{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:42:48Z","timestamp":1786984968743,"version":"build-2736575974"},"reference-count":116,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500596"],"award-info":[{"award-number":["82500596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbadis.2025.168136","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T07:58:13Z","timestamp":1765526293000},"page":"168136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The role of AP-1 in distinct cardiac cell types: Pathological repair and maladaptive remodeling"],"prefix":"10.1016","volume":"1872","author":[{"given":"Shengnan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 25","key":"10.1016\/j.bbadis.2025.168136_bb0005","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: quarrel and harmony among siblings","volume":"117","author":"Hess","year":"2004","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.bbadis.2025.168136_bb0010","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"2\u20133","key":"10.1016\/j.bbadis.2025.168136_bb0015","first-page":"129","article-title":"The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation","volume":"1072","author":"Angel","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.bbadis.2025.168136_bb0020","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"Pt 24","key":"10.1016\/j.bbadis.2025.168136_bb0025","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1242\/jcs.00812","article-title":"Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells","volume":"116","author":"Vial","year":"2003","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1365-2443.2003.00631.x","article-title":"Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway","volume":"8","author":"Terasawa","year":"2003","journal-title":"Genes Cells"},{"issue":"33","key":"10.1016\/j.bbadis.2025.168136_bb0035","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1038\/onc.2010.211","article-title":"Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein","volume":"29","author":"Talotta","year":"2010","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbcan.2019.04.003","article-title":"The AP-1 transcriptional complex: local switch or remote command?","volume":"1872","author":"Bejjani","year":"2019","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.bbadis.2025.168136_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1224892","article-title":"The potential of activator protein 1 (AP-1) in cancer targeted therapy","volume":"14","author":"Song","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0050","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s42003-023-04534-6","article-title":"The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions","volume":"6","author":"Stellato","year":"2023","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41392-020-0114-1","article-title":"SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation","volume":"5","author":"Palomer","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bbadis.2025.168136_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110408","article-title":"Ginsenoside Rg5 alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the JNK\/AP-1 pathway","volume":"120","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s13105-021-00812-1","article-title":"Mir-137 regulates low-intensity shear stress-induced human aortic endothelial cell apoptosis via JNK\/AP-1 signaling","volume":"77","author":"Li","year":"2021","journal-title":"J. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.trsl.2008.11.004","article-title":"Transcription factor decoys for activator protein-1 (AP-1) inhibit oxidative stress-induced proliferation and matrix metalloproteinases in rat cardiac fibroblasts","volume":"153","author":"Xie","year":"2009","journal-title":"Transl. Res."},{"key":"10.1016\/j.bbadis.2025.168136_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102020","article-title":"Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1\/IL-11 signaling","volume":"44","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.bbadis.2025.168136_bb0080","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/CIRCRESAHA.119.316167","article-title":"AP-1 contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during zebrafish heart regeneration","volume":"126","author":"Beisaw","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0085","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/cvr\/cvt094","article-title":"Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction","volume":"99","author":"Hill","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10856-024-06854-3","article-title":"Degraded products generated by iron stent inhibit the vascular smooth muscle cell proliferation by downregulating AP-1","volume":"36","author":"Huang","year":"2025","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0095","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/cvr\/cvac088","article-title":"AP-1 activation mediates post-natal cardiomyocyte maturation","volume":"119","author":"Zhang","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.bbadis.2025.168136_bb0100","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s13238-022-00908-4","article-title":"Postnatal state transition of cardiomyocyte as a primary step in heart maturation","volume":"13","author":"Li","year":"2022","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1073\/pnas.85.2.339","article-title":"Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload","volume":"85","author":"Izumo","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"23","key":"10.1016\/j.bbadis.2025.168136_bb0110","doi-asserted-by":"crossref","first-page":"13809","DOI":"10.1016\/S0021-9258(18)77420-6","article-title":"Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. Fos\/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response","volume":"265","author":"Iwaki","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0115","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cvr\/cvw228","article-title":"ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance","volume":"113","author":"Kalfon","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbadis.2025.168136_bb0120","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/scitranslmed.aaw6419","article-title":"Control of cytokinesis by \u03b2-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment","volume":"11","author":"Liu","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073294","article-title":"The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart","volume":"8","author":"Windak","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cardiores.2006.02.032","article-title":"JunD attenuates phenylephrine-mediated cardiomyocyte hypertrophy by negatively regulating AP-1 transcriptional activity","volume":"71","author":"Hilfiker-Kleiner","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0135","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/jmcc.2000.1324","article-title":"Hypertrophy-associated gene induction after beta-adrenergic stimulation in adult cardiomyocytes","volume":"33","author":"Taimor","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0140","doi-asserted-by":"crossref","first-page":"H2369","DOI":"10.1152\/ajpheart.00741.2003","article-title":"Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes","volume":"286","author":"Taimor","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cardiores.2005.02.021","article-title":"SMAD proteins are involved in apoptosis induction in ventricular cardiomyocytes","volume":"67","author":"Schneiders","year":"2005","journal-title":"Cardiovasc. Res."