{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:32:13Z","timestamp":1793233933845,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102625"],"award-info":[{"award-number":["82102625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172498"],"award-info":[{"award-number":["82172498"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bbadis.2024.167058","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T19:09:17Z","timestamp":1707246557000},"page":"167058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis"],"prefix":"10.1016","volume":"1870","author":[{"given":"Haigang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcai","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2024.167058_bb0005","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1182\/bloodadvances.2022007028","article-title":"The potential role of protease systems in hemophilic arthropathy","volume":"6","author":"Hauw","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.bbadis.2024.167058_bb0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.phrs.2016.11.032","article-title":"Pathophysiology of hemophilic arthropathy and potential targets for therapy","volume":"115","author":"Pulles","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2024.167058_bb0015","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1111\/jth.15444","article-title":"Hemophilic arthropathy: current knowledge and future perspectives","volume":"19","author":"Gualtierotti","year":"2021","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2024.167058_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121172","article-title":"Desferoxamine protects against hemophilic arthropathy through the upregulation of HIF-1\u03b1-BNIP3 mediated mitophagy","volume":"312","author":"Lin","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2024.167058_bb0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13244-021-01050-1","article-title":"Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence","volume":"12","author":"Prasetyo","year":"2021","journal-title":"Insights Imaging"},{"key":"10.1016\/j.bbadis.2024.167058_bb0030","article-title":"Iron overload is associated with accelerated progression of osteoarthritis: the role of DMT1 mediated iron homeostasis","volume":"8","author":"Jing","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101481","article-title":"Iron homeostasis in arthropathies: from pathogenesis to therapeutic potential","volume":"72","author":"Sun","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120555","article-title":"The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration","volume":"268","author":"Peng","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbadis.2024.167058_bb0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S1063-4584(03)00168-7","article-title":"Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro","volume":"11","author":"Wang","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbadis.2024.167058_bb0050","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/ard.58.6.357","article-title":"In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage","volume":"58","author":"Freemont","year":"1999","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbadis.2024.167058_bb0055","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22203\/eCM.v021a16","article-title":"Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis","volume":"21","author":"Goldring","year":"2011","journal-title":"Eur. Cell. Mater."},{"key":"10.1016\/j.bbadis.2024.167058_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/rhe.31.3.151.157","article-title":"New potential markers for cartilage degradation of the knee joint","volume":"31","author":"Schmidt-Rohlfing","year":"2002","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2018.07.020","article-title":"DMT1 and iron transport","volume":"133","author":"Yanatori","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2024.167058_bb0070","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1182\/blood-2004-07-2966","article-title":"Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload","volume":"105","author":"Mims","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2024.167058_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.966478","article-title":"Neuronal ferroptosis after intracerebral hemorrhage","volume":"9","author":"Ren","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bbadis.2024.167058_bb0080","doi-asserted-by":"crossref","first-page":"9800794","DOI":"10.1155\/2021\/9800794","article-title":"Hepcidin promoted ferroptosis through iron metabolism which is associated with DMT1 signaling activation in early brain injury following subarachnoid hemorrhage","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0085","doi-asserted-by":"crossref","first-page":"9069825","DOI":"10.1155\/2022\/9069825","article-title":"Activation of SIRT1 alleviates ferroptosis in the early brain injury after subarachnoid hemorrhage","volume":"2022","author":"Yuan","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.trsl.2020.09.002","article-title":"Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats","volume":"229","author":"Yang","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2024.167058_bb0095","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1182\/blood-2017-12-820571","article-title":"Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2\/ADAM17\/TNF-\u03b1 pathway","volume":"132","author":"Haxaire","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.bbadis.2024.167058_bb0100","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2516.2008.01689.x","article-title":"Experimental haemophilic arthropathy in a mouse model of a massive haemarthrosis: gross, radiological and histological changes","volume":"14","author":"Hakobyan","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.bbadis.2024.167058_bb0105","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1365-2516.2006.01348.x","article-title":"Histological changes in murine haemophilic synovitis: a quantitative grading system to assess blood-induced synovitis","volume":"12","author":"Valentino","year":"2006","journal-title":"Haemophilia"},{"key":"10.1016\/j.bbadis.2024.167058_bb0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41420-023-01406-0","article-title":"Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy","volume":"9","author":"Sun","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2024.167058_bb0115","article-title":"Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2024.167058_bb0125","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1073\/pnas.88.9.3671","article-title":"Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1","volume":"88","author":"Smiley","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2024.167058_bb0130","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2024.167058_bb0135","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1210\/jc.2007-2616","article-title":"Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa","volume":"93","author":"Koppers","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2024.167058_bb0140","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41564-021-00912-0","article-title":"Gut microbiome alterations in high-fat-diet-fed mice are associated with antibiotic