{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:35:24Z","timestamp":1792650924660,"version":"4.5.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG064420"],"award-info":[{"award-number":["R01AG064420"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020065","name":"San Antonio Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbadis.2024.167584","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T21:42:39Z","timestamp":1732311759000},"page":"167584","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease"],"prefix":"10.1016","volume":"1871","author":[{"given":"Emma","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Miserlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evlampia","family":"Papoutsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb","family":"Haynatzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal","family":"Pacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Koutakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2024.167584_bb0005","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/CIRCRESAHA.121.318266","article-title":"New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease","volume":"128","author":"Annex","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0010","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","article-title":"Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis","volume":"7","author":"Song","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.bbadis.2024.167584_bb0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1479-5876-11-230","article-title":"Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease","volume":"11","author":"Weiss","year":"2013","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0020","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.redox.2014.07.002","article-title":"Oxidative damage in the gastrocnemius of patients with peripheral artery disease is myofiber type selective","volume":"2","author":"Koutakis","year":"2014","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1177\/1538574407311106","article-title":"The myopathy of peripheral arterial occlusive disease: part 1. Functional and histomorphological changes and evidence for mitochondrial dysfunction","volume":"41","author":"Pipinos","year":"2007","journal-title":"Vasc. Endovasc. Surg."},{"key":"10.1016\/j.bbadis.2024.167584_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/1538574408315995","article-title":"The myopathy of peripheral arterial occlusive disease: part 2. Oxidative stress, neuropathy, and shift in muscle fiber type","volume":"42","author":"Pipinos","year":"2008","journal-title":"Vasc. Endovasc. Surg."},{"key":"10.1016\/j.bbadis.2024.167584_bb0035","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1152\/ajpregu.90374.2008","article-title":"Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage","volume":"295","author":"Pipinos","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264598","article-title":"Peripheral artery disease affects the function of the legs of claudicating patients in a diffuse manner irrespective of the segment of the arterial tree primarily involved","volume":"17","author":"Leutzinger","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2024.167584_bb0045","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/SLA.0000000000000643","article-title":"Protein concentration and mitochondrial content in the gastrocnemius predicts mortality rates in patients with peripheral arterial disease","volume":"261","author":"Thompson","year":"2015","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbadis.2024.167584_bb0050","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jcsm.12587","article-title":"Sarcopenia and peripheral arterial disease: a systematic review","volume":"11","author":"Pizzimenti","year":"2020","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.bbadis.2024.167584_bb0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41514-024-00147-3","article-title":"Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease","volume":"10","author":"Koutakis","year":"2024","journal-title":"NPJ Aging"},{"key":"10.1016\/j.bbadis.2024.167584_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63626-3","article-title":"Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants","volume":"14","author":"Wilburn","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2024.167584_bb0065","article-title":"Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle","volume":"8","author":"Paradis","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2024.167584_bb0070","doi-asserted-by":"crossref","first-page":"C968","DOI":"10.1152\/ajpcell.00356.2015","article-title":"Chronology of mitochondrial and cellular events during skeletal muscle ischemia-reperfusion","volume":"310","author":"Paradis","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.234","article-title":"Experimental peripheral arterial disease: new insights into muscle glucose uptake, macrophage, and T-cell polarization during early and late stages","volume":"2","author":"Pellegrin","year":"2014","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bbadis.2024.167584_bb0080","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1152\/ajpregu.00525.2012","article-title":"Morphometric analysis of gastrocnemius muscle biopsies from patients with peripheral arterial disease: objective grading of muscle degeneration","volume":"305","author":"Cluff","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0085","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123235","article-title":"Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants","volume":"3","author":"Ryan","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2024.167584_bb0090","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0741-5214(03)00602-5","article-title":"Abnormal mitochondrial respiration in skeletal muscle in patients with peripheral arterial disease","volume":"38","author":"Pipinos","year":"2003","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2024.167584_bb0095","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trsl.2022.03.003","article-title":"Skeletal muscle MiR-210 expression is associated with mitochondrial function in peripheral artery disease patients","volume":"246","author":"Ismaeel","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.trsl.2020.08.008","article-title":"Cytokine signature of inflammation mediated by autoreactive Th-cells, in calf muscle of claudicating patients with Fontaine stage II peripheral artery disease","volume":"228","author":"Casale","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1358863X9600100110","article-title":"Skeletal muscle metabolism as a target for drug therapy in peripheral arterial disease","volume":"1","author":"Brass","year":"1996","journal-title":"Vasc. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1358836X0000500109","article-title":"Acquired skeletal muscle metabolic myopathy in atherosclerotic peripheral arterial disease","volume":"5","author":"Brass","year":"2000","journal-title":"Vasc. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0115","article-title":"Oxidative stress and arterial dysfunction in peripheral artery disease","volume":"7","author":"Ismaeel","year":"2018","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2024.167584_bb0120","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13650","article-title":"Oxidative stress and antioxidant treatment in patients with peripheral artery disease","volume":"6","author":"Koutakis","year":"2018","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bbadis.2024.167584_bb0125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12929-017-0346-8","article-title":"Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease","volume":"24","author":"Sfyri","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0130","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/0003319710384395","article-title":"Dietary intake of participants with peripheral artery disease and claudication","volume":"62","author":"Gardner","year":"2011","journal-title":"Angiology"},{"key":"10.1016\/j.bbadis.2024.167584_bb0135","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.atherosclerosis.2012.03.029","article-title":"Dietary fatty acids and peripheral artery disease in adults","volume":"222","author":"Naqvi","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbadis.2024.167584_bb0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/oxfordjournals.aje.a115798","article-title":"Diet and peripheral arterial occlusive disease: the role of poly-, mono-, and saturated fatty acids","volume":"133","author":"Katsouyanni","year":"1991","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jvs.2014.10.022","article-title":"Advancing beyond the \u201cheart-healthy diet\u201d for peripheral arterial disease","volume":"61","author":"Nosova","year":"2015","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2024.167584_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2023.05.002","article-title":"Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease","author":"Fletcher","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0155","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.119.002814","article-title":"Alcohol consumption and cardiovascular disease: a Mendelian randomization study","volume":"13","author":"Larsson","year":"2020","journal-title":"Circ. Genom Precis. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0160","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2019.09.031","article-title":"Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy","volume":"145","author":"Kumar","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0165","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1111\/j.1530-0277.2007.00530.x","article-title":"Molecular and cellular events in alcohol-induced muscle disease","volume":"31","author":"Fernandez-Sola","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0170","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2337\/db18-0417","article-title":"High-fat diet causes mitochondrial dysfunction as a result of impaired ADP sensitivity","volume":"67","author":"Miotto","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2024.167584_bb0175","article-title":"Cellular bioenergetics: experimental evidence for alcohol-induced adaptations","volume":"3","author":"Simon","year":"2022","journal-title":"Function (Oxf)"},{"key":"10.1016\/j.bbadis.2024.167584_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu14051016","article-title":"High-fat diet augments the effect of alcohol on skeletal muscle mitochondrial dysfunction in mice","volume":"14","author":"Ismaeel","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2024.167584_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00017.2013","article-title":"Targeting aldehyde dehydrogenase 2: new therapeutic opportunities","volume":"94","author":"Chen","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2024.167584_bb0190","article-title":"Aldehyde dehydrogenase 2 as a therapeutic target in oxidative stress-related diseases: post-translational modifications deserve more attention","volume":"23","author":"Gao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0195","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.3748\/wjg.v24.i27.2984","article-title":"Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: an update","volume":"24","author":"Panisello-Rosello","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0200","doi-asserted-by":"crossref","first-page":"R677","DOI":"10.1152\/ajpregu.00089.2019","article-title":"Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi\/HtrA2 in skeletal muscle","volume":"318","author":"Wakabayashi","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0205","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fphar.2020.00373","article-title":"Aldehyde dehydrogenase 2 protects against post-cardiac arrest myocardial dysfunction through a novel mechanism of suppressing mitochondrial reactive oxygen species production","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2023.111470","article-title":"Commentary: aldehyde dehydrogenase, redox balance and exercise physiology: what is missing?","volume":"283","author":"Pereira","year":"2023","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0215","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.7150\/thno.22414","article-title":"Targeting ALDH2 for therapeutic interventions in chronic pain-related myocardial ischemic