{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:28:06Z","timestamp":1769149686091,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbadis.2019.04.005","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T18:37:58Z","timestamp":1554403078000},"page":"1677-1689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reduction of SIRT1 blunts the protective effects of ischemic post-conditioning in diabetic mice by impairing the Akt signaling pathway"],"prefix":"10.1016","volume":"1865","author":[{"given":"Mingge","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-4628","authenticated-orcid":false,"given":"Feng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.005_bb0010","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1002\/j.2040-4603.2015.tb00650.x","article-title":"Treatment of myocardial ischemia\/reperfusion injury by ischemic and pharmacological postconditioning","volume":"5","author":"Heusch","year":"2015","journal-title":"Compr. Physiol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.04.005_bb0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1042\/CS20100369","article-title":"Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans","volume":"120","author":"Fan","year":"2011","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.005_bb0020","doi-asserted-by":"crossref","first-page":"H579","DOI":"10.1152\/ajpheart.01064.2002","article-title":"Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning","volume":"285","author":"Zhao","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2019.04.005_bb0025","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijcard.2014.10.097","article-title":"The cardioprotection of ischemic postconditioning in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"178","author":"Liu","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.005_bb0030","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.RES.0000138303.76488.fe","article-title":"Postconditioning: a form of \u201cmodified reperfusion\u201d protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway","volume":"95","author":"Tsang","year":"2004","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s00395-014-0452-7","article-title":"Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning","volume":"110","author":"Barsukevich","year":"2015","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0040","first-page":"33","article-title":"Myocardial postconditioning: anaesthetic considerations","volume":"81","author":"Luna-Ortiz","year":"2011","journal-title":"Arch. Cardiol. Mex."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.005_bb0045","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/ars.2010.3318","article-title":"Ischemic postconditioning: from receptor to end-effector","volume":"14","author":"Cohen","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.005_bb0050","doi-asserted-by":"crossref","first-page":"H1580","DOI":"10.1152\/ajpheart.00379.2008","article-title":"Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob\/ob mice","volume":"295","author":"Bouhidel","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.005_bb0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2010.3343","article-title":"Cardioprotection with postconditioning: loss of efficacy in murine models of type-2 and type-1 diabetes","volume":"14","author":"Przyklenk","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijcard.2012.03.136","article-title":"Postconditioning during coronary angioplasty in acute myocardial infarction: the POST-AMI trial","volume":"162","author":"Tarantini","year":"2012","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.005_bb0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00395-014-0403-3","article-title":"Impact of multiple balloon inflations during primary percutaneous coronary intervention on infarct size and long-term clinical outcomes in ST-segment elevation myocardial infarction: real-world postconditioning","volume":"109","author":"Yetgin","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2019.04.005_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/198048","article-title":"Diabetic inhibition of preconditioning- and postconditioning-mediated myocardial protection against ischemia\/reperfusion injury","volume":"2012","author":"Yin","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.bbadis.2019.04.005_bb0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2015.12.020","article-title":"Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus","volume":"91","author":"Lejay","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/2045-3701-4-59","article-title":"Posttranslational regulation of Akt in human cancer","volume":"4","author":"Chan","year":"2014","journal-title":"Cell. Biosci."},{"key":"10.1016\/j.bbadis.2019.04.005_bb0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12933-015-0299-8","article-title":"SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats","volume":"14","author":"Ding","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2019.04.005_bb0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2015.10.126","article-title":"Effect of resveratrol on sirtuins expression and cardiac complications in diabetes","volume":"468","author":"Bagul","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.005_bb0095","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12491","article-title":"Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway","volume":"65","author":"Ding","year":"2018","journal-title":"J. Pineal Res."},{"issue":"182","key":"10.1016\/j.bbadis.2019.04.005_bb0100","doi-asserted-by":"crossref","first-page":"a46","DOI":"10.1126\/scisignal.2001465","article-title":"The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy","volume":"4","author":"Sundaresan","year":"2011","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12933-017-0501-2","article-title":"Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice","volume":"16","author":"Ding","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.005_bb0110","doi-asserted-by":"crossref","first-page":"942","DOI":"10.2337\/db15-0782","article-title":"Hyperglycemia abrogates ischemic postconditioning cardioprotection by impairing AdipoR1\/Caveolin-3\/STAT3 signaling in diabetic rats","volume":"65","author":"Li","year":"2016","journal-title":"Diabetes."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12447","article-title":"Dynamin-related protein 1-mediated mitochondrial fission contributes to post-traumatic cardiac dysfunction in rats and the protective effect of melatonin","volume":"64","author":"Ding","year":"2018","journal-title":"J. Pineal Res."