{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:13:34Z","timestamp":1785730414661,"version":"3.56.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008955","name":"Wilhelmina Kinderziekenhuis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbadis.2019.165607","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T12:10:05Z","timestamp":1574338205000},"page":"165607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Pyridox(am)ine 5\u2032-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations"],"prefix":"10.1016","volume":"1866","author":[{"given":"Jolita","family":"Ciapaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Albersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne M.C.","family":"Savelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Bosma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Tessadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Gerrits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Lansu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Zwakenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen P.W.","family":"Bakkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fried J.T.","family":"Zwartkruis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijs","family":"van Haaften","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith J.","family":"Jans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanda M.","family":"Verhoeven-Duif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.165607_bb0005","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/S0140-6736(03)13312-0","article-title":"Neonatal epileptic encephalopathy","volume":"361","author":"Clayton","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2019.165607_bb0010","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/hmg\/ddi120","article-title":"Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5\u2032-phosphate oxidase","volume":"14","author":"Mills","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2019.165607_bb0015","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/brain\/awu051","article-title":"Epilepsy due to PNPO mutations: genotype, environment and treatment affect presentation and outcome","volume":"137","author":"Mills","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2019.165607_bb0020","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1212\/WNL.0000000000000344","article-title":"Pyridoxine responsiveness in novel mutations of the PNPO gene","volume":"82","author":"Plecko","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2019.165607_bb0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ymgme.2017.08.003","article-title":"Pyridoxine-5\u2032-phosphate oxidase (Pnpo) deficiency: clinical and biochemical alterations associated with the C.347g>A (P. Arg116gln) mutation","volume":"122","author":"di Salvo","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165607_bb0030","first-page":"60","article-title":"Pyridoxine responsive epilepsy caused by a novel homozygous PNPO mutation","volume":"6","author":"Jaeger","year":"2016","journal-title":"Mol Genet Metab Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0035","first-page":"139","article-title":"Partial pyridoxine responsiveness in PNPO deficiency","volume":"9","author":"Pearl","year":"2013","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0040","doi-asserted-by":"crossref","first-page":"30949","DOI":"10.1074\/jbc.M109.038372","article-title":"Molecular basis of reduced pyridoxine 5\u2032-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder","volume":"284","author":"Musayev","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165607_bb0045","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1177\/0883073814550829","article-title":"Pyridox(am)ine-5-phosphate oxidase deficiency treatable cause of neonatal epileptic encephalopathy with burst suppression: case report and review of the literature","volume":"30","author":"Guerin","year":"2015","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/s-0033-1353489","article-title":"Positive outcome following early diagnosis and treatment of pyridoxal-5\u2032-phosphate oxidase deficiency: a case report","volume":"45","author":"Porri","year":"2014","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.bbadis.2019.165607_bb0055","first-page":"91","article-title":"Normal neurodevelopmental outcomes in PNPO deficiency: a case series and literature review","volume":"26","author":"Hatch","year":"2016","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/1471-2105-10-273","article-title":"The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families","volume":"10","author":"Percudani","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.bbadis.2019.165607_bb0065","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jimd.12060","article-title":"Disorders affecting vitamin B6 metabolism","volume":"42","author":"Wilson","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/cells7070084","article-title":"Vitamin B(6) and its role in cell metabolism and physiology","volume":"7","author":"Parra","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2019.165607_bb0075","first-page":"30","article-title":"Transport and metabolism of vitamins","volume":"45","author":"Rose","year":"1986","journal-title":"Fed. Proc."