{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:01:22Z","timestamp":1785549682279,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22zf0127007"],"award-info":[{"award-number":["JP22zf0127007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22714181"],"award-info":[{"award-number":["22714181"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22zf0127007"],"award-info":[{"award-number":["JP22zf0127007"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22ama121038"],"award-info":[{"award-number":["JP22ama121038"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2023"],"award-info":[{"award-number":["JPMJMS2023"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR215T"],"award-info":[{"award-number":["JPMJFR215T"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbadis.2024.167566","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T15:54:03Z","timestamp":1731426843000},"page":"167566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity"],"prefix":"10.1016","volume":"1871","author":[{"given":"Kaito","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Iio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kajino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Yan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.bbadis.2024.167566_bb0005","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.bbadis.2024.167566_bb0010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bbadis.2024.167566_bb0015","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/biom12060824","article-title":"NAFLD: mechanisms, treatments, and biomarkers","volume":"12","author":"Nassir","year":"2022","journal-title":"Biomolecules"},{"issue":"18","key":"10.1016\/j.bbadis.2024.167566_bb0020","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.bbadis.2024.167566_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: deciphering communication from the liver","author":"Jensen-Cody","year":"2021","journal-title":"Molecular Metabolism"},{"issue":"5","key":"10.1016\/j.bbadis.2024.167566_bb0030","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.celrep.2018.10.008","article-title":"Activin E controls energy homeostasis in both Brown and White adipose tissues as a Hepatokine","volume":"25","author":"Hashimoto","year":"2018","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167566_bb0035","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.bbadis.2024.167566_bb0040","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/ijo.2014.27","article-title":"NAG-1\/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism","volume":"38","author":"Chrysovergis","year":"2014","journal-title":"International Journal of Obesity"},{"issue":"3","key":"10.1016\/j.bbadis.2024.167566_bb0045","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2008.08.040","article-title":"Anatomical profiling of G protein-coupled receptor expression","volume":"135","author":"Regard","year":"2008","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0050","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2337\/db17-1502","article-title":"Glucagon receptor signaling regulates energy metabolism via hepatic farnesoid X receptor and fibroblast growth factor 21","volume":"67","author":"Kim","year":"2018","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0055","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1172\/JCI34827","article-title":"Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice","volume":"118","author":"Osei-Hyiaman","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbadis.2024.167566_bb0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbalip.2017.11.002","article-title":"Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120)","volume":"1863","author":"Kang","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"issue":"12","key":"10.1016\/j.bbadis.2024.167566_bb0065","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1172\/JCI97831","article-title":"G\u03b112 ablation exacerbates liver steatosis and obesity by suppressing USP22\/SIRT1-regulated mitochondrial respiration","volume":"128","author":"Kim","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.bbadis.2024.167566_bb0070","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1073\/pnas.0700293104","article-title":"Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand","volume":"104","author":"Armbruster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0075","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00584-16","article-title":"Gs-DREADD Knock-in mice for tissue-specific, temporal stimulation of cyclic AMP signaling","volume":"37","author":"Akhmedov","year":"2017","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.bbadis.2024.167566_bb0080","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI94505","article-title":"Hepatic gi signaling regulates whole-body glucose homeostasis","volume":"128","author":"Rossi","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"10","key":"10.1016\/j.bbadis.2024.167566_bb0085","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1210\/en.2012-2127","article-title":"A novel experimental strategy to assess the metabolic effects of selective activation of a Gq-coupled receptor in hepatocytes in vivo","volume":"154","author":"Li","year":"2013","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.bbadis.2024.167566_bb0090","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.cell.2019.04.044","article-title":"Illuminating G-protein-coupling selectivity of GPCRs","volume":"177","author":"Inoue","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbadis.2024.167566_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01524-2","article-title":"Chemogenetic activation of G12 signaling enhances adipose tissue browning","volume":"8","author":"Ono","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"2","key":"10.1016\/j.bbadis.2024.167566_bb0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/metabo5020389","article-title":"An efficient single phase method for the extraction of plasma lipids","volume":"5","author":"Alshehry","year":"2015","journal-title":"Metabolites"},{"key":"10.1016\/j.bbadis.2024.167566_bb0105","series-title":"Data Acquisition Parameters Optimization of Quadrupole Orbitrap for Global Lipidomics on LC-MS\/MS Time Frame","author":"Ruzicka","year":"2014"},{"key":"10.1016\/j.bbadis.2024.167566_bb0110","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(96)64044-0","article-title":"Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines","volume":"264","author":"Trounce","year":"1996","journal-title":"Methods Enzymol."