{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:26:54Z","timestamp":1784359614235,"version":"3.55.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Centre for Cell Science"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.bbadis.2020.165978","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T20:26:25Z","timestamp":1600979185000},"page":"165978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Evolutionary artificial intelligence based peptide discoveries for effective Covid-19 therapeutics"],"prefix":"10.1016","volume":"1867","author":[{"given":"Ritika","family":"Kabra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailza","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2020.165978_bb0005","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet."},{"key":"10.1016\/j.bbadis.2020.165978_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105955","article-title":"The epidemiology, diagnosis and treatment of COVID-19","volume":"55","author":"Zhai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbadis.2020.165978_bb0015","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1080\/21645515.2020.1735227","article-title":"COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics","volume":"16","author":"Dhama","year":"2020","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.bbadis.2020.165978_bb0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.bbadis.2020.165978_bb0025","article-title":"Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: structural genomics approach","volume":"2020","author":"Naqvi","year":"1866","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/v12020244","article-title":"Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV","volume":"12","author":"Xu","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.bbadis.2020.165978_bb0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/ijmr.IJMR_504_20","article-title":"Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: a mathematical model-based approach","volume":"151","author":"Mandal","year":"2020","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.bbadis.2020.165978_bb0040","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1473-3099(20)30176-6","article-title":"Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study","volume":"20","author":"Yu","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0050","article-title":"Airborne or droplet precautions for health workers treating COVID-19?","volume":"189","author":"Prateek","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0055","first-page":"1","article-title":"Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations","author":"W. World Health Organization","year":"2020","journal-title":"Sci. Br."},{"key":"10.1016\/j.bbadis.2020.165978_bb0060","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.1118391","article-title":"Bats are natural reservoirs of SARS-like coronaviruses","volume":"310","author":"Li","year":"2005","journal-title":"Science (80-. )"},{"key":"10.1016\/j.bbadis.2020.165978_bb0065","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1073\/pnas.0506735102","article-title":"Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats","volume":"102","author":"Lau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0070","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2020.02.054","article-title":"COVID-19: gastrointestinal manifestations and potential fecal\u2013oral transmission","volume":"158","author":"Gu","year":"2020","journal-title":"Gastroenterology."},{"key":"10.1016\/j.bbadis.2020.165978_bb0075","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7326\/M20-1176","article-title":"SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection","volume":"173","author":"Colavita","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0080","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 viral load in upper respiratory specimens of infected patients","volume":"382","author":"Zou","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1473-3099(20)30196-1","article-title":"Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study","volume":"20","author":"To","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0090","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0095","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41591-020-0869-5","article-title":"Temporal dynamics in viral shedding and transmissibility of COVID-19","volume":"26","author":"He","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0100","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.chom.2012.04.011","article-title":"Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology","volume":"11","author":"Zhao","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbadis.2020.165978_bb0105","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0140-6736(04)16255-7","article-title":"Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome","volume":"363","author":"Cheng","year":"2004","journal-title":"Lancet."},{"key":"10.1016\/j.bbadis.2020.165978_bb0110","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1073\/pnas.0809524106","article-title":"Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites","volume":"106","author":"Belouzard","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0115","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.virol.2004.11.038","article-title":"Programmed ribosomal frameshifting in decoding the SARS-CoV genome","volume":"332","author":"Baranov","year":"2005","journal-title":"Virology."