{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:25:07Z","timestamp":1792513507819,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273250"],"award-info":[{"award-number":["82273250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602464"],"award-info":[{"award-number":["81602464"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017534","name":"333 Project of Jiangsu Province","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100017534","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","award":["SWYY-088"],"award-info":[{"award-number":["SWYY-088"]}],"id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012217","name":"Xuzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Jiangsu Provincial Qinglan Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018636","name":"Xuzhou Science and Technology Program","doi-asserted-by":"publisher","award":["KC20145"],"award-info":[{"award-number":["KC20145"]}],"id":[{"id":"10.13039\/501100018636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbadis.2025.167702","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T07:01:13Z","timestamp":1738393273000},"page":"167702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypoxic stress promotes astrocyte infiltration-like growth via HIF-1\u03b1\/GDNF\/LOXL2 axis"],"prefix":"10.1016","volume":"1871","author":[{"given":"Zimu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xugang","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baole","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167702_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114477","article-title":"A novel peptide P1-121aa encoded by STK24P1 regulates vasculogenic mimicry via ELF2 phosphorylation in glioblastoma","volume":"367","author":"Li","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0010","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/s41401-020-00560-w","article-title":"4-Methoxydalbergione is a potent inhibitor of human astroglioma U87 cells in vitro and in vivo","volume":"42","author":"Li","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbadis.2025.167702_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00401-023-02662-1","article-title":"Improved prognostic stratification of patients with isocitrate dehydrogenase-mutant astrocytoma","volume":"147","author":"Weller","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2020.11.022","article-title":"Enhancer II-targeted dsRNA decreases GDNF expression via histone H3K9 trimethylation to inhibit glioblastoma progression","volume":"167","author":"Zhang","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbadis.2025.167702_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neo.2017.10.010","article-title":"The GDNF family: a role in cancer?","volume":"20","author":"Fielder","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.bbadis.2025.167702_bb0030","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.semcancer.2018.07.005","article-title":"The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain","volume":"53","author":"Ayanlaja","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0035","doi-asserted-by":"crossref","first-page":"748","DOI":"10.4103\/1673-5374.322446","article-title":"GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries","volume":"17","author":"Cintron-Colon","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2025.167702_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113037","article-title":"Enhanced regeneration and reinnervation following timed GDNF gene therapy in a cervical ventral root avulsion","volume":"321","author":"Eggers","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0045","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41586-018-0467-6","article-title":"Required growth facilitators propel axon regeneration across complete spinal cord injury","volume":"561","author":"Anderson","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167702_bb0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/PL00007416","article-title":"Glial cell line-derived neurotrophic factor (GDNF) and its receptor (GFR-alpha 1) are strongly expressed in human gliomas","volume":"99","author":"Wiesenhofer","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0055","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12035-013-8443-5","article-title":"Changes in transcriptional factor binding capacity resulting from promoter region methylation induce aberrantly high GDNF expression in human glioma","volume":"48","author":"Yu","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0060","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.12659\/MSM.911669","article-title":"Glial cell line-derived neurotrophic factor (GDNF) promotes angiogenesis through the demethylation of the fibromodulin (FMOD) promoter in glioblastoma","volume":"24","author":"Chen","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.bbadis.2025.167702_bb0065","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5399","article-title":"GDNF regulates lipid metabolism and glioma growth through RET\/ERK\/HIF-1\/SREBP-1","volume":"61","author":"Yu","year":"2022","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0070","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/ijc.29380","article-title":"Paracrine regulation of glioma cells invasion by astrocytes is mediated by glial-derived neurotrophic factor","volume":"137","author":"Shabtay-Orbach","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbadis.2025.167702_bb0075","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00401-013-1079-8","article-title":"GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis","volume":"125","author":"Ku","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0080","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2174\/1568009621666210504091722","article-title":"Rediscovering potential molecular targets for glioma therapy through the analysis of the cell of origin, microenvironment and metabolism","volume":"21","author":"Guo","year":"2021","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.bbadis.2025.167702_bb0085","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1126\/science.1226929","article-title":"Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice","volume":"338","author":"Friedmann-Morvinski","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.167702_bb0090","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020610","article-title":"Cell of origin for malignant gliomas and its implication in therapeutic development","volume":"7","author":"Zong","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0095","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41583-018-0014-3","article-title":"A glial blueprint for gliomagenesis","volume":"19","author":"Laug","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167702_bb0100","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1200\/JCO.2017.72.6737","article-title":"Diffuse infiltrating oligodendroglioma and astrocytoma","volume":"35","author":"van den Bent","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/PAP.0000000000000048","article-title":"Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis","volume":"22","author":"Appin","year":"2015","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.bbadis.2025.167702_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030613","article-title":"Hypoxia-induced reactivity of tumor-associated astrocytes affects glioma cell properties","volume":"10","author":"Pantazopoulou","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167702_bb0115","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41392-019-0075-4","article-title":"The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports","volume":"4","author":"Ghosh","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.167702_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9020456","article-title":"GDNF, A neuron-derived factor upregulated in glial cells during disease","volume":"9","author":"Duarte Azevedo","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbadis.2025.167702_bb0125","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000487853","article-title":"High concentration of glial cell line-derived neurotrophic factor protects primary astrocytes from apoptosis","volume":"40","author":"Wang","year":"2018","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167702_bb0130","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1007\/s12035-022-02978-1","article-title":"GDNF