{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:42:48Z","timestamp":1786984968753,"version":"build-2736575974"},"reference-count":73,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["KY-2025NL-109"],"award-info":[{"award-number":["KY-2025NL-109"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010227","name":"Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau","doi-asserted-by":"publisher","award":["YKK21181"],"award-info":[{"award-number":["YKK21181"]}],"id":[{"id":"10.13039\/501100010227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01719"],"award-info":[{"award-number":["2021J01719"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506300"],"award-info":[{"award-number":["2023YFC2506300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbadis.2025.167866","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:03:48Z","timestamp":1745409828000},"page":"167866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["TSPO participates in the pathogenesis of diabetic periodontitis related to mitophagy"],"prefix":"10.1016","volume":"1871","author":[{"given":"Weiqiu","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiyu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167866_bb0005","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbadis.2025.167866_bb0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jcpe.13901","article-title":"Periodontitis and the risk of all-cause and cause-specific mortality among US adults with diabetes: a population-based cohort study","volume":"51","author":"Li","year":"2024","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111558","article-title":"Association between periodontitis and inflammatory comorbidities: the common role of innate immune cells, underlying mechanisms and therapeutic targets","volume":"128","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0020","series-title":"Periodontitis: Advances in Experimental Research","first-page":"231","article-title":"Update on the bidirectional link between diabetes and periodontitis","author":"Salhi","year":"2022"},{"key":"10.1016\/j.bbadis.2025.167866_bb0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/jcpe.12803","article-title":"An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes","volume":"45","author":"Polak","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0035","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/prd.12318","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves","year":"2020","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bbadis.2025.167866_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bbadis.2025.167866_bb0045","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/eci.12322","article-title":"The implication of periodontitis in vascular endothelial dysfunction","volume":"44","author":"Gurav","year":"2014","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.bbadis.2025.167866_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111796","article-title":"Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus","volume":"130","author":"Pan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0055","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3390\/ijms25021024","article-title":"Mitochondrial dysfunction in periodontitis and associated systemic diseases: implications for pathomechanisms and therapeutic strategies","volume":"25","author":"Deng","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0060","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3390\/cells10092411","article-title":"Diabetes mellitus and periodontitis share intracellular disorders as the main meeting point","volume":"10","author":"Portes","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167866_bb0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5483\/BMBRep.2020.53.1.273","article-title":"Translocator protein (TSPO): the new story of the old protein in neuroinflammation","volume":"53","author":"Lee","year":"2020","journal-title":"BMB Rep."},{"key":"10.1016\/j.bbadis.2025.167866_bb0070","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.freeradbiomed.2024.11.033","article-title":"SIRT3 alleviates mitochondrial dysfunction and senescence in diabetes-associated periodontitis by deacetylating LRPPRC","volume":"227","author":"Tang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.167866_bb0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/JIR.S492041","article-title":"Mitochondrial dysfunction in diabetic periodontitis: mechanisms and therapeutic potential","volume":"18","author":"Meng","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbadis.2025.167866_bb0080","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/jcpe.12711","article-title":"Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes","volume":"44","author":"Sun","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbadis.2025.167866_bb0090","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s00018-018-2990-x","article-title":"Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics","volume":"76","author":"Praharaj","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0095","doi-asserted-by":"crossref","first-page":"222","DOI":"10.7150\/thno.49860","article-title":"Selective autophagy of intracellular organelles: recent research advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2025.167866_bb0100","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.167866_bb0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12903-022-02167-5","article-title":"PINK1 mediated mitophagy attenuates early apoptosis of gingival epithelial cells induced by high glucose","volume":"22","author":"Zhu","year":"2022","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.bbadis.2025.167866_bb0110","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nrd3295","article-title":"Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders","volume":"9","author":"Rupprecht","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbadis.2025.167866_bb0115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3390\/ijms20030594","article-title":"The TSPO ligands 2-Cl-MGV-1, MGV-1, and PK11195 differentially suppress the inflammatory response of BV-2 microglial cell to LPS","volume":"20","author":"Azrad","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0120","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/cells11050856","article-title":"TSPO deficiency exacerbates GSDMD-mediated macrophage pyroptosis in inflammatory bowel disease","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167866_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154484","article-title":"Koumine regulates macrophage M1\/M2 