{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:45:53Z","timestamp":1773384353768,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bbadis.2021.166242","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:52:50Z","timestamp":1628599970000},"page":"166242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats"],"prefix":"10.1016","volume":"1867","author":[{"given":"Chun","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye Chun","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Yin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Gui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei Yang","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao Chang","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2021.166242_bb0005","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1038\/s41467-020-19003-5","article-title":"Defining the impact of dietary macronutrient balance on PCOS traits","volume":"11","author":"Paris","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2021.166242_bb0010","doi-asserted-by":"crossref","first-page":"e1071","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: consequences, challenges, and guiding treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166242_bb0015","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgaa337","article-title":"Insulin sensitizers for improving the endocrine and metabolic profile in overweight women with PCOS","volume":"105","author":"Xing","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166242_bb0020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jcjd.2020.05.015","article-title":"Depression in girls with obesity and polycystic ovary syndrome and\/or type 2 diabetes","volume":"44","author":"Benson","year":"2020","journal-title":"Can. J. Diabetes"},{"key":"10.1016\/j.bbadis.2021.166242_bb0025","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejogrb.2016.08.026","article-title":"Obesity, type 2 diabetes mellitus and cardiovascular disease risk: an uptodate in the management of polycystic ovary syndrome","volume":"207","author":"Orio","year":"2016","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0030","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/apt.14058","article-title":"Polycystic ovary syndrome with hyperandrogenism as a risk factor for non-obese non-alcoholic fatty liver disease","volume":"45","author":"Kim","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2021.166242_bb0035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mam.2018.11.001","article-title":"Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity","volume":"66","author":"Villalobos-Labra","year":"2019","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbadis.2021.166242_bb0040","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molmed.2011.07.010","article-title":"Endoplasmic reticulum stress, obesity and diabetes","volume":"18","author":"Cnop","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbadis.2021.166242_bb0045","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nrd2755","article-title":"Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities","volume":"7","author":"Kim","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2021.166242_bb0050","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.cellsig.2012.03.011","article-title":"Redox signaling loops in the unfolded protein response","volume":"24","author":"Higa","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2021.166242_bb0055","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"\u00d6zcan","year":"2004","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bbadis.2021.166242_bb0060","doi-asserted-by":"crossref","first-page":"788","DOI":"10.15252\/emmm.201404509","article-title":"Divergent androgen regulation of unfolded protein response pathways drives prostate cancer","volume":"7","author":"Sheng","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbadis.2021.166242_bb0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/JHC.S48956","article-title":"The androgen receptor as an emerging target in hepatocellular carcinoma","volume":"2","author":"Kanda","year":"2015","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.bbadis.2021.166242_bb0070","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fendo.2019.00298","article-title":"Kisspeptin and polycystic ovary syndrome","volume":"10","author":"Tang","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2021.166242_bb0075","first-page":"367","article-title":"Kisspeptin in the hypothalamus of 2 rat models of polycystic ovary syndrome","volume":"158","author":"Osuka","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166242_bb0080","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.fertnstert.2005.11.044","article-title":"Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome","volume":"85","author":"Panidis","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbadis.2021.166242_bb0085","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1159\/000493406","article-title":"Kisspeptin\/GPR54 system: what do we know about its role in human reproduction?","volume":"49","author":"Trevisan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbadis.2021.166242_bb0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41574-020-00436-3","article-title":"Cellular and molecular features of EDC exposure: consequences for the GnRH network","volume":"17","author":"Lopez-Rodriguez","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0095","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000479371","article-title":"An international consortium update: pathophysiology, diagnosis, and treatment of polycystic ovarian syndrome in adolescence","volume":"88","author":"Ibanez","year":"2017","journal-title":"Horm Res Paediatr"},{"key":"10.1016\/j.bbadis.2021.166242_bb0100","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ygcen.2017.01.025","article-title":"How is GnRH regulated in GnRH-producing neurons? Studies using GT1-7 cells as a GnRH-producing cell model","volume":"247","author":"Kanasaki","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/REP-15-0044","article-title":"Follicular hyperandrogenism downregulates aromatase in luteinized granulosa cells in polycystic ovary syndrome women","volume":"150","author":"Yang","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.bbadis.2021.166242_bb0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.fertnstert.2018.09.022","article-title":"Elevation of antimullerian hormone in women with polycystic ovary syndrome undergoing assisted reproduction: effect of insulin","volume":"111","author":"Liu","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbadis.2021.166242_bb0115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/JOE-14-0021","article-title":"Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats","volume":"222","author":"Yan","year":"2014","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0120","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.fertnstert.2014.07.739","article-title":"Long-term effects of repeated superovulation on ovarian structure and function in rhesus monkeys","volume":"102","author":"Dong","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbadis.2021.166242_bb0125","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nm.2771","article-title":"Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation","volume":"18","author":"Ruan","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2021.166242_bb0130","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1210\/jc.2005-1852","article-title":"The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism","volume":"91","author":"McCartney","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166242_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2010.50","article-title":"Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78\/BiP in prostate cancer cells","volume":"1","author":"Bennett","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2021.166242_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-12-385114-7.00004-0","article-title":"Measuring ER stress