{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:03:36Z","timestamp":1789038216850,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bbadis.2021.166080","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T20:38:11Z","timestamp":1611261491000},"page":"166080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cardiac hypertrophy drives PGC-1\u03b1 suppression associated with enhanced O-glycosylation"],"prefix":"10.1016","volume":"1867","author":[{"given":"Robert E.","family":"Brainard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heberty T.","family":"Facundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2021.166080_bb0005","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0735-1097(87)80326-1","article-title":"Cardiac hypertrophy: the consequences for diastole","volume":"9","author":"Lorell","year":"1987","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0010","doi-asserted-by":"crossref","unstructured":"H. Taegtmeyer, Energy metabolism of the heart: From basic concepts to clinical applications applications, Curr. Probl. Cardiol., 19 (1994).","DOI":"10.1016\/0146-2806(94)90008-6"},{"key":"10.1016\/j.bbadis.2021.166080_bb0015","first-page":"H742","article-title":"Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts","volume":"267","author":"Allard","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.bbadis.2021.166080_bb0020","doi-asserted-by":"crossref","unstructured":"M.J. El Alaoui-Talibi Z1, Guendouz A, Moravec M, Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine, Am J Physiol. 1997 Apr;272(4 Pt 2)H1615-24., 272 (1997) H1615-24.","DOI":"10.1152\/ajpheart.1997.272.4.H1615"},{"key":"10.1016\/j.bbadis.2021.166080_bb0025","doi-asserted-by":"crossref","unstructured":"S.B. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 - PubMed - NCBI, Cell, 98 (1999) 115\u201324.","DOI":"10.1016\/S0092-8674(00)80611-X"},{"key":"10.1016\/j.bbadis.2021.166080_bb0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1101\/gad.1177604","article-title":"Transcriptional regulatory circuits controlling mitochondrial biogenesis and function","volume":"18","author":"Kelly","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2021.166080_bb0035","doi-asserted-by":"crossref","first-page":"466","DOI":"10.7150\/thno.29130","article-title":"Blossoming 20: the energetic regulator\u2019s birthday unveils its versatility in cardiac diseases","volume":"9","author":"Lv","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2021.166080_bb0040","doi-asserted-by":"crossref","first-page":"10086","DOI":"10.1073\/pnas.0603615103","article-title":"Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha","volume":"103","author":"Arany","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2021.166080_bb0045","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/sj.emboj.7600351","article-title":"Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure","volume":"23","author":"Sano","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2021.166080_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","article-title":"Transcriptional coactivator PGC-1\u03b1 controls the energy state and contractile function of cardiac muscle","volume":"1","author":"Arany","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2021.166080_bb0055","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bbalip.2006.04.007","article-title":"Cell signaling, the essential role of O-GlcNAc!","volume":"1761","author":"Zachara","year":"2006","journal-title":"Biochim. Biophys. Acta - Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbadis.2021.166080_bb0060","doi-asserted-by":"crossref","first-page":"30133","DOI":"10.1074\/jbc.M403773200","article-title":"Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: a survival response of mammalian cells","volume":"279","author":"Zachara","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166080_bb0065","doi-asserted-by":"crossref","unstructured":"V. Champattanachai, R.B. Marchase, J.C. Chatham, Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein O-GlcNAc and increased mitochondrial Bcl-2, Am. J. Physiol. - Cell Physiol., 294 (2008).","DOI":"10.1152\/ajpcell.00456.2007"},{"key":"10.1016\/j.bbadis.2021.166080_bb0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/SHK.0b013e3181598bad","article-title":"Hexosamine biosynthesis and protein O-glycosylation: the first line of defense against stress, ischemia, and trauma","volume":"29","author":"Chatham","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.bbadis.2021.166080_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165712","article-title":"Regulation of cardiac O-GlcNAcylation: more than just nutrient availability","volume":"1866","author":"Collins","year":"2020","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.bbadis.2021.166080_bb0080","doi-asserted-by":"crossref","unstructured":"G.A. Ngoh, H.T. Facundo, T. Hamid, W. Dillmann, N.E. Zachara, S.P. Jones, Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia\/reoxygenation injury, Circ. Res., 104 (2009).","DOI":"10.1161\/CIRCRESAHA.108.189431"},{"key":"10.1016\/j.bbadis.2021.166080_bb0085","doi-asserted-by":"crossref","unstructured":"G.A. Ngoh, H.T. Facundo, A. Zafir, S.P. Jones, O-GlcNAc signaling in the cardiovascular system, Circ. Res., 107 (2010).","DOI":"10.1161\/CIRCRESAHA.110.224675"},{"key":"10.1016\/j.bbadis.2021.166080_bb0090","doi-asserted-by":"crossref","unstructured":"G.A. Ngoh, L.J. Watson, H.T. Facundo, W. Dillmann, S.P. Jones, Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition, J. Mol. Cell. Cardiol., 45 (2008).","DOI":"10.1016\/j.yjmcc.2008.04.009"},{"key":"10.1016\/j.bbadis.2021.166080_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/CIRCRESAHA.108.189431","article-title":"Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia\/reoxygenation injury","volume":"104","author":"Ngoh","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2021.166080_bb0100","doi-asserted-by":"crossref","unstructured":"M.W. Krause, D.C. Love, S.K. Ghosh, P. Wang, S. Yun, T. Fukushige, J.A. Hanover, Nutrient-driven O-GlcNAcylation at promoters impacts genome-wide