{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:48:23Z","timestamp":1792518503967,"version":"4.5.0"},"reference-count":237,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK104708"],"award-info":[{"award-number":["R01-DK104708"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbadis.2019.04.001","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T12:08:49Z","timestamp":1554379729000},"page":"1041-1066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease"],"prefix":"10.1016","volume":"1865","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-104X","authenticated-orcid":false,"given":"Stuart E.","family":"Dryer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hila","family":"Roshanravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0005","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.semnephrol.2018.08.002","article-title":"Cardiovascular disease in children and adolescents with chronic kidney disease","volume":"38","author":"Weaver","year":"2018","journal-title":"Semin. Nephrol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0010","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/MNH.0b013e328358a30e","article-title":"Chronic kidney disease 10\u202fyears on: what have we learned?","volume":"21","author":"Taal","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"3S1","key":"10.1016\/j.bbadis.2019.04.001_bb0015","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2018.01.002","article-title":"Renal Data System 2017 annual data report: epidemiology of kidney disease in the United States","volume":"71","author":"Saran","year":"2018","journal-title":"Am. J. Kidney Dis."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0020","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.mcna.2015.05.003","article-title":"Primary care of the patient with chronic kidney disease","volume":"99","author":"Kiefer","year":"2015","journal-title":"Med Clin North Am."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ki.2011.380","article-title":"Treatment of chronic kidney disease","volume":"81","author":"Turner","year":"2012","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.semnephrol.2016.05.009","article-title":"Established and emerging strategies in the treatment of chronic kidney disease","volume":"36","author":"Pena-Polanco","year":"2016","journal-title":"Semin. Nephrol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0035","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1053\/j.ackd.2014.03.016","article-title":"The treatment of idiopathic focal segmental glomerulosclerosis in adults","volume":"21","author":"Hogan","year":"2014","journal-title":"Adv. Chronic Kidney Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2215\/CJN.05960616","article-title":"Focal segmental glomerulosclerosis","volume":"12","author":"Rosenberg","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0045","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.ackd.2014.06.004","article-title":"Focal segmental glomerulosclerosis recurrence in the renal allograft","volume":"21","author":"Leca","year":"2014","journal-title":"Adv. Chronic Kidney Dis."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0050","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nrd.2016.67","article-title":"The next generation of therapeutics for chronic kidney disease","volume":"15","author":"Breyer","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5729","key":"10.1016\/j.bbadis.2019.04.001_bb0055","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1106215","article-title":"A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis","volume":"308","author":"Winn","year":"2005","journal-title":"Science."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0060","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/geno.1999.5828","article-title":"Linkage of a gene causing familial focal segmental glomerulosclerosis to chromosome 11 and further evidence of genetic heterogeneity","volume":"58","author":"Winn","year":"1999","journal-title":"Genomics."},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0065","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ng1592","article-title":"TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function","volume":"37","author":"Reiser","year":"2005","journal-title":"Nat. Genet."},{"issue":"46","key":"10.1016\/j.bbadis.2019.04.001_bb0070","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.0607465103","article-title":"Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels","volume":"103","author":"Huber","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0075","doi-asserted-by":"crossref","first-page":"F689","DOI":"10.1152\/ajprenal.00298.2010","article-title":"TRPC6 channels and their binding partners in podocytes: role in glomerular filtration and pathophysiology","volume":"299","author":"Dryer","year":"2010","journal-title":"Am J Physiol Renal Physiol."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0080","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1093\/ndt\/gfp229","volume":"24","author":"Sant\u00edn S","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2019.04.001_bb0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrfmmm.2008.11.021","article-title":"Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients","volume":"664","author":"Zhu","year":"2009","journal-title":"Mutat. Res."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0090","doi-asserted-by":"crossref","first-page":"e7771","DOI":"10.1371\/journal.pone.0007771","article-title":"A novel TRPC6 mutation that causes childhood FSGS","volume":"4","author":"Heeringa","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0095","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2215\/CJN.07830910","article-title":"TRPC6 mutations in children with steroid-resistant nephrotic syndrome and atypical phenotype","volume":"6","author":"Gigante","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0100","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/ndt\/gfs572","article-title":"New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis","volume":"28","author":"Hofstra","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0105","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1681\/ASN.2015030318","article-title":"TRPC6 G757D loss-of-function mutation associates with FSGS","volume":"27","author":"Riehle","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0110","doi-asserted-by":"crossref","first-page":"C276","DOI":"10.1152\/ajpcell.00095.2013","article-title":"Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol","volume":"305","author":"Anderson","year":"2013","journal-title":"Am J Physiol Cell Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0115","doi-asserted-by":"crossref","first-page":"F235","DOI":"10.1152\/ajprenal.00140.2008","article-title":"Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface","volume":"295","author":"Kim","year":"2008","journal-title":"Am J Physiol Renal Physiol."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0120","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1091\/mbc.e10-12-0929","article-title":"Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-\u03b31 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis","volume":"22","author":"Kanda","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0125","doi-asserted-by":"crossref","unstructured":"Abramowitz J, Yildirim E, Birnbaumer L (2007). The TRPC family of ion channels: relation to the TRP superfamily and role in receptor-and store-operated calcium entry. In: TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Liedtke WB, Heller S, editors. Boca Raton (FL): CRC Press\/Taylor & Francis; 2007.","DOI":"10.1201\/9781420005844.ch1"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0130","doi-asserted-by":"crossref","unstructured":"Eder P, Schindl R, Romanin C, Groschner K (2007). Protein-pritein interactions in TRPC channel complexes. In: TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Liedtke WB, Heller S, editors. Boca Raton (FL): CRC Press\/Taylor & Francis; 2007.","DOI":"10.1201\/9781420005844.ch24"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0135","doi-asserted-by":"crossref","unstructured":"Wedel BJ, Vazquez G, McKay RR, St J Bird G, Putney JW Jr. A calmodulin\/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin\/IP3 receptor-independent process. J. Biol. Chem. 2003 Jul 11;278(28):25758-65.","DOI":"10.1074\/jbc.M303890200"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0140","doi-asserted-by":"crossref","unstructured":"Storch U, Forst AL, Pardatscher F, Erdogmus S, Philipp M, Gregoritza M, Mederos Y Schnitzler M, Gudermann T. Dynamic NHERF interaction with TRPC4\/5 proteins is required for channel gating by diacylglycerol. Proc. Natl. Acad. Sci. U S A. 2017 Jan 3;114(1):E37-E46.","DOI":"10.1073\/pnas.1612263114"},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0145","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1074\/jbc.M211484200","article-title":"Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth","volume":"278","author":"Jung","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0150","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41422-018-0038-2","article-title":"Structure of the receptor-activated human TRPC6 and TRPC3 ion channels","volume":"28","author":"Tang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0155","doi-asserted-by":"crossref","unstructured":"Fan C, Choi W, Sun W, Du J, Lu W. Structure of the human lipid-gated cation channel TRPC3. Elife. 