{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:15:56Z","timestamp":1778771756552,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT2015-1281"],"award-info":[{"award-number":["PICT2015-1281"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2017-1536"],"award-info":[{"award-number":["PICT 2017-1536"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020170100317BA"],"award-info":[{"award-number":["20020170100317BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020190100041BA"],"award-info":[{"award-number":["20020190100041BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bbadis.2021.166207","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T11:05:26Z","timestamp":1624705526000},"page":"166207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Growth impairment, increased placental glucose uptake and altered transplacental transport in VIP deficient pregnancies: Maternal vs. placental contributions"],"prefix":"10.1016","volume":"1867","author":[{"given":"F\u00e1tima","family":"Merech","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Hauk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Paparini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaira","family":"Naguila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Ramhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Waschek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"P\u00e9rez Leir\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiana","family":"Vota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2021.166207_bb0005","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2021.166207_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2016.00012","article-title":"Placental responses to changes in the maternal environment determine fetal growth","volume":"7","author":"Dimasuay","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0015","doi-asserted-by":"crossref","first-page":"16153","DOI":"10.3390\/ijms150916153","article-title":"Maternal\u2013fetal nutrient transport in pregnancy pathologies: the role of the placenta","volume":"15","author":"Brett","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2021.166207_bb0020","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.placenta.2016.10.012","article-title":"Biological features of placental programming","volume":"48","author":"Thornburg","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2021.166207_bb0025","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0030","doi-asserted-by":"crossref","unstructured":"Lager S, Powell TL. Regulation of nutrient transport across the placenta. J. Pregnancy 2012:1\u201314. doi:https:\/\/doi.org\/10.1155\/2012\/179827.","DOI":"10.1155\/2012\/179827"},{"key":"10.1016\/j.bbadis.2021.166207_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2017.00951","article-title":"Transplacental nutrient transport mechanisms of intrauterine growth restriction in rodent models and humans","volume":"8","author":"Winterhager","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0040","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physiol.00033.2015","article-title":"Intrauterine growth restriction: hungry for an answer","volume":"31","author":"Devaskar","year":"2016","journal-title":"Physiology"},{"key":"10.1016\/j.bbadis.2021.166207_bb0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/ENDO:19:1:13","article-title":"Placental glucose transfer and fetal growth","volume":"19","author":"Baumann","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.bbadis.2021.166207_bb0050","doi-asserted-by":"crossref","unstructured":"Illsley NP, Baumann MU. Human placental glucose transport in fetoplacental growth and metabolism. Biochim. Biophys. Acta Mol. basis Dis. 2020;1866:165359. doi:https:\/\/doi.org\/10.1016\/j.bbadis.2018.12.010.","DOI":"10.1016\/j.bbadis.2018.12.010"},{"key":"10.1016\/j.bbadis.2021.166207_bb0055","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/hmg\/ddl032","article-title":"A mouse model for Glut-1 haploinsufficiency","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2021.166207_bb0060","first-page":"723","article-title":"Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling","volume":"297","author":"Roos","year":"2009","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbadis.2021.166207_bb0065","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1113\/JP272424","article-title":"mTOR folate sensing links folate availability to trophoblast cell function","volume":"595","author":"Rosario","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0070","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2021.166207_bb0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BST0370295","article-title":"Placental mTOR links maternal nutrient availability to fetal growth","volume":"37","author":"Roos","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbadis.2021.166207_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-53676-3","article-title":"Vasoactive intestinal peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cells","volume":"9","author":"Merech","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2021.166207_bb0085","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.peptides.2007.06.007","article-title":"The discovery of VIP: initially looked for in the lung, isolated from intestine, and identified as a neuropeptide","volume":"28","author":"Said","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.bbadis.2021.166207_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/bph.12181","article-title":"VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair","author":"Waschek","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0095","doi-asserted-by":"crossref","unstructured":"McCulloch J, Kelly PAT. A functional role for vasoactive intestinal polypeptide in anterior cingulate cortex. Nature 1983:438\u201340.","DOI":"10.1038\/304438a0"},{"key":"10.1016\/j.bbadis.2021.166207_bb0100","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1210\/jc.2004-1512","article-title":"Placental expression of substance P and vasoactive intestinal peptide: evidence for a local effect on hormone release","volume":"90","author":"Marzioni","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166207_bb0105","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/bph.14609","article-title":"Vasoactive intestinal peptide shapes first-trimester placenta trophoblast, vascular, and immune cell