{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:37:01Z","timestamp":1791599821673,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871286"],"award-info":[{"award-number":["31871286"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170603"],"award-info":[{"award-number":["32170603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-ZD-0779"],"award-info":[{"award-number":["2019-ZD-0779"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007765","name":"Shenyang Municipal Bureau of Science and Technology","doi-asserted-by":"publisher","award":["21-173-9-28"],"award-info":[{"award-number":["21-173-9-28"]}],"id":[{"id":"10.13039\/501100007765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["20180540008"],"award-info":[{"award-number":["20180540008"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-BS-298"],"award-info":[{"award-number":["2019-BS-298"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbadis.2023.166844","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T01:35:21Z","timestamp":1691717721000},"page":"166844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Orexin-A\/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell"],"prefix":"10.1016","volume":"1870","author":[{"given":"Xin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbadis.2023.166844_bb0005","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1001\/jamasurg.2020.3280","article-title":"Evaluation and treatment of patients with hypercortisolism: a review","volume":"155","author":"Miller","year":"2020","journal-title":"JAMA Surg"},{"issue":"5","key":"10.1016\/j.bbadis.2023.166844_bb0010","doi-asserted-by":"crossref","first-page":"R1601","DOI":"10.1152\/ajpregu.91034.2008","article-title":"Hypocretin\/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells","volume":"297","author":"Wenzel","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166844_bb0015","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1210\/jc.2004-2385","article-title":"Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells","volume":"90","author":"Spinazzi","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0020","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"de Lecea","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166844_bb0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s000180300005","article-title":"Orexins and their receptors: structural aspects and role in peripheral tissues","volume":"60","author":"Voisin","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2023.166844_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2021.101573","article-title":"The efficacy and safety of dual orexin receptor antagonists in primary insomnia: a systematic review and network meta-analysis","volume":"61","author":"Xue","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.bbadis.2023.166844_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108013","article-title":"Recent perspectives on orexin\/hypocretin promotion of addiction-related behaviors","volume":"168","author":"Hopf","year":"2020","journal-title":"Neuropharmacology."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166844_bb0045","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11906-017-0729-y","article-title":"Role of orexin-a in hypertension and obesity","volume":"19","author":"Imperatore","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166844_bb0050","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12264-019-00447-9","article-title":"Orexin receptor antagonists as emerging treatments for psychiatric disorders","volume":"36","author":"Han","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbadis.2023.166844_bb0055","article-title":"Orexin signaling: a complex","volume":"16","author":"Dale","year":"2022","journal-title":"Multifaceted Process. Front Cell Neurosci."},{"issue":"19","key":"10.1016\/j.bbadis.2023.166844_bb0060","doi-asserted-by":"crossref","first-page":"16726","DOI":"10.1074\/jbc.M111.223537","article-title":"Temporal profiling of orexin receptor-arrestin-ubiquitin complexes reveals differences between receptor subtypes","volume":"286","author":"Dalrymple","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166844_bb0065","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/bph.12324","article-title":"Orexin\/hypocretin receptor signalling cascades","volume":"171","author":"Kukkonen","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.bbadis.2023.166844_bb0070","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s00018-008-8206-z","article-title":"Multiple phospholipase activation by OX(1) orexin\/hypocretin receptors","volume":"65","author":"Johansson","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166844_bb0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1124\/mol.112.078063","article-title":"OX1 orexin\/hypocretin receptor signaling through arachidonic acid and endocannabinoid release","volume":"82","author":"Turunen","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"16","key":"10.1016\/j.bbadis.2023.166844_bb0080","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.3390\/molecules26164849","article-title":"Orexins\/hypocretins and cancer: a neuropeptide as emerging target","volume":"26","author":"Alain","year":"2021","journal-title":"Molecules."},{"issue":"24","key":"10.1016\/j.bbadis.2023.166844_bb0085","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1111\/bph.12883","article-title":"Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery","volume":"171","author":"Putula","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbadis.2023.166844_bb0090","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1210\/en.2007-1739","article-title":"Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells","volume":"149","author":"Ramanjaneya","year":"2008","journal-title":"Endocrinology."