{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:46:17Z","timestamp":1793385977209,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL126609"],"award-info":[{"award-number":["P01 HL126609"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL134610"],"award-info":[{"award-number":["P01 HL134610"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL094394"],"award-info":[{"award-number":["R01 HL094394"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL141387"],"award-info":[{"award-number":["R01 HL141387"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.bbadis.2022.166562","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T12:06:05Z","timestamp":1664280365000},"page":"166562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation"],"prefix":"10.1016","volume":"1868","author":[{"given":"Jin H.","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Sammani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie L.","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeo","family":"Bermudez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna D.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswanathan","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe G.N.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2022.166562_bb0005","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"2001","key":"10.1016\/j.bbadis.2022.166562_bb0010","first-page":"1487","article-title":"Cytoskeletal regulation of pulmonary vascular permeability","volume":"91","author":"Dudek","year":"1985","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMra1608077","article-title":"Acute respiratory distress syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0020","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1164\/rccm.200712-1822OC","article-title":"Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury","volume":"178","author":"Hong","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0025","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/01.CCM.0000260243.22758.4F","article-title":"Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome","volume":"35","author":"Bajwa","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2022.166562_bb0035","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41598-021-04444-9","article-title":"eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt\/mTORC2 signaling","volume":"12","author":"Bermudez","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.916159","article-title":"eNAMPT neutralization preserves lung fluid balance and reduces acute renal injury in porcine Sepsis\/VILI-induced inflammatory lung injury","volume":"13","author":"Sammani","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.trsl.2020.12.008","article-title":"Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury","volume":"232","author":"Bime","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2022.166562_bb0050","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1086\/688761","article-title":"Endotoxin- and mechanical stress-induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter","volume":"6","author":"Elangovan","year":"2016","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbadis.2022.166562_bb0055","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02536-2020","article-title":"Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody","volume":"57","author":"Quijada","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2022.166562_bb0060","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1038\/s41467-021-23683-y","article-title":"TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection","volume":"12","author":"Geng","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2022.166562_bb0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/15216540051080976","article-title":"The NADPH oxidase of endothelial cells","volume":"50","author":"Babior","year":"2000","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbadis.2022.166562_bb0070","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0955-0674(94)90138-4","article-title":"Regulation of the human neutrophil NADPH oxidase by the rac GTP-binding proteins","volume":"6","author":"Bokoch","year":"1994","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0075","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.RES.0000204727.46710.5e","article-title":"Regulation of NADPH oxidases: the role of rac proteins","volume":"98","author":"Hordijk","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2022.166562_bb0080","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.1074\/jbc.M109.009894","article-title":"The regulation of vascular endothelial growth factor-induced microvascular permeability requires rac and reactive oxygen species","volume":"284","author":"Monaghan-Benson","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2022.166562_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101638","article-title":"Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII\/ERK1\/2\/MLCK and endothelial cell barrier dysfunction","volume":"36","author":"Jiang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0090","first-page":"L297","article-title":"Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury","volume":"312","author":"Palumbo","year":"2017","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbadis.2022.166562_bb0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s40495-016-0053-2","article-title":"Role of Nrf2 and autophagy in acute lung injury","volume":"2","author":"Rojo de la Vega","year":"2016","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0100","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1096\/fj.05-3928com","article-title":"Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1\/Rac1, and alpha-actinin","volume":"19","author":"Singleton","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2022.166562_bb0105","doi-asserted-by":"crossref","first-page":"30643","DOI":"10.1074\/jbc.M702573200","article-title":"CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-met, Tiam1\/Rac1, dynamin 2, and cortactin","volume":"282","author":"Singleton","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2022.166562_bb0110","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2353\/ajpath.2006.050431","article-title":"Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch","volume":"168","author":"Birukova","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1537-1891(03)00008-9","article-title":"Rho GTPases and the regulation of endothelial permeability","volume":"39","author":"Wojciak-Stothard","year":"2002","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0120","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1091\/mbc.e09-10-0876","article-title":"Abl tyrosine kinase phosphorylates nonmuscle myosin light chain kinase to regulate endothelial barrier function","volume":"21","author":"Dudek","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2022.166562_bb0125","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018764171","article-title":"Myosin light chain kinase ( MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions","volume":"8","author":"Wang","year":"2018","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbadis.2022.166562_bb0130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","article-title":"The small GTP-binding protein rac regulates growth factor-induced membrane ruffling","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2022.166562_bb0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/cvr\/cvq086","article-title":"Role of GTPases in control of microvascular permeability","volume":"87","author":"Spindler","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2022.166562_bb0140","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1161\/01.CIR.0000055324.34758.32","article-title":"Small GTP-binding protein rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability","volume":"107","author":"Eriksson","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2022.166562_bb0145","doi-asserted-by":"crossref","first-page":"24111","DOI":"10.1038\/srep24111","article-title":"PTP1B inhibitor promotes endothelial cell motility by activating the DOCK180\/Rac1 pathway","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0150","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1101\/gad.12.21.3331","article-title":"Activation of Rac1 by a crk SH3-binding protein, DOCK180","volume":"12","author":"Kiyokawa","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2022.166562_bb0155","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ncb824","article-title":"Unconventional rac-GEF activity is mediated through the Dock180-ELMO complex","volume":"4","author":"Brugnera","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0160","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1091\/mbc.e08-04-0345","article-title":"An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in rac