{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:44:59Z","timestamp":1776876299160,"version":"3.51.2"},"reference-count":108,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbadis.2024.167652","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T17:32:39Z","timestamp":1735752759000},"page":"167652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epigenetics in autosomal dominant polycystic kidney disease"],"prefix":"10.1016","volume":"1871","author":[{"given":"Zhipeng","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingqing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianhu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqiang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaosheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2024.167652_bb0005","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2215\/CJN.02320220","article-title":"Insights into autosomal dominant polycystic kidney disease from genetic studies","volume":"16","author":"Lanktree","year":"2021","journal-title":"Clinical journal of the American Society of Nephrology\u202f: CJASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0010","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.kint.2023.02.010","article-title":"Drug repurposing in autosomal dominant polycystic kidney disease","volume":"103","author":"Zhou","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2024.167652_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/nu15112621","article-title":"Diet and physical activity in adult dominant polycystic kidney disease: a review of the literature","volume":"15","author":"Capelli","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2024.167652_bb0020","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1001\/jama.2023.2161","article-title":"What is autosomal dominant polycystic kidney disease?","volume":"329","author":"Alam","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.bbadis.2024.167652_bb0025","first-page":"945","article-title":"Polycystic kidney disease. Comprehensive","volume":"7","author":"Ghata","year":"2017","journal-title":"Physiology"},{"key":"10.1016\/j.bbadis.2024.167652_bb0030","first-page":"12","article-title":"Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease","author":"Lu","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0035","doi-asserted-by":"crossref","first-page":"F997","DOI":"10.1152\/ajprenal.00186.2017","article-title":"An inhibitor of histone deacetylase 6 activity, ACY-1215, reduces cAMP and cyst growth in polycystic kidney disease","volume":"313","author":"Yanda","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0040","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1038\/s41467-022-32543-2","article-title":"PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression","volume":"13","author":"Lakhia","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2024.167652_bb0045","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molmed.2023.01.005","article-title":"Polycystic kidney disease: novel insights into polycystin function","volume":"29","author":"Luo","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0050","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1002\/jcp.28094","article-title":"Autosomal dominant polycystic kidney disease: disrupted pathways and potential therapeutic interventions","volume":"234","author":"Malekshahabi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s10020-020-00246-3","article-title":"Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects","volume":"26","author":"Saini","year":"2020","journal-title":"Molecular medicine (Cambridge, Mass)."},{"key":"10.1016\/j.bbadis.2024.167652_bb0060","first-page":"23","article-title":"Autosomal dominant polycystic kidney disease: from pathophysiology of Cystogenesis to advances in the treatment","author":"Reiterov\u00e1","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167652_bb0065","first-page":"9","article-title":"Ciliary genes in renal cystic diseases","author":"Adamiok-Ostrowska","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2024.167652_bb0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/j.ajkd.2020.08.012","article-title":"Ciliopathies and the kidney: a review","volume":"77","author":"McConnachie","year":"2021","journal-title":"American journal of kidney diseases\u202f: the official journal of the National Kidney Foundation."},{"issue":"Suppl. 1","key":"10.1016\/j.bbadis.2024.167652_bb0075","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1513\/AnnalsATS.201507-420MG","article-title":"Epigenetic mechanisms in asthma","volume":"13","author":"DeVries","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.bbadis.2024.167652_bb0080","first-page":"12","article-title":"Epigenetic mechanisms of aging and aging-associated diseases","author":"la Torre","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2024.167652_bb0085","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s13311-014-0302-1","article-title":"Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases","volume":"11","author":"Qureshi","year":"2014","journal-title":"Neurotherapeutics\u202f: the journal of the American Society for Experimental NeuroTherapeutics."},{"key":"10.1016\/j.bbadis.2024.167652_bb0090","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1146\/annurev-nutr-121415-112634","article-title":"Diet, nutrition, and Cancer epigenetics","volume":"36","author":"Sapienza","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbadis.2024.167652_bb0095","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41380-018-0254-7","article-title":"Epigenetics in eating disorders: a systematic review","volume":"24","author":"H\u00fcbel","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbadis.2024.167652_bb0100","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1289\/ehp.1307892","article-title":"Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy","volume":"122","author":"Markunas","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbadis.2024.167652_bb0105","first-page":"6","article-title":"Cross-talk between CDK4\/6 and SMYD2 regulates gene transcription, tubulin methylation, and ciliogenesis","author":"Li","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2024.167652_bb0110","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends in genetics\u202f: TIG."