{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:26Z","timestamp":1791276746980,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018609","name":"High-level Hospital Construction Project of Guangdong Provincial People's Hospital","doi-asserted-by":"publisher","award":["DFJH201901"],"award-info":[{"award-number":["DFJH201901"]}],"id":[{"id":"10.13039\/501100018609","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570474"],"award-info":[{"award-number":["82570474"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870508"],"award-info":[{"award-number":["81870508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170415"],"award-info":[{"award-number":["82170415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017291","name":"Zhongshan Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022B1094"],"award-info":[{"award-number":["2022B1094"]}],"id":[{"id":"10.13039\/501100017291","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020745","name":"Department of Finance of Guangdong Province","doi-asserted-by":"publisher","award":["KS012023323"],"award-info":[{"award-number":["KS012023323"]}],"id":[{"id":"10.13039\/100020745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202102020406"],"award-info":[{"award-number":["202102020406"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515010024"],"award-info":[{"award-number":["2023A1515010024"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515012374"],"award-info":[{"award-number":["2022A1515012374"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bbadis.2025.168061","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:25:49Z","timestamp":1758947149000},"page":"168061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanical stress accelerates vascular calcification by Piezo1\/BMP2 of vascular smooth muscle cells"],"prefix":"10.1016","volume":"1872","author":[{"given":"Bohou","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibao","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.168061_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121148","article-title":"Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications","volume":"311","author":"Kaur","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0010","article-title":"Pathophysiology and Clinical impacts of chronic kidney disease on coronary artery calcification","volume":"10","author":"Dai","year":"2023","journal-title":"J Cardiovasc Dev Dis"},{"key":"10.1016\/j.bbadis.2025.168061_bb0015","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.kint.2016.09.024","article-title":"Vascular calcification in chronic kidney disease: different bricks in the wall?","volume":"91","author":"Vervloet","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbadis.2025.168061_bb0020","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2025.168061_bb0025","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1002\/jcp.31021","article-title":"Vascular calcification in CKD: new insights into its mechanisms","volume":"238","author":"Ding","year":"2023","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ajpath.2020.10.012","article-title":"Lack of endothelial nitric oxide synthase accelerates ectopic calcification in uremic mice fed an adenine and high phosphorus diet","volume":"191","author":"Oe","year":"2021","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0035","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101064RR","article-title":"Mechanical and chemical cues synergistically promote human venous smooth muscle cell osteogenesis through integrin beta1-ERK1\/2 signaling: a cell model of hemodialysis fistula calcification","volume":"35","author":"Yang","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.bbadis.2025.168061_bb0040","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.clinthera.2023.10.004","article-title":"Connecting the dots: how injury in the Arterial Wall contributes to atherosclerotic disease","volume":"45","author":"Belhoul-Fakir","year":"2023","journal-title":"Clin. Ther."},{"key":"10.1016\/j.bbadis.2025.168061_bb0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.yjmcc.2020.11.017","article-title":"Inhibition of endoplasmic reticulum stress mediates the ameliorative effect of apelin on vascular calcification","volume":"152","author":"Li","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0050","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.mcna.2023.03.003","article-title":"Overview of, and preparations for, Dialysis","volume":"107","author":"Gondal","year":"2023","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.bbadis.2025.168061_bb0055","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2019.12.001","article-title":"KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update","volume":"75","author":"Lok","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbadis.2025.168061_bb0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40885-023-00258-1","article-title":"Arterial stiffness and hypertension","volume":"29","author":"Kim","year":"2023","journal-title":"Clin Hypertens"},{"key":"10.1016\/j.bbadis.2025.168061_bb0065","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s11255-017-1515-0","article-title":"Calcification in arteriovenous fistula blood vessels may predict arteriovenous fistula failure: a 5-year follow-up study","volume":"49","author":"Jankovic","year":"2017","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0070","article-title":"Mechanisms of PIEZO Channel inactivation","volume":"24","author":"Zhou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajh\/hpz158","article-title":"Mechanotransduction and uterine blood flow in preeclampsia: the role of Mechanosensing Piezo 1 ion channels","volume":"33","author":"Arishe","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.bbadis.2025.168061_bb0080","article-title":"Piezo1 channels as force sensors in mechanical force-related chronic inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116502","article-title":"Piezo1 and its inhibitors: overview and perspectives","volume":"273","author":"Thien","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbadis.2025.168061_bb0090","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1016\/j.gendis.2022.08.015","article-title":"The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation","volume":"10","author":"Huang","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.bbadis.2025.168061_bb0095","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ydbio.2022.11.002","article-title":"The role of mechanosensor Piezo1 in bone homeostasis and