signaling","volume":"19","author":"Komander","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbadis.2022.166562_bb0165","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/CIRCRESAHA.110.223388","article-title":"DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4","volume":"107","author":"Sanematsu","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2022.166562_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12061","article-title":"Critical role for the lung endothelial nonmuscle myosin light-chain kinase isoform in the severity of inflammatory murine lung injury","volume":"12","author":"Kempf","year":"2022","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbadis.2022.166562_bb0175","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1158\/0008-5472.CAN-10-1977","article-title":"The BH3 mimetic ABT-737 induces cancer cell senescence","volume":"71","author":"Song","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2022.166562_bb0180","doi-asserted-by":"crossref","first-page":"29003","DOI":"10.1038\/srep29003","article-title":"Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility","volume":"6","author":"Garcia Ponce","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0185","first-page":"L289","article-title":"Endothelial cell barrier enhancement by ATP is mediated by the small GTPase rac and cortactin","volume":"291","author":"Jacobson","year":"2006","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.bbadis.2022.166562_bb0190","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/rccm.200404-563OC","article-title":"Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury","volume":"171","author":"Ye","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0195","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.1070238","article-title":"Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists","volume":"296","author":"Mandala","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2022.166562_bb0200","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1016\/j.cellsig.2007.03.011","article-title":"Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor","volume":"19","author":"Dudek","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2022.166562_bb0205","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1183\/09031936.00047810","article-title":"FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-abl","volume":"38","author":"Wang","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2022.166562_bb0210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0215","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.2110101","article-title":"4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease","volume":"166","author":"Rahman","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0220","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/bs.ctm.2018.09.003","article-title":"Cortical actin dynamics in endothelial permeability","volume":"82","author":"Belvitch","year":"2018","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.bbadis.2022.166562_bb0225","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1172\/JCI12450","article-title":"Sphingosine 1-phosphate promotes endothelial cell barrier integrity by edg-dependent cytoskeletal rearrangement","volume":"108","author":"Garcia","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2022.166562_bb0230","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1164\/rccm.200405-684OC","article-title":"Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury","volume":"170","author":"McVerry","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0235","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jcp.1041630311","article-title":"Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation","volume":"163","author":"Garcia","year":"1995","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0240","doi-asserted-by":"crossref","first-page":"10027","DOI":"10.1016\/S0021-9258(17)39206-2","article-title":"Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase","volume":"260","author":"Ikebe","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2022.166562_bb0245","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","article-title":"Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2022.166562_bb0250","doi-asserted-by":"crossref","first-page":"13135","DOI":"10.1038\/srep13135","article-title":"Unique toll-like receptor 4 activation by NAMPT\/PBEF induces NFkappaB signaling and inflammatory lung injury","volume":"5","author":"Camp","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0255","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0092-8674(01)00520-7","article-title":"CED-12\/ELMO, a novel member of the CrkII\/Dock180\/Rac pathway, is required for phagocytosis and cell migration","volume":"107","author":"Gumienny","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2022.166562_bb0260","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.celrep.2017.04.016","article-title":"Targeting ras-driven cancer cell survival and invasion through selective inhibition of DOCK1","volume":"19","author":"Tajiri","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0265","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1086\/685547","article-title":"Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis","volume":"6","author":"Bime","year":"2016","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.bbadis.2022.166562_bb0270","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fphys.2012.00161","article-title":"Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury","volume":"3","author":"Aggarwal","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0275","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2013.12.035","article-title":"Endothelial targeting of liposomes encapsulating SOD\/catalase mimetic EUK-134 alleviates acute pulmonary inflammation","volume":"177","author":"Howard","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.bbadis.2022.166562_bb0280","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s001340050813","article-title":"Antioxidant status in patients with acute respiratory distress syndrome","volume":"25","author":"Metnitz","year":"1999","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0285","first-page":"4911","article-title":"Protective mechanism of sulforaphane in Nrf2 and anti-lung injury in ARDS rabbits","volume":"15","author":"Sun","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0290","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.105.1.190","article-title":"N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study","volume":"105","author":"Suter","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.bbadis.2022.166562_bb0295","doi-asserted-by":"crossref","first-page":"18760","DOI":"10.1038\/srep18760","article-title":"Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner","volume":"6","author":"Tao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0300","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.4049\/jimmunol.0804248","article-title":"Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice","volume":"182","author":"Reddy","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0305","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1165\/ajrcmb.26.2.4501","article-title":"Role of NRF2 in protection against hyperoxic lung injury in mice","volume":"26","author":"Cho","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0310","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1164\/rccm.200701-060OC","article-title":"Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice","volume":"176","author":"Papaiahgari","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2022.166562_bb0315","doi-asserted-by":"crossref","first-page":"17546","DOI":"10.1038\/s41598-021-97006-y","article-title":"Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss","volume":"11","author":"Fu","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2022.166562_bb0320","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1165\/rcmb.2012-0161OC","article-title":"Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization","volume":"47","author":"Kratzer","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0325","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.4049\/jimmunol.173.6.3589","article-title":"Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B","volume":"173","author":"Park","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2022.166562_bb0330","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/japplphysiol.00690.2002","article-title":"S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin","volume":"94","author":"Shikata","year":"2003","journal-title":"J. Appl. Physiol. (1985)"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443922002332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443922002332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:16:10Z","timestamp":1760418970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443922002332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":66,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0925443922002332"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2022.166562","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2022.166562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166562"}}