{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:31:25Z","timestamp":1790767885935,"version":"4.1.0"},"reference-count":157,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.bbadis.2019.165539","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T11:29:04Z","timestamp":1566818944000},"page":"165539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses"],"prefix":"10.1016","volume":"1865","author":[{"given":"Valeria","family":"De Pasquale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Michele","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.165539_bb0005","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/jcs.03432","article-title":"Heparan sulfate proteoglycans at a glance","volume":"120","author":"Kirkpatrick","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0010","doi-asserted-by":"crossref","unstructured":"S. Sarrazin, W.C. Lamanna, J.D. Esko, Heparan sulfate proteoglycans, Cold Spring Harb. Perspect. Biol. 3 (2011) pii: a004952. doi: https:\/\/doi.org\/10.1101\/cshperspect.a004952.","DOI":"10.1101\/cshperspect.a004952"},{"key":"10.1016\/j.bbadis.2019.165539_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: a comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/bs.ircmb.2016.02.009","article-title":"Heparan sulfate: biosynthesis, structure, and function","volume":"325","author":"Li","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0025","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","article-title":"Functions of cell surface heparan sulfate proteoglycans","volume":"68","author":"Bernfield","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0304-4165(02)00390-2","article-title":"The role of glypicans in mammalian development","volume":"1573","author":"Song","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165539_bb0035","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1007\/s00018-009-0096-1","article-title":"Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans","volume":"66","author":"Kirn-Safran","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0040","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/03008207.2015.1045066","article-title":"Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries","volume":"56","author":"Billings","year":"2015","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0045","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cellsig.2018.11.022","article-title":"Heparan sulfate proteoglycan - a common receptor for diverse cytokines","volume":"54","author":"Xie","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2019.165539_bb0050","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1039\/C7OB01058C","article-title":"Targeting heparin and heparan sulfate protein interactions","volume":"15","author":"Weiss","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0055","doi-asserted-by":"crossref","unstructured":"I. Matsuo, C. Kimura-Yoshida, Extracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesis, Philos. Trans. R. Soc. Lond. B Biol. Sci. 369 (2014) pii: 20130545. doi: https:\/\/doi.org\/10.1098\/rstb.2013.0545.","DOI":"10.1098\/rstb.2013.0545"},{"key":"10.1016\/j.bbadis.2019.165539_bb0060","doi-asserted-by":"crossref","first-page":"10826","DOI":"10.1074\/jbc.RA117.000378","article-title":"Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus \u03b1-synuclein and \u03b2-amyloid aggregates","volume":"293","author":"Stopschinski","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0065","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nchembio.2007.41","article-title":"Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate","volume":"3","author":"Escobar Galvis","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0070","doi-asserted-by":"crossref","first-page":"26842","DOI":"10.1074\/jbc.M109.093542","article-title":"Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling","volume":"285","author":"Jastrebova","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0075","first-page":"1663","article-title":"Emerson","volume":"293","author":"Dhoot","year":"2001","journal-title":"Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase, Science"},{"key":"10.1016\/j.bbadis.2019.165539_bb0080","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jbiotec.2007.01.022","article-title":"The heparanome\u2014the enigma of encoding and decoding heparan sulfate sulfation","volume":"129","author":"Lamanna","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.matbio.2013.12.007","article-title":"The role of glypicans in Hedgehog signaling","volume":"35","author":"Filmus","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/febs.13940","article-title":"Syndecans - key regulators of cell signaling and biological functions","volume":"284","author":"Afratis","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2019.165539_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","article-title":"Extracellular atrix structure","volume":"97","author":"Theocharis","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbadis.2019.165539_bb0100","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.2741\/3007","article-title":"The heparanome and regulation of cell function: structures, functions and