2018 May 4;7. pii: e36852.","DOI":"10.7554\/eLife.36852"},{"issue":"26","key":"10.1016\/j.bbadis.2019.04.001_bb0160","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1074\/jbc.RA118.003183","article-title":"Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)","volume":"293","author":"Azumaya","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"41","key":"10.1016\/j.bbadis.2019.04.001_bb0165","doi-asserted-by":"crossref","first-page":"16102","DOI":"10.1074\/jbc.RA118.005066","article-title":"Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating","volume":"293","author":"Sierra-Valdez","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","article-title":"Cell biology of the glomerular podocyte","volume":"83","author":"Pavenst\u00e4dt","year":"2003","journal-title":"Physiol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2019.04.001_bb0175","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000025906","article-title":"How does podocyte damage result in tubular damage?","volume":"22","author":"Kriz","year":"1999","journal-title":"Kidney Blood Press Res."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0180","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1681\/ASN.2014030278","article-title":"A potential role for mechanical forces in the detachment of podocytes and the progression of CKD","volume":"26","author":"Kriz","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0185","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.kint.2017.02.032","article-title":"Potential relevance of shear stress for slit diaphragm and podocyte function","volume":"91","author":"Kriz","year":"2017","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0190","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1523-1755.2005.67097.x","article-title":"Pathways to nephron loss starting from glomerular diseases-insights from animal models","volume":"67","author":"Kriz","year":"2005","journal-title":"Kidney Int."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0195","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI22562","article-title":"Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography","volume":"114","author":"Wartiovaara","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0200","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physrev.00055.2006","article-title":"Properties of the glomerular barrier and mechanisms of proteinuria","volume":"88","author":"Haraldsson","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0205","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fendo.2018.00302","article-title":"Nephrin signaling in the podocyte: An updated view of signal regulation at the slit diaphragm and beyond","volume":"9","author":"Martin","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0210","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1152\/ajprenal.00478.2012","article-title":"The podocyte's response to stress: the enigma of foot process effacement","volume":"304","author":"Kriz","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0215","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1046\/j.1523-1755.2001.060003957.x","article-title":"Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat","volume":"60","author":"Kim","year":"2001","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0220","doi-asserted-by":"crossref","first-page":"C960","DOI":"10.1152\/ajpcell.00191.2013","article-title":"NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex","volume":"305","author":"Kim","year":"2013","journal-title":"Am J Physiol Cell Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0002-9440(10)64357-X","article-title":"Podocin localizes in the kidney to the slit diaphragm area","volume":"60","author":"Roselli","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0230","doi-asserted-by":"crossref","first-page":"120068","DOI":"10.1098\/rsob.120068","article-title":"TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells","volume":"2","author":"Quick","year":"2012","journal-title":"Open Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0235","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1124\/mol.108.051912","article-title":"Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes","volume":"75","author":"Kim","year":"2009","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0240","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/jcp.24461","article-title":"Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species","volume":"229","author":"Anderson","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0245","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/ki.2014.71","article-title":"Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli","volume":"86","author":"Ilatovskaya","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0250","series-title":"Permeation and rectification in canonical transient receptor potential-6 (TRPC6) Channels. Front Physiol","first-page":"1055","volume":"9","author":"Dryer","year":"2018"},{"issue":"145","key":"10.1016\/j.bbadis.2019.04.001_bb0255","doi-asserted-by":"crossref","first-page":"ra77","DOI":"10.1126\/scisignal.2001200","article-title":"Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels","volume":"3","author":"Tian","year":"2010","journal-title":"Sci. Signal."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0260","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.00661.2013","article-title":"ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species","volume":"306","author":"Roshanravan","year":"2014","journal-title":"Am J Physiol Renal Physiol."},{"issue":"6716","key":"10.1016\/j.bbadis.2019.04.001_bb0265","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","article-title":"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol","volume":"397","author":"Hofmann","year":"1999","journal-title":"Nature."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0270","doi-asserted-by":"crossref","first-page":"F298","DOI":"10.1152\/ajprenal.00423.2011","article-title":"Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species","volume":"302","author":"Kim","year":"2012","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0275","doi-asserted-by":"crossref","first-page":"7241","DOI":"10.1074\/jbc.M312042200","article-title":"Exocytotic insertion of TRPC6 channel into the plasma membrane upon Gq protein-coupled receptor activation","volume":"279","author":"Cayouette","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0280","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fphys.2016.00351","article-title":"20-Hydroxyeicosatetraenoic acid (20-HETE) modulates canonical transient receptor potential-6 (TRPC6) channels in podocytes","volume":"7","author":"Roshanravan","year":"2016","journal-title":"Front. Physiol."