{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:35:57Z","timestamp":1789140957444,"version":"build-2803163510"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010229","name":"Natural Science Foundation of Tianjin Municipal Science and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbadis.2019.165604","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:40:20Z","timestamp":1573818020000},"page":"165604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy"],"prefix":"10.1016","volume":"1866","author":[{"given":"Siwei","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.165604_bb0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biocel.2009.10.006","article-title":"Proliferative retinopathies: angiogenesis that blinds","volume":"42","author":"Sapieha","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0010","doi-asserted-by":"crossref","first-page":"3940241","DOI":"10.1155\/2017\/3940241","article-title":"Ischemic retinopathies: oxidative stress and inflammation","volume":"2017","author":"Rivera","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2019.165604_bb0015","first-page":"935","article-title":"Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina","volume":"11","author":"Yang","year":"2018","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.bbadis.2019.165604_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.001","article-title":"Retinal vasculature development in health and disease","volume":"63","author":"Selvam","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165604_bb0025","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.survophthal.2018.04.002","article-title":"Retinopathy of prematurity: a review of risk factors and their clinical significance","volume":"63","author":"Kim","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0030","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMra1005073","article-title":"Diabetic retinopathy","volume":"366","author":"Antonetti","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2019.165604_bb0035","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0161-6420(03)00579-7","article-title":"The long-term effects of laser photocoagulation treatment in patients with diabetic retinopathy: the early treatment diabetic retinopathy follow-up study","volume":"110","author":"Chew","year":"2003","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2019.165604_bb0040","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/IAE.0b013e318042d32c","article-title":"Visual side effects of successful scatter laser photocoagulation surgery for proliferative diabetic retinopathy: a literature review","volume":"27","author":"Fong","year":"2007","journal-title":"Retina"},{"key":"10.1016\/j.bbadis.2019.165604_bb0045","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.ophtha.2014.04.024","article-title":"Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema","volume":"121","author":"Boyer","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2019.165604_bb0050","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ophtha.2010.12.028","article-title":"Long-term benefit of sustained-delivery fluocinolone acetonide vitreous inserts for diabetic macular edema","volume":"e622","author":"Campochiaro","year":"2011","journal-title":"Ophthalmology 118"},{"key":"10.1016\/j.bbadis.2019.165604_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.vph.2015.07.003","article-title":"Significance of the antiangiogenic mechanisms of thalidomide in the therapy of diabetic retinopathy","volume":"92","author":"Behl","year":"2017","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0060","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.2147\/DDDT.S177192","article-title":"The efficacy and safety of aflibercept and conbercept in diabetic macular edema","volume":"12","author":"Cai","year":"2018","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.bbadis.2019.165604_bb0065","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/08820538.2017.1353832","article-title":"Postoperative complications of pars plana vitrectomy for diabetic retinal disease","volume":"33","author":"Yau","year":"2018","journal-title":"Semin. Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0070","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.7150\/thno.19646","article-title":"Decoding noncoding RNAs: role of MicroRNAs and long noncoding RNAs in ocular neovascularization","volume":"7","author":"Zhang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2019.165604_bb0075","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00592-018-1151-x","article-title":"Shall we stay, or shall we switch? Continued anti-VEGF therapy versus early switch to dexamethasone implant in refractory diabetic macular edema","volume":"55","author":"Busch","year":"2018","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0080","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5301\/ejo.5000686","article-title":"Receiver operating characteristic curve to predict anti-VEGF resistance in retinal vein occlusions and efficacy of Ozurdex","volume":"26","author":"Wolfe","year":"2016","journal-title":"Eur. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0085","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc2442","article-title":"Modes of resistance to anti-angiogenic therapy","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2019.165604_bb0090","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1172\/JCI70230","article-title":"Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting","volume":"123","author":"Westenskow","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.165604_bb0095","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/leu.2011.24","article-title":"Immunomodulatory effects of anti-angiogenic drugs","volume":"25","author":"Heine","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.bbadis.2019.165604_bb0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3341\/kjo.2018.0037","article-title":"Switching to aflibercept in diabetic macular edema after unsatisfactory response to other anti-vascular endothelial growth factor drugs","volume":"33","author":"Ibrahim","year":"2019","journal-title":"Korean J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2010.10.011","article-title":"The role of the CXC chemokines platelet factor-4 (CXCL4\/PF-4) and its variant (CXCL4L1\/PF-4var) in inflammation, angiogenesis and cancer","volume":"22","author":"Vandercappellen","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbadis.2019.165604_bb0110","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1756-8722-6-42","article-title":"Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology","volume":"6","author":"Pilatova","year":"2013","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2013.01.006","article-title":"Platelet factor-4 (CXCL4\/PF-4): an angiostatic chemokine for cancer