challenges","volume":"13","author":"Ori","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0105","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(91)90512-W","article-title":"Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor","volume":"64","author":"Yayon","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2019.165539_bb0110","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1646484","article-title":"Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation","volume":"252","author":"Rapraeger","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2019.165539_bb0115","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.1021\/bi011000u","article-title":"Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs","volume":"40","author":"Ye","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbadis.2019.165539_bb0120","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.celrep.2014.12.043","article-title":"Heparan sulfate proteoglycans regulate Fgf signaling and cell polarity during collective cell migration","volume":"10","author":"Venero Galanternik","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2019.165539_bb0125","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.devcel.2006.03.009","article-title":"Heparan sulfate in in trans potentiates VEGFR-mediated angiogenesis","volume":"10","author":"Jakobsson","year":"2006","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2019.165539_bb0130","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00441-016-2452-4","article-title":"Shed proteoglycans in tumor stroma","volume":"365","author":"Piperigkou","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0135","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1242\/dev.079236","article-title":"Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development","volume":"139","author":"Qu","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.bbadis.2019.165539_bb0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/1573402111666150213165054","article-title":"Heparan sulphate as a regulator of leukocyte recruitment in inflammation","volume":"16","author":"Kumar","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4161\/sgtp.19301","article-title":"Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing","volume":"3","author":"Brooks","year":"2012","journal-title":"Small GTPases"},{"key":"10.1016\/j.bbadis.2019.165539_bb0150","first-page":"3799","article-title":"Syndecan-4 signaling at a glance","volume":"126","author":"Elfenbein","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0155","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1161\/01.RES.0000112965.70691.AC","article-title":"Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2","volume":"94","author":"Chua","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0160","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ceb.2009.05.002","article-title":"The signaling mechanisms of syndecan heparan sulfate proteoglycans","volume":"21","author":"Lambaerts","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0165","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.matbio.2013.10.004","article-title":"Heparan sulfate proteoglycan as a cell-surface endocytosis receptor","volume":"35","author":"Christianson","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.21873\/cgp.20007","article-title":"Characterization of heparan sulfate proteoglycan-positive recycling endosomes isolated from glioma cells","volume":"13","author":"Podyma-Inoue","year":"2016","journal-title":"Cancer Genomics Proteomics"},{"key":"10.1016\/j.bbadis.2019.165539_bb0175","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.devcel.2008.03.001","article-title":"Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis","volume":"14","author":"Gallet","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2019.165539_bb0180","doi-asserted-by":"crossref","unstructured":"M.I Capurro, P. Xu, W. Shi, F. Li, A. Jia, J. Filmus, Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding, Dev. Cell. 14 (2008) 700\u2013711.","DOI":"10.1016\/j.devcel.2008.03.006"},{"key":"10.1016\/j.bbadis.2019.165539_bb0185","first-page":"3380","article-title":"LRP1 mediates Hedgehog-induced endocytosis of the GPC3\u2013Hedgehog complex","volume":"125","author":"Capurro","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0190","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1242\/jcs.091876","article-title":"Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling","volume":"125","author":"Sakane","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0195","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm1681","article-title":"Heparan sulphate proteoglycans: the sweet side of development","volume":"6","author":"H\u00e4cker","year":"2005","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0200","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1083\/jcb.200602043","article-title":"N-syndecan deficiency impairs neural migration in brain","volume":"174","author":"Hienola","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0205","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-213X-7-29","article-title":"M Costell, Perlecan controls neurogenesis in the developing telencephalon","volume":"7","author":"Gir\u00f3s","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature11059","article-title":"Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors","volume":"486","author":"Allen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2019.165539_bb0215","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/978-1-4939-1714-3_36","article-title":"Analyzing the role of heparan sulfate proteoglycans in axon guidance in vivo in