},{"issue":"34","key":"10.1016\/j.bbadis.2019.04.001_bb0285","doi-asserted-by":"crossref","first-page":"31709","DOI":"10.1074\/jbc.M304437200","article-title":"20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells","volume":"278","author":"Basora","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0290","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI200112849","article-title":"Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin","volume":"108","author":"Schwarz","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.bbadis.2019.04.001_bb0295","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/hmg\/ddg360","article-title":"Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains","volume":"12","author":"Huber","year":"2003","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0300","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1089\/ars.2013.5616","article-title":"Redox regulation of transient receptor potential channels","volume":"21","author":"Kozai","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0305","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1085\/jgp.201711876","article-title":"Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition","volume":"150","author":"Samanta","year":"2018","journal-title":"J Gen Physiol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0310","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-3-319-26974-0_10","article-title":"Second messenger-operated calcium entry through TRPC6","volume":"898","author":"Bouron","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0315","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ceca.2016.02.009","article-title":"Sensing of redox status by TRP channels","volume":"60","author":"Ogawa","year":"2016","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0320","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12329","article-title":"Redox regulation of transient receptor potential channels in the endothelium","volume":"24","author":"Pires","year":"2017","journal-title":"Microcirculation."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0325","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.bbadis.2017.06.010","article-title":"Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors","volume":"1863","author":"Kim","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0330","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1016\/j.bbadis.2018.08.007","article-title":"Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: role of NADPH oxidases and Src family tyrosine kinases","volume":"1864","author":"Kim","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0335","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-010-0847-8","article-title":"Canonical TRP channels and mechanotransduction: from physiology to disease states","volume":"460","author":"Patel","year":"2010","journal-title":"Pflugers Arch."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0340","doi-asserted-by":"crossref","first-page":"F1018","DOI":"10.1152\/ajprenal.00662.2013","article-title":"A mutation in TRPC6 channels abolishes their activation by hypoosmotic stretch but does not affect activation by diacylglycerol or G protein signaling cascades","volume":"306","author":"Wilson","year":"2014","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0345","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI106667","article-title":"The dynamics of glomerular ultrafiltration in the rat","volume":"50","author":"Brenner","year":"1971","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0350","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.semnephrol.2012.06.004","article-title":"The challenge and response of podocytes to glomerular hypertension","volume":"32","author":"Endlich","year":"2012","journal-title":"Semin. Nephrol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0355","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tcb.2007.06.005","article-title":"The SPFH domain-containing proteins: more than lipid raft markers","volume":"17","author":"Browman","year":"2007","journal-title":"Trends Cell Biol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0360","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/modpathol.2011.58","article-title":"New perspectives on the renal slit diaphragm protein podocin","volume":"24","author":"Relle","year":"2011","journal-title":"Mod. Pathol."},{"issue":"22","key":"10.1016\/j.bbadis.2019.04.001_bb0365","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1113\/jphysiol.2013.261180","article-title":"Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity","volume":"591","author":"Moshourab","year":"2013","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0370","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nn1362","article-title":"The MEC-4 DEG\/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals","volume":"8","author":"O'Hagan","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"51","key":"10.1016\/j.bbadis.2019.04.001_bb0375","doi-asserted-by":"crossref","first-page":"53886","DOI":"10.1074\/jbc.M407708200","article-title":"Stomatin modulates gating of acid-sensing ion channels","volume":"279","author":"Price","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.bbadis.2019.04.001_bb0380","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1038\/emboj.2012.203","article-title":"A stomatin dimer modulates the activity of acid-sensing ion channels","volume":"31","author":"Brand","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0385","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1038\/ncomms4520","article-title":"Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch","volume":"5","author":"Poole","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0390","doi-asserted-by":"crossref","unstructured":"Lewis AH, Grandl J. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension. Elife. 2015 4. pii: e12088.","DOI":"10.7554\/eLife.12088"},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0395","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.yexcr.2012.02.025","article-title":"Mesangial cell biology","volume":"318","author":"Abboud","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0400","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1681\/ASN.2007040471","article-title":"How do mesangial and endothelial cells form the glomerular tuft?","volume":"19","author":"Vaughan","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0405","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0026-895X(25)13455-X","article-title":"Calcium channel current in cultured rat mesangial cells","volume":"43","author":"Nishio","year":"1993","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0410","doi-asserted-by":"crossref","first-page":"F97","DOI":"10.1152\/ajprenal.2000.278.1.F97","article-title":"Dihydropyridine-sensitive Ca2+ channels in human glomerular mesangial cells","volume":"278","author":"Hall","year":"2000","journal-title":"Am J Physiol Renal Physiol."},{"issue":"10 Suppl","key":"10.1016\/j.bbadis.2019.04.001_bb0415","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1681\/ASN.V210s185","article-title":"Growth factors and the mesangium","volume":"2","author":"Abboud","year":"1992","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0420","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/ki.1996.229","article-title":"Roles of the mesangium in glomerular function","volume":"49","author":"Schl\u00f6ndorff","year":"1996","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0425","first-page":"231","article-title":"Crosstalk in glomerular injury and repair","volume":"24","author":"Dimke","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0430","doi-asserted-by":"crossref","first-page":"F1507","DOI":"10.1152\/ajprenal.00268.2005","article-title":"Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells","volume":"290","author":"Sours","year":"2006","journal-title":"Am J Physiol Renal Physiol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0435","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098777","article-title":"Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3\/6 channels in cultured human mesangial cells","volume":"9","author":"Meng","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0440","doi-asserted-by":"crossref","first-page":"F1381","DOI":"10.1152\/ajprenal.00185.2007","article-title":"Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes","volume":"293","author":"Graham","year":"2007","journal-title":"Am J Physiol Renal Physiol."