mechanobiology","volume":"493","author":"Wang","year":"2023","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0100","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/s41467-022-30618-8","article-title":"Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth","volume":"13","author":"Dzamukova","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.168061_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.887253","article-title":"Vascular calcification: new insights into BMP type I receptor a","volume":"13","author":"Niu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1037230","article-title":"The mechanosensitive Piezo1 channels contribute to the arterial medial calcification","volume":"13","author":"Szabo","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0115","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1021\/acs.biomac.3c01045","article-title":"Stiffness and BMP-2 mimetic peptide jointly regulate the osteogenic differentiation of rat bone marrow stromal cells in a gelatin Cryogel","volume":"25","author":"Li","year":"2024","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.bbadis.2025.168061_bb0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cytogfr.2015.11.006","article-title":"BMPs in bone regeneration: less is more effective, a paradigm-shift","volume":"27","author":"Schmidt-Bleek","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbadis.2025.168061_bb0125","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyad200","article-title":"Bone morphogenetic protein signaling: the pathway and its regulation","volume":"226","author":"Akiyama","year":"2024","journal-title":"Genetics"},{"key":"10.1016\/j.bbadis.2025.168061_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115542","article-title":"The role of bone morphogenetic protein signaling in vascular calcification","volume":"141","author":"Yang","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bbadis.2025.168061_bb0135","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s42003-024-06753-x","article-title":"Temporal regulation of BMP2 growth factor signaling in response to mechanical loading is linked to cytoskeletal and focal adhesion remodeling","volume":"7","author":"Gorlitz","year":"2024","journal-title":"Commun Biol"},{"issue":"683","key":"10.1016\/j.bbadis.2025.168061_bb0140","article-title":"MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6","volume":"10","author":"Peng","year":"2022","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.bbadis.2025.168061_bb0145","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jvs.2005.08.008","article-title":"Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy","volume":"43","author":"Hsieh","year":"2006","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.bbadis.2025.168061_bb0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41526-024-00380-w","article-title":"Spaceflight effects on human vascular smooth muscle cell phenotype and function","volume":"10","author":"Scotti","year":"2024","journal-title":"Npj Microgravity"},{"key":"10.1016\/j.bbadis.2025.168061_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105963","article-title":"The role of the Piezo1 channel in osteoblasts under cyclic stretching: a study on osteogenic and osteoclast factors","volume":"163","author":"Kang","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0160","article-title":"Magnetic nanobubble mechanical stress induces the Piezo1-ca(2+) -BMP2\/Smad pathway to modulate neural stem cell fate and MRI\/ultrasound dual imaging surveillance for ischemic stroke","volume":"18","author":"Li","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.bbadis.2025.168061_bb0165","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2020.01.012","article-title":"High hydrostatic pressure induces atrial electrical remodeling through angiotensin upregulation mediating FAK\/Src pathway activation","volume":"140","author":"Li","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.842885","article-title":"Piezo1 participated in decreased L-type calcium current induced by high hydrostatic pressure via. CaM\/Src\/Pitx2 activation in atrial myocytes","volume":"9","author":"Fang","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.bbadis.2025.168061_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10102491","article-title":"Vascular calcification: in vitro models under the magnifying glass","volume":"10","author":"Ceccherini","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbadis.2025.168061_bb0180","article-title":"Mechanisms of the osteogenic switch of smooth muscle cells in vascular calcification: WNT signaling, BMPs, Mechanotransduction, and EndMT","volume":"7","author":"Tyson","year":"2020","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0185","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nrneph.2017.60","article-title":"Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD","volume":"13","author":"Haarhaus","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0190","doi-asserted-by":"crossref","first-page":"19660","DOI":"10.1002\/jcb.29272","article-title":"The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: an in vivo and in vitro analysis","volume":"120","author":"Yan","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbadis.2025.168061_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2021.151847","article-title":"Effects of mechanosensitive ion channel Piezo1 on proliferation and osteogenic differentiation of human dental follicle cells","volume":"239","author":"Xing","year":"2022","journal-title":"Ann. Anat."},{"key":"10.1016\/j.bbadis.2025.168061_bb0200","doi-asserted-by":"crossref","first-page":"L737","DOI":"10.1152\/ajplung.00447.2021","article-title":"Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation","volume":"322","author":"Chen","year":"2022","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0205","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2174\/1574888X14666190628103528","article-title":"Application of cytokines of the bone morphogenetic protein (BMP) family in spinal fusion - effects on the bone, intervertebral disc and mesenchymal stromal cells","volume":"14","author":"May","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bbadis.2025.168061_bb0210","doi-asserted-by":"crossref","first-page":"17696","DOI":"10.1038\/s41598-017-18089-0","article-title":"Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells","volume":"7","author":"Sugimoto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168061_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.918056","article-title":"Endoplasmic reticulum stress and pathogenesis of vascular calcification","volume":"9","author":"Rao","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.bbadis.2025.168061_bb0220","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/FJC.0000000000001303","article-title":"The ameliorative