cooperation","volume":"176","author":"Paparini","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0110","article-title":"Decidual factors and vasoactive intestinal peptide guide monocytes to higher migration, efferocytosis and wound healing in term human pregnancy","author":"Paparini","year":"2020","journal-title":"Acta Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1189\/jlb.1A1014-492RR","article-title":"VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction","volume":"98","author":"Fraccaroli","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0120","doi-asserted-by":"crossref","DOI":"10.1111\/j.1476-5381.2008.00055.x","article-title":"VIP modulates the pro-inflammatory maternal response, inducing tolerance to trophoblast cells","author":"Fraccaroli","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0125","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1016\/S0021-9258(18)86943-5","article-title":"Vasoactive intestinal peptide increases intracellular cAMP and gonadotropin-a gene activity in JEG-3 syncytial trophoblasts: constraints posed by desensitization","volume":"265","author":"Deutsch","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166207_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep26364","article-title":"Vasoactive intestinal peptide modulates trophoblast-derived cell line function and interaction with phagocytic cells through autocrine pathways","volume":"6","author":"Vota","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2021.166207_bb0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/nyas.13632","article-title":"Control of the inflammatory response during pregnancy: potential role of VIP as a regulatory peptide","volume":"1437","author":"Ramhorst","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2021.166207_bb0140","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI43824","article-title":"VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling","volume":"121","author":"Passemard","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2021.166207_bb0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/aji.12167","article-title":"Vasoactive intestinal peptide induces an immunosuppressant microenvironment in the maternal-fetal interface of non-obese diabetic mice and improves early pregnancy outcome","volume":"71","author":"Hauk","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep18633","article-title":"VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model","volume":"6","author":"Gallino","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2021.166207_bb0155","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0748730414549767","article-title":"Disrupted reproduction, estrous cycle, and circadian rhythms in female vasoactive intestinal peptide deficient mice","volume":"29","author":"Loh","year":"2015","journal-title":"J Biol Rythm"},{"key":"10.1016\/j.bbadis.2021.166207_bb0160","first-page":"816","article-title":"Growth factor function of vasoactive intestinal peptide in whole cultured mouse embryos","volume":"333","author":"Gressens","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2021.166207_bb0165","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1096\/fj.201800592RR","article-title":"Trophoblast VIP deficiency entails immune homeostasis loss and adverse pregnancy outcome in mice","volume":"33","author":"Hauk","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2021.166207_bb0170","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ijdevneu.2008.03.002","article-title":"Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior","volume":"26","author":"Lim","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbadis.2021.166207_bb0175","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2337\/db09-0807","article-title":"Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression","volume":"59","author":"Martin","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2021.166207_bb0180","first-page":"939","article-title":"Disrupted circadian rhythms in VIP- and PHI-deficient mice","volume":"285","author":"Colwell","year":"2003","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.bbadis.2021.166207_bb0185","doi-asserted-by":"crossref","first-page":"E1241","DOI":"10.1152\/ajpendo.00344.2006","article-title":"Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction","volume":"292","author":"Ganguly","year":"2007","journal-title":"AJP Endocrinol Metab"},{"key":"10.1016\/j.bbadis.2021.166207_bb0190","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1210\/en.2011-1973","article-title":"Placental glucose and amino acid transport in calorie-restricted Wil-type and Glut3 null heterozygus mice","volume":"153","author":"Ganguly","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166207_bb0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.expneurol.2008.01.003","article-title":"Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice","volume":"211","author":"Stack","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0200","first-page":"1","article-title":"Review: transport across the placenta of mice and women","volume":"44","author":"Dilworth","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2021.166207_bb0205","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-20-0012","article-title":"Altered pancreas remodeling following glucose intolerance in pregnancy in mice","author":"Szlapinski","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0210","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.placenta.2017.04.023","article-title":"Placental glucose transporter (GLUT)-1 is down-regulated in preeclampsia","volume":"55","author":"L\u00fcscher","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2021.166207_bb0215","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.placenta.2013.08.010","article-title":"Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction","volume":"34","author":"Janzen","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2021.166207_bb0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1203\/00006450-200003000-00005","article-title":"Glucose metabolism is elevated and vascular resistance and maternofetal transfer is normal in perfused placental cotyledons from severely growth-restricted