tolerance","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0150","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41467-017-00833-9","article-title":"Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice","volume":"8","author":"Vincent","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2024.167058_bb0155","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1538-7836.2010.03962.x","article-title":"Blood-induced joint disease: the pathophysiology of hemophilic arthropathy","volume":"8","author":"Valentino","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2024.167058_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197292","article-title":"The progression of hemophilic arthropathy: the role of biomarkers","volume":"21","author":"Pasta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167058_bb0165","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2017.11.003","article-title":"Cytokines in the pathogenesis of hemophilic arthropathy","volume":"39","author":"Wojdasiewicz","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/art.22304","article-title":"Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study","volume":"56","author":"Jansen","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbadis.2024.167058_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100885","article-title":"Improving assessment and management of pain in hemophilia: an Italian Delphi consensus statement","volume":"51","author":"Santoro","year":"2022","journal-title":"Blood Rev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0180","article-title":"Pain in hemophilia: unexplored role of oxidative stress","volume":"11","author":"Fouda","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2024.167058_bb0185","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12264-017-0200-8","article-title":"Regulation of pain and itch by TRP channels","volume":"34","author":"Moore","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbadis.2024.167058_bb0190","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13075-023-03075-x","article-title":"STING mediates experimental osteoarthritis and mechanical allodynia in mouse","volume":"25","author":"Shin","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.bbadis.2024.167058_bb0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2516.2007.01527.x","article-title":"The impact of joint bleeding and synovitis on physical ability and joint function in a murine model of haemophilic synovitis","volume":"14","author":"Mejia-Carvajal","year":"2008","journal-title":"Haemophilia"},{"key":"10.1016\/j.bbadis.2024.167058_bb0200","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminhematol.2015.10.005","article-title":"Advances and challenges in hemophilic arthropathy","volume":"53","author":"Wyseure","year":"2016","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0205","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12975-018-0669-0","article-title":"Brain ceruloplasmin expression after experimental intracerebral hemorrhage and protection against Iron-induced brain injury","volume":"10","author":"Liu","year":"2019","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.bbadis.2024.167058_bb0210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1020702213099","article-title":"DMT1: a mammalian transporter for multiple metals","volume":"16","author":"Garrick","year":"2003","journal-title":"Biometals"},{"key":"10.1016\/j.bbadis.2024.167058_bb0215","article-title":"Iron dysregulation in mitochondrial dysfunction and Alzheimer\u2019s disease","volume":"11","author":"Onukwufor","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2024.167058_bb0220","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/10715760802008114","article-title":"The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells","volume":"42","author":"Li","year":"2008","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbadis.2024.167058_bb0225","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abe7548","article-title":"Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice","volume":"7","author":"Lei","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2024.167058_bb0230","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2019.02.038","article-title":"Interleukin-1\u03b2 induces mtDNA release to activate innate immune signaling via cGAS-STING","volume":"74","author":"Aarreberg","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2024.167058_bb0235","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0240","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/acs.jafc.1c06681","article-title":"Iron activates cGAS-STING signaling and promotes hepatic inflammation","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbadis.2024.167058_bb0245","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/15548627.2022.2062887","article-title":"Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD","volume":"19","author":"Gupta","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2024.167058_bb0250","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0255","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2024.167058_bb0260","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0265","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1080\/15548627.2021.1874209","article-title":"Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability","volume":"17","author":"Chao","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2024.167058_bb0270","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7150\/ijbs.65019","article-title":"Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer","volume":"18","author":"Yan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2024.167058_bb0275","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-019-0451-9","article-title":"Mitochondria-targeted cyclosporin a delivery system to treat myocardial ischemia reperfusion injury of rats","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.bbadis.2024.167058_bb0280","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.1111\/hae.13196","article-title":"Serological biomarkers detect active joint destruction and inflammation in patients with haemophilic arthropathy","volume":"23","author":"Hua","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.bbadis.2024.167058_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100781","article-title":"Biochemical marker research in hemophilic arthropathy: a systematic review","volume":"47","author":"van Bergen","year":"2021","journal-title":"Blood Rev."},{"key":"10.1016\/j.bbadis.2024.167058_bb0290","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jth.12176","article-title":"IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia","volume":"11","author":"Narkbunnam","year":"2013","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.bbadis.2024.167058_bb0295","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12974-022-02511-0","article-title":"Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis","volume":"19","author":"Ding","year":"2022","journal-title":"J. Neuroinflammation"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924000474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924000474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T16:57:22Z","timestamp":1751216242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443924000474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0925443924000474"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167058","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DMT1-mediated iron overload accelerates cartilage degeneration in Hemophilic Arthropathy through the mtDNA-cGAS-STING axis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167058"}}