{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:38:19Z","timestamp":1784003899513,"version":"3.55.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310413\/2023-0"],"award-info":[{"award-number":["310413\/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403194\/2023-7"],"award-info":[{"award-number":["403194\/2023-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306733\/2023-4"],"award-info":[{"award-number":["306733\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311105\/2020-3"],"award-info":[{"award-number":["311105\/2020-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04164-22"],"award-info":[{"award-number":["APQ-04164-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03519-22"],"award-info":[{"award-number":["APQ-03519-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00126-18"],"award-info":[{"award-number":["APQ-00126-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bbadis.2024.167264","type":"journal-article","created":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T17:42:28Z","timestamp":1716745348000},"page":"167264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis"],"prefix":"10.1016","volume":"1870","author":[{"given":"Elisa","family":"Liz Belli Cassa Domingues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elda","family":"Gon\u00e7alves-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Santana Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reggiani","family":"Vilela Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Edson","family":"Caetano-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizi\u00e1ria","family":"Cardoso Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvania","family":"M\u00f3l Pelinsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia","family":"Figueiredo Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo","family":"Dias Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbadis.2024.167264_bb0005","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1017\/S0031182016002675","article-title":"Nonsteroidal anti-inflammatory is more effective than anti-oxidant therapy in counteracting oxidative\/nitrosative stress and heart disease in T. cruzi-infected mice","volume":"144","author":"Novaes","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.bbadis.2024.167264_bb0010","article-title":"Oxidative stress, cardiomyocytes senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease","volume":"106950","author":"Nogueira","year":"2023","journal-title":"Acta Trop."},{"issue":"13","key":"10.1016\/j.bbadis.2024.167264_bb0015","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1017\/S0031182019000970","article-title":"Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?","volume":"146","author":"Santos","year":"2019","journal-title":"Parasitology"},{"key":"10.1016\/j.bbadis.2024.167264_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/190354","article-title":"Oxidative stress in Chagas disease","volume":"2009","author":"Gupta","year":"2009","journal-title":"Interdiscip Perspect Infect Dis."},{"key":"10.1016\/j.bbadis.2024.167264_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9081813","article-title":"Potential role of antioxidants as adjunctive therapy in Chagas disease","volume":"2020","author":"S\u00e1nchez-Villamil","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.bbadis.2024.167264_bb0030","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.freeradbiomed.2004.09.011","article-title":"Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection","volume":"37","author":"Wen","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bbadis.2024.167264_bb0035","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10863-008-9184-4","article-title":"Mitochondrial generation of reactive oxygen species is enhanced at the Q(o) site of the complex III in the myocardium of Trypanosoma cruzi-infected mice: beneficial effects of an antioxidant","volume":"40","author":"Wen","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"issue":"14(4)","key":"10.1016\/j.bbadis.2024.167264_bb0040","article-title":"ROS and Trypanosoma cruzi: fuel to infection, poison to the heart","volume":"19","author":"Paiva","year":"2018","journal-title":"PLoS Pathog."},{"issue":"8","key":"10.1016\/j.bbadis.2024.167264_bb0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S1473-3099(20)30844-6","article-title":"BENDITA study group. New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial","volume":"21","author":"Torrico","year":"2021","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167264_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/jeu.12184","article-title":"Recent clinical trials for the etiological treatment of chronic Chagas disease: advances, challenges and perspectives","volume":"62","author":"Urbina","year":"2015","journal-title":"J. Eukaryot. Microbiol."},{"issue":"15","key":"10.1016\/j.bbadis.2024.167264_bb0055","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1080\/14656566.2019.1650915","article-title":"An evaluation of benznidazole as a Chagas disease therapeutic","volume":"20","author":"Caldas","year":"2019","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.bbadis.2024.167264_bb0060","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.actatropica.2015.02.012","article-title":"Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease","volume":"145","author":"Lo Presti","year":"2015","journal-title":"Acta Trop."},{"key":"10.1016\/j.bbadis.2024.167264_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8676578","article-title":"Relevance of trypanothione reductase inhibitors on Trypanosoma cruzi infection: a systematic review, meta-analysis, and in silico integrated approach","volume":"2018","author":"Mendon\u00e7a","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2024.167264_bb0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.lfs.2019.05.059","article-title":"Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis","volume":"230","author":"Mendon\u00e7a","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2024.167264_bb0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-4020-6051-9_11","article-title":"The trypanothione system","volume":"44","author":"Krauth-Siegel","year":"2007","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.bbadis.2024.167264_bb0080","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0076-6879(02)47024-3","article-title":"Tryparedoxin and tryparedoxin peroxidase","volume":"347","author":"Floh\u00e9","year":"2002","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167264_bb0085","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0022-2836(92)90701-K","article-title":"Active site of trypanothione reductase. A target for rational drug design","volume":"227","author":"Hunter","year":"1992","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167264_bb0090","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/1568006023337745","article-title":"Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas\u2019 disease evolution","volume":"2","author":"Rivarola","year":"2002","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord."},{"key":"10.1016\/j.bbadis.2024.167264_bb0095","series-title":"New Approaches for Chagas\u2019 Disease Chemotherapy. Chagas Disease - Basic Investigations and Challenges","author":"Li\u00f1ares","year":"2018"},{"issue":"5","key":"10.1016\/j.bbadis.2024.167264_bb0100","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.bmcl.2006.12.016","article-title":"High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity","volume":"17","author":"Martyn","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bbadis.2024.167264_bb0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/117739280700200007","article-title":"Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design","volume":"2","author":"Khan","year":"2007","journal-title":"Drug Target Insights."},{"issue":"24(11)","key":"10.1016\/j.bbadis.2024.167264_bb0110","first-page":"1066","article-title":"Trypanothione reductase and superoxide dismutase as current drug targets for Trypanosoma cruzi: an overview of compounds with activity against Chagas disease","volume":"31","author":"Beltran-Hortelano","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2024.167264_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104907","article-title":"Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?","volume":"158","author":"Mendon\u00e7a","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbadis.2024.167264_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106611","article-title":"Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice","volume":"85","author":"Mendon\u00e7a","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0125","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2958.2000.01721.x","article-title":"Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress","volume":"35","author":"Krieger","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118067","article-title":"Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: an in vitro and in vivo study","volume":"257","author":"Souza-Silva","year":"2020","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.bbadis.2024.167264_bb0135","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00401-18","article-title":"Outcome of E1224-Benznidazole Combination Treatment for infection with a multidrug-resistant Trypanosoma cruzi strain in mice","volume":"62","author":"Diniz","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbadis.2024.167264_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105961","article-title":"Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy","volume":"77","author":"Gon\u00e7alves-Santos","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.bbadis.2024.167264_bb0145","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0092-8674(05)80061-3","article-title":"Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells","volume":"71","author":"Tardieux","year":"1992","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bbadis.2024.167264_bb0150","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02264-18","article-title":"Synergic effect of allopurinol in combination with nitroheterocyclic compounds against Trypanosoma cruzi","volume":"63","author":"Mazzeti","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.bbadis.2024.167264_bb0155","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3390\/ijms20030473","article-title":"Thioridazine enhances p62-mediated autophagy and apoptosis through wnt\/\u03b2-catenin signaling pathway in glioma cells","volume":"20","author":"Chu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167264_bb0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jes.2020.04.029","article-title":"Rat cardiomyocyte H9c2(2-1)-based sulforhodamine B assay as a promising in vitro method to assess the biological component of effluent toxicity","volume":"96","author":"Rodrigues","year":"2020","journal-title":"J. Environ. Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2024.167264_bb0165","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbadis.2024.167264_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110416","article-title":"Pharmacological potential of new metronidazole\/eugenol\/dihydroeugenol hybrids against Trypanosoma cruzi in vitro and in vivo","volume":"121","author":"Gon\u00e7alves-Santos","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bbadis.2024.167264_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005852","article-title":"Cardiomyocyte oxidants production may signal to T. cruzi intracellular development","volume":"11","author":"Dias","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bbadis.2024.167264_bb0180","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2014.04.034","article-title":"Simplified 2,4-dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins","volume":"458","author":"Mesquita","year":"2014","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167264_bb0185","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/AAC.00751-13","article-title":"Simple colorimetric trypanothione reductase-based assay for high-throughput screening of drugs against Leishmania intracellular amastigotes","volume":"58","author":"Van den Bogaart","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbadis.2024.167264_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110416","article-title":"Pharmacological potential of new metronidazole\/eugenol\/dihydroeugenol hybrids against Trypanosoma cruzi in vitro and in vivo","volume":"121","author":"Gon\u00e7alves-Santos","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0195","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.fct.2013.11.032","article-title":"Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis","volume":"64","author":"Sequetto","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.bbadis.2024.167264_bb0200","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ijantimicag.2007.01.014","article-title":"Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy","volume":"29","author":"Bustamante","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.bbadis.2024.167264_bb0205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bcp.2018.01.005","article-title":"Time and dose-dependence evaluation of nitroheterocyclic drugs for improving efficacy following Trypanosoma cruzi infection: a pre-clinical study","volume":"148","author":"Mazzeti","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0210","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.niox.2017.02.013","article-title":"S. mansoni-T. cruzi co-infection modulates arginase-1\/iNOS expression, liver and heart disease in mice","volume":"66","author":"Rodrigues","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbadis.2024.167264_bb0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.freeradbiomed.2018.09.031","article-title":"Impact of Trypanosoma cruzi infection on nitric oxide synthase and arginase expression and activity in young and elderly