},{"key":"10.1016\/j.bbadis.2019.165607_bb0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng0995-45","article-title":"Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6","volume":"11","author":"Waymire","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2019.165607_bb0085","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/S0021-9258(17)38084-5","article-title":"Transport and metabolism of vitamin B6 in rabbit brain and choroid plexus","volume":"253","author":"Spector","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165607_bb0090","first-page":"519","article-title":"HPLC analysis of vitamin B6 in foods","volume":"8","author":"Ollilainen","year":"1999","journal-title":"Agri Food Sci"},{"key":"10.1016\/j.bbadis.2019.165607_bb0095","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/jn\/114.9.1664","article-title":"Metabolism of vitamin B-6 by human liver","volume":"114","author":"Merrill","year":"1984","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbadis.2019.165607_bb0100","doi-asserted-by":"crossref","first-page":"e54113","DOI":"10.1371\/journal.pone.0054113","article-title":"The intestine plays a substantial role in human vitamin B6 metabolism: a Caco-2 cell model","volume":"8","author":"Albersen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165607_bb0105","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0006-291X(74)91010-9","article-title":"Regulation of pyridoxal 5\u2032-phosphate metabolism in liver","volume":"61","author":"Li","year":"1974","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2019.165607_bb0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbadis.2018.08.018","article-title":"Improved cognition, mild anxiety-like behavior and decreased motor performance in pyridoxal phosphatase-deficient mice","volume":"1865","author":"Jeanclos","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0115","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.ajhg.2016.10.011","article-title":"Mutations in PROSC disrupt cellular pyridoxal phosphate homeostasis and cause vitamin-B6-dependent epilepsy","volume":"99","author":"Darin","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2019.165607_bb0120","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/dmd.117.075937","article-title":"Direct comparison of the enzymatic characteristics and superoxide production of the four aldehyde oxidase enzymes present in mouse","volume":"45","author":"Kucukgoze","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.bbadis.2019.165607_bb0125","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.bbagen.2019.03.019","article-title":"Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism","volume":"1863","author":"Ramos","year":"2019","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbadis.2019.165607_bb0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pediatrneurol.2012.11.006","article-title":"Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid","volume":"48","author":"Goyal","year":"2013","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0135","first-page":"67","article-title":"Normal cerebrospinal fluid pyridoxal 5\u2032-phosphate level in a PNPO-deficient patient with neonatal-onset epileptic encephalopathy","volume":"22","author":"Levtova","year":"2015","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0140","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ymgme.2007.10.003","article-title":"A new fatal case of pyridox(am)ine 5\u2032-phosphate oxidase (PNPO) deficiency","volume":"93","author":"Ruiz","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2019.165607_bb0145","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/dmcn.12346","article-title":"Typical and atypical phenotypes of PNPO deficiency with elevated CSF and plasma pyridoxamine on treatment","volume":"56","author":"Ware","year":"2014","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10545-012-9493-y","article-title":"Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS\/MS method","volume":"36","author":"Footitt","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pediatrneurol.2017.05.024","article-title":"Systemic manifestations in pyridox(am)ine 5'-phosphate oxidase deficiency","volume":"76","author":"Guerriero","year":"2017","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0160","series-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Westerfield","year":"2000"},{"key":"10.1016\/j.bbadis.2019.165607_bb0165","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2144\/000114116","article-title":"A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies","volume":"55","author":"Wilkinson","year":"2013","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbadis.2019.165607_bb0170","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1101\/gr.162339.113","article-title":"Analysis of off-target effects of CRISPR\/Cas-derived RNA-guided endonucleases and nickases","volume":"24","author":"Cho","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.bbadis.2019.165607_bb0175","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12864-016-2563-z","article-title":"Efficient identification of CRISPR\/Cas9-induced insertions\/deletions by direct germline screening in zebrafish","volume":"17","author":"Brocal","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbadis.2019.165607_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098186","article-title":"Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs","volume":"9","author":"Gagnon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165607_bb0185","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.035469","article-title":"Effective CRISPR\/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders","volume":"11","author":"Tessadori","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbadis.2019.165607_bb0190","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aca.2011.11.018","article-title":"M.G. de Sain-van der Velden, Quantification of vitamin B6 vitamers in human cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometry","volume":"712","author":"van der Ham","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.bbadis.2019.165607_bb0195","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/brain\/awy346","article-title":"PLPHP deficiency: clinical, genetic, biochemical, and mechanistic insights","volume":"142","author":"Johnstone","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.bbadis.2019.165607_bb0200","doi-asserted-by":"crossref","first-page":"8892","DOI":"10.1021\/acs.analchem.7b01358","article-title":"An LC-MS\/MS-based method for the quantification of pyridox(am)ine 5'-phosphate oxidase activity in dried blood spots from patients with