},{"key":"10.1016\/j.bbadis.2024.167652_bb0115","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1111\/jipb.13422","article-title":"DNA methylation dynamics during germline development","volume":"64","author":"He","year":"2022","journal-title":"J. Integr. Plant Biol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0120","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1177\/0271678X221116192","article-title":"Epigenetic mechanisms and potential therapeutic targets in stroke","volume":"42","author":"Morris-Blanco","year":"2022","journal-title":"Journal of cerebral blood flow and metabolism\u202f: official journal of the International Society of Cerebral Blood Flow and Metabolism."},{"key":"10.1016\/j.bbadis.2024.167652_bb0125","first-page":"105","volume":"2","author":"Fouse","year":"2010","journal-title":"Genome-scale DNA methylation analysis. Epigenomics."},{"key":"10.1016\/j.bbadis.2024.167652_bb0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41580-020-0274-4","article-title":"Am-bivalency towards DNA methylation","volume":"21","author":"Zlotorynski","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0135","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/ndt\/gfy009","article-title":"Targeting epigenetic DNA and histone modifications to treat kidney disease","volume":"33","author":"Fontecha-Barriuso","year":"2018","journal-title":"Nephrology, dialysis, transplantation\u202f: official publication of the European Dialysis and Transplant Association - European Renal Association."},{"key":"10.1016\/j.bbadis.2024.167652_bb0140","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/2413","article-title":"Transcription of IAP endogenous retroviruses is constrained by cytosine methylation","volume":"20","author":"Walsh","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2024.167652_bb0145","doi-asserted-by":"crossref","first-page":"15238","DOI":"10.1038\/srep15238","article-title":"Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD","volume":"5","author":"Woo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2024.167652_bb0150","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1096\/fj.201800563RR","article-title":"Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.bbadis.2024.167652_bb0155","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.kint.2024.04.017","article-title":"DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease","volume":"106","author":"Zhou","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2024.167652_bb0160","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00439-013-1378-0","article-title":"Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development","volume":"133","author":"Woo","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbadis.2024.167652_bb0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000494739","article-title":"Genome-scale single nucleotide resolution analysis of DNA methylation in human autosomal dominant polycystic kidney disease","volume":"48","author":"Bowden","year":"2018","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3389\/fgene.2020.00348","article-title":"Extensive inter-cyst DNA methylation variation in autosomal dominant polycystic kidney disease revealed by genome scale sequencing","volume":"11","author":"Bowden","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbadis.2024.167652_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109509","article-title":"Epigenetics and cell cycle regulation in cystogenesis","volume":"68","author":"Li","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2024.167652_bb0180","article-title":"Chromatin methylation abnormalities in autosomal dominant polycystic kidney disease","volume":"9","author":"Xu","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0185","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/sctm.18-0283","article-title":"Cystic renal-epithelial derived induced pluripotent stem cells from polycystic kidney disease patients","volume":"9","author":"Kenter","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3724\/abbs.2021016","article-title":"Epigenetics in the pathogenesis of diabetic nephropathy","volume":"54","author":"Li","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.bbadis.2024.167652_bb0195","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1681\/ASN.2022070750","article-title":"Decorating histones in polycystic kidney disease","volume":"33","author":"Ramalingam","year":"2022","journal-title":"Journal of the American Society of Nephrology\u202f: JASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0200","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications - cause and consequence of genome function","volume":"23","author":"Mill\u00e1n-Zambrano","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbadis.2024.167652_bb0205","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.semcdb.2022.02.012","article-title":"Histone variant-specific post-translational modifications","volume":"135","author":"Joseph","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcdb.2022.06.015","article-title":"Histone variants: the architects of chromatin","volume":"135","author":"Berger","year":"2023","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0215","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/path.4647","article-title":"The complexity of epigenetic diseases","volume":"238","author":"Brazel","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0220","first-page":"23","article-title":"Impact of histone modifications and their therapeutic targeting in hematological malignancies","author":"Markouli","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167652_bb0225","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s13148-022-01371-y","article-title":"Investigating