{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:41:06Z","timestamp":1790372466390,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["81722040"],"award-info":[{"award-number":["81722040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770626"],"award-info":[{"award-number":["81770626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573174"],"award-info":[{"award-number":["81573174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570574"],"award-info":[{"award-number":["81570574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai","award":["PWZzk2017-10"],"award-info":[{"award-number":["PWZzk2017-10"]}]},{"DOI":"10.13039\/501100002949","name":"Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2014010296"],"award-info":[{"award-number":["SBK2014010296"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of China","doi-asserted-by":"publisher","award":["213015A"],"award-info":[{"award-number":["213015A"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Flagship Major Development of Jiangsu Higher Education Institutions"},{"DOI":"10.13039\/501100011329","name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology","doi-asserted-by":"publisher","award":["KF2015-01"],"award-info":[{"award-number":["KF2015-01"]}],"id":[{"id":"10.13039\/501100011329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.bbadis.2019.06.016","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T02:34:39Z","timestamp":1561516479000},"page":"2576-2585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["FMO3 and its metabolite TMAO contribute to the formation of gallstones"],"prefix":"10.1016","volume":"1865","author":[{"given":"Yaoyao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkun","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaobo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11\u221212","key":"10.1016\/j.bbadis.2019.06.016_bb0005","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.nut.2015.05.006","article-title":"TMAO: a small molecule of great expectations[J]","volume":"31","author":"Ufnal","year":"2015","journal-title":"Nutrition"},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0010","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis[J]","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00008571-200402000-00006","article-title":"Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters[J]","volume":"14","author":"Hernandez","year":"2004","journal-title":"Pharmacogenetics"},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.pharmthera.2005.01.001","article-title":"Mammalian flavin-containing monooxygenases: structure\/function, genetic polymorphisms and role in drug metabolism[J]","volume":"106","author":"Krueger","year":"2005","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2012.12.011","article-title":"Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation[J]","volume":"17","author":"Bennett","year":"2013","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.bbadis.2019.06.016_bb0030","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.celrep.2017.05.077","article-title":"The TMAO-producing enzyme Flavin-containing monooxygenase 3 regulates obesity and the Beiging of white adipose tissue[J]","volume":"19","author":"Schugar","year":"2017","journal-title":"Cell Rep."},{"issue":"7341","key":"10.1016\/j.bbadis.2019.06.016_bb0035","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature09922","article-title":"Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease[J]","volume":"472","author":"Wang","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/humu.10252","article-title":"Trimethylaminuria and a human FMO3 mutation database[J]","volume":"22","author":"Hernandez","year":"2003","journal-title":"Hum. Mutat."},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0045","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/MOL.0000000000000215","article-title":"Emerging roles of flavin monooxygenase 3 in cholesterol metabolism and atherosclerosis[J]","volume":"26","author":"Schugar","year":"2015","journal-title":"Curr. Opin. Lipidol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.celrep.2014.12.036","article-title":"The TMAO-generating enzyme Flavin monooxygenase 3 is a central regulator of cholesterol balance[J]","volume":"10","author":"Warrier","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2019.06.016_bb0055","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1038\/ncomms7498","article-title":"Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis[J]","volume":"6","author":"Miao","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0060","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13059-017-1194-2","article-title":"Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort[J]","volume":"18","author":"Org","year":"2017","journal-title":"Genome Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0065","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jhep.2017.04.003","article-title":"Gallstone disease: optimal timing of treatment[J]","volume":"67","author":"Scherber","year":"2017","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15430-5","article-title":"The relation between gallstone disease and cardiovascular disease[J]","volume":"7","author":"Fan","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0075","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.25604","article-title":"Intestinal absorption, hepatic synthesis, and biliary secretion of cholesterol: where are we for cholesterol gallstone formation?[J]","volume":"55","author":"Portincasa","year":"2012","journal-title":"Hepatology"},{"issue":"19\u201320","key":"10.1016\/j.bbadis.2019.06.016_bb0080","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cca.2012.06.015","article-title":"Mucin genes in gallstone disease[J]","volume":"413","author":"Chuang","year":"2012","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/gast.2001.20878","article-title":"Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map[J]","volume":"120","author":"Lammert","year":"2001","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.bbadis.2019.06.016_bb0090","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1111\/j.1365-2982.2012.01935.x","article-title":"Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease[J]","volume":"24","author":"Lavoie","year":"2012","journal-title":"Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society"},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0095","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/j.gastro.2008.12.031","article-title":"Roles of infection, inflammation, and the immune system in cholesterol gallstone formation[J]","volume":"136","author":"Maurer","year":"2009","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0100","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbalip.2004.12.005","article-title":"High cholesterol absorption efficiency and rapid biliary secretion of chylomicron remnant cholesterol enhance cholelithogenesis in gallstone-susceptible mice[J]","volume":"1733","author":"Wang","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.bbadis.2019.06.016_bb0105","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1053\/jhep.2001.24373","article-title":"Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI[J]","volume":"33","author":"Fuchs","year":"2001","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0110","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0016-5085(03)01053-9","article-title":"FXR and ABCG5\/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice[J]","volume":"125","author":"Wittenburg","year":"2003","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.bbadis.2019.06.016_bb0115","first-page":"605","article-title":"[Morphological structure of the hemisection surface and chemical composition of biliary calculi][J]","volume":"167","author":"Fu","year":"1983","journal-title":"Bull. Acad. Natl Med."