{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:15:46Z","timestamp":1791389746680,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbadis.2025.168121","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:22:34Z","timestamp":1764001354000},"page":"168121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["NR5A2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting MMP25 transcription"],"prefix":"10.1016","volume":"1872","author":[{"given":"Xiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei min","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.168121_bb0005","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1152\/physrev.00027.2022","article-title":"Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis","volume":"103","author":"N\u00f8rregaard","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2025.168121_bb0010","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.168121_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.678524","article-title":"The genomic response to TGF-\u03b21 dictates failed repair and progression of fibrotic disease in the obstructed kidney","volume":"9","author":"Higgins","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0020","article-title":"Epithelial-mesenchymal plasticity in kidney fibrosis","volume":"62","author":"Hadpech","year":"2000","journal-title":"Genesis (New York, N.Y)"},{"key":"10.1016\/j.bbadis.2025.168121_bb0025","article-title":"TGF-\u03b2\/Smad signaling pathway in tubulointerstitial fibrosis","volume":"13","author":"Yu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0030","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41581-020-00343-w","article-title":"WNT-\u03b2-catenin signalling - a versatile player in kidney injury and repair","volume":"17","author":"Schunk","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0035","article-title":"Confrontation with kidney inflammation through a HMGB1-targeted peptide augments anti-fibrosis therapy","volume":"1871","author":"Deng","year":"2025","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.168121_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010137","article-title":"Kidney fibrosis and oxidative stress: from molecular pathways to new pharmacological opportunities","volume":"14","author":"Patera","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2025.168121_bb0045","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1681\/ASN.0000000000000141","article-title":"Unbiased human kidney tissue proteomics identifies matrix metalloproteinase 7 as a kidney disease biomarker","volume":"34","author":"Hirohama","year":"2023","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117824","article-title":"Cornus officinalis var. koreana Kitam extracts alleviate cadmium-induced renal fibrosis by targeting matrix metallopeptidase 9","volume":"325","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0055","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1023\/A:1012213604731","article-title":"Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion","volume":"53","author":"Fillmore","year":"2001","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168121_bb0065","article-title":"A prognostic model based on clusters of molecules related to epithelial-mesenchymal transition for idiopathic pulmonary fibrosis","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbadis.2025.168121_bb0070","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.abn7478","article-title":"Zygotic genome activation by the totipotency pioneer factor Nr5a2","volume":"378","author":"Gassler","year":"2022","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbadis.2025.168121_bb0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41420-021-00462-8","article-title":"NR5A2 transcriptional activation by BRD4 promotes pancreatic cancer progression by upregulating GDF15","volume":"7","author":"Guo","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.168121_bb0080","article-title":"Identification of stemness-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma by integrated bioinformatics analysis","volume":"9","author":"Guo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0085","first-page":"2016","article-title":"Nuclear receptor NR5A2 is involved in the calreticulin gene regulation during renal fibrosis","volume":"1774-1785","author":"Arvaniti","year":"1862","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.168121_bb0090","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1124\/mol.114.095554","article-title":"Antiproliferation activity of a small molecule repressor of liver receptor homolog 1","volume":"87","author":"Corzo","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0095","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1440-1797.2012.01567.x","article-title":"Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney","volume":"17","author":"Abraham","year":"2012","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.bbadis.2025.168121_bb0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jso.24639","article-title":"NR5A2 discovering compounds that block tumor growth in PDAC","volume":"116","author":"Fletterick","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2011.12.017","article-title":"Therapeutic potential of liver receptor homolog-1 modulators","volume":"130","author":"Lazarus","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0110","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3389\/fphys.2019.01549","article-title":"Lower Nr5a2 level downregulates the \u03b2-catenin and TCF-4 expression in caerulein-induced pancreatic inflammation","volume":"10","author":"Sun","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814019","article-title":"Pathway from acute kidney injury to chronic kidney disease: molecules involved in renal fibrosis","volume":"24","author":"Niculae","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168121_bb0120","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.stem.2025.07.014","article-title":"Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease","volume":"32","author":"Zhao","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbadis.2025.168121_bb0125","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.ajpath.2023.07.005","article-title":"Renal fibrosis is alleviated through targeted inhibition of IL-11-induced renal tubular epithelial-to-mesenchymal transition","volume":"193","author":"Li","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0130","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2025.168121_bb0135","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbadis.2025.168121_bb0140","article-title":"Curcumin ameliorates glyoxylate-induced calcium oxalate deposition and renal injuries in mice","volume":"61","author":"Li","year":"2019","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bbadis.2025.168121_bb0145","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/mc.22604","article-title":"Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers","volume":"56","author":"Luo","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbadis.2025.168121_bb0150","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/iub.2386","article-title":"Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer","volume":"73","author":"Michalek","year":"2021","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbadis.2025.168121_bb0155","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/s41380-023-01981-9","article-title":"Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia","volume":"28","author":"Zapata","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbadis.2025.168121_bb0160","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/15384047.2015.1045693","article-title":"Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer","volume":"16","author":"Nadolny","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.bbadis.2025.168121_bb0165","first-page":"276","article-title":"WNT signaling and the regulation of ovarian steroidogenesis","volume":"3","author":"Lapointe","year":"2011","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"10.1016\/j.bbadis.2025.168121_bb0170","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1095\/biolreprod.106.059121","article-title":"Impaired progesterone production in Nr5a2+\/\u2212 mice leads to a reduction in female reproductive function","volume":"77","author":"Labelle-Dumais","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbadis.2025.168121_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113513","article-title":"Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death","volume":"42","author":"Lambrecht","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbadis.2025.168121_bb0180","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167903","article-title":"Cannabinoid enhancement of lncRNA MMP25-AS1\/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV\/SIV infection","volume":"8","author":"Premadasa","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbadis.2025.168121_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12967-023-04052-3","article-title":"Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma","volume":"21","author":"Liu","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbadis.2025.168121_bb0190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.canlet.2019.03.023","article-title":"Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8\/A9 binding in the original skin lesion","volume":"452","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbadis.2025.168121_bb0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-213X-10-93","article-title":"Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-\u03b23","volume":"10","author":"Brown","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.bbadis.2025.168121_bb0200","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1111\/bph.15193","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"177","author":"Percie du Sert","year":"2020","journal-title":"Br. J. Pharmacol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:27:19Z","timestamp":1769506039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925004715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0925443925004715"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168121","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NR5A2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting MMP25 transcription","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"168121"}}