{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:16:33Z","timestamp":1791645393106,"version":"4.3.4"},"reference-count":282,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167758","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T06:21:39Z","timestamp":1741155699000},"page":"167758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Update in the molecular mechanism and biomarkers of diabetic retinopathy"],"prefix":"10.1016","volume":"1871","author":[{"given":"Hui","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinkang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167758_bb0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","volume":"402","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2025.167758_bb0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","article-title":"Diabetic retinopathy","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2025.167758_bb0015","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194755","article-title":"Proteomic biomarkers of retinal inflammation in diabetic retinopathy","volume":"20","author":"Youngblood","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0025","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.ophtha.2018.04.007","article-title":"Guidelines on diabetic eye care: the International Council of Ophthalmology recommendations for screening, follow-up, referral, and treatment based on resource settings","volume":"125","author":"Wong","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0030","doi-asserted-by":"crossref","first-page":"Bio68","DOI":"10.1167\/iovs.17-21769","article-title":"Local and systemic inflammatory biomarkers of diabetic retinopathy: an integrative approach","volume":"58","author":"Vujosevic","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.preteyeres.2014.03.003","article-title":"Phenotypes and biomarkers of diabetic retinopathy","volume":"41","author":"Cunha-Vaz","year":"2014","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells12091342","article-title":"Retinal cell damage in diabetic retinopathy","volume":"12","author":"Zhou","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167758_bb0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10456-024-09911-1","article-title":"Microglia in retinal angiogenesis and diabetic retinopathy","volume":"27","author":"Hu","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbadis.2025.167758_bb0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41574-020-00451-4","article-title":"Current understanding of the molecular and cellular pathology of diabetic retinopathy","volume":"17","author":"Antonetti","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.preteyeres.2019.01.001","article-title":"Retinal capillary perfusion: spatial and temporal heterogeneity","volume":"70","author":"Yu","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0060","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1172\/JCI80297","article-title":"Neurovascular crosstalk between interneurons and capillaries is required for vision","volume":"125","author":"Usui","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.167758_bb0065","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.preteyeres.2012.04.004","article-title":"Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease","volume":"31","author":"Kur","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"37","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109650","article-title":"A correlation between oxidative stress and diabetic retinopathy: an updated review","volume":"236","author":"Hussain","year":"2023","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0080","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.2337\/diabetes.53.9.2404","article-title":"Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy","volume":"53","author":"Dagher","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.me.26.020175.002513","article-title":"Hyperglycemia, polyol metabolism, and complications of diabetes mellitus","volume":"26","author":"Gabbay","year":"1975","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0090","doi-asserted-by":"crossref","first-page":"R277","DOI":"10.1152\/ajpregu.00758.2002","article-title":"Vascular NAD(P)H oxidases: specific features, expression, and regulation","volume":"285","author":"Lass\u00e8gue","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090999","article-title":"Hyperglycemia-induced aberrant cell proliferation; a metabolic challenge mediated by protein O-GlcNAc modification","volume":"8","author":"Nagy","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167758_bb0100","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167758_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/md18070357","article-title":"Impact of astaxanthin on diabetes pathogenesis and chronic complications","volume":"18","author":"Landon","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbadis.2025.167758_bb0110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tips.2006.04.003","article-title":"PKD at the crossroads of DAG and PKC signaling","volume":"27","author":"Wang","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0115","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2337\/db12-1744","article-title":"Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy","volume":"62","author":"Titchenell","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0120","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1167\/iovs.05-0757","article-title":"Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients","volume":"47","author":"Aiello","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0125","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.biopha.2018.10.185","article-title":"A non-invasive, multi-target approach to treat diabetic retinopathy","volume":"109","author":"Julius","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.167758_bb0130","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.2337\/diabetes.51.9.2826","article-title":"The AGE inhibitor pyridoxamine inhibits development of retinopathy in experimental diabetes","volume":"51","author":"Stitt","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0135","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","article-title":"The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality","volume":"28","author":"Chaudhuri","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbadis.2025.167758_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114713","article-title":"Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs\/RAGE and p38 MAPK\/NF-\u03baB pathway","volume":"283","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0145","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s00125-023-05995-4","article-title":"Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy","volume":"66","author":"Dharmarajan","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2025.167758_bb0150","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1158\/0008-5472.CAN-10-2664","article-title":"Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with doxorubicin chemotherapy","volume":"70","author":"Zhao","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0155","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.2337\/db15-0422","article-title":"Diabetic stroke severity: epigenetic remodeling and neuronal, glial, and vascular dysfunction","volume":"64","author":"Kalani","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0160","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1167\/iovs.06-1280","article-title":"Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase","volume":"48","author":"Kanwar","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0165","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.7150\/thno.30398","article-title":"SIRT3-dependent mitochondrial dynamics remodeling contributes to oxidative stress-induced melanocyte degeneration in vitiligo","volume":"9","author":"Yi","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2025.167758_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/cells12020300","article-title":"Cross talks between oxidative stress, inflammation and epigenetics in diabetic retinopathy","volume":"12","author":"Kowluru","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167758_bb0175","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.freeradbiomed.2003.08.018","article-title":"Hyperglycemia increases mitochondrial superoxide in retina and retinal cells","volume":"35","author":"Du","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0180","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.molcel.2016.06.016","article-title":"A small molecule that protects the integrity of the electron transfer chain blocks the mitochondrial apoptotic pathway","volume":"63","author":"Jiang","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.167758_bb0185","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/10715760310001604189","article-title":"Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants","volume":"37","author":"Kowluru","year":"2003","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0190","doi-asserted-by":"crossref","first-page":"14782","DOI":"10.1073\/pnas.1417253111","article-title":"Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis","volume":"111","author":"Jiang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2025.167758_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3096470","article-title":"Adjuvant