{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:22:49Z","timestamp":1788582169936,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018JJ2461"],"award-info":[{"award-number":["2018JJ2461"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"project to introduce intelligence from oversea experts to the Changsha City","award":["2089901"],"award-info":[{"award-number":["2089901"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.bbadis.2020.165916","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T21:06:04Z","timestamp":1596747964000},"page":"165916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation"],"prefix":"10.1016","volume":"1866","author":[{"given":"Bingsheng","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2020.165916_bb0005","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jmoldx.2013.10.001","article-title":"Efficient identification of miRNAs for classification of tumor origin","volume":"16","author":"Sokilde","year":"2014","journal-title":"The Journal of Molecular Diagnostics: JMD"},{"key":"10.1016\/j.bbadis.2020.165916_bb0010","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1002\/pon.3244","article-title":"Psychiatric manifestations, personality traits and health-related quality of life in cancer of unknown primary site","volume":"22","author":"Hyphantis","year":"2013","journal-title":"Psycho-oncology"},{"key":"10.1016\/j.bbadis.2020.165916_bb0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2353\/jmoldx.2010.090197","article-title":"Hybrid model integrating immunohistochemistry and expression profiling for the classification of carcinomas of unknown primary site","volume":"12","author":"Centeno","year":"2010","journal-title":"J. Mol. Diagn."},{"key":"10.1016\/j.bbadis.2020.165916_bb0020","doi-asserted-by":"crossref","unstructured":"G. Huebner, L. Morawietz, A. Floore, R. Buettner, G. Folprecht, L. Stork-Sloots, M. Dietel, 503 POSTER Comparative analysis of microarray testing and immunohistochemistry in patients with carcinoma of unknown primary \u2013 CUP syndrome, 5 (2007) 90\u201391.","DOI":"10.1016\/S1359-6349(07)70442-1"},{"key":"10.1016\/j.bbadis.2020.165916_bb0025","doi-asserted-by":"crossref","unstructured":"S. Janick, L.-M. Elodie, M. Marie-Christine, R. Philippe, I. Marius, Immunohistochemistry for diagnosis of metastatic carcinomas of unknown primary site, Cancers, 10 (2018) 108-.","DOI":"10.3390\/cancers10040108"},{"key":"10.1016\/j.bbadis.2020.165916_bb0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.5858\/arpa.2015-0173-CP","article-title":"Practical applications in immunohistochemistry: carcinomas of unknown primary site","volume":"140","author":"Kandalaft","year":"2015","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"10.1016\/j.bbadis.2020.165916_bb0035","first-page":"693","volume":"10","author":"Voigt","year":"2008","journal-title":"Immunohistochemistry: A Major Progress in the Classification of Carcinoma of Unknown Primary"},{"key":"10.1016\/j.bbadis.2020.165916_bb0040","series-title":"Prognostic and Diagnostic Accuracy of [18F]FDG-PET\/CT in 190 Patients with Carcinoma of Unknown Primary, 34 (2007)","author":"Fencl","year":"1783"},{"key":"10.1016\/j.bbadis.2020.165916_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/RLU.0000000000002463","article-title":"Diagnosis of primary clear cell carcinoma of the vagina by 18F-FDG PET\/CT","volume":"44","author":"Fu","year":"2019","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.bbadis.2020.165916_bb0050","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00259-009-1295-6","article-title":"FDG PET\/CT in carcinoma of unknown primary","volume":"37","author":"Kwee","year":"2010","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.bbadis.2020.165916_bb0055","doi-asserted-by":"crossref","unstructured":"V. Ambrosini, C. Nanni, D. Rubello, A. Moretti, G. Battista, P. Castellucci, M. Farsad, L. Rampin, G. Fiorentini, R. Franchi, 18F-FDG PET\/CT in the assessment of carcinoma of unknown primary origin, 111 (2006) 1146\u20131155.","DOI":"10.1007\/s11547-006-0112-6"},{"key":"10.1016\/j.bbadis.2020.165916_bb0060","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jmoldx.2011.04.004","article-title":"Performance and clinical evaluation of the 92-gene real-time PCR assay for tumor