{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:08:11Z","timestamp":1778555291818,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,18]],"date-time":"2026-12-18T00:00:00Z","timestamp":1797552000000},"content-version":"am","delay-in-days":292,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["935207"],"award-info":[{"award-number":["935207"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL156594"],"award-info":[{"award-number":["R01HL156594"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001340","name":"W W Smith Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HL176747"],"award-info":[{"award-number":["R01HL176747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R00 HL138268"],"award-info":[{"award-number":["R00 HL138268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","award":["1 S10 OD026980\\u201301"],"award-info":[{"award-number":["1 S10 OD026980\\u201301"]}],"id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbadis.2025.168130","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:27:50Z","timestamp":1765499270000},"page":"168130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lactate-induced mitochondrial magnesium uptake and its metabolic implications in the McArdle disease model"],"prefix":"10.1016","volume":"1872","author":[{"given":"Thiruvelselvan","family":"Ponnusamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haris","family":"Waseem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Assogba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha Parveen","family":"Sakkarai Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibani","family":"Kudchadkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Herold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalimuthusamy","family":"Natarajaseenivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santhanam","family":"Shanmughapriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.168130_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2024.108532","article-title":"Metabolic aspects of glycogenolysis with special attention to McArdle disease","volume":"142","author":"Stefanik","year":"2024","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbadis.2025.168130_bb0010","first-page":"35","article-title":"Muscle glycogenoses: an overview","volume":"26","author":"Di Mauro","year":"2007","journal-title":"Acta Myol"},{"key":"10.1016\/j.bbadis.2025.168130_bb0015","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archneur.59.9.1395","article-title":"Spontaneous \u201csecond wind\u201d and glucose-induced second \u201csecond wind\u201d in McArdle disease: oxidative mechanisms","volume":"59","author":"Haller","year":"2002","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0020","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1212\/01.wnl.0000343002.74480.e4","article-title":"Fat metabolism during exercise in patients with McArdle disease","volume":"72","author":"Orngreen","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2025.168130_bb0025","doi-asserted-by":"crossref","first-page":"E1096","DOI":"10.1210\/jc.2015-1339","article-title":"Lactate and energy Metabolism during exercise in patients with blocked Glycogenolysis (McArdle disease)","volume":"100","author":"Orngreen","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 2","key":"10.1016\/j.bbadis.2025.168130_bb0030","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1055\/s-2007-1024861","article-title":"Metabolism of branched-chain amino acids and ammonia during exercise: clues from McArdle\u2019s disease","volume":"11","author":"Wagenmakers","year":"1990","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.bbadis.2025.168130_bb0035","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0040","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168130_bb0045","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.molcel.2020.11.023","article-title":"O-Mg! Lactate drives Mg(2+) mobilization","volume":"80","author":"Wilde","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.168130_bb0050","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cell.2020.08.049","article-title":"Lactate elicits ER-mitochondrial Mg(2+) dynamics to integrate cellular Metabolism","volume":"183","author":"Daw","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.168130_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2011.05.010","article-title":"Cellular magnesium homeostasis","volume":"512","author":"Romani","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.168130_bb0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbamcr.2004.10.013","article-title":"Mitochondria are intracellular magnesium stores: investigation by simultaneous fluorescent imagings in PC12 cells","volume":"1744","author":"Kubota","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbadis.2025.168130_bb0065","first-page":"225","article-title":"Concentration, compartmentation and metabolic function of intracellular free Mg2+","volume":"19","author":"Gunther","year":"2006","journal-title":"Magnes. Res."},{"key":"10.1016\/j.bbadis.2025.168130_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6797460","article-title":"The involvement of Mg(2+) in regulation of cellular and mitochondrial functions","volume":"2017","author":"Pilchova","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.bbadis.2025.168130_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/srep30027","article-title":"Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress","volume":"6","author":"Yamanaka","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168130_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mito.2024.101877","article-title":"Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial ca(2+) uptake and viability","volume":"76","author":"Ponnusamy","year":"2024","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbadis.2025.168130_bb0085","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1016022730880","article-title":"Structural and catalytic chemistry of magnesium-dependent enzymes","volume":"15","author":"Cowan","year":"2002","journal-title":"Biometals"},{"key":"10.1016\/j.bbadis.2025.168130_bb0090","doi-asserted-by":"crossref","first-page":"28853","DOI":"10.1074\/jbc.274.41.28853","article-title":"Chemical mechanism of ATP synthase. Magnesium plays a pivotal role in formation of the transition state where ATP is synthesized from ADP and inorganic