{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:17:38Z","timestamp":1783336658914,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K11444"],"award-info":[{"award-number":["24K11444"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H04030"],"award-info":[{"award-number":["19H04030"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbadis.2025.168008","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:14:01Z","timestamp":1754428441000},"page":"168008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ectopic laminin \u03b12 accumulation in the glomerular basement membrane exacerbates podocyte injury in Alport syndrome"],"prefix":"10.1016","volume":"1871","author":[{"given":"Kozue","family":"Uchio-Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Oh-Hashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.168008_bb0005","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1681\/ASN.2008101086","article-title":"Cellular origins of type IV collagen networks in developing glomeruli","volume":"20","author":"Abrahamson","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0010","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1083\/jcb.127.3.879","article-title":"Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches","volume":"127","author":"Miner","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0015","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.137.3.685","article-title":"The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform","volume":"137","author":"Miner","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0020","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1369\/0022155413501677","article-title":"Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes","volume":"61","author":"Abrahamson","year":"2013","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbadis.2025.168008_bb0025","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41581-020-0329-y","article-title":"Complexities of the glomerular basement membrane","volume":"17","author":"Naylor","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0030","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/ng0895-400","article-title":"The renal glomerulus of mice lacking s-laminin\/laminin \u03b22: nephrosis despite molecular compensation by laminin \u03b21","volume":"10","author":"Noakes","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2025.168008_bb0035","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1006\/dbio.1999.9546","article-title":"Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane","volume":"217","author":"Miner","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0040","doi-asserted-by":"crossref","first-page":"e01149","DOI":"10.7554\/eLife.01149","article-title":"Nanoscale protein architecture of the kidney glomerular basement membrane","volume":"2","author":"Suleiman","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.bbadis.2025.168008_bb0045","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1242\/dev.01037","article-title":"Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development","volume":"131","author":"P\u00f6schl","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.bbadis.2025.168008_bb0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fendo.2014.00160","article-title":"The importance of podocyte adhesion for a healthy glomerulus","volume":"5","author":"Lennon","year":"2014","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.168008_bb0055","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nrneph.2012.291","article-title":"Cell-matrix adhesion of podocytes in physiology and disease","volume":"9","author":"Sachs","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0060","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1242\/dev.122.11.3537","article-title":"\u03b13\u03b21 integrin has a crucial role in kidney and lung organogenesis","volume":"122","author":"Kreidberg","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.bbadis.2025.168008_bb0065","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI69778","article-title":"Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance","volume":"124","author":"Tian","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.168008_bb0070","doi-asserted-by":"crossref","first-page":"F1520","DOI":"10.1152\/ajprenal.00055.2020","article-title":"Tensin2 is important for podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier","volume":"318","author":"Uchio-Yamada","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0075","doi-asserted-by":"crossref","first-page":"F124","DOI":"10.1152\/ajprenal.00192.2022","article-title":"Abnormal glomerular basement membrane maturation impairs mesangial cell differentiation during murine postnatal nephrogenesis","volume":"324","author":"Uchio-Yamada","year":"2023","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0080","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2353\/ajpath.2008.071149","article-title":"Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane","volume":"173","author":"Baleato","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0085","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1056\/NEJMra022296","article-title":"Alport's syndrome, Goodpasture's syndrome, and type IV collagen","volume":"348","author":"Hudson","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbadis.2025.168008_bb0090","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1083\/jcb.135.5.1403","article-title":"Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome","volume":"135","author":"Miner","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0095","doi-asserted-by":"crossref","DOI":"10.1101\/gad.10.23.2981","article-title":"Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome","volume":"10","author":"Cosgrove","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbadis.2025.168008_bb0100","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ki.2009.324","article-title":"Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease","volume":"76","author":"Meehan","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2025.168008_bb0105","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1172\/JCI119431","article-title":"Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis","volume":"99","author":"Kalluri","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.168008_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099083","article-title":"Laminin \u03b12-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis","volume":"9","author":"Delimont","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.168008_bb0115","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1681\/ASN.V122252","article-title":"Abnormal glomerular basement membrane laminins in murine, canine, and human Alport syndrome: aberrant laminin alpha2 deposition is