},{"issue":"15","key":"10.1016\/j.bbadis.2019.04.005_bb0120","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1042\/CS20180510","article-title":"Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia\/reperfusion injury","volume":"132","author":"Maneechote","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/apha.12812","article-title":"High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects","volume":"220","author":"Yu","year":"2017","journal-title":"Acta. Physiol. (Oxford)"},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1142\/S0192415X14500062","article-title":"Semen cassiae attenuates myocardial ischemia and reperfusion injury in high-fat diet streptozotocin-induced type 2 diabetic rats","volume":"42","author":"Fu","year":"2014","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12576-012-0228-5","article-title":"Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart","volume":"63","author":"Li","year":"2013","journal-title":"J. Physiol. Sci."},{"issue":"35","key":"10.1016\/j.bbadis.2019.04.005_bb0140","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1200\/JCO.2011.35.5263","article-title":"First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors","volume":"29","author":"Yap","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2019.04.005_bb0145","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cca.2014.10.036","article-title":"SIRT1: role in cardiovascular biology","volume":"440","author":"Ma","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"21","key":"10.1016\/j.bbadis.2019.04.005_bb0150","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.005_bb0155","doi-asserted-by":"crossref","first-page":"H1506","DOI":"10.1152\/ajpheart.00587.2011","article-title":"SIRT1-mediated acute cardioprotection","volume":"301","author":"Nadtochiy","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.005_bb0160","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/cvr\/cvq287","article-title":"Lysine deacetylation in ischaemic preconditioning: the role of SIRT1","volume":"89","author":"Nadtochiy","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0165","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/1074248412458723","article-title":"Loss of cardioprotection with ischemic preconditioning in aging hearts: role of sirtuin 1?","volume":"18","author":"Adam","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210654","article-title":"Activation of AMPK\/SIRT1 axis is required for adiponectin-mediated preconditioning on myocardial ischemia-reperfusion (I\/R) injury in rats","volume":"14","author":"Potenza","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.005_bb0175","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","article-title":"Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning","volume":"116","author":"Heusch","year":"2015","journal-title":"Circ. Res."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2019.04.005_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-014-2014-6","article-title":"Ischemic postconditioning: mechanisms, comorbidities, and clinical application","volume":"392","author":"Buchholz","year":"2014","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.bbadis.2019.04.005_bb0185","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/bja\/aeu302","article-title":"Ischaemic conditioning strategies reduce ischaemia\/reperfusion-induced organ injury","volume":"114","author":"Pac-Soo","year":"2015","journal-title":"Br. J. Anaesth."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.005_bb0190","doi-asserted-by":"crossref","first-page":"E614","DOI":"10.3390\/ijms18030614","article-title":"Myocardial ischemic postconditioning promotes autophagy against ischemia reperfusion injury via the activation of the nNOS\/AMPK\/mTOR pathway","volume":"18","author":"Hao","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0195","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cardiores.2006.06.027","article-title":"Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB\/Akt reperfusion injury salvage kinase pathway","volume":"72","author":"Zhu","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.bbadis.2019.04.005_bb0200","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1582-4934.2011.01376.x","article-title":"Type 2 diabetic obese db\/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase delta and Echs1","volume":"16","author":"Zhu","year":"2012","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.005_bb0205","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/CS20150496","article-title":"Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K\/Akt and JAK2\/STAT3 pathways","volume":"130","author":"Xue","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"issue":"17","key":"10.1016\/j.bbadis.2019.04.005_bb0210","doi-asserted-by":"crossref","first-page":"6908","DOI":"10.1158\/0008-5472.CAN-08-1107","article-title":"PTEN acetylation modulates its interaction with PDZ domain","volume":"68","author":"Ikenoue","year":"2008","journal-title":"Cancer. Res."},{"issue":"3","key":"10.1016\/j.bbadis.2019.04.005_bb0215","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","article-title":"New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway","volume":"61","author":"Hausenloy","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.bbadis.2019.04.005_bb0220","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00395-007-0664-1","article-title":"Postconditioning protects human atrial muscle through the activation of the RISK pathway","volume":"102","author":"Sivaraman","year":"2007","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.04.005_bb0225","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/CIRCRESAHA.108.186429","article-title":"Ischemic postconditioning in pigs: no causal role for RISK activation","volume":"104","author":"Skyschally","year":"2009","journal-title":"Circ. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919301164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919301164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:50:11Z","timestamp":1760417411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919301164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0925443919301164"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.04.005","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction of SIRT1 blunts the protective effects of ischemic post-conditioning in diabetic mice by impairing the Akt signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}