therapies in diabetic retinopathy as an early approach to delay its progression: the importance of oxidative stress and inflammation","volume":"2020","author":"Robles-Rivera","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.167758_bb0200","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00125-010-1943-1","article-title":"The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy","volume":"54","author":"Zhou","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2025.167758_bb0205","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2018.10.419","article-title":"Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium","volume":"130","author":"Chen","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0210","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11154-008-9090-4","article-title":"Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives","volume":"9","author":"Madsen-Bouterse","year":"2008","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbadis.2025.167758_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3420187","article-title":"The oxidative stress and mitochondrial dysfunction during the pathogenesis of diabetic retinopathy","volume":"2018","author":"Wu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.167758_bb0220","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/213130","article-title":"Inflammation and pharmacological treatment in diabetic retinopathy","volume":"2013","author":"Ka\u0161telan","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbadis.2025.167758_bb0225","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/582060","article-title":"Diabetic retinopathy: vascular and inflammatory disease","volume":"2015","author":"Semeraro","year":"2015","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0230","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123123","article-title":"Nexus of NF\u03baB\/VEGF\/MMP9 signaling in diabetic retinopathy-linked dementia: management by phenolic acid-enabled nanotherapeutics","volume":"358","author":"Singh","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0240","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004557","article-title":"Noncanonical NF-\u03baB signaling is limited by classical NF-\u03baB activity","volume":"7","author":"Gray","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbadis.2025.167758_bb0245","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-010-9235-2","article-title":"Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals","volume":"29","author":"Gupta","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbadis.2025.167758_bb0250","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1196\/annals.1352.026","article-title":"Transcription factor NF-kappaB: a sensor for smoke and stress signals","volume":"1056","author":"Ahn","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0255","first-page":"830","article-title":"Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy","volume":"18","author":"Cheung","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0260","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1167\/iovs.13-12518","article-title":"Identification of VEGF-independent cytokines in proliferative diabetic retinopathy vitreous","volume":"54","author":"Bromberg-White","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194603","article-title":"Anti-inflammatory cytokine and angiogenic factors levels in vitreous samples of diabetic retinopathy patients","volume":"13","author":"Tsai","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb0270","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/j.1464-5491.2008.02466.x","article-title":"Increased levels of monokine induced by interferon-gamma (Mig) in the vitreous of patients with diabetic retinopathy","volume":"25","author":"Wakabayashi","year":"2008","journal-title":"Diabet. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0275","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/aos.12812","article-title":"Proteome analysis of retinal glia cells-related inflammatory cytokines in the aqueous humour of diabetic patients","volume":"94","author":"Vujosevic","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0280","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4103\/0301-4738.136220","article-title":"Roles of elevated intravitreal IL-1\u03b2 and IL-10 levels in proliferative diabetic retinopathy","volume":"62","author":"Mao","year":"2014","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0285","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1464-5491.2005.01538.x","article-title":"Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy","volume":"22","author":"Hern\u00e1ndez","year":"2005","journal-title":"Diabet. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0290","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00417-011-1905-4","article-title":"IL-12 concentrations in the aqueous humor and serum of diabetic retinopathy patients","volume":"250","author":"Gverovi\u0107 Antunica","year":"2012","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137358","article-title":"Elevated levels of cytokines associated with Th2 and Th17 cells in vitreous fluid of proliferative diabetic retinopathy patients","volume":"10","author":"Takeuchi","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb0300","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8546423","article-title":"Levels of inflammatory cytokines IL-1\u03b2, IL-6, IL-8, IL-17A, and TNF-\u03b1 in aqueous humour of patients with diabetic retinopathy","volume":"2018","author":"Feng","year":"2018","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0305","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.eye.6702138","article-title":"Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy","volume":"20","author":"Demircan","year":"2006","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0310","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00417-008-0868-6","article-title":"Assessment of selected adhesion molecule and proinflammatory cytokine levels in the vitreous body of patients with type 2 diabetes\u2014role of the inflammatory-immune process in the pathogenesis of proliferative diabetic retinopathy","volume":"246","author":"Adamiec-Mroczek","year":"2008","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0315","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cyto.2009.11.004","article-title":"Roles of endothelin-1 and selected proinflammatory cytokines in the pathogenesis of proliferative diabetic retinopathy: analysis of vitreous samples","volume":"49","author":"Adamiec-Mroczek","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.bbadis.2025.167758_bb0320","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12886-017-0572-6","article-title":"Assessment of biomarkers using multiplex assays in aqueous humor of patients with diabetic retinopathy","volume":"17","author":"Chen","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0325","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1167\/iovs.61.2.26","article-title":"Correlation of aqueous, vitreous, and plasma cytokine levels in patients with proliferative diabetic retinopathy","volume":"61","author":"Wu","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0330","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1001\/archopht.116.12.1597","article-title":"Interferon-induced protein 10 and interleukin 8. C-X-C chemokines present in proliferative diabetic retinopathy","volume":"116","author":"Elner","year":"1998","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.bbadis.2025.167758_bb0335","doi-asserted-by":"crossref","DOI":"10.1177\/1178641816686078","article-title":"Characterization of vitreous and aqueous proteome in humans with proliferative diabetic retinopathy and its clinical correlation","volume":"8","author":"Balaiya","year":"2017","journal-title":"Proteomics Insights"},{"key":"10.1016\/j.bbadis.2025.167758_bb0340","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/ijmr.IJMR_1293_19","article-title":"Selective decrease in alpha1-antitrypsin levels in diabetic retinopathy: could the levels of it be playing a role in the pathophysiology of diabetic retinopathy?","volume":"156","author":"Kunder","year":"2022","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0345","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/prca.200800017","article-title":"Proteome profiling of vitreoretinal diseases by cluster analysis","volume":"2","author":"Shitama","year":"2008","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.bbadis.2025.167758_bb0350","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.12669\/pjms.38.8.5579","article-title":"Glycated albumin and angiopoietin-2: possible indicators of diabetic retinopathy in type-two diabetes","volume":"38","author":"Ijaz","year":"2022","journal-title":"Pak J Med Sci"},{"key":"10.1016\/j.bbadis.2025.167758_bb0355","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fimmu.2020.00154","article-title":"A systematic investigation on complement pathway activation in diabetic retinopathy","volume":"11","author":"Shahulhameed","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0360","first-page":"1104","article-title":"Extensive deposits of complement C3d and C5b-9 in the choriocapillaris