promotes astrocyte abnormal proliferation and migration through the GFRalpha1\/RET\/MAPK\/pCREB\/LOXL2 signaling axis","volume":"59","author":"Wang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0135","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8328216","article-title":"ADAM17 mediates hypoxia-induced keratinocyte migration via the p38\/MAPK pathway","volume":"2021","author":"Zhu","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbadis.2025.167702_bb0140","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neures.2006.04.019","article-title":"Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1\/2 and p38 MAPK signaling pathways","volume":"56","author":"Song","year":"2006","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbadis.2025.167702_bb0145","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167702_bb0150","first-page":"2840","article-title":"MiR-130b functions as a tumor promoter in glioma via regulation of ERK\/MAPK pathway","volume":"21","author":"Li","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbadis.2025.167702_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2020.188435","article-title":"LOXL2 in cancer: regulation, downstream effectors and novel roles","volume":"1874","author":"Wen","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbadis.2025.167702_bb0160","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1139\/bcb-2014-0046","article-title":"Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 Deltae13, in esophageal squamous cell carcinoma","volume":"92","author":"Lv","year":"2014","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0165","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1186\/bcr3461","article-title":"LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling","volume":"15","author":"Chang","year":"2013","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167702_bb0170","first-page":"1161","article-title":"Egr-1 participates in abnormally high gdnf gene transcription mediated by histone hyperacetylation in glioma cells","volume":"2014","author":"Zhang","year":"1839","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.167702_bb0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13148-020-00835-3","article-title":"Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells","volume":"12","author":"Zhang","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.bbadis.2025.167702_bb0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2020.05.026","article-title":"Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy","volume":"488","author":"Ferrer","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2025.167702_bb0185","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12929-020-00705-3","article-title":"FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis","volume":"28","author":"Cai","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2025.167702_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2014.21","article-title":"Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation","volume":"3","author":"Daniel","year":"2014","journal-title":"Oncogenesis"},{"key":"10.1016\/j.bbadis.2025.167702_bb0195","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1038\/s41598-020-67325-7","article-title":"TGF-beta induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167702_bb0200","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.immuni.2023.06.017","article-title":"Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression","volume":"56","author":"Sattiraju","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2025.167702_bb0205","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1006\/exnr.2000.7416","article-title":"Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRalpha1 as well as GDNF in vivo","volume":"164","author":"Bresjanac","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1750-3639.2004.tb00064.x","article-title":"Gene expression profiles of reactive astrocytes in dopamine-depleted striatum","volume":"14","author":"Nakagawa","year":"2004","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2025.167702_bb0215","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12031-019-01416-7","article-title":"MES23.5 DA immortalized neuroblastoma cells self-protect against early injury by overexpressing glial cell-derived neurotrophic factor via Akt1\/Eya1\/Six2 signaling","volume":"70","author":"Gao","year":"2020","journal-title":"Journal of Molecular Neuroscience"},{"key":"10.1016\/j.bbadis.2025.167702_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.10003","article-title":"Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats","volume":"37","author":"Yamagata","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.bbadis.2025.167702_bb0225","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12974-018-1251-0","article-title":"Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson\u2019s disease animal model","volume":"15","author":"Fujita","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbadis.2025.167702_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2019.07.021","article-title":"Age-associated dopaminergic neuron loss and midbrain glia cell phenotypic polarization","volume":"415","author":"Wang","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2025.167702_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2021.103655","article-title":"GDNF requires HIF-1alpha and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge","volume":"115","author":"Kearon","year":"2021","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167702_bb0240","article-title":"LOXL2 inhibitors and breast cancer progression","volume":"10","author":"Ferreira","year":"2021","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.bbadis.2025.167702_bb0245","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejca.2021.01.011","article-title":"The pathological significance of LOXL2 in pre-metastatic niche formation of HCC and its related molecular mechanism","volume":"147","author":"Wu","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.bbadis.2025.167702_bb0250","article-title":"TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling","author":"Zhang","year":"2022","journal-title":"Cell. Oncol. (Dordr.)"},{"key":"10.1016\/j.bbadis.2025.167702_bb0255","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/gutjnl-2021-325564","article-title":"Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma","volume":"72","author":"Alonso-Nocelo","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.bbadis.2025.167702_bb0260","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1016\/j.neuron.2024.07.026","article-title":"Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier","volume":"112","author":"Xie","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.bbadis.2025.167702_bb0265","doi-asserted-by":"crossref","first-page":"14013","DOI":"10.1074\/jbc.M209702200","article-title":"MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300","volume":"278","author":"Sang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167702_bb0270","doi-asserted-by":"crossref","first-page":"1103075","DOI":"10.3389\/fendo.2022.1103075","article-title":"Hypoxia signaling pathway: a central mediator in endocrine tumors","volume":"13","author":"Watts","year":"2022","journal-title":"Front Endocrinol (Lausanne)."},{"key":"10.1016\/j.bbadis.2025.167702_bb0275","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13659","article-title":"Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis","volume":"21","author":"Wu","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbadis.2025.167702_bb0280","article-title":"Nobiletin alleviates astrocyte activation and oxidative stress induced by hypoxia in vitro","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392500047X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392500047X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:14:24Z","timestamp":1772457264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392500047X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S092544392500047X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167702","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxic stress promotes astrocyte infiltration-like growth via HIF-1\u03b1\/GDNF\/LOXL2 axis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167702"}}