{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:29:59Z","timestamp":1790612999206,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167766","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T02:43:36Z","timestamp":1740969816000},"page":"167766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardioprotective potential of transcription factor PRRX1 silencing against myocardial ischemia\/reperfusion injury by regulating excessive mitophagy and ferroptosis through FKBP5-p38 MAPK axis"],"prefix":"10.1016","volume":"1871","author":[{"given":"Yongpeng","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","article-title":"Myocardial ischemia\/reperfusion: translational pathophysiology of ischemic heart disease","volume":"5","author":"Heusch","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.bbadis.2025.167766_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104565","article-title":"Myocardial ischemia-reperfusion injury; molecular mechanisms and prevention","volume":"149","author":"Liu","year":"2023","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.bbadis.2025.167766_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122368","article-title":"Biomaterials-mediated targeted therapeutics of myocardial ischemia-reperfusion injury","volume":"303","author":"Luo","year":"2023","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.bbadis.2025.167766_bb0020","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1080\/17425247.2024.2409906","article-title":"Hydrogel formulations for orthotopic treatment of myocardial infarction","volume":"21","author":"Luo","year":"2024","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.bbadis.2025.167766_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116337","article-title":"The Janus face of mitophagy in myocardial ischemia\/reperfusion injury and recovery","volume":"173","author":"Deng","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.167766_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116457","article-title":"Emerging regulatory mechanisms in cardiovascular disease: ferroptosis","volume":"174","author":"Jin","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.167766_bb0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-3-031-44087-8_16","article-title":"Cardiac transcription factors and regulatory networks","volume":"1441","author":"Grunert","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1\u20132","key":"10.1016\/j.bbadis.2025.167766_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10495-022-01786-1","article-title":"Regulation of autophagy of the heart in ischemia and reperfusion","volume":"28","author":"Popov","year":"2023","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.bbadis.2025.167766_bb0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/antiox13030298","article-title":"Antioxidant systems as modulators of ferroptosis: focus on transcription factors","volume":"13","author":"Punziano","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2025.167766_bb0050","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.2147\/OTT.S316102","article-title":"The regulatory role of PRRX1 in cancer epithelial-mesenchymal transition","volume":"14","author":"Du","year":"2021","journal-title":"Onco. Targets Ther."},{"issue":"2","key":"10.1016\/j.bbadis.2025.167766_bb0055","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1111\/ejn.15669","article-title":"Extracellular vesicles from bone marrow stromal cells reduce the impact of stroke on glial cell activation and blood brain-barrier permeability via a putative miR-124\/PRX1 signalling pathway","volume":"56","author":"Tian","year":"2022","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0060","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cbin.11944","article-title":"The paired-related homeobox protein 1 promotes cardiac fibrosis via the Twist1-Prrx1-tenascin-C loop","volume":"47","author":"Wang","year":"2023","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/npp.2015.235","article-title":"Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications","volume":"41","author":"Zannas","year":"2016","journal-title":"Neuropsycho-pharmacology"},{"key":"10.1016\/j.bbadis.2025.167766_bb0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fncel.2020.00193","article-title":"FKBP5 exacerbates impairments in cerebral ischemic stroke by inducing autophagy via the AKT\/FOXO3 pathway","volume":"14","author":"Yu","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167766_bb0075","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s12864-016-2713-3","article-title":"Molecular profile of dissociative drug ketamine in relation to its rapid antidepressant action","volume":"17","author":"Ficek","year":"2016","journal-title":"BMC Genomics"},{"issue":"19","key":"10.1016\/j.bbadis.2025.167766_bb0080","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.3390\/ijms21197412","article-title":"p38 MAPK pathway in the heart: new insights in health and disease","volume":"21","author":"Romero-Becerra","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167766_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117730","article-title":"Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-mediated autophagy via MAPK signaling pathway","volume":"253","author":"Liu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2025.167766_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116794","article-title":"Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway","volume":"482","author":"Chen","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbadis.2025.167766_bb0095","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The human transcription factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167766_bb0100","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.crtox.2021.08.001","article-title":"Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database","volume":"2","author":"Grondin","year":"2021","journal-title":"Curr. Res. Toxicol."},{"issue":"D1","key":"10.1016\/j.bbadis.2025.167766_bb0105","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.bbadis.2025.167766_bb0110","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.bbadis.2025.167766_bb0115","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1536\/ihj.21-511","article-title":"LncRNA SNHG15 modulates ischemia-reperfusion injury in human AC16 cardiomyocytes depending on the regulation of the miR-335-3p\/TLR4\/NF-kappaB pathway","volume":"63","author":"Du","year":"2022","journal-title":"Int. Heart J."},{"issue":"10","key":"10.1016\/j.bbadis.2025.167766_bb0120","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1097\/MS9.0000000000001139","article-title":"Ischemia-reperfusion injury in human AC16 cardiomyocytes is modulated by AXIN1 depending on c-Myc regulation","volume":"85","author":"Li","year":"2023","journal-title":"Ann. Med. Surg. (Lond.)"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103247","article-title":"Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury","volume":"103","author":"Yang","year":"2024","journal-title":"Poult. Sci."