zebrafish","volume":"1229","author":"Poulain","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0220","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jnc.13508","article-title":"Proteoglycans and axon guidance: a new relationship between old partners","volume":"139","author":"Masu","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0225","article-title":"The extracellular and cytoplasmic domains of syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction","volume":"11","author":"Nguyen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165539_bb0230","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnint.2017.00028","article-title":"Exploiting heparan sulfate proteoglycans in human neurogenesis-controlling lineage specification and fate","volume":"11","author":"Yu","year":"2017","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0235","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.semcdb.2018.08.007","article-title":"Extracellular matrix scaffolding in angiogenesis and capillary homeostasis","volume":"89","author":"Marchand","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0240","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/dvdy.24555","article-title":"Diverse roles for glycosaminoglycans in neural patterning","volume":"247","author":"Saied-Santiago","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbadis.2019.165539_bb0245","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/dbio.2000.9831","article-title":"Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development","volume":"225","author":"Paine-Saunders","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0250","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jcp.20450","article-title":"Heparan sulfates in skeletal muscle development and physiology","volume":"206","author":"Jenniskens","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0255","doi-asserted-by":"crossref","first-page":"C1387","DOI":"10.1152\/ajpcell.00346.2007","article-title":"Endogenous heparin sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity","volume":"294","author":"Khan","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0260","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s00264-013-1906-5","article-title":"Cell biology of osteochondromas: bone morphogenic protein signalling and heparan sulphates","volume":"37","author":"Cuellar","year":"2013","journal-title":"Int. Orthop."},{"key":"10.1016\/j.bbadis.2019.165539_bb0265","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/cbf.2939","article-title":"Boning up on glypicans-opportunities for new insights into bone biology","volume":"31","author":"Dwivedi","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.bbadis.2019.165539_bb0270","doi-asserted-by":"crossref","unstructured":"A.J. Hayes, RE Mitchell, A. Bashford, S. Reynolds, B. Caterson, CL. Hammond, Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis, Dev. Dyn. 242 (2013) 778\u2013789.","DOI":"10.1002\/dvdy.23970"},{"key":"10.1016\/j.bbadis.2019.165539_bb0275","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/dvdy.24010","article-title":"Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses","volume":"242","author":"Huegel","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbadis.2019.165539_bb0280","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.matbio.2013.11.003","article-title":"Heparan sulfate as a regulator of endochondral ossification and osteochondroma development","volume":"34","author":"Jochmann","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0285","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1136\/annrheumdis-2015-207316","article-title":"Agrin mediates chondrocyte homeostasis and requires both LRP4 and \u03b1-dystroglycan to enhance cartilage formation in vitro and in vivo","volume":"75","author":"Eldridge","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0290","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1083\/jcb.201605119","article-title":"Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling","volume":"216","author":"Capurro","year":"2017","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0295","doi-asserted-by":"crossref","unstructured":"R. Mansouri, Y. Jouan, E. Hay, C. Blin-Wakkach, M. Frain, A. Ostertag, C. Le Henaff, C. Marty, V. Geoffroy, P.J. Marie, M. Cohen-Solal, D. Modrowski, Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells, Cell Death Dis. 8 (2017) e2902. doi: https:\/\/doi.org\/10.1038\/cddis.2017.287. Erratum in: Cell Death Dis. 9 (2018) 788.","DOI":"10.1038\/s41419-018-0830-4"},{"key":"10.1016\/j.bbadis.2019.165539_bb0300","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/bs.ctdb.2018.11.020","article-title":"Fibroblast growth factors in skeletal development","volume":"133","author":"Ornitz","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0305","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00418-018-1631-7","article-title":"Heparan sulfate accumulation and perlecan\/HSPG2 up-regulation in tumour tissue predict low relapse-free survival for patients with glioblastoma","volume":"149","author":"Kazanskaya","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0310","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1369\/0022155417742147","article-title":"Heparan sulfate proteoglycans as relays of neuroinflammation","volume":"66","author":"O'Callaghan","year":"2018","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0315","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1002\/1873-3468.13026","article-title":"Proteoglycans