{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:27:21Z","timestamp":1769556441292,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773965"],"award-info":[{"award-number":["81773965"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873064"],"award-info":[{"award-number":["81873064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274167"],"award-info":[{"award-number":["82274167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbadis.2025.168133","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:15:36Z","timestamp":1765296936000},"page":"168133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperthermia induces reductive stress in murine macrophages"],"prefix":"10.1016","volume":"1872","author":[{"given":"Rong","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-wen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-hai","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-wen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-jian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-hui","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-bing","family":"Zha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-yun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2025.168133_bb0005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/CCM.0000000000006170","article-title":"Management of Heat-Related Illness and Injury in the ICU: a concise definitive review","volume":"52","author":"Barletta","year":"2024","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0010","doi-asserted-by":"crossref","first-page":"112s","DOI":"10.1177\/10806032241227924","article-title":"Wilderness medical society clinical practice guidelines for the prevention and treatment of heat illness: 2024 update","volume":"35","author":"Eifling","year":"2024","journal-title":"Wilderness Environ. Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0015","doi-asserted-by":"crossref","first-page":"e490","DOI":"10.1097\/CCM.0000000000006551","article-title":"Society of Critical Care Medicine guidelines for the treatment of heat stroke","volume":"53","author":"Barletta","year":"2025","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0020","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00484-022-02351-w","article-title":"Effect of heat stress on DNA damage: a systematic literature review","volume":"66","author":"Habibi","year":"2022","journal-title":"Int. J. Biometeorol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0025","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/s41467-024-45466-x","article-title":"NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress","volume":"15","author":"Han","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.168133_bb0030","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1126\/science.abg5251","article-title":"Z-DNA binding protein 1 promotes heatstroke-induced cell death","volume":"376","author":"Yuan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbadis.2025.168133_bb0035","doi-asserted-by":"crossref","DOI":"10.3724\/abbs.2025173","article-title":"Reductive stress in cancer immunology and targeted therapy","author":"Ji","year":"2025","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.bbadis.2025.168133_bb0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2016.09.011","article-title":"Thioredoxin and redox signaling: roles of the thioredoxin system in control of cell fate","volume":"617","author":"Matsuzawa","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbadis.2025.168133_bb0045","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0050","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s41390-024-03370-6","article-title":"Thioredoxin: an antioxidant, a therapeutic target and a possible biomarker","volume":"96","author":"Sudhadevi","year":"2024","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbadis.2025.168133_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41392-024-02095-6","article-title":"Redox regulation: mechanisms, biology and therapeutic targets in diseases","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2025.168133_bb0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.apsb.2020.07.014","article-title":"Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling","volume":"11","author":"Ye","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbadis.2025.168133_bb0065","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41423-022-00891-0","article-title":"Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis","volume":"19","author":"Zeng","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/srep04469","article-title":"Heat stress induces apoptosis through transcription-independent p53-mediated mitochondrial pathways in human umbilical vein endothelial cell","volume":"4","author":"Gu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2025.168133_bb0075","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41420-024-02210-0","article-title":"The mechanisms behind heatstroke-induced intestinal damage","volume":"10","author":"Sun","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbadis.2025.168133_bb0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.freeradbiomed.2023.12.029","article-title":"Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked","volume":"212","author":"Xu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0085","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41419-024-07015-8","article-title":"Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis","volume":"15","author":"Tang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2025.168133_bb0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molcel.2009.10.011","article-title":"Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis","volume":"36","author":"Autret","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbadis.2025.168133_bb0095","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1089\/ars.2019.7803","article-title":"Metabolic responses to reductive stress","volume":"32","author":"Xiao","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2025.168133_bb0100","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/15230860260196209","article-title":"Redox control of cell death","volume":"4","author":"Ueda","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2025.168133_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/toxsci\/kfh050","article-title":"Thioredoxin