pathological epigenetic aberrations by epi-proteomics","volume":"14","author":"Robusti","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbadis.2024.167652_bb0230","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13072-018-0251-8","article-title":"Histone H3 lysine K4 methylation and its role in learning and memory","volume":"12","author":"Collins","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.bbadis.2024.167652_bb0235","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1038\/s41467-023-43378-w","article-title":"SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer","volume":"14","author":"Rao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2024.167652_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012281","article-title":"The histone methyltransferase SETD2 regulates HIV expression and latency","volume":"20","author":"Bussey-Sutton","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbadis.2024.167652_bb0245","doi-asserted-by":"crossref","unstructured":"Ibarrola J, Xiang RR, Sun Z, et al. Inhibition of the Histone Methyltransferase EZH2 Induces Vascular Stiffness. Clinical Science (London, England : 1979). vol. 2024; 138: 251\u201368.","DOI":"10.1042\/CS20231478"},{"key":"10.1016\/j.bbadis.2024.167652_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116048","article-title":"Protein arginine methyltransferases (PRMTs): orchestrators of cancer pathogenesis, immunotherapy dynamics, and drug resistance","volume":"221","author":"Gao","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0255","doi-asserted-by":"crossref","first-page":"15931","DOI":"10.1021\/acs.jmedchem.4c00490","article-title":"Structure, function, and activity of small molecule and peptide inhibitors of protein arginine methyltransferase 1","volume":"67","author":"Hendrickson-Rebizant","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbadis.2024.167652_bb0260","article-title":"Methylation and phosphorylation of formin homology domain proteins (Fhod1 and Fhod3) by protein arginine methyltransferase 7 (PRMT7) and rho kinase (ROCK1)","volume":"107857","author":"Lowe","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2024.167652_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113703","article-title":"Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis","volume":"43","author":"Lu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2024.167652_bb0270","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1002\/tox.24370","article-title":"Histone methyltransferase SUV39H2 supports nasopharyngeal carcinoma cell metastasis by regulation of SIRT1","volume":"39","author":"You","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2024.02.030","article-title":"H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation","volume":"84","author":"Kubo","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2024.167652_bb0280","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41388-024-02945-1","article-title":"Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide","volume":"43","author":"Li","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2024.167652_bb0285","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1172\/JCI90921","article-title":"Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2024.167652_bb0290","doi-asserted-by":"crossref","first-page":"F227","DOI":"10.1152\/ajprenal.00452.2021","article-title":"Cross talk between lysine methyltransferase Smyd2 and TGF-\u03b2-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease","volume":"323","author":"Li","year":"2022","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0295","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1186\/s12967-024-05785-5","article-title":"EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease","volume":"22","author":"Lv","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101815","article-title":"Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer","volume":"39","author":"Wang","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0305","doi-asserted-by":"crossref","first-page":"21819","DOI":"10.1073\/pnas.0911987106","article-title":"Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models","volume":"106","author":"Cao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2024.167652_bb0310","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s10020-018-0027-4","article-title":"Inhibition of HDAC6 activity in kidney diseases: a new perspective","volume":"24","author":"Ke","year":"2018","journal-title":"Molecular medicine (Cambridge, Mass)."},{"key":"10.1016\/j.bbadis.2024.167652_bb0315","doi-asserted-by":"crossref","first-page":"i27","DOI":"10.1093\/ckj\/sfy089","article-title":"Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease","volume":"11","author":"Weimbs","year":"2018","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.bbadis.2024.167652_bb0320","doi-asserted-by":"crossref","first-page":"17897","DOI":"10.1074\/jbc.M117.803775","article-title":"Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and ca(2+) in knock-out mouse models of polycystic kidney disease","volume":"292","author":"Yanda","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2024.167652_bb0325","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.kint.2022.08.039","article-title":"Enhancer and super-enhancer landscape in polycystic kidney disease","volume":"103","author":"Lakhia","year":"2023","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2024.167652_bb0330","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1172\/JCI64401","article-title":"Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease","volume":"123","author":"Zhou","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2024.167652_bb0335","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1073\/pnas.0409875102","article-title":"Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation","volume":"102","author":"Kuzmichev","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2024.167652_bb0340","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","article-title":"Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification","volume":"146","author":"Tan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2024.167652_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2020.12.009","article-title":"Histone