},{"issue":"22","key":"10.1016\/j.bbadis.2019.04.001_bb0445","doi-asserted-by":"crossref","first-page":"19439","DOI":"10.1074\/jbc.M110.210294","article-title":"cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1\/2 signaling pathway","volume":"286","author":"Shen","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0450","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.bbrc.2012.04.075","article-title":"The upregulation of TRPC6 contributes to Ca2+ signaling and actin assembly in human mesangial cells after chronic hypoxia","volume":"421","author":"Liao","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0455","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10238-013-0232-y","article-title":"Ang II-induced glomerular mesangial cell proliferation inhibited by losartan via changes in intracellular calcium ion concentration","volume":"14","author":"Qiu","year":"2014","journal-title":"Clin. Exp. Med."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0460","doi-asserted-by":"crossref","first-page":"C304","DOI":"10.1152\/ajpcell.00014.2011","article-title":"Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes","volume":"301","author":"Graham","year":"2011","journal-title":"Am J Physiol Cell Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0465","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1038\/s41598-017-04067-z","article-title":"Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"18","key":"10.1016\/j.bbadis.2019.04.001_bb0470","doi-asserted-by":"crossref","first-page":"12852","DOI":"10.1074\/jbc.M112.410357","article-title":"Nuclear factor \u03baB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cells","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0475","doi-asserted-by":"crossref","first-page":"F1241","DOI":"10.1152\/ajprenal.00376.2005","article-title":"Identification and localization of TRPC channels in the rat kidney","volume":"290","author":"Goel","year":"2006","journal-title":"Am J Physiol Renal Physiol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0480","doi-asserted-by":"crossref","first-page":"F1476","DOI":"10.1152\/ajprenal.00186.2007","article-title":"Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct","volume":"293","author":"Goel","year":"2007","journal-title":"Am J Physiol Renal Physiol."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0485","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1097\/CCM.0000000000000542","article-title":"Recombinant human erythropoietin pretreatment attenuates acute renal tubular injury against ischemia-reperfusion by restoring transient receptor potential channel-6 expression and function in collecting ducts","volume":"42","author":"Shen","year":"2014","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0490","doi-asserted-by":"crossref","unstructured":"Ramkumar N, Gao Y, Kohan DE. Characterization of flow-regulated cortical collecting duct endothelin-1 production. Physiol Rep. 2017 5(4). pii: e13126.","DOI":"10.14814\/phy2.13126"},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0495","doi-asserted-by":"crossref","first-page":"F212","DOI":"10.1152\/ajprenal.00244.2007","article-title":"Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+\/Ca2+ exchange","volume":"294","author":"Fellner","year":"2008","journal-title":"Am J Physiol Renal Physiol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0500","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1748-1716.2010.02141.x","article-title":"Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels","volume":"200","author":"Salomonsson","year":"2010","journal-title":"Acta Physiol (Oxf)."},{"issue":"47","key":"10.1016\/j.bbadis.2019.04.001_bb0505","doi-asserted-by":"crossref","first-page":"E6486","DOI":"10.1073\/pnas.1518966112","article-title":"TRPC6 channel translocation into phagosomal membrane augments phagosomal function","volume":"112","author":"Riazanski","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0510","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.devcel.2012.08.017","article-title":"A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo","volume":"23","author":"Davis","year":"2012","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0515","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrneph.2014.170","article-title":"Dendritic cells and macrophages in the kidney: a spectrum of good and evil","volume":"10","author":"Rogers","year":"2014","journal-title":"Nat Rev Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0520","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5414\/CN107320","article-title":"Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients","volume":"78","author":"B\u00fcscher","year":"2012","journal-title":"Clin. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0525","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2215\/CJN.02690806","article-title":"Recessive NPHS2 (Podocin) mutations are rare in adult-onset idiopathic focal segmental glomerulosclerosis","volume":"2","author":"He","year":"2007","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0530","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1681\/ASN.V12122742","article-title":"Prevalence, genetics, and clinical features of patients carrying podocin mutations in steroid-resistant focal segmental glomerulosclerosis","volume":"12","author":"Caridi","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0535","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1681\/ASN.2006091010","article-title":"Induction of TRPC6 channel in acquired forms of proteinuric kidney disease","volume":"18","author":"M\u00f6ller","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0540","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI81061","article-title":"MicroRNA-30 family members regulate calcium\/calcineurin signaling in podocytes","volume":"125","author":"Wu","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0545","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00109-018-1648-3","article-title":"TRPC6 inactivation confers protection in a model of severe nephrosis in rats","volume":"96","author":"Kim","year":"2018","journal-title":"J Mol Med (Berl)."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0550","first-page":"139","article-title":"TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions","volume":"17","author":"Kim","year":"2019","journal-title":"Biochem Biophys Rep."},{"issue":"7773","key":"10.1016\/j.bbadis.2019.04.001_bb0555","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0140-6736(72)91734-5","article-title":"Recurrence of idiopathic nephrotic syndrome after renal transplantation","volume":"2","author":"Hoyer","year":"1972","journal-title":"Lancet."},{"issue":"14","key":"10.1016\/j.bbadis.2019.04.001_bb0560","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJM199604043341402","article-title":"Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis","volume":"334","author":"Savin","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 4","key":"10.1016\/j.bbadis.2019.04.001_bb0565","first-page":"S48","article-title":"Humoral permeability factors in the nephrotic syndrome: a compendium and prospectus","volume":"14","author":"Musante","year":"2001","journal-title":"J Nephrol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0570","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s40620-016-0272-y","article-title":"Focal segmental glomerular sclerosis: do not overlook the role of immune response","volume":"29","author":"Reggiani","year":"2016","journal-title":"J Nephrol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0575","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.2411","article-title":"Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis","volume":"17","author":"Wei","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0580","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2068691","article-title":"Soluble urokinase receptors in focal segmental glomerulosclerosis: a review on the scientific point of view","volume":"2016","author":"Kronbichler","year":"2016","journal-title":"J Immunol Res"},{"issue":"20","key":"10.1016\/j.bbadis.2019.04.001_bb0585","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1056\/NEJMoa1506362","article-title":"Soluble urokinase receptor and chronic kidney disease","volume":"373","author":"Hayek","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0590","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2017.2914","article-title":"ESCAPE Trial Consortium and the 4C Study Group. Association of serum soluble urokinase receptor levels with progression of kidney disease in children","volume":"171","author":"Schaefer","year":"2017","journal-title":"JAMA Pediatr."