{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:34:20Z","timestamp":1793381660009,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2023M151"],"award-info":[{"award-number":["WJ2023M151"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170418"],"award-info":[{"award-number":["82170418"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070372"],"award-info":[{"award-number":["82070372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271618"],"award-info":[{"award-number":["82271618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2022BGE237"],"award-info":[{"award-number":["2022BGE237"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023BCB139"],"award-info":[{"award-number":["2023BCB139"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2022CFA015"],"award-info":[{"award-number":["2022CFA015"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbadis.2025.167959","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T11:06:55Z","timestamp":1750504015000},"page":"167959","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["LILRB4 exacerbates myocardial ischemia-reperfusion injury by promoting inflammation and pyroptosis"],"prefix":"10.1016","volume":"1871","author":[{"given":"Jian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.167959_bb0005","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1038\/s41467-020-18165-6","article-title":"Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy","volume":"11","author":"Luczak","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.167959_bb0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jjcc.2022.07.003","article-title":"Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond","volume":"81","author":"Saito","year":"2023","journal-title":"J. Cardiol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154681","article-title":"Ginsenoside Re attenuates myocardial ischemia\/reperfusion induced ferroptosis via miR-144-3p\/SLC7A11","volume":"113","author":"Ye","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2025.167959_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101884","article-title":"Research progress on the effects of novel hypoglycemic drugs in diabetes combined with myocardial ischemia\/reperfusion injury","volume":"86","author":"Yang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbadis.2025.167959_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2018.09.086","article-title":"Multitarget strategies to reduce myocardial ischemia\/reperfusion injury: JACC review topic of the week","volume":"73","author":"Davidson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0030","article-title":"Regulated cell death in myocardial ischemia-reperfusion injury","author":"Xiang","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2025.167959_bb0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.apsb.2022.08.007","article-title":"Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: cumulative evidence for future cardioprotective strategies","volume":"13","author":"Yanpiset","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbadis.2025.167959_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1093\/cvr\/cvt091","article-title":"The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury","volume":"99","author":"Sandanger","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2025.167959_bb0045","article-title":"Inhibition of GSDMD activates poly(ADP-ribosyl)ation and promotes myocardial ischemia-reperfusion injury","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.167959_bb0050","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.18632\/aging.103215","article-title":"Salidroside ameliorates Parkinson\u2019s disease by inhibiting NLRP3-dependent pyroptosis","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbadis.2025.167959_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101534","article-title":"Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway","volume":"32","author":"Jia","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0060","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00395-014-0415-z","article-title":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia\/reperfusion injury","volume":"109","author":"Liu","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0065","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1111\/jcmm.12618","article-title":"Functions of Shp2 in cancer","volume":"19","author":"Zhang","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.167959_bb0070","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1038\/s41467-018-05768-3","article-title":"The tyrosine phosphatase SHP2 controls TGFbeta-induced STAT3 signaling to regulate fibroblast activation and fibrosis","volume":"9","author":"Zehender","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.167959_bb0075","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.devcel.2010.03.009","article-title":"Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis","volume":"18","author":"Stewart","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbadis.2025.167959_bb0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/MOH.0000000000000345","article-title":"Role of SHP2 in hematopoiesis and leukemogenesis","volume":"24","author":"Pandey","year":"2017","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20150830","article-title":"Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP","volume":"473","author":"Liu","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbadis.2025.167959_bb0090","first-page":"3149","article-title":"LILRB4, from the immune system to the disease target","volume":"12","author":"Liu","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbadis.2025.167959_bb0095","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00262-017-2023-x","article-title":"LILRB receptor-mediated regulation of myeloid cell maturation and function","volume":"66","author":"van der Touw","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbadis.2025.167959_bb0100","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1074\/jbc.273.2.1070","article-title":"Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene","volume":"273","author":"Kuroiwa","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167959_bb0105","doi-asserted-by":"crossref","first-page":"34839","DOI":"10.1074\/jbc.M109.035683","article-title":"Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases","volume":"284","author":"Lu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.167959_bb0110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00109-020-01896-w","article-title":"Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-kappaB pathway","volume":"98","author":"Zhou","year":"2020","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.bbadis.2025.167959_bb0115","article-title":"Downregulated microRNA-327 attenuates oxidative stress-mediated myocardial ischemia reperfusion injury through regulating the FGF10\/Akt\/Nrf2 signaling pathway","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143221","article-title":"Rapid and efficient production of coronary artery ligation and myocardial infarction in mice using surgical clips","volume":"10","author":"Andrade","year":"2015","journal-title":"PLoS One"},{"issue":"2018","key":"10.1016\/j.bbadis.2025.167959_bb0125","first-page":"119","volume":"39","author":"Ibanez","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbadis.2025.167959_bb0130","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury","volume":"123","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2025.167959_bb0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jacbts.2021.07.001","article-title":"Clec4e-receptor signaling in myocardial repair after ischemia-reperfusion injury","volume":"6","author":"Veltman","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.bbadis.2025.167959_bb0140","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1089\/ars.2016.6940","article-title":"Lymphocyte communication in myocardial ischemia\/reperfusion injury","volume":"26","author":"Boag","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2025.167959_bb0145","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"Myocardial ischemia-reperfusion injury and the influence of inflammation","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2025.167959_bb0150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12964-022-01022-y","article-title":"NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis","volume":"21","author":"Sun","year":"2023","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.bbadis.2025.167959_bb0155","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00011-021-01530-6","article-title":"Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia\/reperfusion injury","volume":"71","author":"Chen","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbadis.2025.167959_bb0160","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13046-024-03110-y","article-title":"LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2\/NF-kappaB\/RELT signal pathway","volume":"43","author":"Wang","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbadis.2025.167959_bb0165","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00109-020-01896-w","article-title":"Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-kappaB pathway","volume":"98","author":"Zhou","year":"2020","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.bbadis.2025.167959_bb0170","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCULATIONAHA.107.728865","article-title":"Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase\/mitogen-activated protein kinase and RhoA signaling pathways","volume":"117","author":"Kontaridis","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2025.167959_bb0175","doi-asserted-by":"crossref","first-page":"15564","DOI":"10.1038\/s41598-024-66482-3","article-title":"LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2\/STAT3 signaling pathway","volume":"14","author":"Xiong","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.167959_bb0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41586-018-0615-z","article-title":"LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration","volume":"562","author":"Deng","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.167959_bb0185","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-6143.2005.01162.x","article-title":"Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells","volume":"6","author":"Kim-Schulze","year":"2006","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbadis.2025.167959_bb0190","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13071-023-05856-4","article-title":"LILRB4 regulates the function of decidual MDSCs via the SHP-2\/STAT6 pathway during Toxoplasma gondii infection","volume":"16","author":"Li","year":"2023","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.bbadis.2025.167959_bb0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/path.5177","article-title":"The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration","volume":"247","author":"Gagne-Sansfacon","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2025.167959_bb0200","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2019.03.034","article-title":"Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis","volume":"42","author":"Heun","year":"2019","journal-title":"Ebiomedicine"},{"key":"10.1016\/j.bbadis.2025.167959_bb0205","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/CIRCULATIONAHA.107.728865","article-title":"Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase\/mitogen-activated protein kinase and RhoA signaling pathways","volume":"117","author":"Kontaridis","year":"2008","journal-title":"Circulation"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925003072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925003072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:48:48Z","timestamp":1788295728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925003072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0925443925003072"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167959","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LILRB4 exacerbates myocardial ischemia-reperfusion injury by promoting inflammation and pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.167959","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"167959"}}