{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:15:32Z","timestamp":1777875332084,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013191","name":"South Carolina Center of Economic Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0640"],"award-info":[{"award-number":["W81XWH-16-1-0640"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RX000444"],"award-info":[{"award-number":["RX000444"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX003050"],"award-info":[{"award-number":["BX003050"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY019320"],"award-info":[{"award-number":["R01EY019320"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["BR"],"award-info":[{"award-number":["BR"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbadis.2019.165608","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:40:20Z","timestamp":1573818020000},"page":"165608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers"],"prefix":"10.1016","volume":"1866","author":[{"given":"Crystal","family":"Nicholson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navjot","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasubramaniam","family":"Annamalai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlene","family":"Brandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessalyn","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Nowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e4rbel","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2019.165608_bb0005","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/cddiscovery.2016.71","article-title":"Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks","volume":"3","author":"Ishii","year":"2017","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.bbadis.2019.165608_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.449","article-title":"Mechanisms of bystander effects in retinal pigment epithelium cell networks","volume":"8","author":"Ishii","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2019.165608_bb0015","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1016\/j.bbadis.2018.04.016","article-title":"Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers","volume":"1864","author":"Shah","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2019.165608_bb0020","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12929-015-0174-7","article-title":"Molecular characterisation of plasma membrane-derived vesicles","volume":"22","author":"Antwi-Baffour","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2019.165608_bb0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/02713683.2018.1518458","article-title":"Photo-oxidative blue-light stimulation in retinal pigment epithelium cells promotes exosome secretion and increases the activity of the NLRP3 inflammasome","volume":"44","author":"Zhang","year":"2019","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0030","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1128\/JVI.01310-13","article-title":"Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells","volume":"87","author":"Nanbo","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0035","doi-asserted-by":"crossref","first-page":"22258","DOI":"10.1074\/jbc.M114.588046","article-title":"Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery","volume":"289","author":"Tian","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165608_bb0040","doi-asserted-by":"crossref","unstructured":"K.J. Svensson, H.C. Christianson, A. Wittrup, E. Bourseau-Guilmain, E. Lindqvist, L.M. Svensson, M. Morgelin, M. Belting, Exosome uptake depends on ERK1\/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1, J. Biol. Chem., 288 (2013) 17713\u201317724.","DOI":"10.1074\/jbc.M112.445403"},{"key":"10.1016\/j.bbadis.2019.165608_bb0045","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1600-0854.2010.01041.x","article-title":"Cellular internalization of exosomes occurs through phagocytosis","volume":"11","author":"Feng","year":"2010","journal-title":"Traffic"},{"key":"10.1016\/j.bbadis.2019.165608_bb0050","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12885-017-3958-1","article-title":"Mechanism of recipient cell-dependent differences in exosome uptake","volume":"18","author":"Horibe","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbadis.2019.165608_bb0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature01451","article-title":"Regulated portals of entry into the cell","volume":"422","author":"Conner","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2019.165608_bb0060","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"Pt 22","key":"10.1016\/j.bbadis.2019.165608_bb0065","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1242\/jcs.113.22.3931","article-title":"Intact Ca(2+)-binding sites are required for targeting of annexin 1 to endosomal membranes in living HeLa cells","volume":"113","author":"Rescher","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbadis.2019.165608_bb0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12951-018-0388-4","article-title":"Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display","volume":"16","author":"Antes","year":"2018","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.bbadis.2019.165608_bb0075","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.24641","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.bbadis.2019.165608_bb0080","doi-asserted-by":"crossref","first-page":"17380","DOI":"10.1073\/pnas.1304266110","article-title":"Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity","volume":"110","author":"Christianson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2019.165608_bb0085","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1128\/JVI.78.22.12665-12667.2004","article-title":"Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium","volume":"78","author":"Matrosovich","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5772\/61186","article-title":"Exosomes: mechanisms of uptake","volume":"4","author":"McKelvey","year":"2015","journal-title":"J Circ Biomark"},{"key":"10.1016\/j.bbadis.2019.165608_bb0095","first-page":"98","article-title":"Exosome\/microvesicle-mediated epigenetic reprogramming of cells","volume":"1","author":"Camussi","year":"2010","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1541-7786.MCR-16-0163","article-title":"Exosomal annexin II promotes angiogenesis and breast cancer metastasis","volume":"15","author":"Maji","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0110","doi-asserted-by":"crossref","first-page":"14662","DOI":"10.1038\/s41598-018-33044-3","article-title":"Bridging of membrane surfaces by annexin A2","volume":"8","author":"Grill","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2019.165608_bb0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000107533","article-title":"Methyl-beta-cyclodextrin