in brain development and pathogenesis","volume":"592","author":"Schwartz","year":"2018","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2019.165539_bb0320","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/s41598-018-37476-9","article-title":"Contribution of syndecans to cellular internalization and fibrillation of amyloid-\u03b2(1-42)","volume":"9","author":"Letoha","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2019.165539_bb0325","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.bbagen.2009.08.001","article-title":"Glycosaminoglycans and syndecan-4 are involved in SDF-1\/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells","volume":"1790","author":"Brule","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165539_bb0330","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jcb.10184","article-title":"Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy","volume":"85","author":"Alvarez","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0335","doi-asserted-by":"crossref","first-page":"57R","DOI":"10.1093\/glycob\/12.4.57R","article-title":"Chondrodysplasias due to proteoglycan defects","volume":"12","author":"Schwartz","year":"2002","journal-title":"Glycobiology"},{"key":"10.1016\/j.bbadis.2019.165539_bb0340","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.1998","article-title":"Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis","volume":"15","author":"Echtermeyer","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2019.165539_bb0345","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.matbio.2016.09.003","article-title":"A current view of perlecan in physiology and pathology: a mosaic of functions","volume":"57\u201358","author":"Gubbiotti","year":"2017","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0350","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ajpath.2018.11.011","article-title":"Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage","volume":"189","author":"Chanalaris","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0355","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jnr.10278","article-title":"Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo syndrome type B","volume":"69","author":"Li","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0360","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1182\/blood-2005-02-0657","article-title":"Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cells","volume":"106","author":"Pan","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2019.165539_bb0365","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/nen.0b013e31812571c8","article-title":"Abnormalities in neural progenitor cells in a dog model of lysosomal storage disease","volume":"66","author":"Walton","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0370","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2353\/ajpath.2008.070564","article-title":"Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases","volume":"172","author":"Simonaro","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0375","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1651-2227.2008.01153.x","article-title":"Correlation between severity of mucopolysaccharidoses and combination of the residual enzyme activity and efficiency of glycosaminoglycan synthesis","volume":"98","author":"Piotrowska","year":"2009","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.bbadis.2019.165539_bb0380","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.matbio.2009.09.001","article-title":"A novel functional role of iduronate-2-sulfatase in zebrafish early development","volume":"29","author":"Moro","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0385","doi-asserted-by":"crossref","first-page":"37515","DOI":"10.1074\/jbc.M111.287474","article-title":"Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking a-l-iduronidase","volume":"286","author":"Holley","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0390","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11011-010-9230-x","article-title":"Differential distribution of heparan sulfate glycoforms and elevated expression of heparan sulfate biosynthetic enzyme genes in the brain of mucopolysaccharidosis IIIB mice","volume":"26","author":"McCarty","year":"2011","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0395","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.bbadis.2011.07.013","article-title":"Bone, joint and tooth development in mucopolysaccharidoses: relevance to therapeutic options","volume":"1812","author":"Oussoren","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165539_bb0400","doi-asserted-by":"crossref","first-page":"36194","DOI":"10.1074\/jbc.M114.599944","article-title":"Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I","volume":"289","author":"Watson","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0405","doi-asserted-by":"crossref","unstructured":"J. Bruy\u00e8re, E. Roy, J. Ausseil, T. Lemonnier, G. Teyre, D. Bohl, S. Etienne- Manneville, H. Lortat-Jacob, J.M. Heard, S. Vitry, Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology, J. Mol. Biol. 427 (2015) 775\u2013791.","DOI":"10.1016\/j.jmb.2014.09.012"},{"key":"10.1016\/j.bbadis.2019.165539_bb0410","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ymgme.2014.09.012","article-title":"Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I","volume":"114","author":"Heppner","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0415","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131662","article-title":"The