},{"issue":"3","key":"10.1016\/j.bbadis.2024.167566_bb0115","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2015.01.019","article-title":"Cdk5rap1-mediated 2-Methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans","volume":"21","author":"Wei","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2024.167566_bb0120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74101","article-title":"Effector membrane translocation biosensors reveal G protein and Parrestin coupling profiles of 100 therapeutically relevant GPCRs","volume":"11","author":"Avet","year":"2022","journal-title":"ELife"},{"issue":"1","key":"10.1016\/j.bbadis.2024.167566_bb0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","article-title":"Dual roles for Glucokinase in glucose homeostasis as determined by liver and pancreatic \u03b2 cell-specific Gene Knock-outs using Cre recombinase","volume":"274","author":"Postic","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbadis.2024.167566_bb0130","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10735-013-9532-5","article-title":"Potential role of hedgehog signaling and microRNA-29 in liver fibrosis of IKK\u03b2-deficient mouse","volume":"45","author":"Hyun","year":"2014","journal-title":"J. Mol. Histol."},{"issue":"5","key":"10.1016\/j.bbadis.2024.167566_bb0135","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"27","key":"10.1016\/j.bbadis.2024.167566_bb0140","doi-asserted-by":"crossref","first-page":"16710","DOI":"10.1074\/jbc.273.27.16710","article-title":"Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor \u03b1 and \u03b3 activators in a tissue- and inducer-specific manner","volume":"273","author":"Motojima","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2024.167566_bb0145","doi-asserted-by":"crossref","unstructured":"Flippo, K.H., Potthoff, M.J., 2021. Metabolic messengers: FGF21. Nature Metabolism 3(3): 309\u201317, Doi:https:\/\/doi.org\/10.1038\/s42255-021-00354-2.","DOI":"10.1038\/s42255-021-00354-2"},{"issue":"6","key":"10.1016\/j.bbadis.2024.167566_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101331","article-title":"A retinoic acid receptor \u03b22 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease","volume":"297","author":"Tang","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0155","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41569-022-00676-y","article-title":"Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia","volume":"19","author":"Bor\u00e9n","year":"2022","journal-title":"Nature Reviews Cardiology"},{"issue":"51","key":"10.1016\/j.bbadis.2024.167566_bb0160","doi-asserted-by":"crossref","first-page":"33047","DOI":"10.1074\/jbc.271.51.33047","article-title":"Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk Core lipids in the second step","volume":"271","author":"Gordon","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.bbadis.2024.167566_bb0165","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1074\/jbc.275.14.10506","article-title":"The assembly and secretion of apolipoprotein B-48-containing very low density lipoproteins in McA-RH7777 cells","volume":"275","author":"Stillemark","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbadis.2024.167566_bb0170","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cmet.2014.07.012","article-title":"FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure and weight loss","volume":"20","author":"Owen","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2024.167566_bb0175","article-title":"The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic","volume":"654\u201367","author":"Geng","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.bbadis.2024.167566_bb0180","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gad.177857.111","article-title":"FGF21 regulates PGC-1\u03b1 and browning of white adipose tissues in adaptive thermogenesis","volume":"26","author":"Fisher","year":"2012","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.bbadis.2024.167566_bb0185","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/me.2010-0142","article-title":"Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse","volume":"24","author":"Tacer","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"36","key":"10.1016\/j.bbadis.2024.167566_bb0190","doi-asserted-by":"crossref","first-page":"27561","DOI":"10.1074\/jbc.M110.144279","article-title":"Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by Proprotein convertases","volume":"285","author":"Liu","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0195","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1194\/jlr.RA120000888","article-title":"Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance","volume":"61","author":"Adam","year":"2020","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.bbadis.2024.167566_bb0200","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41591-023-02222-w","article-title":"Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial","volume":"29","author":"Rosenson","year":"2023","journal-title":"Nature Medicine"},{"issue":"6","key":"10.1016\/j.bbadis.2024.167566_bb0205","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/CIRCULATIONAHA.118.039107","article-title":"Inhibition of angiopoietin-like protein 3 with a monoclonal antibody reduces triglycerides in hypertriglyceridemia","volume":"140","author":"Ahmad","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bbadis.2024.167566_bb0210","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacc.2021.04.091","article-title":"Inhibition of angiopoietin-like protein 3 with Evinacumab in subjects with high and severe hypertriglyceridemia","volume":"78","author":"Ahmad","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.bbadis.2024.167566_bb0215","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/hep.27592","article-title":"Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression","volume":"61","author":"Nagahashi","year":"2015","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.bbadis.2024.167566_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072449","article-title":"Plasma Sphingosine-1-phosphate is elevated in obesity","volume":"8","author":"Kowalski","year":"2013","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.bbadis.2024.167566_bb0225","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1210\/en.2004-1427","article-title":"Apelin, a newly identified Adipokine up-regulated by insulin and obesity","volume":"146","author":"Boucher","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2024.167566_bb0230","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cellsig.2017.08.003","article-title":"Apelin protects against liver X receptor-mediated steatosis through AMPK and PPAR\u03b1 in human and mouse hepatocytes","volume":"39","author":"Huang","year":"2017","journal-title":"Cell. Signal."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392400560X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392400560X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:36:39Z","timestamp":1777584999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392400560X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S092544392400560X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167566","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemogenetic activation of hepatic G12 signaling ameliorates hepatic steatosis and obesity","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167566"}}