{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:13:23Z","timestamp":1792260803447,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bbadis.2019.165557","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T01:57:13Z","timestamp":1568339833000},"page":"165557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage\/senescence and liver fibrosis in Mdr2\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"1865","author":[{"given":"Vik","family":"Meadows","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hargrove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Demieville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohaib","family":"Virani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Reinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Kyritsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Invernizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthat","family":"Liangpunsakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Alpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.165557_bb0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.suc.2018.11.003","article-title":"Autoimmune diseases of the biliary tract: a review","volume":"99","author":"Lee","year":"2019","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.bbadis.2019.165557_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4291\/wjgp.v10.i1.1","article-title":"Current therapies and novel approaches for biliary diseases","volume":"10","author":"Rajapaksha","year":"2019","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2006.07.023","article-title":"Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver","volume":"132","author":"Alvaro","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2019.165557_bb0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: pathological mechanisms and translational significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.165557_bb0025","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.ajpath.2018.06.015","article-title":"The secretin\/secretin receptor axis modulates ductular reaction and liver fibrosis through changes in transforming growth factor-beta1-mediated biliary senescence","volume":"188","author":"Wu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0030","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0035","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41374-018-0093-9","article-title":"Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(\u2212\/\u2212) mice by diminishing senescence of cholangiocytes","volume":"98","author":"Zhou","year":"2018","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbadis.2019.165557_bb0040","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jhep.2005.06.025","article-title":"Mdr2 (Abcb4)\u2212\/\u2212 mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes","volume":"43","author":"Popov","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000282072","article-title":"New insights into autoimmune cholangitis through animal models","volume":"28","author":"Trauner","year":"2010","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2019.165557_bb0050","doi-asserted-by":"crossref","unstructured":"Fickert P, Wagner M, Marschall HU, Fuchsbichler A, Zollner G, Tsybrovskyy O, Zatloukal K, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2006;130:465\u2013481.","DOI":"10.1053\/j.gastro.2005.10.018"},{"issue":"3","key":"10.1016\/j.bbadis.2019.165557_bb0055","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/hep.29898","article-title":"Blocking H1\/H2 histamine receptors inhibits damage\/fibrosis in Mdr2(\u2212\/\u2212) mice and human cholangiocarcinoma tumorigenesis","volume":"68","author":"Kennedy","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.165557_bb0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fimmu.2012.00119","article-title":"Mast cell chemotaxis - chemoattractants and signaling pathways","volume":"3","author":"Halova","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0065","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/eji.201444546","article-title":"Mast cell activation: a complex interplay of positive and negative signaling pathways","volume":"44","author":"Sibilano","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0070","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1002\/hep.29079","article-title":"Bile duct ligation-induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell-deficient Kit(W-sh) mice","volume":"65","author":"Hargrove","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.165557_bb0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ajpath.2015.09.016","article-title":"Inhibition of mast cell-derived histamine decreases human cholangiocarcinoma growth and differentiation via c-kit\/stem cell factor-dependent signaling","volume":"186","author":"Johnson","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0080","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.24673","article-title":"Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration","volume":"55","author":"Meng","year":"2012","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.bbadis.2019.165557_bb0085","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/hep.28704","article-title":"Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2\u2212\/\u2212 mice","volume":"64","author":"Jones","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.bbadis.2019.165557_bb0090","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/labinvest.2014.129","article-title":"Inhibition of mast cell-derived histamine secretion by cromolyn sodium treatment decreases biliary hyperplasia in cholestatic rodents","volume":"94","author":"Kennedy","year":"2014","journal-title":"Lab. Investig."},{"issue":"3","key":"10.1016\/j.bbadis.2019.165557_bb0095","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ajpath.2017.11.016","article-title":"Knockout of l-histidine decarboxylase prevents cholangiocyte damage and hepatic fibrosis in mice subjected to high-fat diet feeding via disrupted histamine\/leptin signaling","volume":"188","author":"Kennedy","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0100","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ajpath.2017.03.013","article-title":"Knockdown of hepatic gonadotropin-releasing hormone by Vivo-Morpholino decreases liver fibrosis in multidrug resistance gene 2 knockout mice by down-regulation of miR-200b","volume":"187","author":"Kyritsi","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0105","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1016\/j.ajpath.2017.08.027","article-title":"Regulation of cellular senescence by miR-34a in alcoholic liver injury","volume":"187","author":"Wan","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1478-3231.2003.00876.x","article-title":"Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice","volume":"23","author":"Ueno","year":"2003","journal-title":"Liver Int."},{"key":"10.1016\/j.bbadis.2019.165557_bb0115","first-page":"965","article-title":"The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others","volume":"142","author":"Galli","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2019.165557_bb0120","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/labinvest.2009.15","article-title":"Expression of stem cell factor and its receptor c-Kit during the development of intrahepatic cholangiocarcinoma","volume":"89","author":"Mansuroglu","year":"2009","journal-title":"Lab. Investig."},{"key":"10.1016\/j.bbadis.2019.165557_bb0125","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1182\/blood.V79.4.958.bloodjournal794958","article-title":"The c-kit receptor ligand functions as a mast cell chemoattractant","volume":"79","author":"Meininger","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2019.165557_bb0130","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1089\/jir.2006.0158","article-title":"Tumor necrosis factor (TNF) is a potent rat mast cell chemoattractant","volume":"27","author":"Brzezinska-Blaszczyk","year":"2007","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.bbadis.2019.165557_bb0135","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-065X.2007.00518.x","article-title":"Regulation of the mast cell response to the type 1 Fc epsilon receptor","volume":"217","author":"Abramson","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbadis.2019.165557_bb0140","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/pr.2015.275","article-title":"Antagonism of stem cell factor\/c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary vascular remodeling","volume":"79","author":"Young","year":"2016","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2019.165557_bb0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2011.01.017","article-title":"Stem cell factor\/c-kit signaling enhances invasion of pancreatic cancer cells via HIF-1alpha under normoxic condition","volume":"303","author":"Zhang","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2019.165557_bb0150","first-page":"7356","article-title":"Tranilast prevents renal interstitial fibrosis by blocking mast cell infiltration in a rat model of diabetic kidney disease","volume":"17","author":"Yin","year":"2018","journal-title":"Mol. Med. Rep."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919302807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:49:04Z","timestamp":1760417344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919302807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0925443919302807"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165557","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of hepatic stem cell factor by Vivo-Morpholino treatment inhibits mast cell migration and decreases biliary damage\/senescence and liver fibrosis in Mdr2\u2212\/\u2212 mice","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165557"}}