{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:52:14Z","timestamp":1790790734720,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.bbadis.2023.166755","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T17:19:38Z","timestamp":1684171178000},"page":"166755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Estrogen receptor \u03b2 attenuates renal fibrosis by suppressing the transcriptional activity of Smad3"],"prefix":"10.1016","volume":"1869","author":[{"given":"Rong","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfang","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Ake","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-yao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9889","key":"10.1016\/j.bbadis.2023.166755_bb0005","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(13)60595-4","article-title":"Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention","volume":"382","author":"Gansevoort","year":"2013","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.bbadis.2023.166755_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158765","article-title":"Global prevalence of chronic kidney disease - a systematic review and Meta-analysis","volume":"11","author":"Hill","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbadis.2023.166755_bb0015","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/ki.2013.243","article-title":"Comments on \u2018KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease\u2019","volume":"84","author":"Andrassy","year":"2013","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166755_bb0020","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/ki.1993.312","article-title":"Interstitial fibrosis in obstructive nephropathy","volume":"44","author":"Sharma","year":"1993","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166755_bb0025","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ki.1993.246","article-title":"Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation","volume":"44","author":"Kaneto","year":"1993","journal-title":"Kidney Int."},{"issue":"4 Suppl 1","key":"10.1016\/j.bbadis.2023.166755_bb0035","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1053\/ajkd.2001.27422","article-title":"Role of connective tissue growth factor in profibrotic action of transforming growth factor-beta: a potential target for preventing renal fibrosis","volume":"38","author":"Yokoi","year":"2001","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166755_bb0040","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/ki.1996.111","article-title":"Risk of developing end-stage renal disease in a cohort of mass screening","volume":"49","author":"Iseki","year":"1996","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1681\/ASN.V112319","article-title":"Effect of gender on the progression of nondiabetic renal disease: a meta-analysis","volume":"11","author":"Neugarten","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166755_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2014.03.031","article-title":"Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK","volume":"20","author":"Martinez","year":"2014","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166755_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000108","article-title":"Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma","volume":"4","author":"Foryst-Ludwig","year":"2008","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166755_bb0060","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1097\/01.ASN.0000128219.65330.EA","article-title":"Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat","volume":"15","author":"Maric","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.ASN.0000105993.63023.D8","article-title":"Beneficial effects of estrogens on indices of renal damage in uninephrectomized SHRsp rats","volume":"15","author":"Gross","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166755_bb0070","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ki.2009.69","article-title":"17 beta-estradiol and tamoxifen upregulate estrogen receptor beta expression and control podocyte signaling pathways in a model of type 2 diabetes","volume":"75","author":"Catanuto","year":"2009","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0075","doi-asserted-by":"crossref","first-page":"F399","DOI":"10.1152\/ajprenal.00195.2004","article-title":"17beta-estradiol replacement improves renal function and pathology associated with diabetic nephropathy","volume":"288","author":"Mankhey","year":"2005","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166755_bb0080","first-page":"368","article-title":"Chronic renal failure in male and female rats","volume":"18","author":"Lemos","year":"2005","journal-title":"J. Nephrol."},{"issue":"12","key":"10.1016\/j.bbadis.2023.166755_bb0085","first-page":"4258","article-title":"Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern","volume":"82","author":"Enmark","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0090","doi-asserted-by":"crossref","first-page":"R794","DOI":"10.1152\/ajpregu.00424.2006","article-title":"Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats","volume":"292","author":"Rogers","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166755_bb0095","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000317934","article-title":"A gender comparison of postobstructive injury in the rat kidney","volume":"33","author":"Quinlan","year":"2010","journal-title":"Kidney Blood Press Res."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166755_bb0100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2023.166755_bb0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-981-13-8871-2_16","article-title":"TGF-beta\/Smad and renal fibrosis","volume":"1165","author":"Ma","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"25","key":"10.1016\/j.bbadis.2023.166755_bb0110","doi-asserted-by":"crossref","first-page":"14769","DOI":"10.1073\/pnas.95.25.14769","article-title":"SMAD3\/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta","volume":"95","author":"Vindevoghel","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bbadis.2023.166755_bb0115","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-beta\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"issue":"46","key":"10.1016\/j.bbadis.2023.166755_bb0125","doi-asserted-by":"crossref","first-page":"42908","DOI":"10.1074\/jbc.M105316200","article-title":"Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3","volume":"276","author":"Matsuda","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166755_bb0130","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1177\/0961203320984231","article-title":"Low expression of estrogen receptor beta in renal tubular epithelial cells may cause hyperuricemia in premenopausal patients with systemic lupus erythematosus","volume":"30","author":"Liu","year":"2021","journal-title":"Lupus"},{"issue":"5","key":"10.1016\/j.bbadis.2023.166755_bb0135","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0002-9440(10)64277-0","article-title":"Estrogen deficiency accelerates progression of glomerulosclerosis in susceptible mice","volume":"162","author":"Elliot","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166755_bb0140","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1210\/me.2010-0154","article-title":"Estrogen receptor-beta prevents cardiac fibrosis","volume":"24","author":"Pedram","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.bbadis.2023.166755_bb0145","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1086\/651276","article-title":"Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study","volume":"201","author":"Christaki","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.bbadis.2023.166755_bb0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2015.00082","article-title":"TGF-beta\/Smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166755_bb0155","doi-asserted-by":"crossref","first-page":"F164","DOI":"10.1152\/ajprenal.0318.2000","article-title":"Estradiol upregulates mesangial cell MMP-2 activity via the transcription factor AP-2","volume":"282","author":"Guccione","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"26","key":"10.1016\/j.bbadis.2023.166755_bb0160","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1038\/sj.onc.1204448","article-title":"Smad3\/AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner","volume":"20","author":"Verrecchia","year":"2001","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.bbadis.2023.166755_bb0165","first-page":"2319","article-title":"Estrogen receptor alpha expression in renal tissue and its relationship with prognosis in immunoglobulin A nephropathy","volume":"13","author":"Yu","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbadis.2023.166755_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111003","article-title":"Tamoxifen attenuates renal fibrosis in human kidney slices and rats subjected to unilateral ureteral obstruction","volume":"133","author":"Tingskov","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166755_bb0175","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/ndt\/gfu240","article-title":"Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor alpha-mediated transforming growth factor-beta1\/Smad signaling pathway","volume":"29","author":"Kim","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbadis.2023.166755_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.02.007","article-title":"Update on ERbeta","volume":"191","author":"Gustafsson","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166755_bb0185","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1073\/pnas.242735799","article-title":"Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain","volume":"100","author":"Wang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"updated-by":[{"DOI":"10.1016\/j.bbadis.2026.168426","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000}},{"DOI":"10.1016\/j.bbadis.2026.168426","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000}}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923001217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923001217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T22:11:05Z","timestamp":1722550265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443923001217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0925443923001217"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166755","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen receptor \u03b2 attenuates renal fibrosis by suppressing the transcriptional activity of Smad3","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166755","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166755"}}