of eyes of patients with diabetic retinopathy","volume":"43","author":"Gerl","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0365","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00417-012-2024-6","article-title":"Correlation of complement fragment C5a with inflammatory cytokines in the vitreous of patients with proliferative diabetic retinopathy","volume":"251","author":"Muramatsu","year":"2013","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0370","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/279393","article-title":"Elevated serum levels of soluble TNF receptors and adhesion molecules are associated with diabetic retinopathy in patients with type-1 diabetes","volume":"2015","author":"Sharma","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bbadis.2025.167758_bb0375","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dsx.2014.05.004","article-title":"Correlation of C-reactive protein and body mass index with diabetic retinopathy in Indian population","volume":"9","author":"Sen","year":"2015","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.bbadis.2025.167758_bb0380","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/bjo.81.3.228","article-title":"Intravitreal growth factors in proliferative diabetic retinopathy: correlation with neovascular activity and glycaemic management","volume":"81","author":"Boulton","year":"1997","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0385","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.exer.2012.11.023","article-title":"Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry","volume":"108","author":"Wang","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0390","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cyto.2017.10.014","article-title":"Levels of adhesion molecules in peripheral blood correlat with stages of diabetic retinopathy and may serve as bio markers for microvascular complications","volume":"106","author":"Blum","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.bbadis.2025.167758_bb0395","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00417-016-3411-1","article-title":"Plasma E-selectin levels can play a role in the development of diabetic retinopathy","volume":"255","author":"Kasza","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0400","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1167\/iovs.15-16554","article-title":"Aqueous humor biomarkers of M\u00fcller cell activation in diabetic eyes","volume":"56","author":"Vujosevic","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0405","first-page":"1829","article-title":"High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy","volume":"17","author":"El-Asrar","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0410","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.jprot.2011.12.006","article-title":"Proteomic analysis and identification of aqueous humor proteins with a pathophysiological role in diabetic retinopathy","volume":"75","author":"Chiang","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bbadis.2025.167758_bb0415","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1167\/iovs.14-14864","article-title":"Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus","volume":"55","author":"Yang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0420","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10735-007-9159-5","article-title":"Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes","volume":"39","author":"Khalfaoui","year":"2008","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0425","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exer.2013.01.008","article-title":"Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy","volume":"109","author":"Nawaz","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0430","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.metabol.2015.04.005","article-title":"Low blood and vitreal BDNF, LXA4 and altered Th1\/Th2 cytokine balance are potential risk factors for diabetic retinopathy","volume":"64","author":"Kaviarasan","year":"2015","journal-title":"Metabolism"},{"key":"10.1016\/j.bbadis.2025.167758_bb0435","article-title":"High mannose-binding lectin serum levels are associated with diabetic retinopathy in Chinese patients with type 2 diabetes","volume":"10","author":"Huang","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb0440","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1755-3768.2009.01661.x","article-title":"Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in patients with non-proliferative diabetic retinopathy and clinically significant macula oedema","volume":"89","author":"Praidou","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0445","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.2337\/diacare.25.12.2352","article-title":"Vitreous levels of placenta growth factor and vascular endothelial growth factor in patients with proliferative diabetic retinopathy","volume":"25","author":"Mitamura","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2025.167758_bb0450","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/j.1464-5491.2004.01334.x","article-title":"Aqueous levels of macrophage migration inhibitory factor and monocyte chemotactic protein-1 in patients with diabetic retinopathy","volume":"21","author":"Tashimo","year":"2004","journal-title":"Diabet. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0455","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/gtmb.2015.0238","article-title":"Serum and vitreous pentraxin 3 concentrations in patients with diabetic retinopathy","volume":"20","author":"Zhou","year":"2016","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.bbadis.2025.167758_bb0460","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1167\/iovs.04-1057","article-title":"Serum inflammatory markers in diabetic retinopathy","volume":"46","author":"Meleth","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0465","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181100","article-title":"Elevated RBP4 plasma levels were associated with diabetic retinopathy in type 2 diabetes","volume":"38","author":"Li","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2025.167758_bb0470","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/147323001003800111","article-title":"Serum retinol-binding protein 4 levels in patients with diabetic retinopathy","volume":"38","author":"Li","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0475","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1167\/iovs.15-16470","article-title":"Increased plasma S100A12 levels are associated with diabetic retinopathy and prognostic biomarkers of macrovascular events in type 2 diabetic patients","volume":"56","author":"Dong","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0480","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI22869","article-title":"SDF-1 is both necessary and sufficient to promote proliferative retinopathy","volume":"115","author":"Butler","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.167758_bb0485","first-page":"984","article-title":"Expression of stromal cell-derived factor-1 in diabetic retinopathy","volume":"123","author":"Chen","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0490","first-page":"1760","article-title":"Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus","volume":"19","author":"Jain","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0495","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.ophtha.2011.10.040","article-title":"Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics","volume":"119","author":"Kuo","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0500","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2337\/diacare.24.3.516","article-title":"Vitreous levels of vascular cell adhesion molecule and vascular endothelial growth factor in patients with proliferative diabetic retinopathy: a case-control study","volume":"24","author":"Hern\u00e1ndez","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2025.167758_bb0505","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2020.030502","article-title":"Inflammatory and angiogenic biomarkers in diabetic retinopathy","volume":"30","author":"Ka\u0161telan","year":"2020","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0510","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1582-4934.2005.tb00379.x","article-title":"Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)","volume":"9","author":"Byrne","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0515","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/07853890.2022.2064541","article-title":"VEGF-targeting drugs for the treatment of retinal neovascularization in diabetic retinopathy","volume":"54","author":"Arrigo","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0520","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/13543784.2021.1879791","article-title":"Faricimab: an investigational agent targeting the Tie-2\/angiopoietin pathway and VEGF-A for the treatment of retinal diseases","volume":"30","author":"Nicol\u00f2","year":"2021","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.bbadis.2025.167758_bb0525","first-page":"1029","article-title":"Vascular permeability factor\/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis","volume":"146","author":"Dvorak","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.100954","article-title":"VEGFR1 