therapy","volume":"331","author":"Wang","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2019.165604_bb0120","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0125","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbadis.2019.165604_bb0130","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2019.165604_bb0135","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1101\/gad.2042011","article-title":"Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism","volume":"25","author":"Kim","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2019.165604_bb0140","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/nprot.2009.187","article-title":"Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis","volume":"4","author":"Connor","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbadis.2019.165604_bb0145","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1167\/iovs.06-0082","article-title":"Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR","volume":"48","author":"Barnett","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2019.165604_bb0150","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nm.2186","article-title":"MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis","volume":"16","author":"Anand","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2019.165604_bb0155","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1128\/MCB.00343-13","article-title":"MicroRNA 329 suppresses angiogenesis by targeting CD146","volume":"33","author":"Wang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0160","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1159\/000487029","article-title":"Alpha-melanocyte-stimulating hormone protects early diabetic retina from blood-retinal barrier breakdown and vascular leakage via MC4R","volume":"45","author":"Cai","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2019.165604_bb0165","doi-asserted-by":"crossref","first-page":"21818","DOI":"10.18632\/oncotarget.15631","article-title":"HES1 promotes extracellular matrix protein expression and inhibits proliferation and migration in human trabecular meshwork cells under oxidative stress","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2019.165604_bb0170","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1074\/jbc.M116.761205","article-title":"Kinetic modeling and analysis of the Akt\/mechanistic target of rapamycin complex 1 (mTORC1) signaling Axis reveals cooperative, feedforward regulation","volume":"292","author":"Rahman","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165604_bb0175","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.0712168105","article-title":"A chemical method for fast and sensitive detection of DNA synthesis in vivo","volume":"105","author":"Salic","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.165604_bb0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.preteyeres.2017.10.001","article-title":"Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye","volume":"62","author":"Lutty","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165604_bb0185","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2019.165604_bb0190","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1096\/fj.201700336R","article-title":"Animal models of ocular angiogenesis: from development to pathologies","volume":"31","author":"Liu","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2019.165604_bb0195","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"Grossniklaus","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165604_bb0200","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3892\/ijmm.2013.1410","article-title":"Effects of a rho kinase inhibitor on the sequential expression of ICAM-1, HIF-1alpha, Bcl-2 and caspase-3 in the retina of rats with oxygen-induced retinopathy","volume":"32","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2019.165604_bb0205","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI11871","article-title":"A major role for VCAM-1, but not ICAM-1, in early atherosclerosis","volume":"107","author":"Cybulsky","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2019.165604_bb0210","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1160\/TH07-01-0066","article-title":"Platelet-derived chemokines in vascular biology","volume":"97","author":"von Hundelshausen","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2019.165604_bb0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1350-9462(02)00058-7","article-title":"Retinal vascular development and oxygen-induced retinopathy: a role for adenosine","volume":"22","author":"Lutty","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165604_bb0220","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exer.2013.01.008","article-title":"Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy","volume":"109","author":"Nawaz","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165604_bb0225","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ejcb.2010.12.002","article-title":"Molecular pathways of platelet factor 4\/CXCL4 signaling","volume":"90","author":"Kasper","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165604_bb0230","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","article-title":"The functional role of the ELR motif in CXC chemokine-mediated angiogenesis","volume":"270","author":"Strieter","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165604_bb0235","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1182\/blood-2009-11-253591","article-title":"Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3","volume":"117","author":"Struyf","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2019.165604_bb0240","doi-asserted-by":"crossref","first-page":"15059","DOI":"10.1074\/jbc.270.25.15059","article-title":"Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms","volume":"270","author":"Gengrinovitch","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165604_bb0245","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20021897","article-title":"An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4","volume":"197","author":"Lasagni","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.bbadis.2019.165604_bb0250","doi-asserted-by":"crossref","first-page":"27160","DOI":"10.1074\/jbc.M116.763235","article-title":"G protein-coupled receptors (GPCRs) that signal via protein kinase a (PKA) cross-talk at insulin receptor substrate 1 (IRS1) to activate the phosphatidylinositol 3-kinase (PI3K)\/AKT pathway","volume":"291","author":"Law","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165604_bb0255","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919303278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919303278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:55:07Z","timestamp":1760417707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919303278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0925443919303278"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165604","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PF4 antagonizes retinal neovascularization via inhibiting PRAS40 phosphorylation in a mouse model of oxygen-induced retinopathy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165604"}}