{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:10:51Z","timestamp":1789708251735,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010167"],"award-info":[{"award-number":["2023A1515010167"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J1010"],"award-info":[{"award-number":["2024A03J1010"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167787","type":"journal-article","created":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T03:04:56Z","timestamp":1741489496000},"page":"167787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["DDR2 alleviates retinal vaso-obliteration and pathological neovascularization by modulating microglia M1\/M2 phenotypic polarization in a mouse model of proliferative retinopathy"],"prefix":"10.1016","volume":"1871","author":[{"given":"Qinjin","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongcheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaguo","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167787_bb0005","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2021-053924","article-title":"Retinopathy of prematurity: a global perspective and recent developments","volume":"150","author":"Sabri","year":"2022","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbadis.2025.167787_bb0010","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s12098-017-2404-3","article-title":"An update on retinopathy of prematurity (ROP)","volume":"84","author":"Dogra","year":"2017","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.bbadis.2025.167787_bb0015","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.167787_bb0020","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.ophtha.2022.06.042","article-title":"A network Meta-analysis of retreatment rates following bevacizumab, ranibizumab, aflibercept, and laser for retinopathy of prematurity","volume":"129","author":"Chang","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbadis.2025.167787_bb0025","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/aos.14852","article-title":"Ranibizumab in retinopathy of prematurity - one-year follow-up of ophthalmic outcomes and two-year follow-up of neurodevelopmental outcomes from the CARE-ROP study","volume":"100","author":"Stahl","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0030","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S2352-4642(21)00195-4","article-title":"2-year outcomes of ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW extension study): prospective follow-up of an open label, randomised controlled trial","volume":"5","author":"Marlow","year":"2021","journal-title":"The Lancet. Child & adolescent health"},{"key":"10.1016\/j.bbadis.2025.167787_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094809","article-title":"Concurrent physiological and pathological angiogenesis in retinopathy of prematurity and emerging therapies","volume":"22","author":"Dai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167787_bb0040","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/JTO.0000000000000164","article-title":"Discoidin domain receptor 2 signaling networks and therapy in lung cancer","volume":"9","author":"Payne","year":"2014","journal-title":"Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer"},{"key":"10.1016\/j.bbadis.2025.167787_bb0045","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1167\/iovs.07-1456","article-title":"Collagen distribution in the human vitreoretinal interface","volume":"49","author":"Ponsioen","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2025.167787_bb0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/eye.1987.34","article-title":"Structure, function and ageing of the collagens of the eye","volume":"1","author":"Bailey","year":"1987","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.bbadis.2025.167787_bb0055","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3389\/fcell.2020.00731","article-title":"Distribution and function of glycosaminoglycans and proteoglycans in the development, homeostasis and pathology of the ocular surface","volume":"8","author":"Puri","year":"2020","journal-title":"Frontiers in cell and developmental biology"},{"key":"10.1016\/j.bbadis.2025.167787_bb0060","first-page":"1830","article-title":"Effect of collagenIon the DDR2\uff0cHIF-1\u03b1 and VEGF expression of human retinal pigment epithelial cells under hypoxia","volume":"12","author":"Zhang","year":"2012","journal-title":"International Eye Science"},{"key":"10.1016\/j.bbadis.2025.167787_bb0065","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/mt.2016.109","article-title":"Targeting of Discoidin domain receptor 2 (DDR2) prevents myofibroblast activation and neovessel formation during pulmonary fibrosis","volume":"24","author":"Zhao","year":"2016","journal-title":"Molecular therapy\u202f: the journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.bbadis.2025.167787_bb0070","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/path.4311","article-title":"A host deficiency of discoidin domain receptor 2 (DDR2) inhibits both tumour angiogenesis and metastasis","volume":"232","author":"Zhang","year":"2014","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0075","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ajhg.2018.10.013","article-title":"Recurrent, activating variants in the receptor tyrosine kinase DDR2 cause Warburg-Cinotti syndrome","volume":"103","author":"Xu","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbadis.2025.167787_bb0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00109-014-1213-7","article-title":"The anti-angiogenic role of discoidin domain receptor 2 (DDR2) in laser-induced choroidal neovascularization","volume":"93","author":"Zhu","year":"2015","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167787_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2017.07.009","article-title":"Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models","volume":"311","author":"Hebron","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0090","first-page":"101","article-title":"Oxygen-induced retinopathy in the mouse","volume":"35","author":"Smith","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167787_bb0095","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.exer.2008.11.034","article-title":"Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells","volume":"88","author":"Zhu","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167787_bb0100","first-page":"257","article-title":"Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy","volume":"26","author":"Mezu-Ndubuisi","year":"2020","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbadis.2025.167787_bb0105","doi-asserted-by":"crossref","first-page":"15822","DOI":"10.1096\/fj.202001295R","article-title":"Protective effects of rapamycin on the retinal vascular bed during the vaso-obliteration phase in mouse oxygen-induced retinopathy model","volume":"34","author":"Zhang","year":"2020","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.bbadis.2025.167787_bb0110","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1167\/iovs.10-5176","article-title":"The mouse retina as an angiogenesis