effect of Berberine on vascular calcification by inhibiting endoplasmic reticulum stress","volume":"80","author":"Li","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0225","doi-asserted-by":"crossref","first-page":"H1302","DOI":"10.1152\/ajpheart.00305.2020","article-title":"Oxidative stress by ca(2+) overload is critical for phosphate-induced vascular calcification","volume":"319","author":"Nguyen","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0230","article-title":"The role of ultrasound examination in the assessment of suitability of calcified arteries for vascular access creation-Mini review","volume":"13","author":"Gubensek","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0235","article-title":"Progression of vascular calcification and Clinical outcomes in patients receiving maintenance Dialysis","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbadis.2025.168061_bb0240","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s12933-024-02318-8","article-title":"Association of diabetes with cardiovascular calcification and all-cause mortality in end-stage renal disease in the early stages of hemodialysis: a retrospective cohort study","volume":"23","author":"Li","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0245","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jacc.2012.03.060","article-title":"High-density lipoprotein cholesterol and particle concentrations, carotid atherosclerosis, and coronary events: MESA (multi-ethnic study of atherosclerosis)","volume":"60","author":"Mackey","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13030457","article-title":"Atherosclerosis calcification: focus on lipoproteins","volume":"13","author":"Neels","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbadis.2025.168061_bb0255","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2147\/DMSO.S438618","article-title":"Similarities and differences of vascular calcification in diabetes and chronic kidney disease","volume":"17","author":"Wang","year":"2024","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.bbadis.2025.168061_bb0260","article-title":"Progression of vascular calcification and Clinical outcomes in patients receiving maintenance Dialysis","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbadis.2025.168061_bb0265","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2368091","article-title":"Association of plasma microRNA-16-5p and abdominal aortic calcification in maintenance hemodialysis patients","volume":"46","author":"Liang","year":"2024","journal-title":"Ren. Fail."},{"key":"10.1016\/j.bbadis.2025.168061_bb0270","article-title":"Increased serum soluble PD-l1 levels in patients with advanced stages of chronic kidney disease","volume":"12","author":"Hayashi","year":"2025","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0275","first-page":"807","article-title":"Dialysis vintage stratified comparison of body composition, hydration and nutritional state in peritoneal dialysis and hemodialysis patients","volume":"14","author":"Hoppe","year":"2018","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0280","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/CS20190895","article-title":"Inflammation: a putative link between phosphate metabolism and cardiovascular disease","volume":"135","author":"Voelkl","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107819","article-title":"Nutritional assessment of older adults with diabetes mellitus","volume":"155","author":"Saintrain","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.bbadis.2025.168061_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1120308","article-title":"Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone-vascular paradox, a therapeutic target, and a biomarker","volume":"14","author":"Williams","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0295","article-title":"Vascular Calcification Heterogeneity from Bench to Bedside: Implications for Manifestations, Pathogenesis, and Treatment Considerations","author":"Lu","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.bbadis.2025.168061_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413536","article-title":"Vascular calcification: key roles of phosphate and pyrophosphate","volume":"22","author":"Villa-Bellosta","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252313096","article-title":"Understanding vascular calcification in chronic kidney disease: pathogenesis and therapeutic implications","volume":"25","author":"Siracusa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0310","article-title":"Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)","volume":"8","author":"Ruospo","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbadis.2025.168061_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113283","article-title":"Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1alpha and SOD2","volume":"153","author":"Byun","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2025.168061_bb0320","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00844-2023","article-title":"RUNX2 is stabilised by TAZ and drives pulmonary artery calcification and lung vascular remodelling in pulmonary hypertension due to left heart disease","volume":"64","author":"Liu","year":"2024","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbadis.2025.168061_bb0325","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbrc.2022.11.060","article-title":"Piezo1 in endothelial cells is involved in vitamin D-induced vascular calcification","volume":"638","author":"Liu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2025.168061_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27175430","article-title":"Piezo1 Mechano-activation is augmented by resveratrol and differs between colorectal Cancer cells of primary and metastatic origin","volume":"27","author":"Greenlee","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbadis.2025.168061_bb0335","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbadis.2025.168061_bb0340","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vph.2016.04.005","article-title":"A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification","volume":"86","author":"Zhu","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2022.100122","article-title":"Extracellular matrix profiling and disease modelling in engineered vascular smooth muscle cell tissues","volume":"16","author":"Reed","year":"2022","journal-title":"Matrix Biol Plus"},{"key":"10.1016\/j.bbadis.2025.168061_bb0350","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3389\/fendo.2020.00369","article-title":"An investigation into the role of osteocalcin in human arterial smooth muscle cell