RNA Pol II distribution, Front. Endocrinol. (Lausanne)., 9 (2018).","DOI":"10.3389\/fendo.2018.00521"},{"key":"10.1016\/j.bbadis.2021.166080_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0092-8674(02)00810-3","article-title":"Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression","volume":"110","author":"Yang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2021.166080_bb0110","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1073\/pnas.111099998","article-title":"O-linkage of N-acetylglucosamine to Sp1 activation domain inhibits its transcriptional capability","volume":"98","author":"Yang","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2021.166080_bb0115","doi-asserted-by":"crossref","first-page":"14056","DOI":"10.1074\/jbc.M115.684365","article-title":"Human RNA polymerase II promoter recruitment in vitro is regulated by O-linked N-acetylglucosaminyltransferase (OGT)","volume":"291","author":"Lewis","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166080_bb0120","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1074\/jbc.AW119.003226","article-title":"Nutrient regulation of signaling and transcription","volume":"294","author":"Hart","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166080_bb0125","doi-asserted-by":"crossref","first-page":"44230","DOI":"10.1074\/jbc.M303810200","article-title":"Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation","volume":"278","author":"Clark","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166080_bb0130","doi-asserted-by":"crossref","first-page":"H2122","DOI":"10.1152\/ajpheart.00775.2011","article-title":"O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy","volume":"302","author":"Facundo","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0135","doi-asserted-by":"crossref","unstructured":"H.T. Facundo, R.E. Brainard, L.J. Watson, G.A. Ngoh, T. Hamid, S.D. Prabhu, S.P. Jones, O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy, Am. J. Physiol. - Hear. Circ. Physiol., 302 (2012).","DOI":"10.1152\/ajpheart.00775.2011"},{"key":"10.1016\/j.bbadis.2021.166080_bb0140","doi-asserted-by":"crossref","first-page":"7933","DOI":"10.1073\/pnas.0702683104","article-title":"A fundamental system of cellular energy homeostasis regulated by PGC-1\u03b1","volume":"104","author":"Rohas","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2021.166080_bb0145","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1074\/jbc.M808890200","article-title":"A PGC-1\u03b1-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose","volume":"284","author":"Housley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166080_bb0150","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1073\/pnas.1001907107","article-title":"O-linked $\u03b2$-N-acetylglucosamine transferase is indispensable in the failing heart","volume":"107","author":"Watson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2021.166080_bb0155","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00726-010-0728-7","article-title":"Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes","volume":"40","author":"Ngoh","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbadis.2021.166080_bb0160","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nrm3334","article-title":"Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation","volume":"13","author":"Hanover","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0165","doi-asserted-by":"crossref","unstructured":"P.J. Fernandez-Marcos, J. Auwerx, Regulation of PGC-1\u03b1, a nodal regulator of mitochondrial biogenesis, in: Am. J. Clin. Nutr., American Society for Nutrition, 2011: p. 884S.","DOI":"10.3945\/ajcn.110.001917"},{"key":"10.1016\/j.bbadis.2021.166080_bb0170","doi-asserted-by":"crossref","unstructured":"S.B. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle - PubMed - NCBI, Cell Metab., 4 (2005) 259\u201371.","DOI":"10.1016\/j.cmet.2005.03.002"},{"key":"10.1016\/j.bbadis.2021.166080_bb0175","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.yjmcc.2008.10.025","article-title":"PGC-1\u03b1 and ERR\u03b1 target gene downregulation is a signature of the failing human heart","volume":"46","author":"Sihag","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0180","doi-asserted-by":"crossref","first-page":"H1307","DOI":"10.1152\/ajpheart.00280.2014","article-title":"Promoting PGC-1\u03b1-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts","volume":"307","author":"Karamanlidis","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00395-017-0612-7","article-title":"Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy","volume":"112","author":"Dassanayaka","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2021.166080_bb0190","doi-asserted-by":"crossref","unstructured":"L.J. Watson, B.W. Long, A.M. DeMartino, K.R. Brittian, R.D. Readnower, R.E. Brainard, T.D. Cummins, L. Annamalai, B.G. Hill, S.P. Jones, Cardiomyocyte Ogt is essential for postnatal viability, Am. J. Physiol. - Hear. Circ. Physiol., 306 (2014).","DOI":"10.1152\/ajpheart.00438.2013"},{"key":"10.1016\/j.bbadis.2021.166080_bb0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0968-0004(01)02031-X","article-title":"MEF2: a calcium-dependent regulator of cell division, differentiation and death","volume":"27","author":"McKinsey","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbadis.2021.166080_bb0200","series-title":"O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1\u03b1, PLoS One, 12","author":"Latorre","year":"2017"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443921000132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443921000132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T04:59:48Z","timestamp":1760417988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443921000132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0925443921000132"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166080","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac hypertrophy drives PGC-1\u03b1 suppression associated with enhanced O-glycosylation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166080"}}