murine model of mucopolysaccharidosis IIIB develops cardiopathies over time leading to heart failure","volume":"10","author":"Schiattarella","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165539_bb0420","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bone.2016.01.029","article-title":"Altered interaction and distribution of glycosaminoglycans and growth factors in mucopolysaccharidosis type I bone disease","volume":"88","author":"Kingma","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2019.165539_bb0425","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/hmg\/ddx069","article-title":"Perturbations in cell signaling elicit early cardiac defects in mucopolysaccharidosis type II","volume":"26","author":"Costa","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2019.165539_bb0430","doi-asserted-by":"crossref","first-page":"46576","DOI":"10.1038\/srep46576","article-title":"Neurodevelopmental changes in excitatory synaptic structure and function in the cerebral cortex of Sanfilippo syndrome IIIA mice","volume":"7","author":"Dwyer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2019.165539_bb0435","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10545-017-0044-4","article-title":"A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome","volume":"40","author":"Lau","year":"2017","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0440","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41419-017-0187-0","article-title":"EGFR activation triggers cellular hypertrophy and lysosomal disease in NAGLU-depleted cardiomyoblasts, mimicking the hallmarks of mucopolysaccharidosis IIIB","volume":"9","author":"De Pasquale","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0445","doi-asserted-by":"crossref","unstructured":"S. Bellesso, M. Salvalaio, S. Lualdi, E. Tognon, R. Costa, P. Braghetta, C. Giraudo, R. Stramare, L. Rigon, M. Filocamo, R. Tomanin, E. Moro, FGF signaling deregulation is associated with early developmental skeletal defects in animal models for mucopolysaccharidosis type II (MPSII), Hum. Mol. Genet. 27 (2018) 2262\u20132275. Erratum in: Hum Mol Genet. 27(2018) 2407.","DOI":"10.1093\/hmg\/ddy131"},{"key":"10.1016\/j.bbadis.2019.165539_bb0450","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.expneurol.2018.01.020","article-title":"Neuronal-specific impairment of heparan sulfate degradation in Drosophila reveals pathogenic mechanisms for Mucopolysaccharidosis type IIIA","volume":"303","author":"Webber","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0455","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/bs.ircmb.2016.02.008","article-title":"Functions of heparan sulfate proteoglycans in development: insights from Drosophila models","volume":"325","author":"Nakato","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102919","article-title":"Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development","volume":"9","author":"Kinnunen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165539_bb0465","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ydbio.2014.04.010","article-title":"Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis","volume":"391","author":"Ramsbottom","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0470","doi-asserted-by":"crossref","first-page":"a002493","DOI":"10.1101\/cshperspect.a002493","article-title":"Shaping morphogen gradients by proteoglycans","volume":"1","author":"Yan","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0475","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/jdb4030023","article-title":"Regulation of Hedgehog signalling inside and outside the cell","volume":"4","author":"Ramsbottom","year":"2016","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0480","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/1389203716666150213162649","article-title":"Sweet on Hedgehogs: regulatory roles of heparan sulfate proteoglycans in Hedgehog-dependent cell proliferation and differentiation","volume":"16","author":"Bandari","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0485","doi-asserted-by":"crossref","first-page":"22691","DOI":"10.1074\/jbc.M112.368241","article-title":"Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells","volume":"287","author":"Kraushaar","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0490","doi-asserted-by":"crossref","unstructured":"C. Fuerer, S.J. Habib, R. Nusse, A study on the interactions between heparan sulfate proteoglycans and Wnt proteins, Dev. Dyn. 239 (2010)184\u2013190.","DOI":"10.1002\/dvdy.22067"},{"key":"10.1016\/j.bbadis.2019.165539_bb0495","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.tibs.2016.06.003","article-title":"Novel regulation of Wnt signaling at the proximal membrane level","volume":"41","author":"Jiang","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0500","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/iep.12180","article-title":"The role of heparan sulphate in development: the ectodermal story","volume":"97","author":"Coulson-Thomas","year":"2016","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0505","doi-asserted-by":"crossref","unstructured":"D.H. Rowitch, A.R. Kriegstein, Developmental genetics of vertebrate glial-cell specification, Nature 