{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:38:42Z","timestamp":1767969522380,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673636"],"award-info":[{"award-number":["81673636"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.bbadis.2022.166487","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T02:52:14Z","timestamp":1657767134000},"page":"166487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Deacetylation mechanism and potential reversal strategy of long QT syndrome on hERG K+ channel under hypoxia"],"prefix":"10.1016","volume":"1868","author":[{"given":"Hui","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengrong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbadis.2022.166487_bb0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel","volume":"81","author":"Sanguinetti","year":"1995","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bbadis.2022.166487_bb0010","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/01.CIR.102.10.1178","article-title":"Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2","volume":"102","author":"Splawski","year":"2000","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.bbadis.2022.166487_bb0015","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.hrthm.2020.05.041","article-title":"High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1","volume":"17","author":"Kozek","year":"2020","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.bbadis.2022.166487_bb0020","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/212178","article-title":"Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review","volume":"2012","author":"Kallergis","year":"2012","journal-title":"ScientificWorldJournal"},{"issue":"12","key":"10.1016\/j.bbadis.2022.166487_bb0025","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/aps.2014.101","article-title":"Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects","volume":"35","author":"Zhang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.bbadis.2022.166487_bb0030","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","article-title":"Long-QT syndrome: from genetics to management","volume":"5","author":"Schwartz","year":"2012","journal-title":"Circ. Arrhythm. Electrophysiol."},{"issue":"5A","key":"10.1016\/j.bbadis.2022.166487_bb0035","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1582-4934.2008.00398.x","article-title":"Hypoxia response and microRNAs: no longer two separate worlds","volume":"12","author":"Ivan","year":"2008","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"10.1016\/j.bbadis.2022.166487_bb0040","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.jacc.2006.11.035","article-title":"Prolongation of the QTc interval is seen uniformly during early transmural ischemia","volume":"49","author":"Kenigsberg","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.bbadis.2022.166487_bb0045","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1161\/01.CIR.57.6.1074","article-title":"QT interval prolongation as predictor of sudden death in patients with myocardial infarction","volume":"57","author":"Schwartz","year":"1978","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bbadis.2022.166487_bb0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/CIRCRESAHA.109.209338","article-title":"Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors","volume":"106","author":"Bush","year":"2010","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.bbadis.2022.166487_bb0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/cvr\/cvv265","article-title":"Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation","volume":"109","author":"Zhang","year":"2016","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.bbadis.2022.166487_bb0060","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.molcel.2005.04.021","article-title":"HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor","volume":"18","author":"Kovacs","year":"2005","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.bbadis.2022.166487_bb0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.tcb.2008.04.003","article-title":"HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions","volume":"18","author":"Valenzuela-Fern\u00e1ndez","year":"2008","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2022.166487_bb0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/86507","article-title":"Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes","volume":"7","author":"Kim","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2022.166487_bb0075","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.yjmcc.2018.01.009","article-title":"Restoration of mutant hERG stability by inhibition of HDAC6","volume":"115","author":"Li","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.bbadis.2022.166487_bb0080","first-page":"2203","article-title":"Loss of conserved ubiquitylation sites in conserved proteins during human evolution","volume":"42","author":"Park","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.bbadis.2022.166487_bb0085","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12943-017-0751-3","article-title":"The Jun\/miR-22\/HuR regulatory axis contributes to tumourigenesis in colorectal cancer","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.bbadis.2022.166487_bb0090","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1515\/hsz-2017-0155","article-title":"HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8","volume":"398","author":"Tang","year":"2017","journal-title":"Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbadis.2022.166487_bb0095","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1111\/jcmm.16292","article-title":"Rutaecarpine targets hERG channels and participates in regulating electrophysiological properties leading to ventricular arrhythmia","volume":"25","author":"Zhan","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"11","key":"10.1016\/j.bbadis.2022.166487_bb0100","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1111\/bph.15757","article-title":"Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation","volume":"179","author":"TeBay","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2022.166487_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bcp.2012.09.002","article-title":"Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression","volume":"85","author":"Zhang","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbadis.2022.166487_bb0110","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pharmthera.2013.03.008","article-title":"Cardiac ion channel trafficking defects and drugs","volume":"139","author":"de Git","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bbadis.2022.166487_bb0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/toxsci\/kfx098","article-title":"Mechanism of As2O3-induced action potential prolongation and using hiPS-CMs to evaluate the rescue efficacy of drugs with different rescue mechanism","volume":"158","author":"Yan","year":"2017","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2022.166487_bb0120","doi-asserted-by":"crossref","first-page":"E416","DOI":"10.1073\/pnas.1612383114","article-title":"Tbx20 controls the expression of the KCNH2 gene and of hERG channels","volume":"114","author":"Caballero","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbadis.2022.166487_bb0125","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1182\/blood-2004-07-2958","article-title":"Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1","volume":"105","author":"Manalo","year":"2005","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bbadis.2022.166487_bb0130","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.bbadis.2022.166487_bb0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"issue":"12","key":"10.1016\/j.bbadis.2022.166487_bb0140","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.tibs.2017.10.004","article-title":"Histone Marks in the \u2018Driver\u2019s Seat\u2019: functional roles in steering the transcription cycle","volume":"42","author":"Gates","year":"2017","journal-title":"Trends Biochem. Sci."},{"issue":"4","key":"10.1016\/j.bbadis.2022.166487_bb0145","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1152\/physrev.00037.2019","article-title":"Role of the epigenome in heart failure","volume":"100","author":"Papait","year":"2020","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.bbadis.2022.166487_bb0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/15563650500514558","article-title":"Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia","volume":"44","author":"Chen","year":"2006","journal-title":"Clin. Toxicol. (Phila.)"},{"issue":"5","key":"10.1016\/j.bbadis.2022.166487_bb0155","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/RHU.0b013e31829d5e50","article-title":"Suspected hydroxychloroquine-associated QT-interval prolongation in a patient with systemic lupus erythematosus","volume":"19","author":"Morgan","year":"2013","journal-title":"J. Clin. Rheumatol."},{"key":"10.1016\/j.bbadis.2022.166487_bb0160","article-title":"Life threatening severe QTc prolongation in patient with systemic lupus erythematosus due to hydroxychloroquine","volume":"2016","author":"O\u2019Laughlin","year":"2016","journal-title":"Case Rep. Cardiol."},{"issue":"3","key":"10.1016\/j.bbadis.2022.166487_bb0165","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1097-2765(02)00639-1","article-title":"Control of Smad7 stability by competition between acetylation and ubiquitination","volume":"10","author":"Gr\u00f6nroos","year":"2002","journal-title":"Mol. Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443922001582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443922001582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:09:40Z","timestamp":1760418580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443922001582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0925443922001582"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2022.166487","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deacetylation mechanism and potential reversal strategy of long QT syndrome on hERG K+ channel under hypoxia","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2022.166487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166487"}}