{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:13:10Z","timestamp":1787652790776,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.bbadis.2023.166820","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:37:33Z","timestamp":1691408253000},"page":"166820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid"],"prefix":"10.1016","volume":"1869","author":[{"given":"Genshen","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbadis.2023.166820_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol."},{"issue":"20","key":"10.1016\/j.bbadis.2023.166820_bb0010","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166820_bb0015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166820_bb0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/imr.12447","article-title":"Priming of the neutrophil respiratory burst: role in host defense and inflammation","volume":"273","author":"El-Benna","year":"2016","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166820_bb0025","doi-asserted-by":"crossref","first-page":"629","DOI":"10.33594\/000000245","article-title":"The critical role of cell metabolism for essential neutrophil functions","volume":"54","author":"Curi","year":"2020","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166820_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10545-011-9382-9","article-title":"Mitochondrial ATP synthase: architecture, function and pathology","volume":"35","author":"Jonckheere","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.bbadis.2023.166820_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.917203","article-title":"The F1Fo-ATPase inhibitor protein IF1 in pathophysiology","volume":"13","author":"Gatto","year":"2022","journal-title":"Front. Physiol."},{"issue":"4\u20136","key":"10.1016\/j.bbadis.2023.166820_bb0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/ars.2021.0137","article-title":"The multifaceted ATPase inhibitory factor 1 (IF1) in energy metabolism reprogramming and mitochondrial dysfunction: a new player in age-associated disorders?","volume":"37","author":"Gore","year":"2022","journal-title":"Antioxid. Redox Signal."},{"issue":"7425","key":"10.1016\/j.bbadis.2023.166820_bb0045","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nature11536","article-title":"Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts","volume":"491","author":"Shah","year":"2012","journal-title":"Nature."},{"issue":"10","key":"10.1016\/j.bbadis.2023.166820_bb0050","doi-asserted-by":"crossref","DOI":"10.1172\/JCI155333","article-title":"Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts","volume":"132","author":"Zhou","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166820_bb0055","doi-asserted-by":"crossref","first-page":"2114740","DOI":"10.1080\/2162402X.2022.2114740","article-title":"scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity","volume":"11","author":"Zhong","year":"2022","journal-title":"Oncoimmunology."},{"key":"10.1016\/j.bbadis.2023.166820_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107980","article-title":"IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa","volume":"99","author":"Zhong","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166820_bb0065","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.apsb.2021.02.002","article-title":"Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1) secretion function of the mouse intestine","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.bbadis.2023.166820_bb0070","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.celrep.2018.02.067","article-title":"Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death","volume":"22","author":"Kambara","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2023.166820_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.760999","article-title":"Inhibitor of Differentiation-2 protein ameliorates DSS-induced ulcerative colitis by inhibiting NF-\u03baB activation in neutrophils","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.bbadis.2023.166820_bb0080","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/imcb.12575","article-title":"A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis","volume":"100","author":"Zhang","year":"2022","journal-title":"Immunol. Cell Biol."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166820_bb0085","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00011-014-0766-9","article-title":"TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis","volume":"63","author":"van Lieshout","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbadis.2023.166820_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.888412","article-title":"Long lasting antibodies from convalescent pertussis patients induce ROS production and bacterial killing by human neutrophils","volume":"12","author":"Kroes","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166820_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010700","article-title":"Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling","volume":"18","author":"Herring","year":"2022","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166820_bb0100","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051606","article-title":"OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential","volume":"22","author":"Liu","year":"2021","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166820_bb0105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-glucose and its analogs: from diagnostic to therapeutic agents","volume":"21","author":"Pajak","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166820_bb0110","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2012.01.008","article-title":"The mitochondrial ATPase inhibitory factor 1 triggers a ROS-mediated retrograde prosurvival and proliferative response","volume":"45","author":"Formentini","year":"2012","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.bbadis.2023.166820_bb0115","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/embj.201386392","article-title":"In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning","volume":"33","author":"Formentini","year":"2014","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166820_bb0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.celrep.2014.02.046","article-title":"Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells","volume":"7","author":"ChenK","year":"2014","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166820_bb0125","doi-asserted-by":"crossref","DOI":"10.4110\/in.2020.20.e46","article-title":"Current understanding on the metabolism of neutrophils","volume":"20","author":"Jeon","year":"2020","journal-title":"Immune Netw."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166820_bb0130","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/acs.biochem.5b01385","article-title":"Alternative conformations of cytochrome c: structure, function, and detection","volume":"55","author":"Hannibal","year":"2016","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/j.bbadis.2023.166820_bb0135","doi-asserted-by":"crossref","first-page":"13386","DOI":"10.1038\/ncomms13386","article-title":"Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases","volume":"16","author":"Padovani","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166820_bb0140","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2020.11.016","article-title":"Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis","volume":"33","author":"AdikuJ","year":"2021","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166820_bb0145","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1083\/jcb.95.3.933","article-title":"Glycogen accumulation in polymorphonuclear leukocytes, and other intracellular alterations that occur during inflammation","volume":"95","author":"Robinson","year":"1982","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166820_bb0150","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1210\/me.2013-1268","article-title":"Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis","volume":"28","author":"Zhang","year":"2014","journal-title":"Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166820_bb0155","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12676","article-title":"Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system","volume":"69","author":"NaveenKumar","year":"2020","journal-title":"J. Pineal Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923001862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923001862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T12:24:38Z","timestamp":1733055878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443923001862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0925443923001862"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166820","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166820","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166820"}}