{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T03:59:07Z","timestamp":1754107147488,"version":"3.41.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2019JJ40449","2019JJ50863"],"award-info":[{"award-number":["2019JJ40449","2019JJ50863"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500171","81470323"],"award-info":[{"award-number":["81500171","81470323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167765","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:43:19Z","timestamp":1740987799000},"page":"167765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Germline mutation in Cbl proto-oncogene B is associated with inherited thrombocytopenia and predisposes megakaryocytes to ferroptosis"],"prefix":"10.1016","volume":"1871","author":[{"given":"Xiang","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongli","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangsen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167765_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/09537104.2016.1171835","article-title":"Inherited thrombocytopenias-recent advances in clinical and molecular aspects","volume":"28","author":"Balduini","year":"2017","journal-title":"Platelets"},{"key":"10.1016\/j.bbadis.2025.167765_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100784","article-title":"Inherited thrombocytopenias: an updated guide for clinicians","volume":"48","author":"Pecci","year":"2021","journal-title":"Blood Rev."},{"key":"10.1016\/j.bbadis.2025.167765_bb0015","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcvm.2019.00080","article-title":"Inherited thrombocytopenia: update on genes and genetic variants which may be associated with bleeding","volume":"6","author":"Almazni","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"issue":"22","key":"10.1016\/j.bbadis.2025.167765_bb0020","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1182\/blood.2020009300","article-title":"Genetics of inherited thrombocytopenias","volume":"139","author":"Warren","year":"2022","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.bbadis.2025.167765_bb0025","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3324\/haematol.2022.280993","article-title":"Exome sequencing in 116 patients with inherited thrombocytopenia that remained of unknown origin after systematic phenotype-driven diagnostic workup","volume":"108","author":"Marconi","year":"2023","journal-title":"Haematologica"},{"issue":"42","key":"10.1016\/j.bbadis.2025.167765_bb0030","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1038\/sj.onc.1207952","article-title":"CBLB interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and CBLB","volume":"23","author":"Davies","year":"2004","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.bbadis.2025.167765_bb0035","first-page":"2367","article-title":"Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene","volume":"10","author":"Keane","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2025.167765_bb0040","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4049\/jimmunol.1202068","article-title":"T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells","volume":"191","author":"Qiao","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2025.167765_bb0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.immuni.2004.07.013","article-title":"Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction","volume":"21","author":"Jeon","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2025.167765_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2018.11.002","article-title":"Regulation of immune responses by E3 ubiquitin ligase CBLB","volume":"340","author":"Tang","year":"2019","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbadis.2025.167765_bb0055","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.4161\/cc.29213","article-title":"E3 ubiquitin ligase cbl-b in innate and adaptive immunity","volume":"13","author":"Liu","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbadis.2025.167765_bb0060","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni0901-870","article-title":"Proteolysis-independent regulation of PI3K by cbl-b-mediated ubiquitination in T cells","volume":"2","author":"Fang","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbadis.2025.167765_bb0065","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/ni855","article-title":"c-cbl and cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation","volume":"3","author":"Naramura","year":"2002","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.bbadis.2025.167765_bb0070","first-page":"4473","article-title":"Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B","volume":"179","author":"Qiao","year":"2007"},{"key":"10.1016\/j.bbadis.2025.167765_bb0075","doi-asserted-by":"crossref","first-page":"36754","DOI":"10.1074\/jbc.M300664200","article-title":"The roles of CBLB and c-Cbl in insulin-stimulated glucose transport","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167765_bb0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-1119(03)00471-2","article-title":"Comparative genomic organization of the cbl genes","volume":"308","author":"Nau","year":"2003","journal-title":"Gene"},{"issue":"6766","key":"10.1016\/j.bbadis.2025.167765_bb0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/35003235","article-title":"CBLB regulates the CD28 dependence of T-cell activation","volume":"403","author":"Chiang","year":"2000","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.bbadis.2025.167765_bb0090","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.3390\/ijms20235821","article-title":"Beyond the cell surface: targeting intracellular negative regulators to enhance T cell anti-tumor activity","volume":"20","author":"Sitaram","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bbadis.2025.167765_bb0095","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.4049\/jimmunol.0901243","article-title":"The E3 ubiquitin ligase CBLB regulates expansion but not functional activity of self-reactive CD4 T cells","volume":"183","author":"St Rose","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbadis.2025.167765_bb0100","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fonc.2015.00058","article-title":"Modulation of immune cell functions by the E3 ligase CBLB","volume":"5","author":"Lutz-Nicoladoni","year":"2015","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.bbadis.2025.167765_bb0105","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1172\/JCI41991","article-title":"Abrogating CBLB in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice","volume":"120","author":"Stromnes","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.bbadis.2025.167765_bb0110","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrc3120","article-title":"RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis","volume":"11","author":"Lipkowitz","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.bbadis.2025.167765_bb0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.584","article-title":"Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis","volume":"42","author":"Sanna","year":"2010","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.bbadis.2025.167765_bb0120","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1177\/0961203310394896","article-title":"Expression and function of CBLB