increases permeability of Caco-2 cell monolayers by displacing specific claudins from cholesterol rich domains associated with tight junctions","volume":"20","author":"Lambert","year":"2007","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2019.165608_bb0120","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jcp.26064","article-title":"Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells","volume":"233","author":"Wilkinson","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0125","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-0-387-74904-4_43","article-title":"Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor","volume":"613","author":"Nandrot","year":"2008","journal-title":"two functions, Adv Exp Med Biol"},{"key":"10.1016\/j.bbadis.2019.165608_bb0130","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004952","article-title":"Heparan sulfate proteoglycans","volume":"3","author":"Sarrazin","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/glycob\/cww086","article-title":"Biological roles of glycans","volume":"27","author":"Varki","year":"2017","journal-title":"Glycobiology"},{"key":"10.1016\/j.bbadis.2019.165608_bb0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/MMBR.00063-15","article-title":"Extracellular vesicles exploit viral entry routes for cargo delivery","volume":"80","author":"van Dongen","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbadis.2019.165608_bb0145","first-page":"1","article-title":"Sialic acid receptors of viruses","volume":"367","author":"Matrosovich","year":"2015","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.bbadis.2019.165608_bb0150","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ejphar.2018.11.014","article-title":"Sialidase activity in human pathologies","volume":"842","author":"Glanz","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0155","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2174\/1874357901812010134","article-title":"Exosome biogenesis and biological function in response to viral infections","volume":"12","author":"Crenshaw","year":"2018","journal-title":"Open Virol J"},{"key":"10.1016\/j.bbadis.2019.165608_bb0160","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1021\/acs.biochem.7b00665","article-title":"Exosomes secreted by HeLa cells shuttle on their surface the plasma membrane-associated sialidase NEU3","volume":"56","author":"Paolini","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbadis.2019.165608_bb0165","doi-asserted-by":"crossref","unstructured":"J. Yu, Z. Ma, S. Shetty, M. Ma, J. Fu, Selective HDAC6 inhibition prevents TNF-alpha-induced lung endothelial cell barrier disruption and endotoxin-induced pulmonary edema, Am J Physiol Lung Cell Mol Physiol, 311 (2016) L39\u201347.","DOI":"10.1152\/ajplung.00051.2016"},{"key":"10.1016\/j.bbadis.2019.165608_bb0170","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/emboj\/cdg115","article-title":"HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo","volume":"22","author":"Zhang","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2019.165608_bb0175","doi-asserted-by":"crossref","first-page":"22516","DOI":"10.1074\/jbc.M113.489328","article-title":"Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells","volume":"288","author":"Asthana","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2019.165608_bb0180","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/417455a","article-title":"HDAC6 is a microtubule-associated deacetylase","volume":"417","author":"Hubbert","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2019.165608_bb0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.exer.2004.09.013","article-title":"Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown","volume":"80","author":"Edelman","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0190","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s11892-014-0510-4","article-title":"Anti-VEGF therapy for diabetic macular edema","volume":"14","author":"Stewart","year":"2014","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.bbadis.2019.165608_bb0195","doi-asserted-by":"crossref","first-page":"8614","DOI":"10.1167\/iovs.11-8021","article-title":"Human retinal pigment epithelium cells as functional models for the RPE in vivo","volume":"52","author":"Ablonczy","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2019.165608_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162596","article-title":"Histone Deacetylase inhibition restores retinal pigment epithelium function in hyperglycemia","volume":"11","author":"Desjardins","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2019.165608_bb0205","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1038\/s41598-017-05102-9","article-title":"Directional exosome proteomes reflect polarity-specific functions in retinal pigmented epithelium monolayers","volume":"7","author":"Klingeborn","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2019.165608_bb0210","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1021\/pr800658c","article-title":"Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)","volume":"8","author":"Gonzalez-Begne","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0215","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2415-5-25","article-title":"A functional profile of gene expression in ARPE-19 cells","volume":"5","author":"Sharma","year":"2005","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0220","first-page":"54","article-title":"Effects of neuraminidase on lectin binding sites in photoreceptor cells of monkey retina","volume":"29","author":"Uehara","year":"1985","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2019.165608_bb0225","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3109\/02713689009003476","article-title":"Characterization of galactose-containing glycoconjugates in the human retina: a lectin histochemical study","volume":"9","author":"Kivela","year":"1990","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbadis.2019.165608_bb0230","first-page":"640","article-title":"Cytochemical characterization of sialoglycoconjugates on rat photoreceptor cell surface","volume":"28","author":"Cohen","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544391930331X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544391930331X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:35:14Z","timestamp":1777584914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544391930331X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S092544391930331X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165608","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2019.165608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165608"}}