susceptibility","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2024.167584_bb0220","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.freeradbiomed.2006.04.003","article-title":"Mitochondrial defects and oxidative damage in patients with peripheral arterial disease","volume":"41","author":"Pipinos","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0225","series-title":"Guide for the Care and Use of Laboratory Animals","author":"I.f.L.A.R.U.S. National Research Council (U.S.)","year":"2011"},{"key":"10.1016\/j.bbadis.2024.167584_bb0230","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-1-61779-430-8_27","article-title":"A mouse model of diet-induced obesity and insulin resistance","volume":"821","author":"Wang","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0235","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-59745-242-7_4","article-title":"A practical method of chronic ethanol administration in mice","volume":"447","author":"Coleman","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0240","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2050-490X-1-2","article-title":"Chronic alcohol ingestion delays skeletal muscle regeneration following injury","volume":"1","author":"Dekeyser","year":"2013","journal-title":"Regen. Med. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0245","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fcvm.2018.00144","article-title":"Activation of toll-like receptor 9 impairs blood flow recovery after hind-limb ischemia","volume":"5","author":"Nishimoto","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0250","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/apnm-2020-0655","article-title":"Obesity-induced alterations to the immunoproteasome: a potential link to intramuscular lipotoxicity","volume":"46","author":"Fletcher","year":"2021","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bbadis.2024.167584_bb0255","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1139\/apnm-2021-0764","article-title":"Impaired proteostasis in obese skeletal muscle relates to altered immunoproteasome activity","volume":"47","author":"Fletcher","year":"2022","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bbadis.2024.167584_bb0260","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-1-4939-9236-2_22","article-title":"Microplate assays for spectrophotometric measurement of mitochondrial enzyme activity","volume":"1978","author":"Janssen","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0265","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.trsl.2023.05.002","article-title":"Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease","volume":"260","author":"Fletcher","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0270","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.jchromb.2010.08.004","article-title":"Chemical probes for analysis of carbonylated proteins: a review","volume":"879","author":"Yan","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0275","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1021\/pr900890k","article-title":"Profiling carbonylated proteins in human plasma","volume":"9","author":"Madian","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0280","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3389\/fphys.2015.00336","article-title":"Mitochondrial regulation of the muscle microenvironment in critical limb ischemia","volume":"6","author":"Ryan","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0285","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.2337\/db16-0387","article-title":"Targeted expression of catalase to mitochondria protects against ischemic myopathy in high-fat diet-fed mice","volume":"65","author":"Ryan","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2024.167584_bb0290","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2310\/6670.2007.00054","article-title":"Mitochondriopathy of peripheral arterial disease","volume":"15","author":"Makris","year":"2007","journal-title":"Vascular"},{"key":"10.1016\/j.bbadis.2024.167584_bb0295","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mas.21381","article-title":"Protein carbonylation as a major hallmark of oxidative damage: update of analytical strategies","volume":"33","author":"Fedorova","year":"2014","journal-title":"Mass Spectrom. Rev."},{"key":"10.1016\/j.bbadis.2024.167584_bb0300","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1210\/en.2011-1957","article-title":"The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress","volume":"153","author":"Pillon","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2024.167584_bb0305","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1452696","article-title":"PGC-1alpha, inflammation, and oxidative stress: an integrative view in metabolism","volume":"2020","author":"Rius-Perez","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2024.167584_bb0310","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1038\/s41598-018-20901-4","article-title":"Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling","volume":"8","author":"Coleman","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2024.167584_bb0315","doi-asserted-by":"crossref","first-page":"C1176","DOI":"10.1152\/ajpcell.00017.2014","article-title":"Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts","volume":"306","author":"Iqbal","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0320","doi-asserted-by":"crossref","first-page":"C461","DOI":"10.1152\/ajpcell.00388.2021","article-title":"The importance of mitochondrial quality control for maintaining skeletal muscle function across health span","volume":"322","author":"Sligar","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0325","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2024.167584_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122125","article-title":"The rise of mitochondria in peripheral arterial disease physiopathology: experimental and clinical data","volume":"8","author":"Pizzimenti","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbadis.2024.167584_bb0335","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biocel.2014.02.013","article-title":"Mitochondria: mitochondrial participation in ischemia-reperfusion injury in skeletal muscle","volume":"50","author":"Lejay","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168478","article-title":"The