},{"issue":"46","key":"10.1016\/j.bbadis.2023.166844_bb0095","doi-asserted-by":"crossref","first-page":"31950","DOI":"10.1074\/jbc.M114.600015","article-title":"Orexin\/hypocretin activates mTOR complex 1 (mTORC1) via an Erk\/Akt-independent and calcium-stimulated lysosome v-ATPase pathway","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166844_bb0100","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1096\/fj.07-098723","article-title":"A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism","volume":"22","author":"Voisin","year":"2008","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.bbadis.2023.166844_bb0105","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1096\/fj.09-131367","article-title":"Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis","volume":"23","author":"El Firar","year":"2009","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166844_bb0110","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s10620-021-07077-0","article-title":"Orexin a suppresses the expression of exosomal PD-L1 in colon cancer and promotes T cell activity by inhibiting JAK2\/STAT3 signaling pathway","volume":"67","author":"Wen","year":"2022","journal-title":"Dig. Dis. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166844_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111497","article-title":"Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity","volume":"41","author":"Tsuneki","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2023.166844_bb0120","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fendo.2018.00647","article-title":"The orexin-A-regulated Akt\/mTOR pathway promotes cell proliferation through inhibiting apoptosis in pancreatic cancer cells","volume":"9","author":"Suo","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166844_bb0125","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1124\/jpet.102.048025","article-title":"Distinct recognition of OX1 and OX2 receptors by orexin peptides","volume":"305","author":"Ammoun","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"21","key":"10.1016\/j.bbadis.2023.166844_bb0130","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.1111\/febs.16109","article-title":"Eat, sleep, repeat - endocrine regulation of behavioural circadian rhythms","volume":"289","author":"Koop","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2023.166844_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/405157","article-title":"Effect of orexin-a on cortisol secretion in H295R cells via p70S6K\/4EBP1 signaling pathway","volume":"2015","author":"Chang","year":"2015","journal-title":"Int. J. Endocrinol."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166844_bb0140","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3892\/ijmm.2014.1959","article-title":"Orexin-a stimulates 3\u03b2-hydroxysteroid dehydrogenase expression and cortisol production in H295R human adrenocortical cells through the AKT pathway","volume":"34","author":"Chang","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166844_bb0145","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3757","article-title":"Making new contacts: the mTOR network in metabolism and signalling crosstalk","volume":"15","author":"Shimobayashi","year":"2014","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/15548627.2018.1505155","article-title":"Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy","volume":"15","author":"Jia","year":"2019","journal-title":"Autophagy."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-019-0754-1","article-title":"Targeting mTOR for cancer therapy","volume":"12","author":"Hua","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"6","key":"10.1016\/j.bbadis.2023.166844_bb0160","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell."},{"key":"10.1016\/j.bbadis.2023.166844_bb0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2022.07.005","article-title":"Low-dose cadmium exposure promotes osteoclastogenesis by enhancing autophagy via inhibiting the mTOR\/p70S6K1 signaling pathway","volume":"367","author":"Wang","year":"2022","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.bbadis.2023.166844_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104165","article-title":"Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis","volume":"25","author":"Bassi","year":"2022","journal-title":"iScience."},{"issue":"8","key":"10.1016\/j.bbadis.2023.166844_bb0175","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/cells10081851","article-title":"The expanding role of mitochondria, autophagy and Lipophagy in steroidogenesis","volume":"10","author":"Bassi","year":"2021","journal-title":"Cells."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166844_bb0180","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0185","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12957-016-0946-x","article-title":"Prognostic relevance of autophagy-related markers LC3, p62\/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status","volume":"14","author":"Schmitz","year":"2016","journal-title":"World J Surg Oncol."},{"issue":"5","key":"10.1016\/j.bbadis.2023.166844_bb0190","first-page":"873","article-title":"Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation","volume":"25","author":"Goiran","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2023.166844_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109839","article-title":"Orexin-a protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK\/ERK\/mTOR pathway","volume":"79","author":"Xu","year":"2021","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/15548627.2018.1505155","article-title":"Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy","volume":"15","author":"Jia","year":"2019","journal-title":"Autophagy."