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0595","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1600-6143.2009.02550.x","article-title":"Successful anti-TNFalpha treatment in a child with posttransplant recurrent focal segmental glomerulosclerosis","volume":"9","author":"Leroy","year":"2009","journal-title":"Am. J. Transplant."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0600","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1007\/s00467-012-2163-3","article-title":"TNF\u03b1 pathway blockade ameliorates toxic effects of FSGS plasma on podocyte cytoskeleton and \u03b23 integrin activation","volume":"27","author":"Bitzan","year":"2012","journal-title":"Pediatr. Nephrol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0605","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00467-003-1122-4","article-title":"Tumor necrosis factor-alpha production from mononuclear cells in nephrotic syndrome","volume":"18","author":"Bakr","year":"2003","journal-title":"Pediatr. Nephrol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0610","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0272-6386(12)80742-6","article-title":"Elevated levels of tumor necrosis factor-alpha in the nephrotic syndrome in humans","volume":"21","author":"Suranyi","year":"1993","journal-title":"Am. J. Kidney Dis."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0615","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00467-015-3082-x","article-title":"The glomerular permeability factors in idiopathic nephrotic syndrome","volume":"31","author":"Davin","year":"2016","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0620","doi-asserted-by":"crossref","unstructured":"Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, DiBartolo S, H\u00e4gele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein JB, Sever S, Shattil SJ, Arnaout MA, Reiser J. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 Feb 7. pii: 124793.","DOI":"10.1172\/JCI124793"},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0625","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0022-3476(86)80876-9","article-title":"Role of respiratory viruses in exacerbations of primary nephrotic syndrome","volume":"108","author":"MacDonald","year":"1986","journal-title":"J. Pediatr."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0630","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2215\/CJN.01850310","article-title":"Daily corticosteroids reduce infection-associated relapses in frequently relapsing nephrotic syndrome: a randomized controlled trial","volume":"6","author":"Gulati","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0635","doi-asserted-by":"crossref","unstructured":"Kim EY, Roshanravan H, Dryer SE. Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: an essential role for integrin signaling. Biochim. Biophys. Acta 2015 1853(10 Pt A):2610\u201320.","DOI":"10.1016\/j.bbamcr.2015.07.011"},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0640","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1172\/JCI85939","article-title":"Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury","volume":"126","author":"Pedigo","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0645","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2174\/187152010794728639","article-title":"Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation","volume":"10","author":"Mas-Moruno","year":"2010","journal-title":"Anti Cancer Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0650","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI123386","article-title":"Nonimmune cell-derived ICOS ligand functions as a renoprotective \u03b1v\u03b23 integrin-selective antagonist","volume":"129","author":"Koh","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0655","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.4049\/jimmunol.173.2.1313","article-title":"TNF-induced beta2 integrin activation involves Src kinases and a redox-regulated activation of p38 MAPK","volume":"173","author":"Bouaouina","year":"2004","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0660","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1096\/fj.12-225771","article-title":"Endothelial cell adhesion to soluble vascular endothelial growth factor receptor-1 triggers a cell dynamic and angiogenic phenotype","volume":"28","author":"Orecchia","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0665","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1681\/ASN.V1281589","article-title":"The glomerular epithelial cell anti-adhesin podocalyxin associated with the actin cytoskeleton through interactions with ezrin","volume":"12","author":"Orlando","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0670","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1681\/ASN.2010050522","article-title":"TRPC6 enhances angiotensin II-induced albuminuria","volume":"22","author":"Eckel","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0675","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012859","article-title":"Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease","volume":"5","author":"Krall","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0680","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI76767","article-title":"Gq signaling causes glomerular injury by activating TRPC6","volume":"125","author":"Wang","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0685","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.ajpath.2011.06.033","article-title":"Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway","volume":"179","author":"Nijenhuis","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb0690","doi-asserted-by":"crossref","first-page":"C558","DOI":"10.1152\/ajpcell.00077.2008","article-title":"TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription","volume":"296","author":"Schl\u00f6ndorff","year":"2009","journal-title":"Am J Physiol Cell Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0695","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.ajpath.2012.12.011","article-title":"Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease","volume":"182","author":"Sonneveld","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0700","doi-asserted-by":"crossref","first-page":"F1442","DOI":"10.1152\/ajprenal.00212.2013","article-title":"Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity","volume":"306","author":"Hall","year":"2014","journal-title":"Am J Physiol Renal Physiol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0705","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1681\/ASN.2015080885","article-title":"Sildenafil prevents podocyte injury via PPAR-\u03b3-mediated TRPC6 inhibition","volume":"28","author":"Sonneveld","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0710","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13059-017-1237-8","article-title":"CRISPR\/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion","volume":"18","author":"Mou","year":"2017","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0715","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13059-018-1532-z","article-title":"CRISPR-induced exon skipping is dependent on premature termination codon mutations","volume":"19","author":"Sui","year":"2018","journal-title":"Genome Biol."},{"issue":"16","key":"10.1016\/j.bbadis.2019.04.001_bb0720","doi-asserted-by":"crossref","first-page":"6980","DOI":"10.1128\/MCB.25.16.6980-6989.2005","article-title":"Increased vascular smooth muscle contractility in TRPC6\u2212\/\u2212 mice","volume":"25","author":"Dietrich","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0725","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.kint.2016.09.039","article-title":"Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho","volume":"91","author":"Wu","year":"2017","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0730","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bbamcr.2013.02.031","article-title":"High glucose induces podocyte apoptosis by stimulating TRPC6 via elevation of reactive oxygen species","volume":"1833","author":"Liu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0735","doi-asserted-by":"crossref","unstructured":"Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A. A NOX4\/TRPC6 pathway in podocyte calcium regulation and renal damage in diabetic kidney disease. J. Am. Soc. Nephrol. 