},{"key":"10.1016\/j.bbadis.2020.165978_bb0120","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1099\/0022-1317-81-4-853","article-title":"Virus-encoded proteinases and proteolytic processing in the Nidovirales","volume":"81","author":"Ziebuhr","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0022-2836(03)00865-9","article-title":"Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage","volume":"331","author":"Snijder","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0130","series-title":"Coronaviruses Methods Protoc","first-page":"1","article-title":"Coronaviruses: an overview of their replication and pathogenesis","author":"Fehr","year":"2015"},{"key":"10.1016\/j.bbadis.2020.165978_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.00569","article-title":"Recent aspects on the pathogenesis mechanism, animal models and novel therapeutic interventions for middle east respiratory syndrome coronavirus infections","volume":"10","author":"Skariyachan","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41573-020-00151-8","article-title":"The COVID-19 vaccine development landscape","volume":"19","author":"Le","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2020.165978_bb0145","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.apsb.2020.02.008","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods","volume":"10","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbadis.2020.165978_bb0150","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1073\/pnas.2005456117","article-title":"Avoiding pitfalls in the pursuit of a COVID-19 vaccine","volume":"117","author":"Peeples","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0155","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(20)30763-7","article-title":"Ensuring global access to COVID-19 vaccines","volume":"395","author":"Yamey","year":"2020","journal-title":"Lancet."},{"key":"10.1016\/j.bbadis.2020.165978_bb0160","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0165","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s40475-020-00201-6","article-title":"The SARS-CoV-2 vaccine pipeline: an overview","volume":"7","author":"Chen","year":"2020","journal-title":"Curr. Trop. Med. Rep."},{"key":"10.1016\/j.bbadis.2020.165978_bb0170","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1126\/science.abc5312","article-title":"A strategic approach to COVID-19 vaccine R&D","volume":"368","author":"Corey","year":"2020","journal-title":"Science (80-. )"},{"key":"10.1016\/j.bbadis.2020.165978_bb0175","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.abb8923","article-title":"Rapid COVID-19 vaccine development","volume":"368","author":"Graham","year":"2020","journal-title":"Science (80-. )"},{"key":"10.1016\/j.bbadis.2020.165978_bb0180","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1056\/NEJMp2005630","article-title":"Developing covid-19 vaccines at pandemic speed","volume":"382","author":"Lurie","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0185","first-page":"1","article-title":"Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic","volume":"38","author":"Prompetchara","year":"2020","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0190","doi-asserted-by":"crossref","first-page":"9490","DOI":"10.1073\/pnas.2004168117","article-title":"Effectiveness of convalescent plasma therapy in severe COVID-19 patients","volume":"117","author":"Duan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0195","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJMc070359","article-title":"Treatment with convalescent plasma for influenza A (H5N1) infection [9]","volume":"357","author":"Zhou","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0200","doi-asserted-by":"crossref","first-page":"m1256","DOI":"10.1136\/bmj.m1256","article-title":"Covid-19: FDA approves use of convalescent plasma to treat critically ill patients","volume":"368","author":"Tanne","year":"2020","journal-title":"BMJ."},{"key":"10.1016\/j.bbadis.2020.165978_bb0205","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3851\/IMP3243","article-title":"Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience","volume":"23","author":"Ko","year":"2018","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.bbadis.2020.165978_bb0210","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10096-004-1271-9","article-title":"Use of convalescent plasma therapy in SARS patients in Hong Kong","volume":"24","author":"Cheng","year":"2005","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0215","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/cid\/ciq106","article-title":"Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection","volume":"52","author":"Hung","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0220","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.chest.2020.03.039","article-title":"Treatment with convalescent plasma for critically ill patients with severe acute respiratory syndrome coronavirus 2 infection","volume":"158","author":"Zhang","year":"2020","journal-title":"Chest."},{"key":"10.1016\/j.bbadis.2020.165978_bb0225","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1473-3099(20)30141-9","article-title":"Convalescent plasma as a potential therapy for COVID-19","volume":"20","author":"Chen","year":"2020","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2020.165978_bb0230","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/infdis\/jiaa228","article-title":"Effect of convalescent plasma therapy on viral shedding and survival in COVID-19 patients","volume":"222","author":"Zeng","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbadis.2020.165978_bb0235","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.abb7498","article-title":"Structure of the RNA-dependent RNA polymerase from COVID-19 virus","volume":"368","author":"Gao","year":"2020","journal-title":"Science (80-. )"},{"key":"10.1016\/j.bbadis.2020.165978_bb0240","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1073\/pnas.1922083117","article-title":"Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection","volume":"117","author":"de Wit","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0245","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1056\/NEJMoa2007016","article-title":"Compassionate use of remdesivir for patients with severe Covid-19","volume":"382","author":"Grein","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2020.165978_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105932","article-title":"Chloroquine and hydroxychloroquine as available weapons to fight COVID-19","volume":"55","author":"Colson","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbadis.2020.165978_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-020-0156-0","article-title":"Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro","volume":"6","author":"Liu","year":"2020","journal-title":"Cell Discov."