},{"issue":"15","key":"10.1016\/j.bbadis.2025.168136_bb0150","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1007\/s00018-021-03883-x","article-title":"AP-1 activity is a major barrier of human somatic cell reprogramming","volume":"78","author":"Liu","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0155","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/jcp.21805","article-title":"SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes","volume":"220","author":"Heger","year":"2009","journal-title":"J. Cell. Physiol."},{"issue":"13","key":"10.1016\/j.bbadis.2025.168136_bb0160","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1096\/fj.01-0353fje","article-title":"Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes","volume":"15","author":"Taimor","year":"2001","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0165","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1159\/000430180","article-title":"RP105 protects against apoptosis in ischemia\/reperfusion-induced myocardial damage in rats by suppressing TLR4-mediated signaling pathways","volume":"36","author":"Yang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"10","key":"10.1016\/j.bbadis.2025.168136_bb0170","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/CIRCULATIONAHA.118.038944","article-title":"Conserved NPPB+ border zone switches from MEF2- to AP-1-driven gene program","volume":"140","author":"van Duijvenboden","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2025.168136_bb0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/cells11244060","article-title":"Vascular smooth muscle cells phenotypic switching in cardiovascular diseases","volume":"11","author":"Tang","year":"2022","journal-title":"Cells"},{"issue":"14","key":"10.1016\/j.bbadis.2025.168136_bb0180","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.120.046528","article-title":"Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue","volume":"142","author":"Li","year":"2020","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41421-021-00362-2","article-title":"Single-cell RNA sequencing identifies an Il1rn(+)\/Trem1(+) macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Discov."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13073-019-0635-9","article-title":"TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression","volume":"11","author":"Zhao","year":"2019","journal-title":"Genome Med"},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0195","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/eurheartj\/ehad534","article-title":"The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture","volume":"45","author":"Luo","year":"2024","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0200","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/CS20110234","article-title":"Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study","volume":"122","author":"Meijer","year":"2012","journal-title":"Clin. Sci. (Lond.)"},{"issue":"5","key":"10.1016\/j.bbadis.2025.168136_bb0205","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/ars.2009.2854","article-title":"Age-related changes in redox signaling and VSMC function","volume":"12","author":"Li","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0210","article-title":"Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis","volume":"11","author":"Li","year":"2024","journal-title":"Genes Dis"},{"key":"10.1016\/j.bbadis.2025.168136_bb0215","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2015.05.006","article-title":"Mechanical stretch enhances the expression and activity of osteopontin and MMP-2 via the Akt1\/AP-1 pathways in VSMC","volume":"85","author":"Seo","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0220","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/emm.2005.31","article-title":"Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells","volume":"37","author":"Hong","year":"2005","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0225","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jdermsci.2016.09.015","article-title":"The skin aging exposome","volume":"85","author":"Krutmann","year":"2017","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0230","doi-asserted-by":"crossref","first-page":"50","DOI":"10.31083\/j.fbl2702050","article-title":"Identification of biomarkers and regulatory networks for cartilage damage patients","volume":"27","author":"Liu","year":"2022","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0235","first-page":"2542","article-title":"Identification of COL1A1 as an invasion-related gene in malignant astrocytoma","volume":"53","author":"Sun","year":"2018","journal-title":"Int. J. Oncol."},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0240","first-page":"287","article-title":"Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins","volume":"14","author":"Kucukguven","year":"2013","journal-title":"Curr. Drug Targets"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0245","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s004240000253","article-title":"Rapid gene transcription induced by stretch in cardiac myocytes and fibroblasts and their paracrine influence on stationary myocytes and fibroblasts","volume":"439","author":"van Wamel","year":"2000","journal-title":"Pflugers Arch."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0250","doi-asserted-by":"crossref","first-page":"H2211","DOI":"10.1152\/ajpheart.00056.2021","article-title":"Regenerative cross talk between cardiac cells and macrophages","volume":"320","author":"Whitehead","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0255","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.anes.0000365960.74268.21","article-title":"Propofol depresses angiotensin II-induced cell proliferation in rat cardiac fibroblasts","volume":"112","author":"Cheng","year":"2010","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.bbadis.2025.168136_bb0260","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"Sadoshima","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbadis.2025.168136_bb0265","article-title":"Activating protein-1 (AP-1): a promising target for the treatment of fibrotic diseases","author":"Pi","year":"2023","journal-title":"Curr. Med. Chem."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0270","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jacbts.2020.07.009","article-title":"Blockade of fibroblast YAP attenuates cardiac fibrosis and dysfunction through MRTF-A inhibition","volume":"5","author":"Francisco","year":"2020","journal-title":"JACC Basic Transl Sci"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0275","doi-asserted-by":"crossref","first-page":"H3356","DOI":"10.1152\/ajpheart.00928.2007","article-title":"IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1\/2-dependent C\/EBP-beta, NF-kappaB, and AP-1 activation","volume":"293","author":"Cortez","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.bbadis.2025.168136_bb0280","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.cellsig.2013.07.013","article-title":"TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation","volume":"25","author":"Valente","year":"2013","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226053","article-title":"The association between microRNA-21 and hypertension-induced cardiac remodeling","volume":"15","author":"Watanabe","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0290","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/cvr\/cvw030","article-title":"Mir-21 promotes fibrosis in an acute cardiac allograft transplantation model","volume":"110","author":"Gupta","year":"2016","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0295","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/01.RES.84.9.1073","article-title":"Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-beta synthesis via transcriptional and posttranscriptional mechanisms","volume":"84","author":"Moriguchi","year":"1999","journal-title":"Circ. Res."