calcification","volume":"11","author":"Millar","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s10020-020-00212-z","article-title":"Deficiency in Aim2 affects viability and calcification of vascular smooth muscle cells from murine aortas and angiotensin-II induced aortic aneurysms","volume":"26","author":"Wortmann","year":"2020","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbadis.2025.168061_bb0360","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.70036","article-title":"Piezo1 is related to the enamel matrix formation in mouse tooth germ development","volume":"240","author":"Wada","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0365","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/1759-7714.15278","article-title":"PIEZO1 acts as a cancer suppressor by regulating the ROS\/Wnt\/beta-catenin axis","volume":"15","author":"Bo","year":"2024","journal-title":"Thorac. Cancer"},{"key":"10.1016\/j.bbadis.2025.168061_bb0370","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231835","article-title":"Piezo1 channels restrain ILC2s and regulate the development of airway hyperreactivity","volume":"221","author":"Hurrell","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbadis.2025.168061_bb0375","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.18063","article-title":"Key regulators of vascular calcification in chronic kidney disease: hyperphosphatemia, BMP2, and RUNX2","volume":"12","author":"Liang","year":"2024","journal-title":"Peerj"},{"key":"10.1016\/j.bbadis.2025.168061_bb0380","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2023.09.040","article-title":"Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin","volume":"62","author":"Gan","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbadis.2025.168061_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12711","article-title":"Inhibition of lysine-specific demethylase 1A suppresses neointimal hyperplasia by targeting bone morphogenetic protein 2 and mediating vascular smooth muscle cell phenotype","volume":"53","author":"Zhang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbadis.2025.168061_bb0390","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.7150\/ijbs.70247","article-title":"Compensatory roles of protein related to DAN and Cerberus (PRDC) decrease in pulmonary arterial hypertension","volume":"18","author":"He","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2025.168061_bb0395","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.acthis.2019.02.002","article-title":"Influence of mechanical fluid shear stress on the osteogenic differentiation protocols for equine adipose tissue-derived mesenchymal stem cells","volume":"121","author":"Elashry","year":"2019","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbadis.2025.168061_bb0400","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/bpa.12721","article-title":"Osteopontin and phospho-SMAD2\/3 are associated with calcification of vessels in D-CAA, an hereditary cerebral amyloid angiopathy","volume":"29","author":"Grand","year":"2019","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0405","doi-asserted-by":"crossref","first-page":"494","DOI":"10.24976\/Discov.Med.202436182.46","article-title":"Mechanical stretch-induced ATP release from osteocytes promotes osteogenesis of bone marrow mesenchymal stem cells","volume":"36","author":"Ru","year":"2024","journal-title":"Discov. Med."},{"key":"10.1016\/j.bbadis.2025.168061_bb0410","article-title":"Oxidative stress related to Plasmalemmal and mitochondrial phosphate transporters in vascular calcification","volume":"11","author":"Nguyen","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbadis.2025.168061_bb0415","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1161\/HYPERTENSIONAHA.120.16629","article-title":"Upregulation of Piezo1 (Piezo type mechanosensitive Ion Channel component 1) enhances the intracellular free calcium in pulmonary arterial smooth muscle cells from idiopathic pulmonary arterial hypertension patients","volume":"77","author":"Liao","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2025.168061_bb0420","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1111\/bph.16294","article-title":"Piezo1-mediated regulation of smooth muscle cell volume in response to enhanced extracellular matrix rigidity","volume":"181","author":"Johnson","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0425","article-title":"Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1\/endoplasmic reticulum stress pathway","volume":"28","author":"Wang","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.168061_bb0430","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00775-013-1078-1","article-title":"Selenium suppresses oxidative-stress-enhanced vascular smooth muscle cell calcification by inhibiting the activation of the PI3K\/AKT and ERK signaling pathways and endoplasmic reticulum stress","volume":"19","author":"Liu","year":"2014","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.bbadis.2025.168061_bb0435","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/ATVBAHA.120.315506","article-title":"Endoplasmic reticulum stress mediates vascular smooth muscle cell calcification via increased release of Grp78 (glucose-regulated protein, 78 kDa)-loaded extracellular vesicles","volume":"41","author":"Furmanik","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbadis.2025.168061_bb0440","article-title":"Mechanosensitive Ion Channel Piezo1 activated by matrix stiffness regulates oxidative stress-induced senescence and apoptosis in human intervertebral disc degeneration","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.168061_bb0445","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1161\/hy1101.092840","article-title":"Cyclic strain increases protease-activated receptor-1 expression in vascular smooth muscle cells","volume":"38","author":"Nguyen","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2025.168061_bb0450","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jcb.22465","article-title":"Cyclic strain modulates migration and proliferation of vascular smooth muscle cells via rho-GDIalpha, Rac1, and p38 pathway","volume":"109","author":"Qi","year":"2010","journal-title":"J. Cell. Biochem."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:37:12Z","timestamp":1777585032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925004090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":90,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0925443925004090"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168061","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanical stress accelerates vascular calcification by Piezo1\/BMP2 of vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168061"}}