2018 29(7):1917-1927.","DOI":"10.1681\/ASN.2018030280"},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0740","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.ajpath.2014.02.008","article-title":"Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner","volume":"184","author":"Sonneveld","year":"2014","journal-title":"Am. J. Pathol."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2019.04.001_bb0745","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11010-014-2242-9","article-title":"The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats","volume":"399","author":"Zhang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0750","first-page":"14063","article-title":"FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression","volume":"8","author":"Ma","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0755","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.3892\/mmr.2016.5167","article-title":"Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6","volume":"13","author":"Yao","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0760","doi-asserted-by":"crossref","first-page":"F1091","DOI":"10.1152\/ajprenal.00155.2018","article-title":"Protective role of Trpc6 knockout in the progression of diabetic kidney disease","volume":"315","author":"Spires","year":"2018","journal-title":"Am J Physiol Renal Physiol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0765","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJM198407123110204","article-title":"Predicting diabetic nephropathy in insulin-dependent patients","volume":"311","author":"Mogensen","year":"1984","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0770","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1139\/y92-152","article-title":"Increased microalbuminuria in diabetic rats is independent of angiotensin II or glomerular proteoglycan synthesis","volume":"70","author":"Whiteside","year":"1992","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0775","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.kint.2018.09.026","article-title":"Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice","volume":"95","author":"Wang","year":"2019","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0780","first-page":"5619","article-title":"Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGF\u03b21 signaling pathway","volume":"9","author":"Liu","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0785","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1159\/000438658","article-title":"Insulin increases expression of TRPC6 channels in podocytes by a calcineurin-dependent pathway","volume":"38","author":"Xia","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0790","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.bbadis.2017.03.002","article-title":"Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGI\u03b1 signaling pathways","volume":"1863","author":"Rogacka","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0795","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1681\/ASN.V10122569","article-title":"Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption","volume":"10","author":"Vallon","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0800","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1748-1716.2010.02147.x","article-title":"Tubular reabsorption and diabetes-induced glomerular hyperfiltration","volume":"200","author":"Persson","year":"2010","journal-title":"Acta Physiol (Oxf)."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0805","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00125-016-4157-3","article-title":"Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition","volume":"60","author":"Vallon","year":"2017","journal-title":"Diabetologia."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0810","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.4049\/jimmunol.1201502","article-title":"TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils","volume":"190","author":"Lindemann","year":"2013","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0815","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1074\/jbc.M608288200","article-title":"Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin","volume":"282","author":"Singh","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0820","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1084\/jem.20150353","article-title":"TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response","volume":"212","author":"Weber","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0825","doi-asserted-by":"crossref","unstructured":"Xie J, Cha SK, An SW, Kuro-O M, Birnbaumer L, Huang CL. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat. Commun. 2012 3:1238.","DOI":"10.1038\/ncomms2240"},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0830","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1681\/ASN.2015080888","article-title":"Klotho may ameliorate proteinuria by targeting TRPC6 channels in podocytes","volume":"28","author":"Kim","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0835","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.3024","article-title":"Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus","volume":"19","author":"Devi","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0840","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1159\/000495236","article-title":"The TRPC6-AMPK pathway is involved in insulin-dependent cytoskeleton reorganization and glucose uptake in cultured rat podocytes","volume":"51","author":"Rachubik","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"51","key":"10.1016\/j.bbadis.2019.04.001_bb0845","doi-asserted-by":"crossref","first-page":"36598","DOI":"10.1074\/jbc.M113.488122","article-title":"Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease","volume":"288","author":"Kistler","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0850","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","article-title":"Calcineurin: form and function","volume":"80","author":"Rusnak","year":"2000","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0855","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.76.12.6270","article-title":"Calcineurin: a calcium- and calmodulin-binding protein of the nervous system","volume":"76","author":"Klee","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb0860","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nri1632","article-title":"NFAT proteins: key regulators of T-cell development and function","volume":"5","author":"Macian","year":"2005","journal-title":"Nat Rev Immunol."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0865","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri2818","article-title":"NFAT, immunity and cancer: a transcription factor comes of age","volume":"10","author":"M\u00fcller","year":"2010","journal-title":"Nat Rev Immunol."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0870","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","article-title":"The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A","volume":"14","author":"Faul","year":"2008","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0875","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncb1400","article-title":"Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling","volume":"8","author":"Asanuma","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.bbadis.2019.04.001_bb0880","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s00467-010-1468-3","article-title":"Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations","volume":"25","author":"Gellermann","year":"2010","journal-title":"Pediatr. Nephrol."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0885","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00467-009-1211-0","article-title":"Partial remission with cyclosporine A in a patient with nephrotic syndrome due to NPHS2 mutation","volume":"24","author":"Malina","year":"2009","journal-title":"Pediatr. Nephrol."