and the unfolded protein response using mammalian tissue culture system","volume":"490","author":"Oslowski","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0145","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004424","article-title":"ER stress and its functional link to mitochondria: role in cell survival and death","volume":"3","author":"Malhotra","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0150","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1471-4159.2005.03276.x","article-title":"PERK is responsible for the increased phosphorylation of eIF2\u03b1 and the severe inhibition of protein synthesis after transient global brain ischemia","volume":"94","author":"Owen","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2021.166242_bb0155","doi-asserted-by":"crossref","unstructured":"J.S. Kim, R.W. Heo, H. Kim, C.O. Yi, H.J. Shin, J.W. Han, G.S. Roh, Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death, J. Neural Transm., 121 (2014) 1233\u20131243.","DOI":"10.1007\/s00702-014-1208-0"},{"key":"10.1016\/j.bbadis.2021.166242_bb0160","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbadis.2021.166242_bb0165","doi-asserted-by":"crossref","unstructured":"E. Bahar, H. Kim, H. Yoon, ER stress-mediated signaling: action potential and Ca2+ as key players, Int. J. Mol. Sci., 17 (2016) 1558.","DOI":"10.3390\/ijms17091558"},{"key":"10.1016\/j.bbadis.2021.166242_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.592129","article-title":"The molecular mechanisms underlying mitochondria-associated endoplasmic reticulum membrane-induced insulin resistance","volume":"11","author":"Cheng","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2021.166242_bb0175","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/me.2013-1165","article-title":"Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling","volume":"28","author":"Min","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0180","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1210\/en.2004-0413","article-title":"Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide","volume":"145","author":"Navarro","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166242_bb0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.fertnstert.2013.05.024","article-title":"The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications","volume":"100","author":"Witchel","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbadis.2021.166242_bb0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/JOE-16-0568","article-title":"Effect of androgen on Kiss1 expression and luteinizing hormone release in female rats","volume":"233","author":"Iwata","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2014.07.103","article-title":"Endoplasmic reticulum stress pathway gene expression is altered in the cumulus cells of PCOS patients undergoing IVF","volume":"102","author":"Collins","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbadis.2021.166242_bb0200","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.celrep.2014.08.057","article-title":"Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance","volume":"9","author":"Contreras","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2021.166242_bb0205","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.molmet.2016.08.003","article-title":"Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty","volume":"5","author":"Manfredi-Lozano","year":"2016","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.bbadis.2021.166242_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40618-016-0523-8","article-title":"New markers of insulin resistance in polycystic ovary syndrome","volume":"40","author":"Polak","year":"2017","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.bbadis.2021.166242_bb0215","first-page":"3932","article-title":"Demonstration of a calcium requirement for secretory protein processing and export","volume":"267","author":"Kuznetsov","year":"1992","journal-title":"Differential effects of calcium and dithiothreitol, J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2021.166242_bb0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2021.166242_bb0225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.gene.2016.03.055","article-title":"Androgen-inducible gene 1 increases the ER Ca 2+ content and cell death susceptibility against oxidative stress","volume":"586","author":"Nickel","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bbadis.2021.166242_bb0230","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1210\/en.2008-1313","article-title":"\u03b3-Aminobutyric acid B receptor mediated inhibition of gonadotropin-releasing hormone neurons is suppressed by kisspeptin-G protein-coupled receptor 54 signaling","volume":"150","author":"Zhang","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2021.166242_bb0235","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000194971","article-title":"Obesity and polycystic ovary syndrome","volume":"2","author":"Vrbikova","year":"2009","journal-title":"Obes. Facts"},{"key":"10.1016\/j.bbadis.2021.166242_bb0240","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.tem.2012.06.003","article-title":"New insights into ER stress-induced insulin resistance","volume":"23","author":"Flamment","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2021.166242_bb0245","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"\u00d6zcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2021.166242_bb0250","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1159\/000455865","article-title":"Hypothalamic insulin resistance in obesity: effects on glucose homeostasis","volume":"104","author":"Chen","year":"2017","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbadis.2021.166242_bb0255","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"Schwartz","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2021.166242_bb0260","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbadis.2021.166242_bb0265","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1385\/ENDO:30:1:45","article-title":"Insulin resistance, the metabolic syndrome, diabetes, and cardiovascular disease risk in women with PCOS","volume":"30","author":"Teede","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.bbadis.2021.166242_bb0270","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1172\/JCI89519","article-title":"Kisspeptin modulates sexual and emotional brain processing in humans","volume":"127","author":"Comninos","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2021.166242_bb0275","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","article-title":"The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance","volume":"21","author":"Lee","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2021.166242_bb0280","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/cen.14007","article-title":"Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c)","volume":"91","author":"Ramanjaneya","year":"2019","journal-title":"PCOS and healthy subjects, Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.bbadis.2021.166242_bb0285","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41467-020-20790-0","article-title":"MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis","volume":"12","author":"Reynolds","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2021.166242_bb0290","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1152\/ajpendo.00359.2018","article-title":"Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production","volume":"316","author":"Hu","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443921001757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443921001757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:04:28Z","timestamp":1760418268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443921001757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0925443921001757"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166242","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2021.166242","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166242"}}