},{"key":"10.1016\/j.bbadis.2020.165978_bb0260","first-page":"e21","article-title":"Arbidol monotherapy is superior to lopinavir\/ritonavir in treating COVID-19","volume":"81","author":"Zhu","year":"2020","journal-title":"J. Inf. Secur."},{"key":"10.1016\/j.bbadis.2020.165978_bb0265","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cmi.2020.04.026","article-title":"Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study","volume":"26","author":"Lian","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.bbadis.2020.165978_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.eng.2020.03.007","article-title":"Experimental treatment with favipiravir for COVID-19: an open-label control study","author":"Cai","year":"2020","journal-title":"Engineering"},{"key":"10.1016\/j.bbadis.2020.165978_bb0275","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s10067-020-05073-9","article-title":"Rheumatologists\u2019 perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets","volume":"39","author":"Misra","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0280","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: immunopathology and its implications for therapy","volume":"20","author":"Cao","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0285","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.2005615117","article-title":"Effective treatment of severe COVID-19 patients with tocilizumab","volume":"117","author":"Xu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2020.165978_bb0290","series-title":"Pathol. Prev. Ther. Neurodegener. Dis","first-page":"207","article-title":"Amyotrophic lateral sclerosis: current therapeutic perspectives","author":"Kumar","year":"2018"},{"key":"10.1016\/j.bbadis.2020.165978_bb0295","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jmv.25761","article-title":"The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase","volume":"92","author":"Lung","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0300","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201256","article-title":"Glecaprevir and Maraviroc are high-affinity inhibitors of SARS-CoV-2 main protease: possible implication in COVID-19 therapy","volume":"40","author":"Shamsi","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2020.165978_bb0305","article-title":"Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach","author":"Kanhed","year":"2020","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bbadis.2020.165978_bb0310","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature."},{"key":"10.1016\/j.bbadis.2020.165978_bb0315","first-page":"1","article-title":"Potential inhibitor of COVID-19 main protease (M pro) from several medicinal plant compounds by molecular docking study","author":"Khaerunnisa","year":"2020","journal-title":"Preprints."},{"key":"10.1016\/j.bbadis.2020.165978_bb0320","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ab.2004.10.003","article-title":"Molecular modeling and chemical modification for finding peptide inhibitor against severe acute respiratory syndrome coronavirus main proteinase","volume":"337","author":"Du","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2020.165978_bb0325","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1021\/acsnano.0c02857","article-title":"Computational design of ACE2-based peptide inhibitors of SARS-CoV-2","volume":"14","author":"Han","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.bbadis.2020.165978_bb0330","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/gch2.1018","article-title":"Data, disease and diplomacy: GISAID\u2019s innovative contribution to global health","volume":"1","author":"Elbe","year":"2017","journal-title":"Glob. Challenges (Hoboken, NJ)"},{"key":"10.1016\/j.bbadis.2020.165978_bb0335","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbadis.2020.165978_bb0340","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME suite: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2020.165978_bb0345","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/356539a0","article-title":"The dead-end elimination theorem and its use in protein side-chain positioning","volume":"356","author":"Desmet","year":"1992","journal-title":"Nature."},{"key":"10.1016\/j.bbadis.2020.165978_bb0350","doi-asserted-by":"crossref","first-page":"626","DOI":"10.2174\/092986607781483859","article-title":"PEPstr: a de novo method for tertiary structure prediction of small bioactive peptides","volume":"14","author":"Kaur","year":"2007","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.bbadis.2020.165978_bb0355","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbadis.2020.165978_bb0360","series-title":"AutoDock4 and AutoDockTools4: Automated Docking With Selective Receptor Flexibility","first-page":"2785","volume":"30","author":"Morris","year":"2009"},{"key":"10.1016\/j.bbadis.2020.165978_bb0365","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand-protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.bbadis.2020.165978_bb0370","series-title":"Proc. 2006 ACM\/IEEE Conf. Supercomput. - SC \u201906","first-page":"84","article-title":"Molecular dynamics\u2014scalable algorithms for molecular dynamics simulations on commodity clusters","author":"Bowers","year":"2006"},{"key":"10.1016\/j.bbadis.2020.165978_bb0375","series-title":"Lect. Notes Phys","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-74686-7_1","article-title":"Introduction to molecular dynamics","author":"Schneider","year":"2008"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920303264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443920303264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:57:26Z","timestamp":1760417846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443920303264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0925443920303264"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165978","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolutionary artificial intelligence based peptide discoveries for effective Covid-19 therapeutics","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2020.165978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"165978"}}