species independent","volume":"12","author":"Kashtan","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0120","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1046\/j.1523-1755.2003.00800.x","article-title":"Laminin-1 reexpression in Alport mouse glomerular basement membranes","volume":"63","author":"Abrahamson","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2025.168008_bb0125","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1681\/ASN.2007030328","article-title":"Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects","volume":"18","author":"Abrahamson","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0130","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/ndt\/15.12.1956","article-title":"Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis","volume":"15","author":"Fischer","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbadis.2025.168008_bb0135","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000045294","article-title":"Abnormal distribution of mesangium-specific laminin in glomeruli of patients with idiopathic membranous nephropathy","volume":"81","author":"Horikoshi","year":"1999","journal-title":"Nephron"},{"key":"10.1016\/j.bbadis.2025.168008_bb0140","doi-asserted-by":"crossref","first-page":"F1101","DOI":"10.1152\/ajprenal.00020.2017","article-title":"Accumulation of worn-out GBM material substantially contributes to mesangial matrix expansion in diabetic nephropathy","volume":"312","author":"Kriz","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10157-014-1008-8","article-title":"Glomerular basement membrane injuries in IgA nephropathy evaluated by double immunostaining for \u03b15(IV) and \u03b12(IV) chains of type IV collagen and low-vacuum scanning electron microscopy","volume":"19","author":"Masuda","year":"2015","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142755","article-title":"Simple genome editing of rodent intact embryos by electroporation","volume":"10","author":"Kaneko","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.168008_bb0155","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0002-9440(10)64239-3","article-title":"A new method for large scale isolation of kidney glomeruli from mice","volume":"161","author":"Takemoto","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0160","article-title":"A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168008_bb0165","first-page":"C397","article-title":"Biophysical properties of normal and diseased renal glomeruli","volume":"300","author":"Wyss","year":"2011","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.bbadis.2025.168008_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167924","article-title":"Biochemical and cellular determinants of renal glomerular elasticity","volume":"11","author":"Embry","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.168008_bb0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/path.1711100306","article-title":"The origin, turnover and removal of glomerular basement membrane","volume":"110","author":"Walker","year":"1973","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0180","doi-asserted-by":"crossref","first-page":"35068","DOI":"10.1038\/srep35068","article-title":"Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury","volume":"6","author":"Randles","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168008_bb0185","series-title":"Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition of Laminin in Mammals, bioRxiv [Preprint]","author":"Omachi","year":"2025"},{"key":"10.1016\/j.bbadis.2025.168008_bb0190","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.matbio.2020.02.005","article-title":"Basement membrane ligands initiate distinct signalling networks to direct cell shape","volume":"90","author":"Randles","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0195","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.kint.2017.05.017","article-title":"Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport syndrome","volume":"92","author":"Ding","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2025.168008_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155255","article-title":"Podocyte depletion in thin GBM and Alport syndrome","volume":"11","author":"Wickman","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.168008_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148906","article-title":"Integrin ligation results in Nephrin tyrosine phosphorylation in vitro","volume":"11","author":"Verma","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2025.168008_bb0210","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1681\/ASN.2018040362","article-title":"Nephrin signaling results in integrin beta1 activation","volume":"30","author":"Dlugos","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0215","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/nep.12028","article-title":"When birth comes early: effects on nephrogenesis","volume":"(Carlton)18","author":"Black","year":"2013","journal-title":"Nephrology"},{"key":"10.1016\/j.bbadis.2025.168008_bb0220","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s004670050048","article-title":"The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy","volume":"14","author":"T\u00f3th-Heyn","year":"2000","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0225","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1113\/jphysiol.2014.274449","article-title":"Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment","volume":"592","author":"Savige","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0230","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/path.6231","article-title":"Ramipril therapy in integrin alpha1-null, autosomal recessive Alport mice triples lifespan: mechanistic clues from RNA-seq analysis","volume":"262","author":"Madison","year":"2024","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168008_bb0235","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1046\/j.1523-1755.2003.00779.x","article-title":"Preemptive ramipril therapy delays renal failure and reduces renal fibrosis in COL4A3-knockout mice with Alport syndrome","volume":"63","author":"Gross","year":"2003","journal-title":"Kidney Int."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925003564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925003564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:31:13Z","timestamp":1761993073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925003564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0925443925003564"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168008","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ectopic laminin \u03b12 accumulation in the glomerular basement membrane exacerbates podocyte injury in Alport syndrome","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168008"}}