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Lee, Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain, Brain Res. 1060(1\u20132) (2005) 188\u201392.","DOI":"10.1016\/j.brainres.2005.08.029"},{"key":"10.1016\/j.bbadis.2021.166230_bb0300","doi-asserted-by":"crossref","unstructured":"D.R. Green, J.C. Reed, Mitochondria and apoptosis, Science 281(5381) (1998) 1309\u201312.","DOI":"10.1126\/science.281.5381.1309"},{"issue":"1","key":"10.1016\/j.bbadis.2021.166230_bb0305","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1523\/JNEUROSCI.22-01-00209.2002","article-title":"Overexpression of copper\/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation","volume":"22","author":"Sugawara","year":"2002","journal-title":"J. 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Physiol."},{"issue":"9","key":"10.1016\/j.bbadis.2021.166230_bb0325","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","article-title":"Mitochondria as the central control point of apoptosis","volume":"10","author":"Desagher","year":"2000","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2021.166230_bb0330","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jep.2014.03.057","article-title":"An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: up-regulation of Bcl-2 and down-regulation of Bax and caspase-3","volume":"154","author":"Wang","year":"2014","journal-title":"J. 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