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0890","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1681\/ASN.2015080896","article-title":"Synaptopodin limits TRPC6 podocyte surface expression and attenuates proteinuria","volume":"27","author":"Yu","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0895","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tcb.2010.09.011","article-title":"Interaction of calcineurin with substrates and targeting proteins","volume":"21","author":"Li","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0900","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biochi.2017.09.002","article-title":"Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif","volume":"142","author":"Song","year":"2017","journal-title":"Biochimie."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0905","doi-asserted-by":"crossref","DOI":"10.1038\/srep38920","article-title":"Investigating the human calcineurin interaction network using the \u03c0\u0278LxVP SLiM","volume":"6","author":"Sheftic","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0910","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1681\/ASN.2016111248","article-title":"The calcium-dependent protease calpain-1 links TRPC6 activity to podocyte injury","volume":"29","author":"Verheijden","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb0915","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000455985","article-title":"Inhibition of TRPC6 signal pathway alleviates podocyte injury induced by TGF-\u03b21","volume":"41","author":"Huang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0920","doi-asserted-by":"crossref","DOI":"10.1038\/srep29041","article-title":"TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin\/NFAT and FasL\/Fas signaling pathways","volume":"6","author":"Soni","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb0925","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1159\/000492351","article-title":"TRPC6-mediated Ca2+ signaling is required for hypoxia-induced autophagy in human podocytes","volume":"48","author":"Ji","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0930","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1113\/jphysiol.2004.075051","article-title":"Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells","volume":"561","author":"Shi","year":"2004","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb0935","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuint.2009.11.009","article-title":"(2010) The interactions of the C-terminal region of the TRPC6 channel with calmodulin","volume":"56","author":"Friedlova","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0940","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00424-005-1427-1","article-title":"Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels","volume":"451","author":"Zhu","year":"2005","journal-title":"Pflugers Arch."},{"issue":"24","key":"10.1016\/j.bbadis.2019.04.001_bb0945","doi-asserted-by":"crossref","first-page":"21303","DOI":"10.1074\/jbc.M102316200","article-title":"Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels","volume":"276","author":"Tang","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb0950","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062677","article-title":"Characterization of the S100A1 protein binding site on TRPC6 C-terminus","volume":"8","author":"Bily","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.04.001_bb0955","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2007.01.021","article-title":"Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6","volume":"25","author":"Kwon","year":"2007","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0960","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1073\/pnas.1600371113","article-title":"Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation","volume":"113","author":"Chaudhuri","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb0965","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1113\/jphysiol.2013.251249","article-title":"Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+\/calmodulin-dependent kinase II","volume":"591","author":"Shi","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb0970","doi-asserted-by":"crossref","unstructured":"Estacion M, Sinkins WG, Jones SW, Applegate MA, Schilling WP. Human TRPC6 expressed in HEK 293 cells forms non-selective cation channels with limited Ca2+ permeability. J. Physiol. 2006 572(Pt 2):359-77.","DOI":"10.1113\/jphysiol.2005.103143"},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0975","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1097\/01.ASN.0000145046.24268.0D","article-title":"Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration","volume":"15","author":"Morton","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"issue":"9","key":"10.1016\/j.bbadis.2019.04.001_bb0980","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/jcp.22567","article-title":"Effects of insulin and high glucose on mobilization of Slo1 BKCa channels in podocytes","volume":"226","author":"Kim","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb0985","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.bbadis.2015.04.024","article-title":"Insulin increases glomerular filtration barrier permeability through PKGI\u03b1-dependent mobilization of BKCa channels in cultured rat podocytes","volume":"1852","author":"Piwkowska","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb0990","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/ndt\/17.10.1742","article-title":"Characterization of a Na+-Ca2+ exchanger in podocytes","volume":"17","author":"Fischer","year":"2002","journal-title":"Nephrol. Dial. Transplant."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb0995","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1172\/JCI71165","article-title":"Inhibition of the TRPC5 ion channel protects the kidney filter","volume":"123","author":"Schaldecker","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"6368","key":"10.1016\/j.bbadis.2019.04.001_bb1000","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1126\/science.aal4178","article-title":"A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models","volume":"358","author":"Zhou","year":"2017","journal-title":"Science."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb1005","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/01.ASN.0000127988.42710.A7","article-title":"Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats","volume":"15","author":"Hoffmann","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb1010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1681\/ASN.2017060682","article-title":"TRPC5 does not cause or aggravate glomerular disease","volume":"29","author":"Wang","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb1015","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1002\/anie.201411511","article-title":"Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels","volume":"54","author":"Akbulut","year":"2015","journal-title":"Angew Chem Int Ed Engl."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb1020","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/bph.14128","article-title":"Identification of an (\u2212)-englerin A analogue, which antagonizes (\u2212)-englerin A at TRPC1\/4\/5 channels","volume":"175","author":"Rubaiy","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"51","key":"10.1016\/j.bbadis.2019.04.001_bb1025","doi-asserted-by":"crossref","first-page":"29634","DOI":"10.18632\/oncotarget.25659","article-title":"TRPC4\/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (\u2212)-Englerin A","volume":"9","author":"Cheung","year":"2018","journal-title":"Oncotarget."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb1030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/annrheumdis-2015-208886","article-title":"Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation","volume":"76","author":"Alawi","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.bbadis.2019.04.001_bb1035","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1091\/mbc.e07-08-0765","article-title":"Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement","volume":"19","author":"Chaudhuri","year":"2008","journal-title":"Mol. Biol. Cell"},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb1040","doi-asserted-by":"crossref","first-page":"C541","DOI":"10.1152\/ajpcell.00028.2017","article-title":"Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization","volume":"313","author":"Chaudhuri","year":"2017","journal-title":"Am J Physiol Cell Physiol."