468 (2010) 214\u2013222.","DOI":"10.1038\/nature09611"},{"key":"10.1016\/j.bbadis.2019.165539_bb0510","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1126\/science.1090497","article-title":"Mammalian brain morphogenesis and midline axon guidance require heparan sulfate","volume":"302","author":"Inatani","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2019.165539_bb0515","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1242\/dev.01935","article-title":"Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function","volume":"132","author":"Grobe","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.bbadis.2019.165539_bb0520","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1523\/JNEUROSCI.19-17-07415.1999","article-title":"Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK\/LIN-2 during rat brain development","volume":"19","author":"Hsueh","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0525","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fnmol.2018.00134","article-title":"Heparan sulfate proteoglycans as drivers of neural progenitors derived from human mesenchymal stem cells","volume":"11","author":"Okolicsanyi","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0530","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1749-8104-4-33","article-title":"Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis","volume":"4","author":"Jen","year":"2009","journal-title":"Neural Dev."},{"key":"10.1016\/j.bbadis.2019.165539_bb0535","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.scr.2013.12.009","article-title":"Perlecan is required for FGF-2 signaling in the neural stem cell niche","volume":"12","author":"Kerever","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0540","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/dvdy.10298","article-title":"Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development","volume":"227","author":"Ford-Perriss","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbadis.2019.165539_bb0545","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbagen.2017.06.015","article-title":"Heparan sulfate proteoglycans in Drosophila neuromuscular development","volume":"1861","author":"Kamimura","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbadis.2019.165539_bb0550","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/febs.13932","article-title":"Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy","volume":"284","author":"Sanderson","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2019.165539_bb0555","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3389\/fnmol.2017.00440","article-title":"Fragile X mental retardation protein regulates activity-dependent membrane trafficking and trans-synaptic signaling mediating synaptic remodeling","volume":"10","author":"Sears","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0560","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.200708022","article-title":"A central function for perlecan in skeletal muscle and cardiovascular development","volume":"181","author":"Zoeller","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0565","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cbpa.2018.05.014","article-title":"The effect of syndecan-4 and glypican-1 knockdown on the proliferation and differentiation of turkey satellite cells differing in age and growth rates","volume":"223","author":"Velleman","year":"2018","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0570","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","article-title":"Bone development","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2019.165539_bb0575","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1074\/jbc.M307304200","article-title":"Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds","volume":"279","author":"Nogami","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0580","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2016.08.029","article-title":"Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage","volume":"418","author":"Xu","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0585","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/s41418-017-0050-y","article-title":"Non-canonical Wnt induces chondrocyte de- differentiation through Frizzled 6 and Dvl-2\/B-Raf\/Camkiialpha\/Syndecan 4 axis","volume":"25","author":"Xie","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2019.165539_bb0590","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/dvdy.21038","article-title":"Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development","volume":"236","author":"Pallerla","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.bbadis.2019.165539_bb0595","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.011","article-title":"The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses","volume":"71-72","author":"Pacifici","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0600","unstructured":"E.F. Neufeld, J. Muenzer, The mucopolysaccharidoses, in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds), The Metabolic and Molecular Bases of Inherited Diseases, McGraw-Hill, 2001, pp. 3421\u20133452."