crotonylation promotes mesoendodermal commitment of human embryonic stem cells","volume":"28","author":"Fang","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2024.167652_bb0350","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1242\/dmm.024455","article-title":"Histone lysine crotonylation during acute kidney injury in mice","volume":"9","author":"Ruiz-Andres","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbadis.2024.167652_bb0355","doi-asserted-by":"crossref","first-page":"42414","DOI":"10.1074\/jbc.M111.271064","article-title":"Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2024.167652_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2017.07.011","article-title":"Chromodomain protein CDYL acts as a Crotonyl-CoA hydratase to regulate histone Crotonylation and spermatogenesis","volume":"67","author":"Liu","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2024.167652_bb0365","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1681\/ASN.2021111425","article-title":"Nuclear condensation of CDYL links histone Crotonylation and Cystogenesis in autosomal dominant polycystic kidney disease","volume":"33","author":"Dang","year":"2022","journal-title":"Journal of the American Society of Nephrology\u202f: JASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0370","doi-asserted-by":"crossref","first-page":"1006427","DOI":"10.3389\/fphys.2022.1006427","article-title":"Non-coding RNAs as potential biomarkers and therapeutic targets in polycystic kidney disease","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0375","first-page":"22","article-title":"Non-coding RNAs in hereditary kidney disorders","author":"Zhou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2024.167652_bb0380","doi-asserted-by":"crossref","first-page":"F109","DOI":"10.1152\/ajprenal.00387.2015","article-title":"Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases","volume":"310","author":"Bhatt","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0385","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202400006","article-title":"Spliceosomal snRNAs, the essential players in pre-mRNA processing in eukaryotic nucleus: from biogenesis to functions and spatiotemporal characteristics","volume":"8","author":"Su","year":"2024","journal-title":"Advanced biology."},{"key":"10.1016\/j.bbadis.2024.167652_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109548","article-title":"Modulation of polycystic kidney disease by non-coding RNAs","volume":"71","author":"Ramalingam","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2024.167652_bb0395","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1073\/pnas.1301693110","article-title":"miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease","volume":"110","author":"Patel","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2024.167652_bb0400","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MNH.0000000000000333","article-title":"Therapeutic microRNAs in polycystic kidney disease","volume":"26","author":"Yheskel","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbadis.2024.167652_bb0405","doi-asserted-by":"crossref","first-page":"14395","DOI":"10.1038\/ncomms14395","article-title":"microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism","volume":"8","author":"Hajarnis","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2024.167652_bb0410","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41598-019-38566-y","article-title":"Anti-microRNA screen uncovers miR-17 family within miR-17~92 cluster as the primary driver of kidney cyst growth","volume":"9","author":"Yheskel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2024.167652_bb0415","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1038\/s41467-019-11918-y","article-title":"Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease","volume":"10","author":"Lee","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2024.167652_bb0420","doi-asserted-by":"crossref","first-page":"195","DOI":"10.12659\/MSM.892141","article-title":"Inhibition of MiR-199a-5p reduced cell proliferation in autosomal dominant polycystic kidney disease through targeting CDKN1C","volume":"21","author":"Sun","year":"2015","journal-title":"Medical science monitor\u202f: international medical journal of experimental and clinical research."},{"key":"10.1016\/j.bbadis.2024.167652_bb0425","first-page":"5","article-title":"Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression","author":"Lakhia","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2024.167652_bb0430","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1681\/ASN.2015060634","article-title":"MicroRNA-21 aggravates cyst growth in a model of polycystic kidney disease","volume":"27","author":"Lakhia","year":"2016","journal-title":"Journal of the American Society of Nephrology\u202f: JASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0435","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1681\/ASN.0000000000000265","article-title":"Ablation of long noncoding RNA Hoxb3os exacerbates Cystogenesis in mouse polycystic kidney disease","volume":"35","author":"Weisser","year":"2024","journal-title":"Journal of the American Society of Nephrology\u202f: JASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0440","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1074\/jbc.RA118.001723","article-title":"Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling","volume":"293","author":"Aboudehen","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2024.167652_bb0445","first-page":"13","article-title":"A brief review on the regulatory roles of MicroRNAs in cystic diseases and their use as potential biomarkers","author":"Ruiz-Manriquez","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.bbadis.2024.167652_bb0450","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1096\/fj.201700923R","article-title":"Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis","volume":"32","author":"Shin","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2024.167652_bb0455","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13148-024-01667-1","volume":"16","author":"Ma","year":"2024","journal-title":"Epigenetics in diabetic cardiomyopathy. Clinical epigenetics."