role of mitochondrial function in peripheral arterial disease: insights from translational studies","volume":"22","author":"Gratl","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0345","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1053\/gast.2002.33613","article-title":"Alcohol and mitochondria: a dysfunctional relationship","volume":"122","author":"Hoek","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbadis.2024.167584_bb0350","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/em.20553","article-title":"Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal","volume":"51","author":"Roede","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.bbadis.2024.167584_bb0355","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1440-1681.2011.05641.x","article-title":"Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart","volume":"39","author":"Anderson","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312948","article-title":"Malondialdehyde-acetaldehyde modified (MAA) proteins differentially effect the inflammatory response in macrophage, endothelial cells and animal models of cardiovascular disease","volume":"22","author":"Duryee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0365","first-page":"130","article-title":"Physiological basis of alcohol-induced skeletal muscle injury","volume":"42","author":"Zinovyeva","year":"2016","journal-title":"Fiziol. Cheloveka"},{"key":"10.1016\/j.bbadis.2024.167584_bb0370","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tem.2011.12.008","article-title":"Linking mitochondrial bioenergetics to insulin resistance via redox biology","volume":"23","author":"Fisher-Wellman","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2024.167584_bb0375","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1016\/j.orcp.2013.05.004","article-title":"Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer","volume":"7","author":"Matsuda","year":"2013","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.bbadis.2024.167584_bb0380","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/oby.21654","article-title":"Reactive oxygen species and oxidative stress in obesity-recent findings and empirical approaches","volume":"24","author":"McMurray","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.bbadis.2024.167584_bb0385","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx0501839","article-title":"Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal","volume":"19","author":"Doorn","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0390","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.1158554","article-title":"Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart","volume":"321","author":"Chen","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2024.167584_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158179","article-title":"Mitochondrial dynamics and mitophagy in skeletal muscle health and aging","volume":"22","author":"Leduc-Gaudet","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167584_bb0400","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41419-023-05557-x","article-title":"Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1alpha-mediated biogenesis in acute kidney injury","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2024.167584_bb0405","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbrc.2022.12.001","article-title":"Loss of ALDH2 aggravates mitochondrial biogenesis disorder in cardiac myocytes induced by TAC","volume":"639","author":"Xia","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2024.167584_bb0410","article-title":"Increase of oxidative stress by deficiency of the ALDH2\/UCP2\/Nrf2 axis exacerbates cardiac dysfunction in chronic kidney disease","volume":"23","author":"Xu","year":"2022","journal-title":"RCM"},{"key":"10.1016\/j.bbadis.2024.167584_bb0415","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13998","article-title":"Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle","volume":"7","author":"Kitaoka","year":"2019","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bbadis.2024.167584_bb0420","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exger.2019.01.022","article-title":"Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner","volume":"119","author":"Huang","year":"2019","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0425","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12192-023-01326-z","article-title":"Proteotoxic stress-induced autophagy is regulated by the NRF2 pathway via extracellular vesicles","volume":"28","author":"Okusha","year":"2023","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bbadis.2024.167584_bb0430","doi-asserted-by":"crossref","first-page":"207","DOI":"10.35946\/arcr.v38.2.05","article-title":"Alcoholic myopathy: pathophysiologic mechanisms and clinical implications","volume":"38","author":"Simon","year":"2017","journal-title":"Alcohol Res."},{"key":"10.1016\/j.bbadis.2024.167584_bb0435","first-page":"422","article-title":"Mitochondrial quality control and muscle mass maintenance","volume":"6","author":"Romanello","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2024.167584_bb0440","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2020.34.s1.05150","article-title":"Dietary composition exacerbates sex differences in skeletal muscle myopathy following chronic alcohol intake","volume":"34","author":"Laudato","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2024.167584_bb0445","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCRESAHA.121.320702","article-title":"Sex differences in peripheral artery disease","volume":"130","author":"Pabon","year":"2022","journal-title":"Circ. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924005787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443924005787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:05:12Z","timestamp":1769922312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443924005787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0925443924005787"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167584","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167584","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167584"}}