info":[{"award-number":["81571290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010257","name":"Collaborative Innovation Center for Cardiovascular Disease Translational Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010257","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Provincial Key Discipline of Medicine","award":["ZDXKA2016003"],"award-info":[{"award-number":["ZDXKA2016003"]}]},{"DOI":"10.13039\/501100002949","name":"Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX17_1246"],"award-info":[{"award-number":["KYCX17_1246"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbadis.2019.02.017","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T23:01:16Z","timestamp":1550790076000},"page":"1451-1459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice"],"prefix":"10.1016","volume":"1865","author":[{"given":"Hao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxu","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengnian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.02.017_bb0005","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2016.12.007","article-title":"Adipose tissue CLK2 promotes energy expenditure during high-fat diet intermittent fasting","volume":"25","author":"Hatting","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ni.3746","article-title":"Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure","volume":"18","author":"Wolf","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0020","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/oby.2011.125","article-title":"Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans","volume":"19","author":"Yoneshiro","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0025","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0030","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/nm.3324","article-title":"Tracking adipogenesis during white adipose tissue development, expansion and regeneration","volume":"19","author":"Wang","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0035","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.bbalip.2012.12.002","article-title":"Pharmacological and nutritional agents promoting browning of white adipose tissue","volume":"1831","author":"Bonet","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0040","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nm.4429","article-title":"UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis","volume":"23","author":"Ikeda","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0045","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.cell.2017.09.015","article-title":"Crosstalk between KCNK3-mediated ion current and adrenergic signaling regulates adipose thermogenesis and obesity","volume":"171","author":"Chen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0050","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","article-title":"A switch from white to brown fat increases energy expenditure in cancer-associated cachexia","volume":"20","author":"Petruzzelli","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0055","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/jc.2012-2599","article-title":"Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children","volume":"98","author":"Kraft","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1210\/er.2017-00163","article-title":"Taming the flames: targeting white adipose tissue Browning in hypermetabolic conditions","volume":"38","author":"Abdullahi","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0065","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20130046","article-title":"Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes","volume":"33","author":"Lo","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0070","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.2337\/db14-0619","article-title":"Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance","volume":"63","author":"Liu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature10653","article-title":"Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis","volume":"480","author":"Nguyen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0080","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1073\/pnas.252764399","article-title":"Two Hsp70 family members expressed in atherosclerotic lesions","volume":"100","author":"Han","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0085","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2004.09.005","article-title":"Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia","volume":"56","author":"Pongrac","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0090","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.bbadis.2018.03.006","article-title":"Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke","volume":"1864","author":"Mao","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0095","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/apha.12688","article-title":"Characterization of cold-induced remodelling reveals depot-specific differences across and within brown and white adipose tissues in mice","volume":"217","author":"Jia","year":"2016","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0100","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bbabio.2014.02.008","article-title":"Brite\/beige fat and UCP1 - is it thermogenesis?","volume":"1837","author":"Keipert","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0105","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ebiom.2016.06.017","article-title":"Activation of PPARgamma by a natural flavonoid modulator, apigenin ameliorates obesity-related inflammation via regulation of macrophage polarization","volume":"9","author":"Feng","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0110","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.2337\/db15-0662","article-title":"A synergistic Antiobesity effect by a combination of Capsinoids and cold temperature through promoting beige adipocyte biogenesis","volume":"65","author":"Ohyama","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0120","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.cell.2014.03.066","article-title":"Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat","volume":"157","author":"Qiu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0125","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cmet.2015.06.004","article-title":"Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation","volume":"22","author":"Hui","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0130","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cell.2014.12.011","article-title":"Activated type 2 innate lymphoid cells regulate beige fat biogenesis","volume":"160","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/mr.57.2.402-414.1993","article-title":"Heat shock proteins: molecular chaperones of protein biogenesis","volume":"57","author":"Craig","year":"1993","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0140","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/cvr\/cvt139","article-title":"HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism","volume":"99","author":"Li","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/cvr\/cvq268","article-title":"Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism","volume":"89","author":"Zhou","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1476-511X-13-106","article-title":"Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue","volume":"13","author":"Tiss","year":"2014","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0155","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2337\/db10-1574","article-title":"Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance","volume":"61","author":"Marker","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0160","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1073\/pnas.0705799105","article-title":"HSP72 protects against obesity-induced insulin resistance","volume":"105","author":"Chung","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0165","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1016\/j.celrep.2018.05.065","article-title":"An Hsp20-FBXO4 Axis regulates adipocyte function through modulating PPARgamma ubiquitination","volume":"23","author":"Peng","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0170","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0361-9230(84)90183-7","article-title":"Nonshivering thermogenesis","volume":"12","author":"Himms-Hagen","year":"1984","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0175","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biochi.2016.09.017","article-title":"Transcriptional regulation of the uncoupling protein-1 gene","volume":"134","author":"Villarroya","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0180","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1074\/jbc.M006246200","article-title":"Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell","volume":"276","author":"Barbera","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0185","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2017.08.003","article-title":"The FGF21-CCL11 Axis mediates beiging of white adipose tissues by coupling sympathetic nervous system to type 2 immunity","volume":"26","author":"Huang","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0195","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/hep.24524","article-title":"Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice","volume":"54","author":"Louvet","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0200","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrgastro.2013.140","article-title":"Liver disease: Kupffer cells regulate the progression of ALD and NAFLD","volume":"10","author":"Smith","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0205","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.26607","article-title":"M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease","volume":"59","author":"Wan","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.02.017_bb0210","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cmet.2016.07.023","article-title":"Caloric restriction leads to Browning of white adipose tissue through type 2 immune signaling","volume":"24","author":"Fabbiano","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0215","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1093\/emboj\/cdf528","article-title":"Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage","volume":"21","author":"Yan","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0220","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1093\/emboj\/18.21.5943","article-title":"HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice","volume":"18","author":"Xiao","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0225","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/1389203715666140331111518","article-title":"Chaperones and cardiac misfolding protein diseases","volume":"15","author":"S. Christians","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0230","first-page":"2197","article-title":"Nuclear accumulation of heat-shock protein 90 is associated with poor survival and metastasis in patients with non-small cell lung Cancer","volume":"36","author":"Su","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbadis.2019.02.017_bb0235","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2337\/db18-0035","article-title":"HSPA12A is a novel player in nonalcoholic steatohepatitis via promoting nuclear PKM2-mediated M1 macrophage polarization","volume":"68","author":"Kong","year":"2019","journal-title":"Diabetes"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919300699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919300699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:48:33Z","timestamp":1760417313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919300699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0925443919300699"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.02.017","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of heat shock protein A12A promotes browning of white adipose tissues in mice","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}