polarization via TSPO, alleviating sepsis-associated liver injury in mice","volume":"107","author":"Jin","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2025.167866_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13550-021-00786-7","article-title":"In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease","volume":"11","author":"Schollhammer","year":"2021","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.bbadis.2025.167866_bb0135","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/jcmm.17179","article-title":"Enhancing fractalkine\/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy","volume":"26","author":"Jiang","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167866_bb0140","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41419-023-05643-0","article-title":"ERK1\/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS","volume":"14","author":"Magr\u00ec","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.167866_bb0145","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.4161\/15548627.2014.991665","article-title":"TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control","volume":"10","author":"Gatliff","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbadis.2025.167866_bb0150","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1038\/s41380-021-01050-z","article-title":"The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity","volume":"26","author":"Frison","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbadis.2025.167866_bb0155","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.3390\/ijms21207432","article-title":"Role of TSPO\/VDAC1 upregulation and matrix metalloproteinase-2 localization in the dysfunctional myocardium of hyperglycaemic rats","volume":"21","author":"Gliozzi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2022.12869","article-title":"Increased expression of TSPO-VDAC complex is correlated with NLRP3 inflammasome activation in diabetic retinopathy","volume":"26","author":"Guo","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"Suppl. 20","key":"10.1016\/j.bbadis.2025.167866_bb0165","first-page":"S162","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0170","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/jcpe.12935","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions \u2013 introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0175","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.3390\/ijms24076309","article-title":"Hyperglycemia aggravates periodontitis via autophagy impairment and ROS-inflammasome-mediated macrophage pyroptosis","volume":"24","author":"Zhao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0180","article-title":"Activation of aldehyde dehydrogenase-2 improves ischemic random skin flap survival in rats","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0185","article-title":"Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1\/parkin signaling and intestinal flora","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167866_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1509482","article-title":"Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation","volume":"15","author":"Qin","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113829","article-title":"Geniposide ameliorates glucocorticoid-induced osteoblast apoptosis by activating autophagy","volume":"155","author":"Huang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.167866_bb0200","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3892\/mmr.2021.12076","article-title":"Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK\/mTOR-mediated autophagy","volume":"23","author":"Zhu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbadis.2025.167866_bb0205","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1021\/acsami.4c18945","article-title":"Extracellular matrix-mimicking hydrogel with angiogenic and immunomodulatory properties accelerates healing of diabetic wounds by promoting autophagy","volume":"17","author":"Pan","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.bbadis.2025.167866_bb0210","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/biom13050769","article-title":"[18F]GE-180-PET and post mortem marker characteristics of long-term high-fat-diet-induced chronic neuroinflammation in mice","volume":"13","author":"M\u00fcller","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2025.167866_bb0215","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12974-023-02769-y","article-title":"Pharmacological modulation of TSPO in microglia\/macrophages and neurons in a chronic neurodegenerative model of prion disease","volume":"20","author":"Vicente-Rodr\u00edguez","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbadis.2025.167866_bb0220","first-page":"386","article-title":"The beneficial effect of carvacrol in HL-1 cardiomyocytes treated with LPS-G: anti-inflammatory pathway investigations","volume":"11","author":"Marconi","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.bbadis.2025.167866_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112522","article-title":"Neural epidermal growth factor-like 1 protein (Nell-1) alleviates periodontal tissue destruction in periodontitis by regulating the ratio of M2\/M1 macrophage phenotypes","volume":"137","author":"Ni","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41368-021-00116-6","article-title":"Diabetes fuels periodontal lesions via GLUT1-driven macrophage inflammaging","volume":"13","author":"Wang","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0235","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.2337\/dc19-0018","article-title":"Undetected dysglycemia is an important risk factor for two common diseases, myocardial infarction and periodontitis: a report from the PAROKRANK study","volume":"42","author":"Norhammar","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbadis.2025.167866_bb0240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jdsr.2023.12.002","article-title":"The bidirectional association between diabetes and periodontitis, from basic to clinical","volume":"60","author":"Shinjo","year":"2024","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"10.1016\/j.bbadis.2025.167866_bb0245","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/jcpe.13811","article-title":"Activation of PGC-1\u03b1-dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis","volume":"50","author":"Sun","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0250","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/prd.12235","article-title":"Periodontal complications of hyperglycemia\/diabetes mellitus: epidemiologic