signaling in retinal angiogenesis and microinflammation","volume":"84","author":"Uemura","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0535","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3389\/fnins.2019.01172","article-title":"Relationships between neurodegeneration and vascular damage in diabetic retinopathy","volume":"13","author":"Rossino","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0540","doi-asserted-by":"crossref","first-page":"5731","DOI":"10.1523\/JNEUROSCI.19-14-05731.1999","article-title":"Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system","volume":"19","author":"Sondell","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0545","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bies.20092","article-title":"VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection","volume":"26","author":"Storkebaum","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.bbadis.2025.167758_bb0550","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0555","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0560","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/glia.23727","article-title":"Glia of the human retina","volume":"68","author":"Reichenbach","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.bbadis.2025.167758_bb0565","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1167\/iovs.03-0609","article-title":"RPE cells modulate subretinal neovascularization, but do not cause regression in mice with sustained expression of VEGF","volume":"44","author":"Ida","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0570","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2174\/1389450054021981","article-title":"Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress","volume":"6","author":"Caldwell","year":"2005","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbadis.2025.167758_bb0575","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/er.2003-0027","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"25","author":"Ferrara","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbadis.2025.167758_bb0580","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1056\/NEJMoa041773","article-title":"Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy","volume":"353","author":"Watanabe","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0585","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/35025215","article-title":"Vascular-specific growth factors and blood vessel formation","volume":"407","author":"Yancopoulos","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167758_bb0590","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2004.03.005","article-title":"Insight into the physiological functions of PDGF through genetic studies in mice","volume":"15","author":"Betsholtz","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbadis.2025.167758_bb0595","first-page":"2509","article-title":"Vascular endothelial growth factor-C secretion is increased by advanced glycation end-products: possible implication in ocular neovascularization","volume":"18","author":"Puddu","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0600","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0014-5793(01)02110-X","article-title":"Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization","volume":"489","author":"Gao","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2025.167758_bb0605","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1096\/fj.02-0484fje","article-title":"VEGF-induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor","volume":"17","author":"Behzadian","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2025.167758_bb0610","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ncb1486","article-title":"VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin","volume":"8","author":"Gavard","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0615","first-page":"157","article-title":"VEGF-induced permeability increase is mediated by caveolae","volume":"40","author":"Feng","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0620","article-title":"Diabetic retinopathy","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.bbadis.2025.167758_bb0625","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/705783","article-title":"The role of microglia in diabetic retinopathy","volume":"2014","author":"Grigsby","year":"2014","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0630","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00592-017-0984-z","article-title":"Modulation of microglia in the retina: new insights into diabetic retinopathy","volume":"54","author":"Arroba","year":"2017","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0635","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1001\/archophthalmol.2007.65","article-title":"Microglial activation in human diabetic retinopathy","volume":"126","author":"Zeng","year":"2008","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0640","article-title":"Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis","volume":"2023","author":"Virgili","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.bbadis.2025.167758_bb0645","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070691","article-title":"Physical exercise inhibits inflammation and microglial activation","volume":"8","author":"Mee-Inta","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167758_bb0650","doi-asserted-by":"crossref","DOI":"10.3390\/nu14040792","article-title":"Understanding neurodegeneration from a clinical and therapeutic perspective in early diabetic retinopathy","volume":"14","author":"Fragiotta","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2025.167758_bb0655","article-title":"Percutaneous balloon mitral valvuloplasty (PBMV)","volume":"14","author":"Chen","year":"1986","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"10.1016\/j.bbadis.2025.167758_bb0660","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12031-018-1188-x","article-title":"Molecular mechanisms mediating diabetic retinal neurodegeneration: potential research avenues and therapeutic targets","volume":"66","author":"Chakravarthy","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0665","article-title":"Diabetic retinopathy: pathophysiology and treatments","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0670","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41419-023-05660-z","article-title":"RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy","volume":"14","author":"Huang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108498","article-title":"Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy","volume":"187","author":"Rolev","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0680","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023290118","article-title":"A specific RIP3(+) subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism","volume":"118","author":"He","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbadis.2025.167758_bb0685","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00441-022-03622-z","article-title":"Regulation of inflammation by VEGF\/BDNF signaling in mouse retinal M\u00fcller glial cells exposed to high glucose","volume":"388","author":"Zhu","year":"2022","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0690","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbrc.2014.01.052","article-title":"Effect of hyperglycemia on insulin receptor signaling in the cultured retinal M\u00fcller glial cells","volume":"444","author":"Ola","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2025.167758_bb0695","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050174","article-title":"IL-33 regulates M\u00fcller cell-mediated retinal inflammation and neurodegeneration in diabetic retinopathy","volume":"16","author":"Augustine","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.bbadis.2025.167758_bb0700","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yexcr.2014.08.040","article-title":"IL-1\u03b2 induces IL-6 production in retinal M\u00fcller cells predominantly through the activation of p38 MAPK\/NF-\u03baB signaling pathway","volume":"331","author":"Liu","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0705","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4103\/1673-5374.355743","article-title":"Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy","volume":"18","author":"Tang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0710","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194781","article-title":"The need for multi-omics biomarker signatures in precision medicine","volume":"20","author":"Olivier","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0715","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082712","article-title":"Genotypes and phenotypes: a search for influential genes in diabetic retinopathy","volume":"21","author":"Cabrera","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0720","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ajo.2021.06.014","article-title":"Gene set enrichment analsyes identify pathways involved in genetic risk for diabetic retinopathy","volume":"233","author":"Sobrin","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0725","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1167\/iovs.07-1633","article-title":"Heritability