model","volume":"51","author":"Stahl","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167787_bb0115","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.4103\/1673-5374.133169","article-title":"The development of blood-retinal barrier during the interaction of astrocytes with vascular wall cells","volume":"9","author":"Yao","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2025.167787_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.11.001","article-title":"Retinal vasculature development in health and disease","volume":"63","author":"Selvam","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2025.167787_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41413-024-00391-z","article-title":"Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation","volume":"13","author":"Wu","year":"2025","journal-title":"Bone research"},{"key":"10.1016\/j.bbadis.2025.167787_bb0130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/path.6253","article-title":"Discoidin domain receptor 2 signaling through PIK3C2\u03b1 in fibroblasts promotes lung fibrosis","volume":"262","author":"Ling","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/jpm13020291","article-title":"Systemic cytokines in retinopathy of prematurity","volume":"13","author":"Wu","year":"2023","journal-title":"Journal of personalized medicine"},{"key":"10.1016\/j.bbadis.2025.167787_bb0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1159\/000444901","article-title":"Retinopathy of prematurity: therapeutic strategies based on pathophysiology","volume":"109","author":"Cayabyab","year":"2016","journal-title":"Neonatology"},{"key":"10.1016\/j.bbadis.2025.167787_bb0145","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10456-019-09671-3","article-title":"The role of receptor MAS in microglia-driven retinal vascular development","volume":"22","author":"Foulquier","year":"2019","journal-title":"Angiogenesis"},{"key":"10.1016\/j.bbadis.2025.167787_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015846","article-title":"A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures","volume":"6","author":"Rymo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.167787_bb0155","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1167\/iovs.05-1522","article-title":"Potential role of microglia in retinal blood vessel formation","volume":"47","author":"Checchin","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbadis.2025.167787_bb0160","article-title":"Retinal microglia protect against vascular damage in a mouse model of retinopathy of prematurity","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00441-018-2847-5","article-title":"Microglial density determines the appearance of pathological neovascular tufts in oxygen-induced retinopathy","volume":"374","author":"Xu","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbadis.2025.167787_bb0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00011-020-01427-w","article-title":"The phase changes of M1\/M2 phenotype of microglia\/macrophage following oxygen-induced retinopathy in mice","volume":"70","author":"Li","year":"2021","journal-title":"Inflammation research : official journal of the European Histamine Research Society"},{"key":"10.1016\/j.bbadis.2025.167787_bb0175","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s13577-021-00580-6","article-title":"The metaflammatory and Immunometabolic role of macrophages and microglia in diabetic retinopathy","volume":"34","author":"Wu","year":"2021","journal-title":"Hum. Cell"},{"key":"10.1016\/j.bbadis.2025.167787_bb0180","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167787_bb0185","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41598-017-18787-9","article-title":"Collagen type 1 accelerates healing of ruptured fetal membranes","volume":"8","author":"Mogami","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167787_bb0190","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC bioinformatics"},{"key":"10.1016\/j.bbadis.2025.167787_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.03.021","article-title":"Early fate defines microglia and non-parenchymal brain macrophage development","volume":"181","author":"Utz","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167787_bb0200","doi-asserted-by":"crossref","first-page":"240","DOI":"10.12659\/MSMBR.904014","article-title":"STAT6 upregulation promotes M2 macrophage polarization to suppress atherosclerosis","volume":"23","author":"Gong","year":"2017","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.bbadis.2025.167787_bb0205","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1073\/pnas.1821601116","article-title":"STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation","volume":"116","author":"Nepal","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2025.167787_bb0210","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131355","article-title":"STAT6\/Arg1 promotes microglia\/macrophage efferocytosis and inflammation resolution in stroke mice","volume":"4","author":"Cai","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2025.167787_bb0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body \u03b2-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.bbadis.2025.167787_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41420-022-00821-z","article-title":"Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167787_bb0225","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1177\/1753425913509291","article-title":"Augmentation of LPS-induced vascular endothelial cell growth factor production in macrophages by transforming growth factor-\u03b21","volume":"20","author":"Koide","year":"2014","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbadis.2025.167787_bb0230","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.bbrc.2018.02.104","article-title":"TGF-\u03b21\/T\u03b2RII\/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages","volume":"497","author":"Sun","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2025.167787_bb0235","doi-asserted-by":"crossref","first-page":"15859","DOI":"10.1073\/pnas.2136855100","article-title":"Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo","volume":"100","author":"Shih","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2025.167787_bb0240","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1523\/JNEUROSCI.5648-11.2012","article-title":"Defective retinal vascular endothelial cell development as a consequence of impaired integrin \u03b1V\u03b28-mediated activation of transforming growth factor-\u03b2","volume":"32","author":"Arnold","year":"2012","journal-title":"J. Neurosci."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001322?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001322?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:10Z","timestamp":1762324030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001322"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167787","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DDR2 alleviates retinal vaso-obliteration and pathological neovascularization by modulating microglia M1\/M2 phenotypic polarization in a mouse model of proliferative retinopathy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"167787"}}