{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:15:45Z","timestamp":1768292145658,"version":"3.49.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002781","name":"University of Calcutta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024236","name":"Indian Association for the Cultivation of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbadis.2025.167908","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T02:29:50Z","timestamp":1747362590000},"page":"167908","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Possible role of the mitochondrial pyruvate dehydrogenase in ketorolac mediated onset and progression of gastric ulcers in male Wistar rats: Protection by melatonin"],"prefix":"10.1016","volume":"1871","author":[{"given":"Romit","family":"Majumder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhuri","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrita","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trina","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debasish","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aindrila","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167908_bb0005","series-title":"Stomach, canine and feline gastroenterology","first-page":"606","author":"Simpson","year":"2013"},{"key":"10.1016\/j.bbadis.2025.167908_bb0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/00365528809096277","article-title":"Gastric mucosal defence mechanisms: a brief review","volume":"155","author":"Forssell","year":"1988","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"10.1016\/j.bbadis.2025.167908_bb0015","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0016-5107(04)01311-2","article-title":"Silent peptic ulcer disease: frequency, factors leading to \u201csilence,\u201d and implications regarding the pathogenesis of visceral symptoms","volume":"60","author":"Lu","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.bbadis.2025.167908_bb0020","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1056\/NEJM195403252501202","article-title":"Gastric ulcer","volume":"250","author":"Gott","year":"1954","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.167908_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01658110","article-title":"High gastric ulcer","volume":"11","author":"Jensen","year":"1987","journal-title":"World J. Surg."},{"key":"10.1016\/j.bbadis.2025.167908_bb0030","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1159\/000331517","article-title":"Complications of peptic ulcer disease","volume":"29","author":"Milosavljevic","year":"2011","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbadis.2025.167908_bb0035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.coph.2005.06.004","article-title":"Recent advances in gastric ulcer therapeutics","volume":"5","author":"Wallace","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0040","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0149-2918(00)80043-0","article-title":"Over-the-counter analgesics and antipyretics: a critical assessment","volume":"22","author":"Hersh","year":"2000","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bbadis.2025.167908_bb0045","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00228-014-1734-6","article-title":"Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects","volume":"70","author":"Wehling","year":"2014","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0050","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2165\/00002512-200421080-00001","article-title":"Over-the-counter analgesics in older adults: a call for improved labelling and consumer education","volume":"21","author":"Roumie","year":"2004","journal-title":"Drugs Aging"},{"key":"10.1016\/j.bbadis.2025.167908_bb0055","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.2165\/00002018-200326150-00001","article-title":"Issues related to monitoring the safety of over-the-counter (OTC) medicines","volume":"26","author":"Bond","year":"2003","journal-title":"Drug Saf."},{"key":"10.1016\/j.bbadis.2025.167908_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/fampra\/cmh719","article-title":"How and why are non-prescription analgesics used in Scotland?","volume":"22","author":"Porteous","year":"2005","journal-title":"Fam. Pract."},{"key":"10.1016\/j.bbadis.2025.167908_bb0065","doi-asserted-by":"crossref","DOI":"10.3399\/bjgp14X677815","article-title":"High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional study","volume":"64","author":"Koffeman","year":"2014","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.bbadis.2025.167908_bb0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.2042-7174.2011.00097.x","article-title":"Responsible self-medication: perceived risks and benefits of over-the-counter analgesic use","volume":"19","author":"Stosic","year":"2011","journal-title":"Int. J. Pharm. Pract."},{"key":"10.1016\/j.bbadis.2025.167908_bb0075","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2125.2010.03702.x","article-title":"All-cause mortality of elderly Australian veterans using COX-2 selective or non-selective NSAIDs: a longitudinal study","volume":"71","author":"Kerr","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0080","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00296-011-2263-6","article-title":"A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity","volume":"32","author":"Conaghan","year":"2012","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.bbadis.2025.167908_bb0085","first-page":"865","article-title":"A study on work related musculoskeletal disorders and factors associated with it among occupational computer users","volume":"31","author":"Sundru","year":"2024","journal-title":"J. Popul. Ther. Clin. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0090","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1163\/156856005774415583","article-title":"COX-2 controversy: where are we and where do we go from here?","volume":"13","author":"Khanna","year":"2005","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbadis.2025.167908_bb0095","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/jama.284.10.1247","article-title":"Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study","volume":"284","author":"Silverstein","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.bbadis.2025.167908_bb0100","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane","year":"1971","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110611","article-title":"Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity","volume":"382","author":"Majumder","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbadis.2025.167908_bb0110","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal melatonin: sources, regulation, and potential