},{"key":"10.1016\/j.bbadis.2024.167652_bb0460","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cr.2011.158","article-title":"Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA","volume":"22","author":"Zhang","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.bbadis.2024.167652_bb0465","first-page":"306","article-title":"Potential role of plant microRNAs in the pathogenesis of autosomal dominant polycystic kidney disease: an in silico study","volume":"131","author":"Niemczyk","year":"2021","journal-title":"Polish archives of internal medicine."},{"key":"10.1016\/j.bbadis.2024.167652_bb0470","doi-asserted-by":"crossref","unstructured":"Adam J, Pollard PJ. In the ring with polycystic kidney disease--avoiding the knockout punch. J. Pathol. 2011; 223: 1\u20133.","DOI":"10.1002\/path.2782"},{"key":"10.1016\/j.bbadis.2024.167652_bb0475","first-page":"11","article-title":"Predicting progression of autosomal dominant polycystic kidney disease by changes in the Telomeric epigenome","author":"Kocyigit","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2024.167652_bb0480","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12882-017-0600-z","article-title":"Serum micro-rna profiles in patients with autosomal dominant polycystic kidney disease according to hypertension and renal function","volume":"18","author":"Kocyigit","year":"2017","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0485","first-page":"73","article-title":"Urinary MicroRNAs, possible biomarkers for early detection of patients with autosomal dominant polycystic kidney disease (ADPKD)","volume":"1","author":"Ghasemi","year":"2023","journal-title":"Iran. J. Kidney Dis."},{"key":"10.1016\/j.bbadis.2024.167652_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3674","article-title":"Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease","volume":"26","author":"Ali","year":"2024","journal-title":"J. Gene Med."},{"key":"10.1016\/j.bbadis.2024.167652_bb0495","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1007\/s11033-009-9861-3","article-title":"MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation","volume":"37","author":"Sun","year":"2010","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbadis.2024.167652_bb0500","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1681\/ASN.2012030321","article-title":"MicroRNAs regulate renal tubule maturation through modulation of Pkd1","volume":"23","author":"Patel","year":"2012","journal-title":"Journal of the American Society of Nephrology\u202f: JASN."},{"key":"10.1016\/j.bbadis.2024.167652_bb0505","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053780","article-title":"Parallel analysis of mRNA and microRNA microarray profiles to explore functional regulatory patterns in polycystic kidney disease: using PKD\/Mhm rat model","volume":"8","author":"Dweep","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2024.167652_bb0510","doi-asserted-by":"crossref","first-page":"14151","DOI":"10.1038\/s41598-017-14083-8","article-title":"Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models","volume":"7","author":"Woo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2024.167652_bb0515","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1002\/jcp.26473","article-title":"MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR\/MDM2 pathway in ADPKD cells","volume":"233","author":"de Stephanis","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0520","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/0886022X.2020.1745236","article-title":"miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1","volume":"42","author":"Liu","year":"2020","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbadis.2024.167652_bb0525","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/iub.2255","article-title":"MiR-182 inhibits kidney fibrosis by regulating transforming growth factor \u03b21\/Smad3 pathway in autosomal dominant polycystic kidney disease","volume":"72","author":"Sun","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbadis.2024.167652_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150848","article-title":"Integrated mRNA-seq and miRNA-seq analysis reveals key transcription factors of HNF4\u03b1 and KLF4 in ADPKD","volume":"735","author":"Huang","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2024.167652_bb0535","doi-asserted-by":"crossref","first-page":"F577","DOI":"10.1152\/ajprenal.00607.2016","article-title":"Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression","volume":"312","author":"Streets","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2024.167652_bb0540","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5527\/wjn.v7.i5.108","article-title":"Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease","volume":"7","author":"Patil","year":"2018","journal-title":"World journal of nephrology."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392400646X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392400646X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:16:18Z","timestamp":1772457378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392400646X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":108,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S092544392400646X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167652","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetics in autosomal dominant polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2024.167652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167652"}}