in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A\/G Cblb gene polymorphism in the Mexican mestizo population","volume":"20","author":"Don\u00edz-Padilla","year":"2011","journal-title":"Lupus"},{"issue":"12","key":"10.1016\/j.bbadis.2025.167765_bb0125","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1182\/blood-2013-10-533844","article-title":"Tracing the development of acute myeloid leukemia in CBL syndrome","volume":"123","author":"Becker","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167765_bb0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2018-11-887141","article-title":"Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes","volume":"134","author":"Hadjadj","year":"2019","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.bbadis.2025.167765_bb0135","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1038\/leu.2013.203","article-title":"In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia","volume":"27","author":"Strullu","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.bbadis.2025.167765_bb0140","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/0008-5472.CAN-09-1710","article-title":"The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells","volume":"70","author":"Truitt","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167765_bb0145","doi-asserted-by":"crossref","first-page":"29209","DOI":"10.18632\/oncotarget.4976","article-title":"H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and CBLB","volume":"6","author":"Vennin","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbadis.2025.167765_bb0150","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1002\/cncr.26153","article-title":"An E3 ubiquitin ligase: c-Cbl: a new therapeutic target of lung cancer","volume":"117","author":"Lo","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.bbadis.2025.167765_bb0155","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1038\/sj.bjc.6604774","article-title":"TEAD1 and c-Cbl are novel prostate basal cell markers that correlate with poor clinical outcome in prostate cancer","volume":"99","author":"Knight","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbadis.2025.167765_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077819","article-title":"Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2","volume":"8","author":"Klampfl","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbadis.2025.167765_bb0165","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.4161\/cc.9.6.11034","article-title":"Gain-of- function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms","volume":"9","author":"Ogawa","year":"2010","journal-title":"Cell Cycle"},{"issue":"8016","key":"10.1016\/j.bbadis.2025.167765_bb0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbadis.2025.167765_bb0175","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.molcel.2007.06.023","article-title":"Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase CBLB","volume":"27","author":"Peschard","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.167765_bb0180","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35003228","article-title":"Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor cbl-b","volume":"403","author":"Bachmaier","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbadis.2025.167765_bb0185","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167765_bb0190","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2025.167765_bb0195","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbadis.2025.167765_bb0200","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","article-title":"FTH1 inhibits ferroptosis through ferritinophagy in the 6-OHDA model of Parkinson\u2019s disease","volume":"17","author":"Tian","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167765_bb0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbadis.2025.167765_bb0210","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.bbadis.2025.167765_bb0215","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: the new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.bbadis.2025.167765_bb0220","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3324\/haematol.2014.105924","article-title":"Analysis of 339 pregnancies in 181 women with 13 different forms of inherited thrombocytopenia","volume":"99","author":"Noris","year":"2014","journal-title":"Haematologica"},{"issue":"24","key":"10.1016\/j.bbadis.2025.167765_bb0225","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1182\/blood-2011-02-336537","article-title":"Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families","volume":"117","author":"Noris","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bbadis.2025.167765_bb0230","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jtha.2023.12.032","article-title":"E3 ubiquitin ligase casitas B-lineage lymphoma-b modulates T-cell anergic resistance via phosphoinositide 3-kinase signaling in patients with immune thrombocytopenia","volume":"22","author":"Liu","year":"2024","journal-title":"J. Thromb. Haemost."},{"issue":"10","key":"10.1016\/j.bbadis.2025.167765_bb0235","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2169\/internalmedicine.44.1025","article-title":"Thrombocytosis in iron deficiency anemia","volume":"44","author":"Dank.","year":"2005","journal-title":"Intern. Med."},{"issue":"18","key":"10.1016\/j.bbadis.2025.167765_bb0240","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1182\/blood.2019002039","article-title":"Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid pregenitors in human and mice","volume":"134","author":"Xavier-Ferrucio","year":"2019","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bbadis.2025.167765_bb0245","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/ajh.26189","article-title":"Iron and platelets: a subtle, under- recognized relationship","volume":"96","author":"Brissot","year":"2021","journal-title":"Am. J. Hematol."},{"issue":"5","key":"10.1016\/j.bbadis.2025.167765_bb0250","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ajh.23682","article-title":"Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin","volume":"89","author":"Evstatiev","year":"2014","journal-title":"Am. J. Hematol."},{"issue":"6","key":"10.1016\/j.bbadis.2025.167765_bb0255","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/jth.12884","article-title":"Increased expression of HIF2alpha during iron deficiency-associated megakaryocytic differentiation","volume":"13","author":"Jimenez","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.bbadis.2025.167765_bb0260","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1111\/jcmm.17289","article-title":"Inhibition of ferroptosis promotes megakaryocyte differentiation and platelet production","volume":"26","author":"Song","year":"2022","journal-title":"J. Cell. Mol. Med."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:32:39Z","timestamp":1749558759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001103"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167765","relation":{},"ISSN":["0925-4439"],"issn-type":[{"type":"print","value":"0925-4439"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Germline mutation in Cbl proto-oncogene B is associated with inherited thrombocytopenia and predisposes megakaryocytes to ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167765"}}