and its role in toxicology","volume":"78","author":"Watson","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbadis.2025.168133_bb0110","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/s41467-019-10807-8","article-title":"A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbadis.2025.168133_bb0115","article-title":"Protocol for assaying irreversible inhibitors of thioredoxin reductase 1","volume":"5","author":"Sun","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbadis.2025.168133_bb0120","doi-asserted-by":"crossref","first-page":"15058","DOI":"10.1074\/jbc.M601968200","article-title":"Thioredoxin is required for deoxyribonucleotide pool maintenance during S phase","volume":"281","author":"Koc","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2025.168133_bb0125","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168133_bb0130","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/02656736.2014.971446","article-title":"Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review","volume":"30","author":"Slimen","year":"2014","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.bbadis.2025.168133_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156747","article-title":"Hesperidin mitigated deoxynivalenol-induced liver injury by inhibiting ROS\/ P53\/ PGC-1\u03b1-mediated disruption of mitochondrial dynamics and PANoptosis","volume":"142","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbadis.2025.168133_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112710","article-title":"Scutellarin inhibits inflammatory PANoptosis by diminishing mitochondrial ROS generation and blocking PANoptosome formation","volume":"139","author":"Yuan","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Suppl. 2","key":"10.1016\/j.bbadis.2025.168133_bb0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1463-1326.2010.01266.x","article-title":"Redox compartmentalization and cellular stress","volume":"12","author":"Jones","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbadis.2025.168133_bb0150","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000519784","article-title":"The pentose phosphate pathway in Cancer: regulation and therapeutic opportunities","volume":"66","author":"Ghanem","year":"2021","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bbadis.2025.168133_bb0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jas\/skx083","article-title":"Short-term heat stress altered metabolism and insulin signaling in skeletal muscle","volume":"96","author":"Ganesan","year":"2018","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.bbadis.2025.168133_bb0160","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111680","article-title":"Extracellular ATP contributes to the reactive oxygen species burst and exaggerated mitochondrial damage in D-galactosamine and lipopolysaccharide-induced fulminant hepatitis","volume":"130","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108609","article-title":"Mitochondrial trafficking of MLKL, Bak\/Bax, and Drp1 is mediated by RIP1 and ROS which leads to decreased mitochondrial membrane integrity during the hyperglycemic shift to necroptosis","volume":"24","author":"Deragon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2025.168133_bb0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168133_bb0180","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41401-023-01182-8","article-title":"Blocking reverse electron transfer-mediated mitochondrial DNA oxidation rescues cells from PANoptosis","volume":"45","author":"Shi","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbadis.2025.168133_bb0185","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/CIRCRESAHA.111.247932","article-title":"Regulation of cell survival and death by pyridine nucleotides","volume":"111","author":"Oka","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2025.168133_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101084","article-title":"ROS and the DNA damage response in cancer","volume":"25","author":"Srinivas","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0195","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1038\/onc.2014.155","article-title":"Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies","volume":"34","author":"Aye","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.bbadis.2025.168133_bb0200","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/s41556-024-01463-2","article-title":"Full-length GSDME mediates pyroptosis independent from cleavage","volume":"26","author":"Zhou","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0205","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.freeradbiomed.2008.07.018","article-title":"DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae","volume":"45","author":"Rowe","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbadis.2025.168133_bb0210","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41586-024-07265-8","article-title":"Necroptosis blockade prevents lung injury in severe influenza","volume":"628","author":"Gautam","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbadis.2025.168133_bb0215","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1007\/s13277-015-4621-6","article-title":"RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma","volume":"37","author":"Das","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0220","first-page":"65","article-title":"Pyroptosis in antiviral immunity","volume":"442","author":"Kuriakose","year":"2023","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbadis.2025.168133_bb0225","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41586-020-2129-8","article-title":"Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation","volume":"580","author":"Jiao","year":"2020","journal-title":"Nature"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:27:55Z","timestamp":1769506075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925004831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0925443925004831"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168133","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperthermia induces reductive stress in murine macrophages","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168133"}}