functions","volume":"71","author":"Acu\u00f1a-Castroviejo","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"issue":"22","key":"10.1016\/j.bbadis.2025.167908_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212143","article-title":"Possible role of pineal and extra-pineal melatonin in surveillance, immunity, and first-line defense","volume":"22","author":"Markus","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167908_bb0120","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052809","article-title":"Impact of melatonin deficit on emotional status and oxidative stress-induced changes in sphingomyelin and cholesterol level in young adult, mature, and aged rats","volume":"23","author":"Tchekalarova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.167908_bb0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.167908_bb0135","doi-asserted-by":"crossref","first-page":"7563","DOI":"10.1073\/pnas.96.13.7563","article-title":"Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis","volume":"96","author":"Warner","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167908_bb0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1600-079X.2004.00118.x","article-title":"Melatonin protects against piroxicam-induced gastric ulceration","volume":"36","author":"Bandyopadhyay","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00936440","article-title":"Effect of stress on the antioxidant enzymes and gastric ulceration","volume":"125","author":"Das","year":"1993","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0160","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0165","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0170","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/0003-2697(68)90092-4","article-title":"Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman\u2019s reagent","volume":"25","author":"Sedlak","year":"1968","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0175","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0021-9258(18)91395-5","article-title":"Xanthine oxidase","volume":"239","author":"Greenlee","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0180","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/jpi.12213","article-title":"Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin","volume":"58","author":"Mukherjee","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0185","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1196\/annals.1378.010","article-title":"Using Janus green B to study paraquat toxicity in rat liver mitochondria: role of ACE inhibitors (thiol and nonthiol ACEi)","volume":"1090","author":"Ghazi-Khansari","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbadis.2025.167908_bb0190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/15376510309841","article-title":"Comparative measurement of in vitro T-2 toxin cytotoxicity using three different cytotoxicity assays","volume":"13","author":"Heidari","year":"2003","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.bbadis.2025.167908_bb0195","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/B978-0-12-416618-9.00013-3","article-title":"Methods to monitor ROS production by fluorescence microscopy and fluorometry","volume":"542","author":"Wojtala","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0200","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3128","article-title":"Analysis of the mitochondrial membrane potential using the cationic JC-1 dyeas a sensitive fluorescent probe","volume":"9","author":"Sivandzade","year":"2019","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.bbadis.2025.167908_bb0205","article-title":"Mitochondrial Ca2+ retention capacity assay and Ca2+-triggered mitochondrial swelling assay","volume":"2018","author":"Li","year":"2018","journal-title":"JoVE (Journal of Visualized Experiments)"},{"key":"10.1016\/j.bbadis.2025.167908_bb0210","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1600-079X.2012.00984.x","article-title":"Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats","volume":"53","author":"Mukherjee","year":"2012","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.12691\/ajcp-1-2-1","article-title":"Glycoregulatory enzymes as early diagnostic markers during premalignant stage in hepatocellular carcinoma","volume":"1","author":"Abdel-Hamid","year":"2013","journal-title":"Am J Cancer Prev"},{"key":"10.1016\/j.bbadis.2025.167908_bb0220","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0076-6879(66)09089-X","article-title":"[77c] phosphofructokinase: III. Yeast","volume":"9","author":"Sols","year":"1966","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0225","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1021\/ol0625482","article-title":"Fructose-6-phosphate aldolase in organic synthesis: preparation of D-fagomine, N-alkylated derivatives, and preliminary biological assays","volume":"8","author":"Castillo","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.bbadis.2025.167908_bb0230","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0076-6879(82)90120-3","article-title":"[24] Pyruvate kinase from bovine muscle and liver","volume":"90","author":"Cardenas","year":"1982","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0235","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1073\/pnas.48.4.698","article-title":"The isolation of yeast ribosomes associated with triose phosphate dehydrogenase","volume":"48","author":"Warren","year":"1962","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2025.167908_bb0240","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0003-9861(72)90151-8","article-title":"\u0391-keto acid dehydrogenase complexes: XV. purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart","volume":"148","author":"Linn","year":"1972","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.167908_bb0245","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0076-6879(69)13007-4","article-title":"Citrate synthase from yeast: [EC 4.1.3.7 citrate oxaloacetage-lyase (CoA-acetylating)]","volume":"13","author":"Parvin","year":"1969","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0250","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/jb.137.1.415-419.1979","article-title":"Alpha-ketoglutarate dehydrogenase mutant of Rhizobium meliloti","volume":"137","author":"Duncan","year":"1979","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0255","first-page":"85","article-title":"Succinate dehydrogenase. [EC 1.3.99.1 succinate: (acceptor) oxidoreductase]","volume":"13","author":"Veeger","year":"1969","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0260","series-title":"Methods of Enzymatic Analysis","first-page":"613","article-title":"Malate dehydrogenase","author":"Bergmeyer","year":"1974"},{"key":"10.1016\/j.bbadis.2025.167908_bb0265","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0022149X00013778","article-title":"Oxidation and reduction of cytochrome c by mitochondrial