complexity and clinical challenge","volume":"78","author":"Kocher","year":"2018","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bbadis.2025.167866_bb0255","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/JLB.3A1219-729RR","article-title":"Surface Translocator Protein 18 kDa (TSPO) localization on immune cells upon stimulation with lipopolysaccharide and in ART-treated HIV+ subjects","volume":"110","author":"Blevins","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0260","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s12031-019-01454-1","article-title":"TSPO modulates IL-4-induced microglia\/macrophage M2 polarization via PPAR-\u03b3 pathway","volume":"70","author":"Zhou","year":"2020","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0265","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/jnen\/nlad093","article-title":"Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas","volume":"82","author":"Blum","year":"2023","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0270","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101198R","article-title":"Decoding the role of macrophages in periodontitis and type 2 diabetes using single-cell RNA-sequencing","volume":"36","author":"Agrafioti","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2025.167866_bb0275","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"64","author":"Cekici","year":"2014","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.bbadis.2025.167866_bb0280","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jre.13074","article-title":"Macrophages contribute to periodontal wound healing mainly in the tissue proliferation stage","volume":"58","author":"Chen","year":"2023","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.bbadis.2025.167866_bb0285","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-2094-11-3","article-title":"Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis","volume":"11","author":"Karlstetter","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbadis.2025.167866_bb0290","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/ijms18040786","article-title":"Classical and novel TSPO ligands for the mitochondrial TSPO can modulate nuclear gene expression: implications for mitochondrial retrograde signaling","volume":"18","author":"Yasin","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0295","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.3390\/ijms19123740","article-title":"TSPO ligands promote cholesterol efflux and suppress oxidative stress and inflammation in choroidal endothelial cells","volume":"19","author":"Biswas","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167866_bb0300","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainresbull.2016.02.001","article-title":"TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration","volume":"121","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbadis.2025.167866_bb0305","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biochi.2023.11.013","article-title":"The mitochondrial translocator protein (TSPO, 18 kDa): a key multifunctional molecule in liver diseases","volume":"224","author":"Li","year":"2024","journal-title":"Biochimie"},{"key":"10.1016\/j.bbadis.2025.167866_bb0310","article-title":"The TSPO-specific ligand PK11195 protects against LPS-induced cognitive dysfunction by inhibiting cellular autophagy","volume":"11","author":"Lan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0315","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/cells9020512","article-title":"The translocator protein (TSPO) in mitochondrial bioenergetics and immune processes","volume":"9","author":"Betlazar","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2025.167866_bb0320","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1007\/s12035-021-02294-0","article-title":"The protective effect of PK-11195 on cognitive impairment in rats survived of polymicrobial sepsis","volume":"58","author":"Dominguini","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0325","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.bbadis.2025.167866_bb0330","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.167866_bb0335","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/s41386-018-0293-4","article-title":"TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation","volume":"44","author":"Scaini","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbadis.2025.167866_bb0340","first-page":"476","article-title":"PK11195 inhibits mitophagy targeting the F1Fo-ATPsynthase in Bcl-2 knock-down cells","volume":"12","author":"Seneviratne","year":"2012","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167866_bb0345","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","article-title":"Mitophagy in human health, ageing and disease","volume":"5","author":"Picca","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.bbadis.2025.167866_bb0350","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/nature04779","article-title":"Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin","volume":"441","author":"Clark","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167866_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109588","article-title":"Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia\/reoxygenation injury","volume":"121","author":"Meng","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.167866_bb0360","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3389\/fphar.2017.00766","article-title":"Role of translocator 18 KDa ligands in the activation of leukotriene B4 activated G-protein coupled receptor and toll like receptor-4 pathways in neutrophils","volume":"8","author":"Kupa","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167866_bb0365","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00011-020-01409-y","article-title":"Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation","volume":"70","author":"Lv","year":"2021","journal-title":"Inflamm. Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925002145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925002145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:09:53Z","timestamp":1778551793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925002145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0925443925002145"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167866","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TSPO participates in the pathogenesis of diabetic periodontitis related to mitophagy","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167866","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167866"}}