{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:17:47Z","timestamp":1785237467925,"version":"3.55.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"DST","doi-asserted-by":"publisher","award":["SB\/YS\/LS-122\/2014"],"award-info":[{"award-number":["SB\/YS\/LS-122\/2014"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"CSIR","doi-asserted-by":"publisher","award":["0264\/12\/EMR-II"],"award-info":[{"award-number":["0264\/12\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbadis.2020.165843","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T11:35:36Z","timestamp":1590233736000},"page":"165843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells"],"prefix":"10.1016","volume":"1866","author":[{"given":"M.","family":"Aloysius Dhivya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aberami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampath","family":"Nikhalashree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Irudayaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.N.","family":"Sulochana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karunakaran","family":"Coral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Bharathi Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2020.165843_bb0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2174\/1381612822666161221154424","article-title":"Hot topics in dry AMD","volume":"23","author":"Narayanan","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbadis.2020.165843_bb0010","series-title":"Age-related Macular Degeneration (AMD)","author":"Hageman","year":"1995"},{"key":"10.1016\/j.bbadis.2020.165843_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1124\/mi.10.5.4","article-title":"Age-related macular degeneration","volume":"10","author":"Chen","year":"2010","journal-title":"Mol. Interv."},{"key":"10.1016\/j.bbadis.2020.165843_bb0025","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1039\/C4MT00058G","article-title":"Correlations in distribution and concentration of calcium, copper and iron with zinc in isolated extracellular deposits associated with age-related macular degeneration","volume":"6","author":"Flinn","year":"2014","journal-title":"Metallomics."},{"key":"10.1016\/j.bbadis.2020.165843_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107718","article-title":"Elemental concentrations in Choroid-RPE and retina of human eyes with age-related macular degeneration","volume":"186","author":"Aberami","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cbi.2006.04.013","article-title":"The lysosomal-mitochondrial axis theory of postmitotic aging and cell death","volume":"163","author":"Terman","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbadis.2020.165843_bb0040","doi-asserted-by":"crossref","DOI":"10.1001\/archopht.121.8.1099","article-title":"Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch\u2019s membrane","volume":"121","author":"Hahn","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exer.2015.05.019","article-title":"Iron accumulation in Bruch\u2019s membrane and melanosomes of donor eyes with age-related macular degeneration","volume":"137","author":"Biesemeier","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.exer.2008.04.013","article-title":"Copper and zinc distribution in the human retina: relationship to cadmium accumulation, age, and gender","volume":"87","author":"Wills","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0301-0082(00)00057-5","article-title":"Zinc in the retina","volume":"64","author":"Ugarte","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0060","first-page":"1","article-title":"Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: a case-control study","volume":"8","author":"Stopa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2020.165843_bb0065","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ajo.2008.08.014","article-title":"Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration","volume":"147","author":"Erie","year":"2009","journal-title":"Am J Ophthalmol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0070","doi-asserted-by":"crossref","first-page":"13850","DOI":"10.1073\/pnas.0405146101","article-title":"Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration","volume":"101","author":"Hahn","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165843_bb0075","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1208\/s12248-010-9183-3","article-title":"Ocular drug delivery","volume":"12","author":"Gaudana","year":"2010","journal-title":"AAPS J."},{"key":"10.1016\/j.bbadis.2020.165843_bb0080","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2020.165843_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-12496-z","article-title":"Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells","volume":"7","author":"Subramani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0090","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.yexcr.2017.10.036","article-title":"Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration","volume":"361","author":"Rajapakse","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-33552-2","article-title":"Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0100","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.3892\/mmr.2017.6838","article-title":"Protective effect of lutein on ARPE-19 cells upon H2O2-induced G2\/M arrest","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbamcr.2008.05.002","article-title":"\u201cPulling the plug\u201d on cellular copper: the role of mitochondria in copper export","volume":"1793","author":"Leary","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0115","first-page":"201","article-title":"Age-related changes in the macula. A histopathological study of fifty Indian donor eyes","volume":"50","author":"Biswas","year":"2002","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0125","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/bioinformatics\/btm091","article-title":"Enhancements and modifications of primer design program