enzymes of Setaria cervi","volume":"69","author":"Goyal","year":"1995","journal-title":"J. Helminthol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0270","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0955-2863(90)90019-H","article-title":"Adenosine triphosphate: enzymatic spectrophotometric determination","volume":"1","author":"Tornheim","year":"1990","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0275","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0003-9861(90)90288-A","article-title":"Quantitation of the hydroxyl radical by reaction with dimethyl sulfoxide","volume":"278","author":"Steiner","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.167908_bb0280","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BJ20061903","article-title":"NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation","volume":"406","author":"Serrander","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2025.167908_bb0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/nprot.2007.473","article-title":"Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine","volume":"3","author":"Zielonka","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbadis.2025.167908_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-190007000-00001","article-title":"I. Perforating ulcer of the stomach","volume":"32","author":"Finney","year":"1900","journal-title":"Ann. Surg."},{"key":"10.1016\/j.bbadis.2025.167908_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph192316263","article-title":"Risk factors for mortality in emergently admitted patients with acute gastric ulcer: an analysis of 15,538 patients in National Inpatient Sample, 2005\u20132014","volume":"19","author":"Idris","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbadis.2025.167908_bb0300","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.redox.2015.11.010","article-title":"Interplay between oxidant species and energy metabolism","volume":"8","author":"Quijano","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2025.167908_bb0305","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.mpaic.2021.04.001","article-title":"The mouth, stomach and intestines","volume":"22","author":"McQuilken","year":"2021","journal-title":"Anaesthesia & Intensive Care Medicine"},{"issue":"2006","key":"10.1016\/j.bbadis.2025.167908_bb0310","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167908_bb0315","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2025.167908_bb0320","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jemt.10249","article-title":"Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix","volume":"60","author":"Li","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bbadis.2025.167908_bb0325","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138949","article-title":"Regulation of glycolysis and the Warburg effect in wound healing","volume":"5","author":"Vinaik","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2025.167908_bb0330","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2025.03.030","article-title":"Inactivation of human glucose 6-phosphate dehydrogenase (G6PDH) by peroxyl radicals is strongly modulated by its substrate and cofactor","volume":"233","author":"Reyes","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.167908_bb0335","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1477-5956-8-38","article-title":"Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia\/reperfusion injury","volume":"8","author":"Folmes","year":"2010","journal-title":"Proteome Sci."},{"key":"10.1016\/j.bbadis.2025.167908_bb0340","series-title":"Encyclopedia of Biol. Chem","first-page":"611","article-title":"Pyruvate dehydrogenase","author":"Johnson","year":"2004"},{"key":"10.1016\/j.bbadis.2025.167908_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105399","article-title":"Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and \u03b1-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress","volume":"299","author":"Chalifoux","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167908_bb0350","article-title":"Inhibition of pyruvate dehydrogenase in the heart as an initiating event in the development of diabetic cardiomyopathy","volume":"12","author":"Elnwasany","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2025.167908_bb0355","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/2394-8108.186256","article-title":"Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury","volume":"2","author":"Thibodeau","year":"2016","journal-title":"Brain Circ"},{"key":"10.1016\/j.bbadis.2025.167908_bb0360","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-7236-1751-8.50013-2","article-title":"Enzymes","author":"Cole","year":"1988","journal-title":"Biochemistry and Oral Biology"},{"key":"10.1016\/j.bbadis.2025.167908_bb0365","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/abbi.1996.0560","article-title":"Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase","volume":"336","author":"Tabatabaie","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.167908_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111754","article-title":"Function of intramitochondrial melatonin and its association with Warburg metabolism","volume":"131","author":"Reiter","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbadis.2025.167908_bb0375","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-079X.1993.tb00498.x","article-title":"Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis","volume":"14","author":"Poeggeler","year":"1993","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0380","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-079X.2002.01107.x","article-title":"Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage","volume":"33","author":"Bandyopadhyay","year":"2002","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbadis.2025.167908_bb0385","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-079X.2000.290303.x","article-title":"Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical","volume":"29","author":"Bandyopadhyay","year":"2000","journal-title":"J. Pineal Res."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392500256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092544392500256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:19Z","timestamp":1762324039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092544392500256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S092544392500256X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167908","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible role of the mitochondrial pyruvate dehydrogenase in ketorolac mediated onset and progression of gastric ulcers in male Wistar rats: Protection by melatonin","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167908","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167908"}}