},{"issue":"23","key":"10.1016\/j.bbadis.2019.04.001_bb1045","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1113\/jphysiol.2008.161257","article-title":"Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels","volume":"586","author":"Gomis","year":"2008","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb1050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122227","article-title":"Plasma membrane mechanical stress activates TRPC5 channels","volume":"10","author":"Shen","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bbadis.2019.04.001_bb1055","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nchembio821","article-title":"Nitric oxide activates TRP channels by cysteine S-nitrosylation","volume":"2","author":"Yoshida","year":"2006","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.001_bb1060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1085\/jgp.200810153","article-title":"Intracellular calcium strongly potentiates agonist-activated TRPC5 channels","volume":"133","author":"Blair","year":"2009","journal-title":"J Gen Physiol."},{"issue":"49","key":"10.1016\/j.bbadis.2019.04.001_bb1065","doi-asserted-by":"crossref","first-page":"34423","DOI":"10.1074\/jbc.M109.018192","article-title":"TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels","volume":"284","author":"Gross","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2019.04.001_bb1070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1113\/jphysiol.2005.097998","article-title":"Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells","volume":"570","author":"Shimizu","year":"2006","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb1075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb1080","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/jcp.24883","article-title":"Phospholipase C epsilon (PLC\u03b5) induced TRPC6 activation: a common but redundant mechanism in primary podocytes","volume":"230","author":"Kalwa","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2019.04.001_bb1085","doi-asserted-by":"crossref","unstructured":"Storch U, Forst AL, Pardatscher F, Erdogmus S, Philipp M, Gregoritza M, Mederos Y Schnitzler M, Gudermann T. Dynamic NHERF interaction with TRPC4\/5 proteins is required for channel gating by diacylglycerol. Proc. Natl. Acad. Sci. U S A. 2017 114(1):E37-E46.","DOI":"10.1073\/pnas.1612263114"},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb1090","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s10157-003-0257-8","article-title":"Podocyte cytoskeleton is connected to the integral membrane protein podocalyxin through Na+\/H+-exchanger regulatory factor 2 and ezrin","volume":"7","author":"Takeda","year":"2003","journal-title":"Clin. Exp. Nephrol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb1095","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ceca.2012.01.001","article-title":"Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction","volume":"51","author":"Urban","year":"2012","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.001_bb1100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/bph.12274","article-title":"In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels \u2014 mirage or pot of gold?","volume":"170","author":"Bon","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb1105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/mol.115.100792","article-title":"Identification and validation of larixyl acetate as a potent TRPC6 inhibitor","volume":"89","author":"Urban","year":"2016","journal-title":"Mol. Pharmacol."},{"issue":"22","key":"10.1016\/j.bbadis.2019.04.001_bb1110","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1111\/bph.13977","article-title":"Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol","volume":"174","author":"Urban","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbadis.2019.04.001_bb1115","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/cmdc.201800021","article-title":"A (+)-larixol congener with high affinity and subtype selectivity toward TRPC6","volume":"13","author":"H\u00e4fner","year":"2018","journal-title":"ChemMedChem."},{"issue":"14","key":"10.1016\/j.bbadis.2019.04.001_bb1120","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1111\/bph.13151","article-title":"Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels","volume":"172","author":"Maier","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb1125","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.bbrc.2011.12.058","article-title":"Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis","volume":"417","author":"Paez Espinosa","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2019.04.001_bb1130","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbr.2015.04.054","article-title":"The possible relationship between expressions of TRPC3\/5 channels and cognitive changes in rat model of chronic unpredictable stress","volume":"290","author":"Qin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbadis.2019.04.001_bb1135","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbr.2015.07.062","article-title":"The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6","volume":"294","author":"Liu","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"18","key":"10.1016\/j.bbadis.2019.04.001_bb1140","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.15252\/embj.201696369","article-title":"Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory","volume":"36","author":"Br\u00f6ker-Lai","year":"2017","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb1145","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm1696","article-title":"Modification of kidney barrier function by the urokinase receptor","volume":"14","author":"Wei","year":"2008","journal-title":"Nat. Med."},{"issue":"13","key":"10.1016\/j.bbadis.2019.04.001_bb1150","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1200\/JCO.2006.06.6514","article-title":"Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma","volume":"25","author":"Nabors","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.001_bb1155","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11060-014-1365-x","article-title":"Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression","volume":"117","author":"Eisele","year":"2014","journal-title":"J. Neuro-Oncol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.001_bb1160","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/labinvest.2017.2","article-title":"APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db\/db mice from renal injury","volume":"97","author":"Cha","year":"2017","journal-title":"Lab. Investig."},{"issue":"3\u20134","key":"10.1016\/j.bbadis.2019.04.001_bb1165","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000491398","article-title":"A pan-NADPH oxidase inhibitor ameliorates kidney injury in type 1 diabetic rats","volume":"102","author":"Dorotea","year":"2018","journal-title":"Pharmacology."},{"issue":"12","key":"10.1016\/j.bbadis.2019.04.001_bb1170","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/bph.13551","article-title":"Redox-based therapeutics in neurodegenerative disease","volume":"174","author":"McBean","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.001_bb1175","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1527-3466.2007.00011.x","article-title":"Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders","volume":"25","author":"Yu","year":"2007","journal-title":"Cardiovasc Drug Rev."},{"key":"10.1016\/j.bbadis.2019.04.001_bb1180","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11947","article-title":"TRPC5 channels participate in pressure-sensing in aortic baroreceptors","volume":"7","author":"Lau","year":"2016","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.001_bb1185","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/ncb1590","article-title":"STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels","volume":"9","author":"Yuan","year":"2007","journal-title":"Nat. Cell Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919301127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919301127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:45:20Z","timestamp":1760417120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919301127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":237,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0925443919301127"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.04.001","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}