mice","volume":"129","author":"Felizardo","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2024.167264_bb0220","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7385639","article-title":"Purinergic antagonist suramin aggravates myocarditis and increases mortality by enhancing parasitism, inflammation, and reactive tissue damage in Trypanosoma cruzi-infected mice","volume":"2018","author":"Novaes","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.bbadis.2024.167264_bb0225","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1128\/AAC.00779-15","article-title":"Concomitant benznidazole and suramin chemotherapy in mice infected with a virulent strain of Trypanosoma cruzi","volume":"59","author":"Santos","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2024.167264_bb0230","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-1759(01)00489-6","article-title":"Cytokine mRNA quantification by real-time PCR","volume":"259","author":"Stordeur","year":"2002","journal-title":"J. Immunol. Methods"},{"issue":"1","key":"10.1016\/j.bbadis.2024.167264_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pim.12008","article-title":"Cardiac damage induced by immunization with heat-killed Trypanosoma cruzi is not antibody mediated","volume":"35","author":"Bonney","year":"2013","journal-title":"Parasite Immunol."},{"issue":"2","key":"10.1016\/j.bbadis.2024.167264_bb0240","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/mutage\/14.2.243","article-title":"A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids","volume":"14","author":"Pantazaki","year":"1999","journal-title":"Mutagenesis"},{"key":"10.1016\/j.bbadis.2024.167264_bb0245","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tox.2015.02.004","article-title":"Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: a structure-activity investigation","volume":"330","author":"de Faria","year":"2015","journal-title":"Toxicology"},{"issue":"8","key":"10.1016\/j.bbadis.2024.167264_bb0250","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1128\/AAC.02754-13","article-title":"Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease","volume":"58","author":"Bahia","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.bbadis.2024.167264_bb0255","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00132-23","article-title":"Frequency variation and dose modification of benznidazole administration for the treatment of Trypanosoma cruzi infection in mice, dogs, and nonhuman primates","volume":"67","author":"Bustamante","year":"2023","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbadis.2024.167264_bb0260","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2016.11.015","article-title":"Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis","volume":"315","author":"Lambertucci","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbadis.2024.167264_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002844","article-title":"Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics","volume":"8","author":"Trochine","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.bbadis.2024.167264_bb0270","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1128\/AAC.00343-16","article-title":"Curcumin enhances the anti-Trypanosoma cruzi activity of benznidazole-based chemotherapy in acute experimental Chagas disease","volume":"60","author":"Novaes","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbadis.2024.167264_bb0275","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10715760100300311","article-title":"Trypanosoma cruzi trypanothione reductase is inactivated by peroxidase generated phenothiazine cationic radicals","volume":"34","author":"Gutierrez-Correa","year":"2001","journal-title":"Free Radic. Res."},{"issue":"9","key":"10.1016\/j.bbadis.2024.167264_bb0280","first-page":"718","article-title":"How is cardiac troponin released from cardiomyocytes?","volume":"11","author":"Hammarsten","year":"2022","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"10.1016\/j.bbadis.2024.167264_bb0285","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.actatropica.2014.07.005","article-title":"Trypanosoma cruzi strains cause different myocarditis patterns in infected mice","volume":"139","author":"Rodriguez","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.bbadis.2024.167264_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.696719","article-title":"Virulence of Trypanosoma cruzi strains is related to the differential expression of innate immune receptors in the heart","volume":"11","author":"Queiroga","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0295","first-page":"10","article-title":"Correlation of parasite burden, kDNA integration, autoreactive antibodies, and cytokine pattern in the pathophysiology of Chagas disease","volume":"1856","author":"Wesley","year":"2019","journal-title":"Front. Microbiol."},{"issue":"6\u20137","key":"10.1016\/j.bbadis.2024.167264_bb0300","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.molimm.2010.12.021","article-title":"Benznidazole treatment attenuates liver NF-\u03baB activity and MAPK in a cecal ligation and puncture model of sepsis","volume":"48","author":"Ronco","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0305","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3389\/fimmu.2019.01267","article-title":"IL-10\/STAT3\/SOCS3 axis is involved in the anti-inflammatory effect of benznidazole","volume":"10","author":"Cevey","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.bbadis.2024.167264_bb0310","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00436-015-4488-x","article-title":"Trypanosoma cruzi infection and benznidazole therapy independently stimulate oxidative status and structural pathological remodeling of the liver tissue in mice","volume":"114","author":"Novaes","year":"2015","journal-title":"Parasitol. Res."},{"issue":"2","key":"10.1016\/j.bbadis.2024.167264_bb0315","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.meegid.2011.12.009","article-title":"The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications","volume":"12","author":"Zingales","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bbadis.2024.167264_bb0320","doi-asserted-by":"crossref","first-page":"32927","DOI":"10.1038\/srep32927","article-title":"During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection","volume":"6","author":"Erdmann","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924002539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924002539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:21:51Z","timestamp":1762323711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443924002539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S0925443924002539"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167264","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of host antioxidant effectors as thioridazine targets: Impact on cardiomyocytes infection and Trypanosoma cruzi-induced acute myocarditis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167264","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167264"}}