of the severity of diabetic retinopathy: the FIND-Eye study","volume":"49","author":"Arar","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0730","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1080\/07853890.2023.2191218","article-title":"The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story","volume":"55","author":"Zhu","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0735","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/861291","article-title":"Identification of diabetic retinopathy genes through a genome-wide association study among Mexican-Americans from Starr County, Texas","volume":"2010","author":"Fu","year":"2010","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0740","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ophtha.2010.07.020","article-title":"Genome-wide association study of diabetic retinopathy in a Taiwanese population","volume":"118","author":"Huang","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0745","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/hmg\/ddt161","article-title":"Genome-wide association study in a Chinese population with diabetic retinopathy","volume":"22","author":"Sheu","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111715","article-title":"A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA","volume":"9","author":"Awata","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb0755","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s00125-015-3697-2","article-title":"Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene","volume":"58","author":"Burdon","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2025.167758_bb0760","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1167\/iovs.16-20094","article-title":"Impact of genetic loci identified in genome-wide association studies on diabetic retinopathy in Chinese patients with type 2 diabetes","volume":"57","author":"Cheung","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0765","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00439-015-1624-8","article-title":"Exome-based case-control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy","volume":"135","author":"Shtir","year":"2016","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0770","doi-asserted-by":"crossref","first-page":"e811","DOI":"10.1111\/aos.13769","article-title":"A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes","volume":"96","author":"Meng","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0775","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12881-018-0587-8","article-title":"Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy","volume":"19","author":"Graham","year":"2018","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0780","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41525-019-0094-7","article-title":"Genome-wide association study for proliferative diabetic retinopathy in Africans","volume":"4","author":"Liu","year":"2019","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0785","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2337\/db18-0567","article-title":"Multiethnic genome-wide association study of diabetic retinopathy using liability threshold modeling of duration of diabetes and glycemic control","volume":"68","author":"Pollack","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0790","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/13816810.2019.1633549","article-title":"A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity","volume":"40","author":"Meng","year":"2019","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0795","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000727","article-title":"Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy","volume":"8","author":"Hsieh","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.bbadis.2025.167758_bb0800","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/hmg\/ddab044","article-title":"Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes","volume":"30","author":"Imamura","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0805","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104161","article-title":"Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank","volume":"82","author":"Xue","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbadis.2025.167758_bb0810","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.cellsig.2008.08.010","article-title":"Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells","volume":"20","author":"Baus","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2025.167758_bb0815","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1210\/en.2009-0332","article-title":"Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis","volume":"150","author":"Suzuki","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2025.167758_bb0820","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1042\/BJ20051664","article-title":"Characterization of COMMD protein-protein interactions in NF-kappaB signalling","volume":"398","author":"de Bie","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2025.167758_bb0825","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2005.10.021","article-title":"TTP specifically regulates the internalization of the transferrin receptor","volume":"123","author":"Tosoni","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167758_bb0830","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1093\/hmg\/dds298","article-title":"Non-syndromic retinal ciliopathies: translating gene discovery into therapy","volume":"21","author":"Estrada-Cuzcano","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbadis.2025.167758_bb0835","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/db09-0653","article-title":"A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose","volume":"59","author":"Paterson","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0840","doi-asserted-by":"crossref","DOI":"10.3390\/genes14030653","article-title":"Genome-wide associations and confirmatory meta-analyses in diabetic retinopathy","volume":"14","author":"Yu","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0845","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0002-9394(14)70861-X","article-title":"Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal membranes","volume":"124","author":"Schneeberger","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0850","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/1566524017666171106114234","article-title":"bmp3 is required for integrity of blood brain barrier by promoting pericyte coverage in zebrafish embryos","volume":"17","author":"Lei","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0855","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1167\/iovs.17-22706","article-title":"Crosstalk between histone and DNA methylation in regulation of retinal matrix metalloproteinase-9 in diabetes","volume":"58","author":"Duraisamy","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0860","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.2337\/db12-1093","article-title":"TCF7L2 variation and proliferative diabetic retinopathy","volume":"62","author":"Luo","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0865","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2337\/dc17-1386","article-title":"TCF7L2 genetic variation augments incretin resistance and influences response to a sulfonylurea and metformin: the study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH)","volume":"41","author":"Srinivasan","year":"2018","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2025.167758_bb0870","first-page":"1123","article-title":"Transcriptome analysis using next generation sequencing reveals molecular signatures of diabetic retinopathy and efficacy of candidate drugs","volume":"18","author":"Kandpal","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0875","article-title":"CD8+T cell-related gene biomarkers in macular edema of diabetic retinopathy","volume":"13","author":"Huang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109194","article-title":"Integrative study of gene expression datasets in retinal samples of diabetic retinopathy","volume":"223","author":"Rajendran","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0885","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277952","article-title":"The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy","volume":"17","author":"Gao","year":"2022","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb0890","article-title":"Gene biomarkers related to Th17 cells in macular edema of diabetic retinopathy: cutting-edge comprehensive bioinformatics analysis and in vivo validation","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0895","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2337\/db22-0619","article-title":"Transcriptomic profiling reveals chemokine CXCL1 as a mediator for neutrophil recruitment associated with blood-retinal barrier alteration in diabetic retinopathy","volume":"72","author":"Monickaraj","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0900","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108043","article-title":"Transcriptomics analysis of pericytes from retinas of diabetic animals reveals novel genes and molecular pathways relevant to blood-retinal barrier alterations in diabetic