},{"issue":"7","key":"10.1016\/j.bbadis.2023.166844_bb0205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2023.166844_bb0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-7827-3-11","article-title":"Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis","volume":"3","author":"Chapman","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0215","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3892\/ijmm.2015.2409","article-title":"Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway","volume":"37","author":"Wen","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbadis.2023.166844_bb0220","doi-asserted-by":"crossref","first-page":"1045034","DOI":"10.3389\/fncel.2022.1045034","article-title":"Orexin-A exerts neuroprotective effect in experimental intracerebral hemorrhage by suppressing autophagy via OXR1-mediated ERK\/mTOR signaling pathway","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.bbadis.2023.166844_bb0225","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s12640-021-00457-4","article-title":"Overexpression of ORX or MCH protects neurological function against ischemic stroke","volume":"40","author":"Wu","year":"2022","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbadis.2023.166844_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2020.111231","article-title":"mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells","volume":"212","author":"Lian","year":"2020","journal-title":"J. Inorg. Biochem."},{"issue":"11","key":"10.1016\/j.bbadis.2023.166844_bb0235","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1080\/15548627.2019.1596481","article-title":"Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease","volume":"15","author":"Han","year":"2019","journal-title":"Autophagy."},{"issue":"9","key":"10.1016\/j.bbadis.2023.166844_bb0240","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1080\/15548627.2016.1191723","article-title":"Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: implications for methamphetamine-mediated neurotoxicity","volume":"12","author":"Zhang","year":"2016","journal-title":"Autophagy."},{"key":"10.1016\/j.bbadis.2023.166844_bb0245","doi-asserted-by":"crossref","first-page":"2514555","DOI":"10.1155\/2022\/2514555","article-title":"Effects of vestibular damage on the sleep and expression level of orexin in the hypothalamus of rats and its correlation with autophagy and Akt tumor signal pathway","volume":"2022","author":"Yan","year":"2022","journal-title":"J Oncol."},{"issue":"2","key":"10.1016\/j.bbadis.2023.166844_bb0250","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3892\/ijmm.2014.2038","article-title":"Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway","volume":"35","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"12","key":"10.1016\/j.bbadis.2023.166844_bb0255","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","article-title":"mTOR signalling and cellular metabolism are mutual determinants in cancer","volume":"18","author":"Mossmann","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.bbadis.2023.166844_bb0260","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/jcp.24351","article-title":"mTOR signaling for biological control and cancer","volume":"228","author":"Alayev","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"30","key":"10.1016\/j.bbadis.2023.166844_bb0265","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1523\/JNEUROSCI.0931-17.2017","article-title":"The mTOR substrate S6 kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for central nervous system injury","volume":"37","author":"Al-Ali","year":"2017","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.bbadis.2023.166844_bb0270","doi-asserted-by":"crossref","first-page":"753.e1","DOI":"10.1016\/j.ajog.2020.05.015","article-title":"Deficiency of the oxidative stress-responsive kinase p70S6K1 restores autophagy and ameliorates neural tube defects in diabetic embryopathy","volume":"223","author":"Cao","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbadis.2023.166844_bb0275","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neurobiolaging.2018.07.021","article-title":"S6K\/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy","volume":"71","author":"Chiku","year":"2018","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.bbadis.2023.166844_bb0280","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1210\/jcem.86.2.7233","article-title":"Orexin a stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade","volume":"86","author":"Mazzocchi","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.bbadis.2023.166844_bb0285","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jsbmb.2005.05.003","article-title":"Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor","volume":"96","author":"Ziolkowska","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.bbadis.2023.166844_bb0290","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41435-020-0096-6","article-title":"Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders","volume":"21","author":"Slominski","year":"2020","journal-title":"Genes Immun."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2023.166844_bb0295","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2003.12.020","article-title":"Adrenocortical cell lines","volume":"228","author":"Rainey","year":"2004","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923002107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443923002107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T05:12:37Z","timestamp":1735708357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443923002107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0925443923002107"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166844","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Orexin-A\/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2023.166844","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"166844"}}