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Neurol."},{"key":"10.1016\/j.bbadis.2021.166203_bb0415","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00415-014-7439-z","article-title":"Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer\u2019s disease dementia","volume":"261","author":"Grothe","year":"2014","journal-title":"J. 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