retinopathy","volume":"195","author":"Rangasamy","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0905","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105961","article-title":"Differences in junction-associated gene expression changes in three rat models of diabetic retinopathy with similar neurovascular phenotype","volume":"176","author":"Kolibabka","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2025.167758_bb0910","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.exer.2016.04.014","article-title":"Diabetic retinopathy and transcriptional regulation of a small molecular weight G-Protein, Rac1","volume":"147","author":"Kowluru","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0915","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1177488","article-title":"Comprehensive analysis of ferritinophagy-related genes and immune infiltration landscape in diabetic retinopathy","volume":"14","author":"Yu","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0920","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.18632\/aging.202678","article-title":"Follistatin-like protein 1 functions as a potential target of gene therapy in proliferative diabetic retinopathy","volume":"13","author":"Niu","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbadis.2025.167758_bb0925","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175215","article-title":"Integrating network pharmacology, transcriptomics, and molecular simulation to reveal the mechanism of tert-butylhydroquinone for treating diabetic retinopathy","volume":"931","author":"Liu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0930","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-40328-w","article-title":"Transcriptomic clock predicts vascular changes of prodromal diabetic retinopathy","volume":"13","author":"Toh","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167758_bb0935","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1167\/iovs.18-25515","article-title":"Bioinformatics analysis of weighted genes in diabetic retinopathy","volume":"59","author":"You","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb0940","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2337\/db20-0839","article-title":"Pathogenesis study based on high-throughput single-cell sequencing analysis reveals novel transcriptional landscape and heterogeneity of retinal cells in type 2 diabetic mice","volume":"70","author":"Niu","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0945","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2337\/db21-0551","article-title":"Single-cell transcriptomics reveals novel role of microglia in fibrovascular membrane of proliferative diabetic retinopathy","volume":"71","author":"Hu","year":"2022","journal-title":"Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb0950","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00125-020-05218-0","article-title":"Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy","volume":"63","author":"Van Hove","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2025.167758_bb0955","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13098-024-01282-3","article-title":"Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy","volume":"16","author":"Wang","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bbadis.2025.167758_bb0960","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167758_bb0965","doi-asserted-by":"crossref","first-page":"E932","DOI":"10.1152\/ajpendo.00051.2020","article-title":"Overexpression of histone deacetylase SIRT1 exerts an antiangiogenic role in diabetic retinopathy via miR-20a elevation and YAP\/HIF1\u03b1\/VEGFA depletion","volume":"319","author":"Pan","year":"2020","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2025.167758_bb0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104488","article-title":"MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF\/PI3K\/AKT signalling pathway in an in vitro model of diabetic retinopathy","volume":"116","author":"Wang","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbadis.2025.167758_bb0975","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.2147\/JIR.S303540","article-title":"Protective role of microRNA-200a in diabetic retinopathy through downregulation of PDLIM1","volume":"14","author":"Wan","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0980","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/iub.1502","article-title":"Role of MicroRNA 126 in screening, diagnosis, and prognosis of diabetic patients in Egypt","volume":"68","author":"Rezk","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbadis.2025.167758_bb0985","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10238-019-00573-8","article-title":"MicroRNA-423 may regulate diabetic vasculopathy","volume":"19","author":"Blum","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb0990","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112737","article-title":"Roles of miR-204 in retinal development and maintenance","volume":"406","author":"Bereimipour","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb0995","doi-asserted-by":"crossref","DOI":"10.1177\/1849454418807827","article-title":"Adipose mesenchymal stem cells-derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits","volume":"7","author":"Safwat","year":"2018","journal-title":"J Circ Biomark"},{"key":"10.1016\/j.bbadis.2025.167758_bb1000","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160589","article-title":"Plasma miR-21 expression: an indicator for the severity of Type 2 diabetes with diabetic retinopathy","volume":"37","author":"Jiang","year":"2017","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbadis.2025.167758_bb1005","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/ars.2016.6844","article-title":"Exosomal microRNA-15a transfer from the pancreas augments diabetic complications by inducing oxidative stress","volume":"27","author":"Kamalden","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2025.167758_bb1010","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40001-020-00416-3","article-title":"Dysregulation of miR-210 is involved in the development of diabetic retinopathy and serves a regulatory role in retinal vascular endothelial cell proliferation","volume":"25","author":"Yin","year":"2020","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1015","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jcp.26871","article-title":"MicroRNA-384-3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy","volume":"234","author":"Xia","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1020","doi-asserted-by":"crossref","first-page":"580","DOI":"10.4103\/1673-5374.205095","article-title":"Regulatory role of microRNA on inflammatory responses of diabetic retinopathy","volume":"12","author":"Ye","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1025","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/8520489","article-title":"Advances in research related to microRNA for diabetic retinopathy","volume":"2024","author":"Luo","year":"2024","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128182","article-title":"Non-coding RNAs and exosomal non-coding RNAs in diabetic retinopathy: a narrative review","volume":"259","author":"Zhong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12929-019-0523-z","article-title":"The emerging roles and functions of circular RNAs and their generation","volume":"26","author":"Yu","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1040","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.18632\/aging.204215","article-title":"Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction","volume":"14","author":"Ma","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ebiom.2019.10.004","article-title":"Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI","volume":"49","author":"Zhu","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbadis.2025.167758_bb1050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13098-022-00787-z","article-title":"Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243\/CARM1 axis","volume":"14","author":"Wang","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bbadis.2025.167758_bb1055","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121774","article-title":"Noncoding RNAs are promising therapeutic targets for diabetic retinopathy: an updated review (2017-2022)","volume":"12","author":"Wang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2025.167758_bb1060","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109152","article-title":"CircFAT1 regulates retinal pigment epithelial cell pyroptosis and autophagy via mediating m6A reader protein YTHDF2 expression in diabetic retinopathy","volume":"222","author":"Huang","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1065","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s10792-023-02636-y","article-title":"Circ_0006667 contributes to high glucose-induced retinal pigment epithelial cell dysfunction by mediating miR-7-5p\/TGFA axis in diabetic retinopathy","volume":"43","author":"Chen","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1070","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.109023","article-title":"Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b\/TIMP3 axis in diabetic retinopathy","volume":"238","author":"Liu","year":"2022","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1075","article-title":"Diabetic