Primer3","volume":"23","author":"Koressaar","year":"2007","journal-title":"Bioinforma. Appl. Note"},{"key":"10.1016\/j.bbadis.2020.165843_bb0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S1516-89132013000100019","article-title":"Real time PCR and importance of housekeepings genes for normalization and quantification of mRNA expression in different tissues","volume":"56","author":"de L Rebou\u00e7as","year":"2013","journal-title":"Brazilian Arch. Biol. Technol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4939-1875-1_3","article-title":"PCR based determination of mitochondrial DNA copy number in multiple species","volume":"1241","author":"Rooney","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0140","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"Spinazzi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbadis.2020.165843_bb0145","author":"Eigentler"},{"key":"10.1016\/j.bbadis.2020.165843_bb0150","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948211","article-title":"Monomeric cohesin state revealed by live-cell single-molecule spectroscopy","volume":"21","author":"Liu","year":"2020","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0155","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13148-019-0620-6","article-title":"Epigenetic biomarker screening by FLIM-FRET for combination therapy in ER+ breast cancer","volume":"11","author":"Liu","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbadis.2020.165843_bb0160","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2337\/diacare.19.8.873","article-title":"Evidence of a relationship between childhood-onset type I diabetes and low groundwater concentration of zinc","volume":"19","author":"Haglund","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2020.165843_bb0165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12011-008-8281-x","article-title":"Hair iron and other minerals\u2019 level in breast cancer patients","volume":"129","author":"Joo","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12011-010-8724-z","article-title":"Abnormal blood levels of trace elements and metals, DNA damage, and breast cancer in the state of Kuwait","volume":"141","author":"Saleh","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101079","article-title":"Mitochondrial Sco proteins are involved in oxidative stress defense","volume":"21","author":"Ekim Kocabey","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0180","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.celrep.2015.01.019","article-title":"The mitochondrial metallochaperone SCO1 is required to sustain expression of the high-affinity copper transporter CTR1 and preserve copper homeostasis","volume":"10","author":"Hlynialuk","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0185","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0190","series-title":"Review Article Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development","author":"Robledinos-Ant\u00f3n","year":"2019"},{"key":"10.1016\/j.bbadis.2020.165843_bb0195","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yexcr.2014.01.013","article-title":"The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription","volume":"322","author":"Song","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0200","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/MCB.25.4.1354-1366.2005","article-title":"Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators","volume":"25","author":"Gleyzer","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003613","article-title":"Mitochondrial fusion is increased by the nuclear coactivator PGC-1\u03b2","volume":"3","author":"Liesa","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2020.165843_bb0210","doi-asserted-by":"crossref","first-page":"e12742","DOI":"10.14814\/phy2.12742","article-title":"A key role of PGC-1 \u03b1 transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts","volume":"4","author":"Igarashi","year":"2016","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0215","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.mito.2010.05.012","article-title":"PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha","volume":"10","author":"Shao","year":"2010","journal-title":"Mitochondrion."},{"key":"10.1016\/j.bbadis.2020.165843_bb0220","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.resp.2013.12.007","article-title":"Altered mitochondrial biogenesis and its fusion gene expression is involved in the high-altitude adaptation of rat lung","volume":"192","author":"Chitra","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0225","unstructured":"J.Z. Nowak, Age-related macular degeneration (AMD): pathogenesis and therapy., Pharmacol. Rep. 58 353\u201363. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16845209 (accessed August 21, 2019) (n.d.)."},{"key":"10.1016\/j.bbadis.2020.165843_bb0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.preteyeres.2017.03.002","article-title":"The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD","volume":"60","author":"Datta","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2020.165843_bb0235","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.taap.2018.09.014","article-title":"Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2\/Nrf2 and mitochondria","volume":"359","author":"Ryoo","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0240","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1167\/iovs.10-5429","article-title":"Biochemistry and molecular biology mitochondrial DNA damage as a potential mechanism for age-related macular degeneration","volume":"51","author":"Karunadharma","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2020.165843_bb0245","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1167\/iovs.05-0976","article-title":"Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration","volume":"47","author":"Nordgaard","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2020.165843_bb0250","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neurobiolaging.2005.05.012","article-title":"Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration","volume":"27","author":"Feher","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbadis.2020.165843_bb0255","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity."},{"key":"10.1016\/j.bbadis.2020.165843_bb0260","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2013.02.004","article-title":"Iron and copper in mitochondrial diseases","volume":"17","author":"Xu","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2020.165843_bb0265","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1039\/C7MT00221A","article-title":"The mitochondrion: a central architect of copper homeostasis","volume":"9","author":"Baker","year":"2017","journal-title":"Metallomics."},{"key":"10.1016\/j.bbadis.2020.165843_bb0270","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2010.04.003","article-title":"Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs","volume":"11","author":"Kim","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2020.165843_bb0275","first-page":"340","article-title":"The cardiomyopathy of iron deficiency","volume":"33","author":"Hegde","year":"2006","journal-title":"Texas Hear. Inst. J."},{"key":"10.1016\/j.bbadis.2020.165843_bb0280","series-title":"How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1","first-page":"32","author":"H.\u00d6.","year":"2015"},{"key":"10.1016\/j.bbadis.2020.165843_bb0285","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.semcdb.2017.08.055","article-title":"Mitochondrial cytochrome c oxidase biogenesis: recent developments","volume":"76","author":"Tim\u00f3n-G\u00f3mez","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0290","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2015.04.036","article-title":"The emerging role of Nrf2 in mitochondrial function","volume":"88","author":"Dinkova-Kostova","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2020.165843_bb0295","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","article-title":"Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165843_bb0300","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2165\/00007256-200333110-00001","article-title":"Regulation of mitochondrial biogenesis in muscle by endurance exercise","volume":"33","author":"Irrcher","year":"2003","journal-title":"Sport. Med."},{"key":"10.1016\/j.bbadis.2020.165843_bb0305","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1038\/ncomms10210","article-title":"The transcriptional coregulator PGC-1\u03b2 controls mitochondrial function and anti-oxidant defence in skeletal muscles","volume":"6","author":"Gali Ramamoorthy","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2020.165843_bb0310","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ab.2004.08.015","article-title":"Evaluation of enzymatic assays and compounds affecting ATP production in mitochondrial respiratory chain complex I deficiency","volume":"335","author":"Saada","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2020.165843_bb0315","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ceca.2011.02.004","article-title":"G37R SOD1 mutant alters mitochondrial complex I activity, Ca2+ uptake and ATP production","volume":"49","author":"Coussee","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbadis.2020.165843_bb0320","doi-asserted-by":"crossref","DOI":"10.1007\/s12012-018-9447-1","article-title":"The involvement of cytochrome c oxidase in mitochondrial fusion in primary cultures of neonatal rat cardiomyocytes","author":"Yin","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bbadis.2020.165843_bb0325","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2020.165843_bb0330","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2020.165843_bb0335","doi-asserted-by":"crossref","unstructured":"S. Pich, D. Bach, P. Briones, M. Liesa, M. Camps, X. Testar, M. Palac\u00edn, A. Zorzano, The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system (n.d.). doi:https:\/\/doi.org\/10.1093\/hmg\/ddi149.","DOI":"10.1093\/hmg\/ddi149"},{"key":"10.1016\/j.bbadis.2020.165843_bb0340","first-page":"1","article-title":"Resveratrol attenuates copper-induced senescence by improving cellular proteostasis","volume":"2017","author":"Matos","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2020.165843_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/srep00640","article-title":"The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status","volume":"2","author":"Guo","year":"2012","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2020.165843_bb0350","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00681.2010","article-title":"Pgc-1\u03b2 regulates angiogenesis in skeletal muscle","volume":"301","author":"Rowe","year":"2011","journal-title":"Am. J. Physiol. - Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2020.165843_bb0355","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/10799893.2014.959592","article-title":"Estrogen-related receptor alpha and mitochondria: tale of the titans","volume":"35","author":"Ranhotra","year":"2015","journal-title":"J. Recept. Signal Transduct."},{"key":"10.1016\/j.bbadis.2020.165843_bb0360","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.2174\/092986712800609698","article-title":"Metal transport and homeostasis within the human body: toxicity associated with transport abnormalities","volume":"19","author":"Potocki","year":"2012","journal-title":"Curr. Med. Chem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920301903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920301903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:58:52Z","timestamp":1760417932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443920301903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0925443920301903"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165843","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper mediates mitochondrial biogenesis in retinal pigment epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165843"}}