},{"key":"10.1016\/j.bbadis.2019.165539_bb0605","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10545-010-9075-9","article-title":"Pathophysiology of neuropathic lysosomal storage disorders","volume":"33","author":"Bellettato","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0610","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.beem.2014.08.010","article-title":"The clinical spectrum and pathophysiology of skeletal complications in lysosomal storage disorders","volume":"29","author":"Clarke","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymgme.2018.03.004","article-title":"Growth impairment in mucopolysaccharidoses","volume":"124","author":"Melbouci","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0620","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymgme.2017.08.009","article-title":"Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations - neurological signs and symptoms","volume":"122S","author":"Shapiro","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0625","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ymgme.2018.08.003","article-title":"Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders","volume":"125","author":"Bigger","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0630","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbamcr.2008.12.001","article-title":"Lysosomal disorders: from storage to cellular damage","volume":"1793","author":"Ballabio","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165539_bb0635","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1080\/15548627.2015.1046671","article-title":"Lysosomal storage of heparan sulfate causes mitochondrial defects, altered autophagy, and neuronal death in the mouse model of mucopolysaccharidosis III type C","volume":"12","author":"Pshezhetsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2019.165539_bb0640","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13052-018-0564-z","article-title":"New treatments for the mucopolysaccharidoses: from pathophysiology to therapy","volume":"44","author":"Fecarotta","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.bbadis.2019.165539_bb0645","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.febslet.2013.02.035","article-title":"Extracellular matrix components: an intricate network of possible biomarkers for lysosomal storage disorders?","volume":"587","author":"Batzios","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2019.165539_bb0650","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.gene.2014.09.054","article-title":"From bedside to cell biology: a century of history on lysosomal dysfunction","volume":"555","author":"Coutinho","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.bbadis.2019.165539_bb0655","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1093\/hmg\/ddy155","article-title":"The pathogenesis of lysosomal storage disorders: beyond the engorgement of lysosomes to abnormal development and neuroinflammation","volume":"27","author":"Fiorenza","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2019.165539_bb0660","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035787","article-title":"Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB","volume":"7","author":"Wilkinson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165539_bb0665","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/iep.12033","article-title":"Characterization of joint disease in mucopolysaccharidosis type I mice","volume":"94","author":"de Oliveira","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0670","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.omtm.2018.05.002","article-title":"Targeting heparan sulfate proteoglycans as a novel therapeutic strategy for Mucopolysaccharidoses","volume":"10","author":"De Pasquale","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.bbadis.2019.165539_bb0675","doi-asserted-by":"crossref","unstructured":"M. Salvalaio, F. D'Avanzo, L. Rigon, A. Zanetti, M. D'Angelo, G. Valle, M. Scarpa, R. Tomanin, Brain RNA-Seq profiling of the Mucopolysaccharidosis type II mouse model, Int. J. Mol. Sci. 18 (2017) pii: E1072. doi: https:\/\/doi.org\/10.3390\/ijms18051072.","DOI":"10.3390\/ijms18051072"},{"key":"10.1016\/j.bbadis.2019.165539_bb0680","first-page":"F105","article-title":"TGF-beta receptor signaling","volume":"1333","author":"Derynck","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165539_bb0685","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1073\/pnas.252784899","article-title":"Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB","volume":"100","author":"Ohmi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.165539_bb0690","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10545-013-9613-3","article-title":"Mucopolysaccharide diseases: a complex interplay between neuroinflammation, microglial activation and adaptive immunity","volume":"37","author":"Archer","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165539_bb0695","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/jnc.14632","article-title":"The role of innate immunity in mucopolysaccharide diseases","volume":"148","author":"Parker","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2019.165539_bb0700","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/JLB.3RU0618-246R","article-title":"Heparan sulfate as a regulator of inflammation and immunity","volume":"105","author":"Collins","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbadis.2019.165539_bb0705","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.brainres.2009.03.071","article-title":"Mucopolysaccharidosis IIIB: oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis","volume":"1279","author":"Villani","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2019.165539_bb0710","doi-asserted-by":"crossref","unstructured":"C. Martins, H. H\u016flkov\u00e1, L. Dridi, V. Dormoy-Raclet, L. Grigoryeva, Y. Choi, A. Langford-Smith, F.L. Wilkinson, K. Ohmi, G. DiCristo, E. Hamel, J. Ausseil, D. Cheillan, A. Moreau, E. Svobodov\u00e1, Z. H\u00e1jkov\u00e1, M. Tesa\u0159ov\u00e1, H. Hans\u00edkov\u00e1, B.W. Bigger, M. Hreb\u00edcek, A.V. Pshezhetsky, Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model, Brain. 