retinopathy: are lncRNAs new molecular players and targets?","volume":"11","author":"Cataldi","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1080","article-title":"Shared and specific biological signalling pathways for diabetic retinopathy, peripheral neuropathy and nephropathy by high-throughput sequencing analysis","volume":"19","author":"Hui","year":"2022","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1085","doi-asserted-by":"crossref","first-page":"346","DOI":"10.15252\/emmm.201505725","article-title":"Long non-coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling","volume":"8","author":"Yao","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb1090","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.466","article-title":"Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167758_bb1095","doi-asserted-by":"crossref","first-page":"213","DOI":"10.18240\/ijo.2020.02.03","article-title":"Targeting long non-coding RNA MALAT1 alleviates retinal neurodegeneration in diabetic mice","volume":"13","author":"Zhang","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1100","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1161\/CIRCRESAHA.114.303265","article-title":"Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth","volume":"114","author":"Michalik","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1105","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108585","article-title":"Knockdown of Malat1 alleviates high-glucose-induced angiogenesis through regulating miR-205-5p\/VEGF-A axis","volume":"207","author":"Tan","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1110","first-page":"7732","article-title":"LncRNA ANRIL knockdown ameliorates retinopathy in diabetic rats by inhibiting the NF-\u03baB pathway","volume":"23","author":"Wei","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1115","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11817","article-title":"LncRNA NEAT1 regulated diabetic retinal epithelial-mesenchymal transition through regulating miR-204\/SOX4 axis","volume":"9","author":"Yang","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.bbadis.2025.167758_bb1120","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/dna.2017.3682","article-title":"Long noncoding RNA MEG3 negatively regulates proliferation and angiogenesis in vascular endothelial cells","volume":"36","author":"He","year":"2017","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1125","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1167\/iovs.16-20569","article-title":"ANRIL: a regulator of VEGF in diabetic retinopathy","volume":"58","author":"Thomas","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1130","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev-anchem-071213-020216","article-title":"High-throughput proteomics","volume":"7","author":"Zhang","year":"2014","journal-title":"Annu Rev Anal Chem (Palo Alto, Calif)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1135","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213362","article-title":"Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167758_bb1140","first-page":"616","article-title":"Proteomic analysis of human serum from diabetic retinopathy","volume":"4","author":"Liu","year":"2011","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1145","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1021\/pr3012073","article-title":"Verification of multimarkers for detection of early stage diabetic retinopathy using multiple reaction monitoring","volume":"12","author":"Kim","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1021\/pr901013d","article-title":"Verification of biomarkers for diabetic retinopathy by multiple reaction monitoring","volume":"9","author":"Kim","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000449261","article-title":"Level of vascular endothelial growth factor in the vitreous fluid of proliferative diabetic retinopathy patients and prognosis after vitrectomy","volume":"236","author":"Suzuki","year":"2016","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.bbadis.2025.167758_bb1160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2020.107641","article-title":"Increased levels of cytokines in the aqueous humor correlate with the severity of diabetic retinopathy","volume":"34","author":"Song","year":"2020","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.bbadis.2025.167758_bb1165","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00592-019-01317-6","article-title":"Comprehensive analysis of vitreous humor chemokines in type 2 diabetic patients with and without diabetic retinopathy","volume":"56","author":"Zeng","year":"2019","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1170","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1001391","article-title":"Proteomic profiling and correlations with clinical features reveal biomarkers indicative of diabetic retinopathy with diabetic kidney disease","volume":"13","author":"Fan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1175","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6571976","article-title":"Development of diagnostic biomarkers for detecting diabetic retinopathy at early stages using quantitative proteomics","volume":"2016","author":"Jin","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clinbiochem.2011.10.006","article-title":"Comparison of tear proteins between healthy and early diabetic retinopathy patients","volume":"45","author":"Kim","year":"2012","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.bbadis.2025.167758_bb1185","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1021\/acs.jproteome.5b00900","article-title":"Quantitative proteomics analysis of vitreous humor from diabetic retinopathy patients","volume":"14","author":"Loukovaara","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1190","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/dmrr.2419","article-title":"Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis","volume":"29","author":"Hern\u00e1ndez","year":"2013","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.bbadis.2025.167758_bb1195","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.4103\/IJO.IJO_276_23","article-title":"Comparative proteomics of proliferative diabetic retinopathy in people with Type 2 diabetes highlights the role of inflammation, visual transduction, and extracellular matrix pathways","volume":"71","author":"Sen","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1570-0232(02)00078-8","article-title":"Catalogue of soluble proteins in the human vitreous humor: comparison between diabetic retinopathy and macular hole","volume":"776","author":"Nakanishi","year":"2002","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1205","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1515\/cclm-2023-1128","article-title":"Proteomic analysis of diabetic retinopathy identifies potential plasma-protein biomarkers for diagnosis and prognosis","volume":"62","author":"Honor\u00e9","year":"2024","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.bbadis.2025.167758_bb1210","doi-asserted-by":"crossref","DOI":"10.1002\/prca.202100016","article-title":"Integrating SWATH-MS proteomics and transcriptome analysis to preliminarily identify three DEGs as biomarkers for proliferative diabetic retinopathy","volume":"16","author":"Wu","year":"2022","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.bbadis.2025.167758_bb1215","article-title":"Putative biomarkers in tears for diabetic retinopathy diagnosis","volume":"9","author":"Amorim","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1220","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12886-018-0821-3","article-title":"Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy","volume":"18","author":"Li","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1225","first-page":"2931","article-title":"Changes to tear cytokines of type 2 diabetic patients with or without retinopathy","volume":"16","author":"Liu","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167758_bb1230","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jprot.2012.01.019","article-title":"Quantitative analysis of proteins in the tear fluid of patients with diabetic retinopathy","volume":"75","author":"Cs\u0151sz","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bbadis.2025.167758_bb1235","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109724","article-title":"Proteomic analysis of aqueous humor reveals novel regulators of diabetic macular edema","volume":"239","author":"Zhang","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1240","doi-asserted-by":"crossref","DOI":"10.3390\/proteomes8030025","article-title":"Serum glycoproteomic alterations in patients with diabetic retinopathy","volume":"8","author":"Sharma","year":"2020","journal-title":"Proteomes"},{"key":"10.1016\/j.bbadis.2025.167758_bb1245","doi-asserted-by":"crossref","first-page":"973","DOI":"10.18632\/aging.202217","article-title":"Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy","volume":"13","author":"Niu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1250","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jdiacomp.2015.05.021","article-title":"Proteomic analysis of plasma proteins in diabetic retinopathy patients by two dimensional electrophoresis and