{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:22:02Z","timestamp":1793726522102,"version":"4.6.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302447"],"award-info":[{"award-number":["82302447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102283"],"award-info":[{"award-number":["82102283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360377"],"award-info":[{"award-number":["82360377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["202117010786"],"award-info":[{"award-number":["202117010786"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["202203022422"],"award-info":[{"award-number":["202203022422"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["202310006771"],"award-info":[{"award-number":["202310006771"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2024GXNSFAA010047"],"award-info":[{"award-number":["2024GXNSFAA010047"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ40872"],"award-info":[{"award-number":["2021JJ40872"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40876"],"award-info":[{"award-number":["2023JJ40876"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ40879"],"award-info":[{"award-number":["2021JJ40879"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022JJ60104"],"award-info":[{"award-number":["2022JJ60104"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["13JJ4026"],"award-info":[{"award-number":["13JJ4026"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ60081"],"award-info":[{"award-number":["2023JJ60081"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011496","name":"Changsha Science and Technology Bureau","doi-asserted-by":"publisher","award":["kq2007051"],"award-info":[{"award-number":["kq2007051"]}],"id":[{"id":"10.13039\/501100011496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbadis.2025.167798","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:36:11Z","timestamp":1741725371000},"page":"167798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2"],"prefix":"10.1016","volume":"1871","author":[{"given":"Yang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingsi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167798_bb0005","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S2213-2600(20)30225-3","article-title":"Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy","volume":"8","author":"George","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01808-2020","article-title":"Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19","volume":"56","author":"Combet","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2025.167798_bb0015","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1183\/09031936.00196412","article-title":"The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance","volume":"43","author":"Burnham","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2025.167798_bb0020","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S2213-2600(21)00017-5","article-title":"Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities","volume":"9","author":"Spagnolo","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0025","doi-asserted-by":"crossref","first-page":"5088","DOI":"10.1172\/JCI139519","article-title":"Contributions of alveolar epithelial cell quality control to pulmonary fibrosis","volume":"130","author":"Katzen","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.167798_bb0030","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-019-1897-5","article-title":"TGF-beta orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1","volume":"577","author":"Su","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167798_bb0035","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/DDDT.S344309","article-title":"Wnt\/beta-catenin participates in the repair of acute respiratory distress syndrome-associated early pulmonary fibrosis via mesenchymal stem cell microvesicles","volume":"16","author":"Zhang","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bbadis.2025.167798_bb0040","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12931-021-01785-x","article-title":"Inhibition of EZH2 prevents acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis by regulating the macrophage polarization phenotype","volume":"22","author":"Bao","year":"2021","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113955","article-title":"Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-beta induced epithelial to mesenchymal transition","volume":"177","author":"Zheng","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0050","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12931-019-1158-z","article-title":"Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial-mesenchymal transition","volume":"20","author":"Yang","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0055","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00415.2018","article-title":"Resolvin D1 attenuates mechanical stretch-induced pulmonary fibrosis via epithelial-mesenchymal transition. American journal of physiology","volume":"316","author":"Yang","year":"2019","journal-title":"Lung cellular and molecular physiology"},{"key":"10.1016\/j.bbadis.2025.167798_bb0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.201412-2326OC","article-title":"Mechanical stress and the induction of lung fibrosis via the Midkine signaling pathway","volume":"192","author":"Zhang","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0065","article-title":"MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program","volume":"7","author":"Wang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2025.167798_bb0070","article-title":"Loss of MBD2 ameliorates LPS-induced alveolar epithelial cell apoptosis and ALI in mice via modulating intracellular zinc homeostasis","volume":"36","author":"Liu","year":"2022","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.bbadis.2025.167798_bb0075","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1158\/0008-5472.CAN-20-2876","article-title":"Hypoxia-induced suppression of alternative splicing of MBD2 promotes breast Cancer metastasis via activation of FZD1","volume":"81","author":"Liu","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0080","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.omtn.2022.02.015","article-title":"Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I\/R-induced renal fibrosis via downregulation of EGR1","volume":"28","author":"Ai","year":"2022","journal-title":"Molecular therapy. Nucleic acids"},{"key":"10.1016\/j.bbadis.2025.167798_bb0085","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aav9810","article-title":"Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2","volume":"5","author":"Kim","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbadis.2025.167798_bb0090","doi-asserted-by":"crossref","first-page":"18504","DOI":"10.1002\/jcp.28486","article-title":"Silencing