classification","volume":"13","author":"Erlander","year":"2011","journal-title":"Journal of Molecular Diagnostics Jmd"},{"key":"10.1016\/j.bbadis.2020.165916_bb0065","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2012.47.1615","article-title":"Cancer of unknown primary or unrecognized adnexal skin primary carcinoma? Limitations of gene expression profiling diagnosis","volume":"31","author":"Greco","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000336300","article-title":"Identifying the primary site using gene expression profiling in patients with carcinoma of an unknown primary (CUP): a feasibility study from the GEFCAPI","volume":"35","author":"Gross-Goupil","year":"2012","journal-title":"Onkologie"},{"key":"10.1016\/j.bbadis.2020.165916_bb0075","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1200\/JCO.2012.43.3755","article-title":"Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the Sarah Cannon Research Institute","volume":"31","author":"Hainsworth","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0080","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2007.25.18_suppl.21024","article-title":"Molecular identification of carcinoma of unknown primary (CUP) with gene expression profiling","volume":"25","author":"Qu","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9440(10)63090-8","article-title":"Multi-platform, multi-site, microarray-based human tumor classification","volume":"164","author":"Bloom","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0090","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/modpathol.2010.57","article-title":"Validation of a microRNA-based qRT-PCR test for accurate identification of tumor tissue origin","volume":"23","author":"Rosenwald","year":"2010","journal-title":"Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc"},{"key":"10.1016\/j.bbadis.2020.165916_bb0095","series-title":"Personalized oncogenomics in the management of gastrointestinal carcinomas\u2014early experiences from a pilot study, Current Oncology, 23","author":"Sheffield","year":"2016"},{"key":"10.1016\/j.bbadis.2020.165916_bb0100","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/hmg\/ddt539","article-title":"Inferring primary tumor sites from mutation spectra: a meta-analysis of histology-specific aberrations in cancer-derived cell lines","volume":"23","author":"Dietlein","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2020.165916_bb0105","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2020.165916_bb0110","article-title":"A deep learning-based chemical system for QSAR prediction","author":"Hu","year":"2020","journal-title":"IEEE Journal of Biomedical"},{"key":"10.1016\/j.bbadis.2020.165916_bb0115","doi-asserted-by":"crossref","first-page":"69","DOI":"10.15403\/jgld.2014.1121.261.haz","article-title":"How to diagnose and treat a cancer of unknown primary site","volume":"26","author":"Tomuleasa","year":"2017","journal-title":"Journal of Gastrointestinal and Liver Diseases: JGLD"},{"key":"10.1016\/j.bbadis.2020.165916_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yexmp.2016.12.006","article-title":"Copy number variation analysis and methylome profiling of a GNAQ-mutant primary meningeal melanocytic tumor and its liver metastasis","volume":"102","author":"Kusters-Vandevelde","year":"2017","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0125","first-page":"58","article-title":"TumorTracer: a method to identify the tissue of origin from the somatic mutations of a tumor specimen","volume":"8","author":"Marquard","year":"2015","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bbadis.2020.165916_bb0130","doi-asserted-by":"crossref","first-page":"x271","DOI":"10.1093\/annonc\/mds357","article-title":"Diagnostic work-up of carcinoma of unknown primary: from immunohistochemistry to molecular profiling","volume":"23","author":"Oien","year":"2012","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbadis.2020.165916_bb0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1010933404324","article-title":"Random forests","volume":"45","author":"Breiman","year":"2001","journal-title":"Mach. Learn."