},{"issue":"12","key":"10.1016\/j.bbadis.2019.06.016_bb0120","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1046\/j.1365-2362.2000.00740.x","article-title":"Biliary lipid composition in patients with cholesterol and pigment gallstones and gallstone-free subjects: deoxycholic acid does not contribute to formation of cholesterol gallstones[J]","volume":"30","author":"Gustafsson","year":"2000","journal-title":"Eur. J. Clin. Investig."},{"issue":"11","key":"10.1016\/j.bbadis.2019.06.016_bb0125","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/S0022-2275(20)32430-5","article-title":"Phenotypic characterization of lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology of biliary lipid secretion[J]","volume":"40","author":"Wang","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbadis.2019.06.016_bb0130","article-title":"Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress[J]","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0135","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1194\/jlr.M500441-JLR200","article-title":"Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice[J]","volume":"47","author":"Wang","year":"2006","journal-title":"J. Lipid Res."},{"issue":"8","key":"10.1016\/j.bbadis.2019.06.016_bb0140","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","article-title":"Critical tables for calculating the cholesterol saturation of native bile[J]","volume":"19","author":"Carey","year":"1978","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0145","first-page":"e268-e76","article-title":"Controversies in odontogenic Tumours: review[J]","volume":"17","author":"Siwach","year":"2017","journal-title":"Sultan Qaboos Univ. Med. J."},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0150","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0022-2275(20)38331-0","article-title":"Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions[J]","volume":"30","author":"Heuman","year":"1989","journal-title":"J. Lipid Res."},{"issue":"7","key":"10.1016\/j.bbadis.2019.06.016_bb0155","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0022-2275(20)37422-8","article-title":"Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile[J]","volume":"38","author":"Wang","year":"1997","journal-title":"J. Lipid Res."},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0160","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/MOG.0000000000000417","article-title":"Mouse models of gallstone disease[J]","volume":"34","author":"Wang","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0165","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.20654","article-title":"Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs[J]","volume":"41","author":"Katsika","year":"2005","journal-title":"Hepatology"},{"issue":"17","key":"10.1016\/j.bbadis.2019.06.016_bb0170","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1073\/pnas.92.17.7729","article-title":"Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice[J]","volume":"92","author":"Khanuja","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bbadis.2019.06.016_bb0175","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/S0022-2275(20)32431-7","article-title":"Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes[J]","volume":"40","author":"Lammert","year":"1999","journal-title":"J. Lipid Res."},{"issue":"9","key":"10.1016\/j.bbadis.2019.06.016_bb0180","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1074\/jbc.M114.618249","article-title":"Transmission of atherosclerosis susceptibility with gut microbial transplantation[J]","volume":"290","author":"Gregory","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MOG.0000000000000423","article-title":"An update on the pathogenesis of cholesterol gallstone disease[J]","volume":"34","author":"Di Ciaula","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"issue":"5","key":"10.1016\/j.bbadis.2019.06.016_bb0190","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI0216001","article-title":"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol[J]","volume":"110","author":"Yu","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbadis.2019.06.016_bb0195","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1194\/jlr.M700295-JLR200","article-title":"Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients[J]","volume":"49","author":"Jiang","year":"2008","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0200","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1194\/jlr.M051680","article-title":"Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis[J]","volume":"56","author":"Shih","year":"2015","journal-title":"J. Lipid Res."},{"issue":"17","key":"10.1016\/j.bbadis.2019.06.016_bb0205","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk[J]","volume":"368","author":"Tang","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.bbadis.2019.06.016_bb0210","first-page":"814","article-title":"Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors[J]","volume":"38","author":"Li","year":"2017","journal-title":"Eur. Heart J."},{"issue":"18","key":"10.1016\/j.bbadis.2019.06.016_bb0215","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.jacc.2014.02.617","article-title":"Fan Y, et al.Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis[J]","volume":"64","author":"Tang","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.bbadis.2019.06.016_bb0220","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/joim.12328","article-title":"Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure[J]","volume":"277","author":"Troseid","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbadis.2019.06.016_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/srep26745","article-title":"Relationship of serum trimethylamine N-oxide (TMAO) levels with early atherosclerosis in humans[J]","volume":"6","author":"Randrianarisoa","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbadis.2019.06.016_bb0230","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/CIRCRESAHA.116.305360","article-title":"Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease[J]","volume":"116","author":"Tang","year":"2015","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2019.06.016_bb0235","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite TMAO enhances platelet Hyperreactivity and thrombosis risk[J]","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.06.016_bb0240","article-title":"Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults[J]","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:47:06Z","timestamp":1760417226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919302157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0925443919302157"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.06.016","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FMO3 and its metabolite TMAO contribute to the formation of gallstones","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}