MALDI-Tof-MS","volume":"29","author":"Gopalakrishnan","year":"2015","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.bbadis.2025.167758_bb1255","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2022","article-title":"Association of potential salivary biomarkers with diabetic retinopathy and its severity in type-2 diabetes mellitus: a proteomic analysis by mass spectrometry","volume":"4","author":"Chee","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.bbadis.2025.167758_bb1260","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1021\/pr800112g","article-title":"Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy","volume":"7","author":"Gao","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1265","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/02713680600557030","article-title":"Differential expression of vitreous proteins in proliferative diabetic retinopathy","volume":"31","author":"Kim","year":"2006","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1270","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1477-5956-10-15","article-title":"Characterisation of the vitreous proteome in proliferative diabetic retinopathy","volume":"10","author":"Wang","year":"2012","journal-title":"Proteome Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1275","doi-asserted-by":"crossref","first-page":"Amd31","DOI":"10.1167\/iovs.18-24122","article-title":"The proteomic landscape in the vitreous of patients with age-related and diabetic retinal disease","volume":"59","author":"Schori","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239251","article-title":"Small-molecule modulation of PPARs for the treatment of prevalent vascular retinal diseases","volume":"21","author":"Dou","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1285","article-title":"Oxidative stress and inflammatory markers in prediabetes and diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1290","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1161\/ATVBAHA.120.315156","article-title":"Free thiol \u03b22-GPI (\u03b2-2-glycoprotein-I) provides a link between inflammation and oxidative stress in atherosclerotic coronary artery disease","volume":"40","author":"Weaver","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1295","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1046\/j.1365-2249.1996.d01-774.x","article-title":"Measurement of anticardiolipin antibodies by ELISA using beta 2-glycoprotein I (beta 2-GPI) in systemic sclerosis","volume":"105","author":"Ihn","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1300","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1074\/jbc.R113.544635","article-title":"Role of metabolic H2O2 generation: redox signaling and oxidative stress","volume":"289","author":"Sies","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167758_bb1305","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/prca.200700105","article-title":"Proteomics in ocular fluids","volume":"1","author":"Grus","year":"2007","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.bbadis.2025.167758_bb1310","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13091009","article-title":"The battle for survival: the role of RNA non-canonical tails in the virus-host interaction","volume":"13","author":"Wen","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbadis.2025.167758_bb1315","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12090814","article-title":"Metabolomics and biomarkers in retinal and choroidal vascular diseases","volume":"12","author":"Hou","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bbadis.2025.167758_bb1320","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1167\/iovs.19-27321","article-title":"Arginine and carnitine metabolites are altered in diabetic retinopathy","volume":"60","author":"Sumarriva","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1325","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.757088","article-title":"Plasma metabolomics reveals metabolic profiling for diabetic retinopathy and disease progression","volume":"12","author":"Sun","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1330","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122751","article-title":"Integrated analysis of metabolomics and lipidomics in plasma of T2DM patients with diabetic retinopathy","volume":"14","author":"Ding","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbadis.2025.167758_bb1335","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1167\/iovs.63.2.17","article-title":"Plasma and vitreous metabolomics profiling of proliferative diabetic retinopathy","volume":"63","author":"Wang","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241365","article-title":"Metabolomics profiles associated with diabetic retinopathy in type 2 diabetes patients","volume":"15","author":"Yun","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.bbadis.2025.167758_bb1345","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12986-019-0358-3","article-title":"Plasma metabolomic profiling of proliferative diabetic retinopathy","volume":"16","author":"Zhu","year":"2019","journal-title":"Nutr. Metab. (Lond.)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1350","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41387-022-00216-0","article-title":"Interpretable machine learning-derived nomogram model for early detection of diabetic retinopathy in type 2 diabetes mellitus: a widely targeted metabolomics study","volume":"12","author":"Li","year":"2022","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.bbadis.2025.167758_bb1355","article-title":"Novel insights into the mechanisms of hard exudate in diabetic retinopathy: findings of serum lipidomic and metabolomics profiling","volume":"9","author":"Shen","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.bbadis.2025.167758_bb1360","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11095-019-2569-8","article-title":"Review of biomarkers in ocular matrices: challenges and opportunities","volume":"36","author":"Tamhane","year":"2019","journal-title":"Pharm. Res."},{"key":"10.1016\/j.bbadis.2025.167758_bb1365","article-title":"Multiplatform metabolomics reveals novel serum metabolite biomarkers in diabetic retinopathy subjects","volume":"7","author":"Xuan","year":"2020","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.bbadis.2025.167758_bb1370","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00125-020-05309-y","article-title":"Vitreous metabolomics profiling of proliferative diabetic retinopathy","volume":"64","author":"Tomita","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2025.167758_bb1375","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612671","article-title":"Simultaneous comparison of aqueous humor and serum metabolic profiles of diabetic and nondiabetic patients undergoing cataract surgery-a targeted and quantitative metabolomics study","volume":"24","author":"Grochowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1380","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00592-019-01363-0","article-title":"Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor","volume":"57","author":"Wang","year":"2020","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbadis.2025.167758_bb1385","doi-asserted-by":"crossref","DOI":"10.1038\/srep41984","article-title":"Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors","volume":"7","author":"Kunikata","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167758_bb1390","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1210\/jc.2016-4015","article-title":"Association between serum lipoprotein(a) and diabetic retinopathy in Han Chinese patients with type 2 diabetes","volume":"102","author":"Tu","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2025.167758_bb1395","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/dc10-0793","article-title":"Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids","volume":"34","author":"Sasongko","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2025.167758_bb1400","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/tobaccocontrol-2021-056896","article-title":"Systemic biomarkers of exposure associated with ENDS use: a scoping review","volume":"32","author":"Hiler","year":"2023","journal-title":"Tob. Control"},{"key":"10.1016\/j.bbadis.2025.167758_bb1405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512053","article-title":"Untargeted multiomics approach coupling lipidomics and metabolomics profiling reveals new insights in diabetic retinopathy","volume":"24","author":"Ancel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167758_bb1410","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.2337\/db10-0110","article-title":"Profile of lipid and protein autacoids in diabetic vitreous correlates with the progression of diabetic retinopathy","volume":"59","author":"Schwartzman","year":"2010","journal-title":"Diabetes"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:31:21Z","timestamp":1762324281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":282,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001036"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167758","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Update in the molecular mechanism and biomarkers of diabetic retinopathy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167758"}}