of a novel lncRNA LOC105369748 suppresses the progression of hepatocellular carcinoma by sponging miR-5095 from MBD2","volume":"234","author":"E","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0095","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1164\/rccm.2201082","article-title":"Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits","volume":"168","author":"Gunther","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173754","article-title":"Significance of nuclear LOXL2 inhibition in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome","volume":"892","author":"Matsuo","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110507","article-title":"L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis","volume":"38","author":"Joshi","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2025.167798_bb0110","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41374-019-0289-7","article-title":"Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis","volume":"99","author":"Cao","year":"2019","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"10.1016\/j.bbadis.2025.167798_bb0115","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/labinvest.2017.123","article-title":"miR-200b\/c attenuates lipopolysaccharide-induced early pulmonary fibrosis by targeting ZEB1\/2 via p38 MAPK and TGF-beta\/smad3 signaling pathways","volume":"98","author":"Cao","year":"2018","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"10.1016\/j.bbadis.2025.167798_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2019.01.005","article-title":"Inhibition of mesenchymal stromal cells\u2019 chemotactic effect to ameliorate paraquat-induced pulmonary fibrosis","volume":"307","author":"Zhang","year":"2019","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbadis.2025.167798_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122148","article-title":"Inhibition of METTL3 alleviated LPS-induced alveolar epithelial cell apoptosis and acute lung injury via restoring neprilysin expression","volume":"333","author":"Jia","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2025.167798_bb0130","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03697-2020","article-title":"The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation","volume":"60","author":"Wang","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2025.167798_bb0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12890-019-0911-x","article-title":"Effects of C\/EBPalpha overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia","volume":"19","author":"Lu","year":"2019","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.509","article-title":"Protective function of interleukin-22 in pulmonary fibrosis","volume":"11","author":"Gu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0145","article-title":"Targeting the HSP47-collagen axis inhibits brain metastasis by reversing M2 microglial polarization and restoring anti-tumor immunity","volume":"5","author":"Wang","year":"2024","journal-title":"Cell reports. Medicine"},{"key":"10.1016\/j.bbadis.2025.167798_bb0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev-biochem-040320-103615","article-title":"The Wnt pathway: from signaling mechanisms to synthetic modulators","volume":"91","author":"Rim","year":"2022","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbadis.2025.167798_bb0155","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-021-03569-1","article-title":"A molecular single-cell lung atlas of lethal COVID-19","volume":"595","author":"Melms","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167798_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12950-018-0191-x","article-title":"MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1alpha","volume":"15","author":"Xu","year":"2018","journal-title":"J. Inflamm."},{"key":"10.1016\/j.bbadis.2025.167798_bb0165","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.yexcr.2018.08.010","article-title":"MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression","volume":"371","author":"Sun","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6249685","article-title":"MBD2 regulates Th17 cell differentiation and experimental severe asthma by affecting IRF4 expression","volume":"2017","author":"Jia","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"692\u2013706","key":"10.1016\/j.bbadis.2025.167798_bb0175","article-title":"Dysregulated lung commensal Bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles","volume":"50","author":"Yang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bbadis.2025.167798_bb0180","doi-asserted-by":"crossref","unstructured":"Celada, L. J., Kropski, J. A., Herazo-Maya, J. D., Luo, W., Creecy, A., Abad, A. T., Chioma, O. S., Lee, G., Hassell, N. E., Shaginurova, G. I., Wang, Y., Johnson, J. E., Kerrigan, A., Mason, W. R., Baughman, R. P., Ayers, G. D., Bernard, G. R., Culver, D. A., Montgomery, C. G., Maher, T. M., Molyneaux, P. L., Noth, I., Mutsaers, S. E., Prele, C. M., Peebles, R. S., Jr., Newcomb, D. C., Kaminski, N., Blackwell, T. S., Van Kaer, L., and Drake, W. P. (2018) PD-1 up-regulation on CD4(+) T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-beta1 production. Science translational medicine 10.","DOI":"10.1126\/scitranslmed.aar8356"},{"key":"10.1016\/j.bbadis.2025.167798_bb0185","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd1206","article-title":"Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis","volume":"13","author":"Zhang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41419-022-04577-3","article-title":"Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages","volume":"13","author":"Ai","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167798_bb0195","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev-pathol-042320-030240","article-title":"Pathogenic mechanisms underlying idiopathic pulmonary fibrosis","volume":"17","author":"Moss","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0200","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute respiratory distress syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bbadis.2025.167798_bb0205","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/s41467-022-29064-3","article-title":"Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis","volume":"13","author":"D\u2019Alessandro-Gabazza","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.167798_bb0210","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/thoraxjnl-2018-211535","article-title":"Fas activation alters tight junction proteins in acute lung injury","volume":"74","author":"Herrero","year":"2019","journal-title":"Thorax"},{"key":"10.1016\/j.bbadis.2025.167798_bb0215","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.jtho.2021.07.002","article-title":"Lung Cancer