138 (2015) 336-355. Erratum in: Brain. 138 (2015) e366.","DOI":"10.1093\/brain\/awu355"},{"key":"10.1016\/j.bbadis.2019.165539_bb0715","first-page":"91","article-title":"Evaluation of disease lesions in the developing canine MPS IIIA brain","volume":"43","author":"Winner","year":"2019","journal-title":"JIMD Rep."},{"key":"10.1016\/j.bbadis.2019.165539_bb0720","doi-asserted-by":"crossref","unstructured":"Guyon A CXCL12 chemokine and its receptors as major players in the interactions between immune and nervous systems, Front. Cell. Neurosci. 8 (2014) 65. doi: https:\/\/doi.org\/10.3389\/fncel.2014.00065.","DOI":"10.3389\/fncel.2014.00065"},{"key":"10.1016\/j.bbadis.2019.165539_bb0725","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1111\/j.1742-4658.2005.04624.x","article-title":"Syndecan-4 is a signaling molecule for stromal cell-derived factor-1 (SDF-1)\/CXCL12","volume":"272","author":"Charnaux","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2019.165539_bb0730","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1080\/13543784.2017.1397130","article-title":"R, Giugliani, Phase I and II clinical trials for the mucopolysaccharidoses","volume":"26","author":"Poswar","year":"2017","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bbadis.2019.165539_bb0735","first-page":"1895","article-title":"Genetically corrected autologous stem cells engraft, but host immune responses limit their utility in canine alpha-L-iduronidase deficiency","volume":"93","author":"Lutzko","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2019.165539_bb0740","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ymgme.2013.11.015","article-title":"Early initiation of enzyme replacement therapy for the mucopolysaccharidoses","volume":"111","author":"Muenzer","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165539_bb0745","first-page":"63","article-title":"Early umbilical cord blood-derived stem cell transplantation does not prevent neurological deterioration in mucopolysaccharidosis type III","volume":"18","author":"Welling","year":"2015","journal-title":"JIMD Rep."},{"key":"10.1016\/j.bbadis.2019.165539_bb0750","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.omtm.2017.07.004","article-title":"Non-clinical safety and efficacy of an AAV2\/8 vector administered intravenously for treatment of Mucopolysaccharidosis type VI","volume":"6","author":"Ferla","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.bbadis.2019.165539_bb0755","doi-asserted-by":"crossref","unstructured":"K. Sawamoto, H.H. Chen, C.J. Alm\u00e9ciga-D\u00edaz, R.W. Mason, S. Tomatsu, Gene therapy for mucopolysaccharidoses, Mol. Genet. Metab. (2017) pii: S1096\u20137192(17)30616\u20139. doi: https:\/\/doi.org\/10.1016\/j.ymgme.2017.12.434.","DOI":"10.1016\/j.ymgme.2017.12.434"},{"key":"10.1016\/j.bbadis.2019.165539_bb0760","series-title":"Essentials of Glycobiology","author":"Varki","year":"2009"},{"key":"10.1016\/j.bbadis.2019.165539_bb0765","doi-asserted-by":"crossref","first-page":"9152","DOI":"10.1021\/acs.chemrev.8b00354","article-title":"Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics","volume":"118","author":"Karamanos","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbadis.2019.165539_bb0770","doi-asserted-by":"crossref","unstructured":"S. Morla, Glycosaminoglycans and glycosaminoglycan mimetics in cancer and inflammation, Int. J. Mol. Sci. 20 (2019) pii: E1963. doi: 0.3390\/ijms20081963.","DOI":"10.3390\/ijms20081963"},{"key":"10.1016\/j.bbadis.2019.165539_bb0775","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1423-0127-16-26","article-title":"Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway","volume":"16","author":"Jak\u00f3bkiewicz-Banecka","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2019.165539_bb0780","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/ajmg.a.34146","article-title":"Improvement in the range of joint motion in seven patients with mucopolysaccharidosis type II during experimental gene expression-targeted isoflavone therapy (GET IT)","volume":"155A","author":"Marucha","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.bbadis.2019.165539_bb0785","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1021\/acs.accounts.7b00289","article-title":"Synthetic Xylosides: probing the glycosaminoglycan biosynthetic machinery for biomedical applications","volume":"50","author":"Chua","year":"2017","journal-title":"Acc. Chem. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:49:43Z","timestamp":1760417383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919302625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":157,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0925443919302625"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165539","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heparan sulfate proteoglycans: The sweet side of development turns sour in mucopolysaccharidoses","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165539"}}