fetuses","volume":"47","author":"Challis","year":"2000","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2021.166207_bb0225","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.earlhumdev.2010.01.001","article-title":"Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction","volume":"86","author":"Lee","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.bbadis.2021.166207_bb0230","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/jc.2018-01154","article-title":"Uteroplacental glucose uptake and fetal glucose consumption: a quantitative study in human pregnancies","volume":"104","author":"Michelsen","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166207_bb0235","doi-asserted-by":"crossref","DOI":"10.1113\/JP273330","article-title":"Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth","author":"Sferruzzi-Perri","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0240","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-17-0512","article-title":"Involvement of leptin in the molecular physiology of the placenta","volume":"155","author":"Schanton","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.bbadis.2021.166207_bb0245","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1210\/endo.142.8.8335","article-title":"IGF-I as a mediator of VIP\/activity-dependent neurotrophic factor-stimulated embryonic growth","volume":"142","author":"Servoss","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166207_bb0250","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1210\/en.2004-0504","article-title":"VPAC2-R mediates the lipolytic effects of pituitary adenylate cyclase-activating polypeptide\/vasoactive intestinal polypeptide in primary rat adipocytes","volume":"146","author":"\u00c5kesson","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166207_bb0255","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0196-9781(89)90039-9","article-title":"Human glucagon and vasoactive intestinal polypeptide (VIP) stimulate free fatty acid release from human adipose tissue in vitro","volume":"10","author":"Richter","year":"1989","journal-title":"Peptides"},{"key":"10.1016\/j.bbadis.2021.166207_bb0260","doi-asserted-by":"crossref","unstructured":"Hauner H, Glatting G, Kaminska D, Pfeiffer EF, I AIM, Ulm U, et al. Effect of vasoactive intestinal polypeptide ( VIP ) on glucose and lipid metabolism of isolated rat adipocytes. Res. Exp. Med. 1988:189\u201395.","DOI":"10.1007\/BF01852320"},{"key":"10.1016\/j.bbadis.2021.166207_bb0265","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12031-015-0556-z","article-title":"Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP)","volume":"56","author":"Vu","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbadis.2021.166207_bb0270","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1113\/jphysiol.2011.208629","article-title":"Dietary composition programmes placental phenotype in mice","volume":"589","author":"Coan","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0275","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1096\/fj.13-234823","article-title":"An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory","volume":"27","author":"Sferruzzi-Perri","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2021.166207_bb0280","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature00819","article-title":"Placental-specific IGF-II is a major modulator of placental and fetal growth","volume":"417","author":"Constancia","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2021.166207_bb0285","doi-asserted-by":"crossref","first-page":"11255","DOI":"10.1073\/pnas.1602012113","article-title":"Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110\u03b1 signaling to modify placental resource allocation","volume":"113","author":"Sferruzzi-Perri","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2021.166207_bb0290","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1074\/jbc.271.3.1660","article-title":"A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide","volume":"271","author":"Straub","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166207_bb0295","doi-asserted-by":"crossref","DOI":"10.1042\/AN20110024","article-title":"Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis","author":"Tan","year":"2011","journal-title":"ASN Neuro"},{"key":"10.1016\/j.bbadis.2021.166207_bb0300","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.2007.129676","article-title":"Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth","volume":"582","author":"Roos","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0305","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2337\/diabetes.51.5.1453","article-title":"A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes","volume":"51","author":"Tsutsumi","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2021.166207_bb0310","first-page":"30","article-title":"The human placenta in gestational diabetes mellitus: the insulin and cytokine network","author":"Desoye","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2021.166207_bb0315","doi-asserted-by":"crossref","DOI":"10.1006\/dbio.1997.8666","article-title":"Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development","author":"Louvi","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2021.166207_bb0320","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.placenta.2018.01.002","article-title":"Placental control of metabolic adaptations in the mother for an optimal pregnancy outcome. What goes wrong in gestational diabetes?","volume":"69","author":"Hill","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.bbadis.2021.166207_bb0325","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00592-019-01304-x","article-title":"Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1\u2013RAGE and VIP\u2013VPAC2 pathways in human gestational diabetes mellitus","volume":"56","author":"Santangelo","year":"2019","journal-title":"Acta Diabetol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392100140X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392100140X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:51:38Z","timestamp":1778770298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392100140X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S092544392100140X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166207","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth impairment, increased placental glucose uptake and altered transplacental transport in VIP deficient pregnancies: Maternal vs. placental contributions","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166207"}}