models reveal severe acute respiratory syndrome coronavirus 2-induced epithelial-to-mesenchymal transition contributes to coronavirus disease 2019 pathophysiology","volume":"16","author":"Stewart","year":"2021","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0220","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41556-020-0542-8","article-title":"Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis","volume":"22","author":"Kobayashi","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0225","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1164\/rccm.201909-1726LE","article-title":"Ineffectual type 2-to-type 1 alveolar epithelial cell differentiation in idiopathic pulmonary fibrosis: persistence of the KRT8(hi) transitional state","volume":"201","author":"Jiang","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0230","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","article-title":"Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.167798_bb0235","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ajpath.2021.11.014","article-title":"Fatal COVID-19 and non-COVID-19 acute respiratory distress syndrome is associated with incomplete alveolar type 1 epithelial cell differentiation from the transitional state without fibrosis","volume":"192","author":"Ting","year":"2022","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0240","article-title":"OC-STAMP overexpression drives lung alveolar epithelial cell type II senescence in silicosis","volume":"2021","author":"Li","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.167798_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.595811","article-title":"Disparate interferon signaling and shared aberrant basaloid cells in single-cell profiling of idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease","volume":"12","author":"Valenzi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0250","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s12276-019-0371-7","article-title":"TGF-beta1\/IL-11\/MEK\/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency","volume":"52","author":"Chen","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167798_bb0255","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167798_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153514","article-title":"Wnt5a\/ca(2+) signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance","volume":"490","author":"Ma","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.bbadis.2025.167798_bb0265","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1165\/rcmb.2022-0074OC","article-title":"Basal cell-derived WNT7A promotes Fibrogenesis at the fibrotic niche in idiopathic pulmonary fibrosis","volume":"68","author":"Huang","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0270","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00441-019-03110-x","article-title":"Wnt4 negatively regulates the TGF-beta1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK","volume":"379","author":"Liu","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0275","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/d41573-023-00116-7","article-title":"Selective activation of Wnt ameliorates idiopathic pulmonary fibrosis","volume":"22","author":"Villanueva","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2995\u20133012","key":"10.1016\/j.bbadis.2025.167798_bb0280","article-title":"Targeted alveolar regeneration with frizzled-specific agonists","volume":"186","author":"Nabhan","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.167798_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103745","article-title":"Elevated Wnt2 and Wnt4 activate NF-kappaB signaling to promote cardiac fibrosis by cooperation of Fzd4\/2 and LRP6 following myocardial infarction","volume":"74","author":"Yin","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbadis.2025.167798_bb0290","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1128\/MCB.00539-08","article-title":"Deficiency of Mbd2 attenuates Wnt signaling","volume":"28","author":"Phesse","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0295","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1158\/0008-5472.CAN-17-1434","article-title":"MBD2 ablation impairs Lymphopoiesis and impedes progression and maintenance of T-ALL","volume":"78","author":"Zhou","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112400","article-title":"Loss of MBD2 affects early T cell development by inhibiting the WNT signaling pathway","volume":"398","author":"Cheng","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0305","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.jcmgh.2022.02.006","article-title":"Targeting HNRNPM inhibits Cancer Stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma","volume":"13","author":"Zhu","year":"2022","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbadis.2025.167798_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073331","article-title":"Hypoxia inducible factor 1A supports a pro-fibrotic phenotype loop in idiopathic pulmonary fibrosis","volume":"22","author":"Epstein Shochet","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167798_bb0315","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12931-019-1100-4","article-title":"Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis","volume":"20","author":"Aquino-Galvez","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.bbadis.2025.167798_bb0320","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.744","article-title":"Pulmonary fibrosis: pathogenesis and therapeutic strategies","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.bbadis.2025.167798_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.109087","article-title":"Histone methyltransferase SETDB1 inhibits TGF-beta-induced epithelial-mesenchymal transition in pulmonary fibrosis by regulating SNAI1 expression and the ferroptosis signaling pathway","volume":"715","author":"Liu","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.167798_bb0330","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41467-023-42571-1","article-title":"A circular RNA activated by TGFbeta promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.167798_bb0335","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41388-021-02067-y","article-title":"Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer","volume":"41","author":"Yu","year":"2022","journal-title":"Oncogene"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925001437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:30:42Z","timestamp":1762324242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925001437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0925443925001437"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167798","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167798"}}