phosphate","volume":"274","author":"Ko","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.168130_bb0095","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/emboj\/cdg122","article-title":"Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria","volume":"22","author":"Kolisek","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.bbadis.2025.168130_bb0100","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1039\/c3mt20201a","article-title":"The G-M-N motif determines ion selectivity in the yeast magnesium channel Mrs2p","volume":"5","author":"Sponder","year":"2013","journal-title":"Metallomics"},{"key":"10.1016\/j.bbadis.2025.168130_bb0105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0110","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1113\/JP286488","article-title":"Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions","volume":"603","author":"Ducrocq","year":"2024","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5690345","article-title":"Skeletal muscle resident progenitor cells Coexpress mesenchymal and myogenic markers and are not affected by chronic heart failure-induced dysregulations","volume":"2019","author":"Dmitrieva","year":"2019","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.bbadis.2025.168130_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169150","article-title":"Cultured myoblasts derived from rat soleus muscle show altered regulation of proliferation and Myogenesis during the course of mechanical unloading","volume":"23","author":"Komarova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168130_bb0125","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1249\/MSS.0000000000000513","article-title":"Caffeine\u2019s ergogenic effects on cycling: neuromuscular and perceptual factors","volume":"47","author":"Black","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.bbadis.2025.168130_bb0130","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0003-9861(88)90010-0","article-title":"Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds","volume":"267","author":"Rousseau","year":"1988","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.168130_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molcel.2015.08.009","article-title":"SPG7 is an essential and conserved component of the mitochondrial permeability transition pore","volume":"60","author":"Shanmughapriya","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.168130_bb0140","doi-asserted-by":"crossref","first-page":"ra23","DOI":"10.1126\/scisignal.2005673","article-title":"Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU","volume":"8","author":"Shanmughapriya","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbadis.2025.168130_bb0145","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1038\/s41598-022-12222-4","article-title":"Influence of caffeine on the maximal isometric and concentric force produced by skinned fibers","volume":"12","author":"Fukutani","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168130_bb0150","doi-asserted-by":"crossref","first-page":"C246","DOI":"10.1152\/ajpcell.00269.2018","article-title":"Toxic doses of caffeine are needed to increase skeletal muscle contractility","volume":"316","author":"Neyroud","year":"2019","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0155","doi-asserted-by":"crossref","first-page":"8317","DOI":"10.1038\/srep08317","article-title":"Optogenetic induction of contractile ability in immature C2C12 myotubes","volume":"5","author":"Asano","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168130_bb0160","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/ijms16011066","article-title":"Ca2+\u2212dependent regulations and signaling in skeletal muscle: from electro-mechanical coupling to adaptation","volume":"16","author":"Gehlert","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168130_bb0165","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jtcme.2021.05.003","article-title":"Preventing c2c12 muscular cells damage combining magnesium and potassium with vitamin D3 and curcumin","volume":"11","author":"Molinari","year":"2021","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.bbadis.2025.168130_bb0170","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate metabolism in human lung tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbadis.2025.168130_bb0175","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1113\/JP280955","article-title":"Lactate in contemporary biology: a phoenix risen","volume":"600","author":"Brooks","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0180","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41574-022-00724-0","article-title":"Lactate as a major myokine and exerkine","volume":"18","author":"Brooks","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbadis.2025.168130_bb0185","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1152\/japplphysiol.00497.2022","article-title":"Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism","volume":"134","author":"Brooks","year":"2023","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.bbadis.2025.168130_bb0190","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1093\/nar\/gks066","article-title":"Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression","volume":"40","author":"Latham","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbadis.2025.168130_bb0195","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168130_bb0200","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1073\/pnas.93.10.4953","article-title":"Role of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase","volume":"93","author":"Yan","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbadis.2025.168130_bb0205","series-title":"Cochrane Database Syst. Rev.","article-title":"Pharmacological and nutritional treatment for McArdle\u2019s disease (glycogen storage disease type V)","author":"Quinlivan","year":"2004"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:10:26Z","timestamp":1778551826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925004806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0925443925004806"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168130","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactate-induced mitochondrial magnesium uptake and its metabolic implications in the McArdle disease model","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168130"}}