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Parasitol."},{"key":"10.1016\/j.bbadis.2020.165707_bb0485","doi-asserted-by":"crossref","first-page":"ra74","DOI":"10.1126\/scisignal.2000374","article-title":"Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy","volume":"2","author":"Chuenkova","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbadis.2020.165707_bb0490","doi-asserted-by":"crossref","first-page":"C206","DOI":"10.1152\/ajpcell.00282.2003","article-title":"Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes","volume":"286","author":"Aoki","year":"2004","journal-title":"Am. J. Physiol. 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