epilepsy","volume":"89","author":"Wilson","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.bbadis.2019.165607_bb0205","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10545-016-9935-z","article-title":"M.G.M. de Sain-van der Velden, G. Visser, P.M. van Hasselt, N.M. Verhoeven-Duif, Rapid quantification of underivatized amino acids in plasma by hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass-spectrometry","volume":"39","author":"Prinsen","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0210","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1128\/jb.177.4.883-891.1995","article-title":"Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5\u2032-phosphate oxidase of Escherichia coli K-12","volume":"177","author":"Zhao","year":"1995","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0215","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","article-title":"Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression","volume":"131","author":"Baraban","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2019.165607_bb0220","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1534\/genetics.117.300137","article-title":"Pyridoxine-dependent epilepsy in zebrafish caused by Aldh7a1 deficiency","volume":"207","author":"Pena","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.bbadis.2019.165607_bb0225","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/jcp.28990","article-title":"Pyridoxine\/pyridoxamine 5\u2032-phosphate oxidase (Sgll\/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila","volume":"235","author":"Mascolo","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2019.165607_bb0230","doi-asserted-by":"crossref","first-page":"50040","DOI":"10.1074\/jbc.M309619200","article-title":"Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution","volume":"278","author":"Jang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165607_bb0235","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10545-011-9279-7","article-title":"Pyridoxal 5\u2032-phosphate in cerebrospinal fluid; factors affecting concentration","volume":"34","author":"Footitt","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0240","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3945\/ajcn.113.082008","article-title":"M.G. de Sain-van der Velden, G. Visser, N.V. Knoers, R.A. Ophoff, N.M. Verhoeven-Duif, Vitamin B-6 vitamers in human plasma and cerebrospinal fluid","volume":"100","author":"Albersen","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbadis.2019.165607_bb0245","doi-asserted-by":"crossref","unstructured":"M. Albersen, M. Bosma, J.J. Jans, F.C. Hofstede, P.M. van Hasselt, M.G. de Sain-van der Velden, G. Visser, N.M. Verhoeven-Duif, Vitamin B6 in plasma and cerebrospinal fluid of children, PLoS One, 10 (2015) e0120972.","DOI":"10.1371\/journal.pone.0120972"},{"key":"10.1016\/j.bbadis.2019.165607_bb0250","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10545-016-9955-8","article-title":"The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies","volume":"39","author":"Mathis","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2019.165607_bb0255","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/jn\/108.4.545","article-title":"Validation of the diagnostic value of plasma pyridoxal 5\u2032-phosphate measurements in vitamin B6 nutrition of the rat","volume":"108","author":"Lumeng","year":"1978","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbadis.2019.165607_bb0260","series-title":"Vitamin B-6 Pyridoxal Phosphate: Chemical, Biochemical and Medical Aspects, John Willey & Sons, New York","first-page":"117","article-title":"Transaminases","author":"Salerno","year":"1986"},{"key":"10.1016\/j.bbadis.2019.165607_bb0265","first-page":"67","article-title":"Cirrhosis associated with pyridoxal 5\u2032-phosphate treatment of pyridoxamine 5\u2032-phosphate oxidase deficiency","volume":"17","author":"Sudarsanam","year":"2014","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0270","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1105\/tpc.15.01033","article-title":"Balancing of B6 vitamers is essential for plant development and metabolism in Arabidopsis","volume":"28","author":"Colinas","year":"2016","journal-title":"Plant Cell"},{"key":"10.1016\/j.bbadis.2019.165607_bb0275","first-page":"71","article-title":"PNPO deficiency and cirrhosis: expanding the clinical phenotype?","volume":"25","author":"Coman","year":"2016","journal-title":"JIMD Rep"},{"key":"10.1016\/j.bbadis.2019.165607_bb0280","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/BMC.2011.030","article-title":"Structures and mechanism of the monoamine oxidase family","volume":"2","author":"Gaweska","year":"2011","journal-title":"Biomol Concepts"},{"key":"10.1016\/j.bbadis.2019.165607_bb0285","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1093\/hmg\/ddz143","article-title":"Pyridox(am)ine 5\u2032-phosphate oxidase deficiency induces seizures in Drosophila melanogaster","volume":"28","author":"Chi","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2019.165607_bb0290","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1113\/jphysiol.2014.271700","article-title":"Activation of glycine receptors modulates spontaneous epileptiform activity in the immature rat hippocampus","volume":"592","author":"Chen","year":"2014","journal-title":"J. Physiol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919303308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443919303308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:56:05Z","timestamp":1760417765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443919303308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":58,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0925443919303308"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165607","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyridox(am)ine 5\u2032-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165607","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165607"}}