},{"key":"10.1016\/j.bbadis.2020.165916_bb0140","doi-asserted-by":"crossref","unstructured":"M. Sandri, P. Zuccolotto, Variable selection using random forests, in: S. Zani, A. Cerioli, M. Riani, M. Vichi (Eds.) Data Analysis, Classification and the Forward Search, Springer Berlin Heidelberg, Berlin, Heidelberg, 2006, pp. 263\u2013270.","DOI":"10.1007\/3-540-35978-8_30"},{"key":"10.1016\/j.bbadis.2020.165916_bb0145","first-page":"471","article-title":"L.M.J.N.C.o.N.A. Liau","volume":"23","author":"Kim","year":"2012","journal-title":"IDH Mutations in Human Glioma"},{"key":"10.1016\/j.bbadis.2020.165916_bb0150","doi-asserted-by":"crossref","unstructured":"H. Yan, D.W. Parsons, G. Jin, R. McLendon, D.D.B.J.N.E.J.o. Medicine, IDH1 and IDH2 Mutations in Gliomas, 360 (2009) 765\u2013773.","DOI":"10.1056\/NEJMoa0808710"},{"key":"10.1016\/j.bbadis.2020.165916_bb0155","doi-asserted-by":"crossref","unstructured":"R.O. Pieper, S. Ohba, J. Mukherjee, Mutant IDH1-driven Cellular Transformation Increases RAD51-mediated Homologous Recombination and Temozolomide (TMZ) Resistance, 74 (2014) 4836\u20134844.","DOI":"10.1158\/0008-5472.CAN-14-0924"},{"key":"10.1016\/j.bbadis.2020.165916_bb0160","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s10014-013-0140-6","article-title":"Secondary glioblastomas with IDH1\/2 mutations have longer glioma history from preceding lower-grade gliomas","volume":"30","author":"Ohno","year":"2013","journal-title":"Brain Tumor Pathology"},{"key":"10.1016\/j.bbadis.2020.165916_bb0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10014-017-0281-0","article-title":"A novel all-in-one intraoperative genotyping system forIDH1-mutant glioma","volume":"34","author":"Ohka","year":"2017","journal-title":"Brain Tumor Pathology"},{"key":"10.1016\/j.bbadis.2020.165916_bb0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14728222.2011.648617","article-title":"Targeting the EGFR Signaling Pathway in Cancer Therapy","volume":"16","author":"Seshacharyulu","year":"2012","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"10.1016\/j.bbadis.2020.165916_bb0175","first-page":"52","article-title":"T.F.J.B.P. Cloughesy","volume":"13","author":"Mischel","year":"2003","journal-title":"Targeted Molecular Therapy of GBM"},{"key":"10.1016\/j.bbadis.2020.165916_bb0180","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41388-018-0459-x","article-title":"miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer","volume":"38","author":"Sun","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2020.165916_bb0185","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1158\/0008-5472.CAN-19-0020","article-title":"The Cdk2-c-Myc-miR-571 Axis regulates DNA replication and genomic stability by targeting geminin","volume":"79","author":"Zhang","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2020.165916_bb0190","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41588-018-0166-0","article-title":"Biallelic loss of human CTNNA2, encoding \u03b1N-catenin, leads to ARP2\/3 complex overactivity and disordered cortical neuronal migration","volume":"50","author":"Schaffer","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2020.165916_bb0195","doi-asserted-by":"crossref","unstructured":"Q.V. Fanjul-Fern\u00e1ndez M, Cabanillas R Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas, Nature Communications, 4 (2013) 2531.","DOI":"10.1038\/ncomms3531"},{"key":"10.1016\/j.bbadis.2020.165916_bb0200","series-title":"The gene ontology resource: 20 years and still going strong, Nucleic Acids Research, 47","author":"Carbon","year":"2019"},{"key":"10.1016\/j.bbadis.2020.165916_bb0205","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/bioinformatics\/btp101","article-title":"ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks","volume":"25","author":"Bindea","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbadis.2020.165916_bb0210","series-title":"The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins, Database 2016","author":"Rouillard","year":"2016"},{"key":"10.1016\/j.bbadis.2020.165916_bb0215","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920302647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920302647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:59:33Z","timestamp":1760417973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443920302647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0925443920302647"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165916","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165916"}}