},{"issue":"11","key":"10.1016\/j.bbadis.2025.167766_bb0130","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1002\/tox.23908","article-title":"Loganin alleviates myocardial ischemia-reperfusion injury through GLP-1R\/NLRP3-mediated pyroptosis pathway","volume":"38","author":"Li","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0135","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s13287-024-04039-x","article-title":"Pretreatment with Notoginsenoside R1 enhances the efficacy of neonatal rat mesenchymal stem cell transplantation in model of myocardial infarction through regulating PI3K\/Akt\/FoxO1 signaling pathways","volume":"15","author":"Cai","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.bbadis.2025.167766_bb0140","article-title":"Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK\/ERK pathway","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167766_bb0145","doi-asserted-by":"crossref","first-page":"11973","DOI":"10.2147\/IJN.S488532","article-title":"Targeted delivery and ROS-responsive release of lutein nanoassemblies inhibit myocardial ischemia-reperfusion injury by improving mitochondrial function","volume":"19","author":"Shi","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.bbadis.2025.167766_bb0150","first-page":"656","article-title":"AEBP1 exacerbates myocardial ischemia-reperfusion injury via inhibition of IkappaBalpha","volume":"83","author":"Xue","year":"2023","journal-title":"Folia Morphol (Warsz)"},{"issue":"22","key":"10.1016\/j.bbadis.2025.167766_bb0155","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","article-title":"Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement","volume":"83","author":"Welt","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2025.167766_bb0160","first-page":"1","article-title":"Management of ROS and regulatory cell death in myocardial ischemia-reperfusion injury","author":"Gong","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbadis.2025.167766_bb0165","doi-asserted-by":"crossref","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"Tsutsui","year":"2011","journal-title":"Am. J Physiol. Heart. Circ. Physiol."},{"key":"10.1016\/j.bbadis.2025.167766_bb0170","article-title":"Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review","volume":"11","author":"Liu","year":"2023","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11655-021-3301-1","article-title":"Role of mitophagy in myocardial ischemia\/reperfusion injury and Chinese medicine treatment","volume":"29","author":"Xia","year":"2023","journal-title":"Chin. J. Integr. Med."},{"issue":"10","key":"10.1016\/j.bbadis.2025.167766_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e30568","article-title":"SIRT3 and RORalpha are two prospective targets against mitophagy during simulated ischemia\/reperfusion injury in H9c2 cells","volume":"10","author":"Wu","year":"2024","journal-title":"Heliyon"},{"issue":"8","key":"10.1016\/j.bbadis.2025.167766_bb0185","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.21037\/tau-22-415","article-title":"PRRX1\/FOXM1 reduces gemcitabin-induced cytotoxicity by regulating autophagy in bladder cancer","volume":"11","author":"Huang","year":"2022","journal-title":"Transl. Androl. Urol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13020-023-00838-1","article-title":"A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis","volume":"18","author":"Wang","year":"2023","journal-title":"Chin. Med."},{"issue":"6","key":"10.1016\/j.bbadis.2025.167766_bb0195","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.21037\/jgo-22-1137","article-title":"PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2\/STAT3 axis by targeting IL-6","volume":"13","author":"Zhong","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12935-024-03436-9","article-title":"PRRX1-OLR1 axis supports CAFs-mediated lung cancer progression and immune suppression","volume":"24","author":"Sun","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"11","key":"10.1016\/j.bbadis.2025.167766_bb0205","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41419-023-06260-7","article-title":"FKBP5 activates mitophagy by ablating PPAR-gamma to shape a benign remyelination environment","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167766_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122508","article-title":"Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-yap-mediated regulation of ferroptosis and ER stress","volume":"343","author":"Lu","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0215","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12872-020-01596-w","article-title":"Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database","volume":"20","author":"Dang","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"issue":"3","key":"10.1016\/j.bbadis.2025.167766_bb0220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/09537104.2015.1083543","article-title":"Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction","volume":"27","author":"Eicher","year":"2016","journal-title":"Platelets"},{"issue":"4","key":"10.1016\/j.bbadis.2025.167766_bb0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/WNR.0000000000001751","article-title":"Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p\/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells","volume":"33","author":"Liu","year":"2022","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.bbadis.2025.167766_bb0230","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13020-023-00726-8","article-title":"The alkaloids of Corydalis hendersonii Hemsl. contribute to the cardioprotective effect against ischemic injury in mice by attenuating cardiomyocyte apoptosis via p38 MAPK signaling pathway","volume":"18","author":"Ge","year":"2023","journal-title":"Chin. Med."},{"issue":"4","key":"10.1016\/j.bbadis.2025.167766_bb0235","first-page":"492","article-title":"A newly synthesized flavone avoids COMT-catalyzed methylation and mitigates myocardial ischemia\/reperfusion injury in H9C2 cells via JNK and P38 pathways","volume":"27","author":"Lin","year":"2024","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.bbadis.2025.167766_bb0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbrc.2021.05.027","article-title":"TNF-alpha released from retinal Muller cells aggravates retinal pigment epithelium cell apoptosis by upregulating mitophagy during diabetic retinopathy","volume":"561","author":"Liu","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbadis.2025.167766_bb0245","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3892\/etm.2020.9182","article-title":"Effect and mechanism of asiatic acid on autophagy in myocardial ischemia-reperfusion injury in vivo and in vitro","volume":"20","author":"Yi","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbadis.2025.167766_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113828","article-title":"Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats","volume":"345","author":"Zhu","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2025.167766_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102315","article-title":"SOX9 depletion attenuates retinal ganglion cell ferroptosis through blocking ERK\/p38 signaling","volume":"87","author":"Wei","year":"2024","journal-title":"Tissue Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T08:32:41Z","timestamp":1749544361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001115"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167766","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective potential of transcription factor PRRX1 silencing against myocardial ischemia\/reperfusion injury by regulating excessive mitophagy and ferroptosis through FKBP5-p38 MAPK axis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167766"}}