},{"issue":"3\u20134","key":"10.1016\/j.bbadis.2025.168136_bb0300","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1357-2725(98)00125-3","article-title":"Angiotensin II and extracellular matrix homeostasis","volume":"31","author":"Weber","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0305","article-title":"Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor \u03b2-independent mechanism","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbadis.2025.168136_bb0310","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/CIRCULATIONAHA.112.094524","article-title":"Microrna-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene\/transforming growth factor-\u03b21 pathway","volume":"126","author":"Pan","year":"2012","journal-title":"Circulation"},{"issue":"23","key":"10.1016\/j.bbadis.2025.168136_bb0315","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261152","article-title":"AP-1 signaling modulates cardiac fibroblast stress responses","volume":"136","author":"Whitehead","year":"2023","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0320","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41551-018-0344-5","article-title":"Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes","volume":"3","author":"Kumar","year":"2019","journal-title":"Nat Biomed Eng"},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0325","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1080\/15592294.2021.1982158","article-title":"The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarction","volume":"17","author":"Li","year":"2022","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbadis.2025.168136_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1022627","article-title":"Exploring the \u201cgene-protein-metabolite\u201d network of coronary heart disease with phlegm and blood stasis syndrome by integrated multi-omics strategy","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbadis.2025.168136_bb0335","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk4694","article-title":"Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells","volume":"10","author":"Dong","year":"2024","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.bbadis.2025.168136_bb0340","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.7150\/ijbs.28103","article-title":"Cardiac fibrosis: new insights into the pathogenesis","volume":"14","author":"Ma","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbadis.2025.168136_bb0345","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mvr.2016.02.004","article-title":"AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation","volume":"105","author":"Jia","year":"2016","journal-title":"Microvasc. Res."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062804","article-title":"Emerging role of AP-1 transcription factor JunB in angiogenesis and vascular development","volume":"22","author":"Yoshitomi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"33","key":"10.1016\/j.bbadis.2025.168136_bb0355","doi-asserted-by":"crossref","first-page":"53269","DOI":"10.18632\/oncotarget.10756","article-title":"The mTOR\/AP-1\/VEGF signaling pathway regulates vascular endothelial cell growth","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0360","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cell.2004.08.025","article-title":"JunD reduces tumor angiogenesis by protecting cells from oxidative stress","volume":"118","author":"Gerald","year":"2004","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.bbadis.2025.168136_bb0365","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCULATIONAHA.104.518472","article-title":"Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart","volume":"112","author":"Hilfiker-Kleiner","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbadis.2025.168136_bb0370","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yjmcc.2014.09.027","article-title":"Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells","volume":"77","author":"Qin","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0375","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.2337\/db23-0167","article-title":"The role of Activator Protein-1 complex in diabetes-associated atherosclerosis: insights from single-cell RNA sequencing","volume":"73","author":"Khan","year":"2024","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0380","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/10641963.2015.1131285","article-title":"The association between oxidative stress, activator protein-1, inflammatory, total antioxidant status and artery stiffness and the efficacy of olmesartan in elderly patients with mild-to-moderate essential hypertension","volume":"38","author":"Liu","year":"2016","journal-title":"Clin. Exp. Hypertens."},{"issue":"38","key":"10.1016\/j.bbadis.2025.168136_bb0385","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022241","article-title":"Quercetin inhibits TNF-\u03b1 induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0390","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.3892\/mmr.2020.11548","article-title":"Monotropein alleviates H2O2-induced inflammation, oxidative stress and apoptosis via NF-\u03baB\/AP-1 signaling","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0395","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopha.2009.04.045","article-title":"JNK\/AP-1 pathway is involved in tumor necrosis factor-alpha induced expression of vascular endothelial growth factor in MCF7 cells","volume":"63","author":"Yin","year":"2009","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.bbadis.2025.168136_bb0400","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1172\/JCI96832","article-title":"Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis","volume":"129","author":"Hannemann","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbadis.2025.168136_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102397","article-title":"AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity","volume":"85","author":"Schnoegl","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbadis.2025.168136_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110587","article-title":"Temporary blockade of interferon-\u03b3 ameliorates doxorubicin-induced cardiotoxicity without influencing the anti-tumor effect","volume":"130","author":"Ma","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"16","key":"10.1016\/j.bbadis.2025.168136_bb0415","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1021\/jm5004733","article-title":"Small molecule inhibitors targeting activator protein 1 (AP-1)","volume":"57","author":"Ye","year":"2014","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0420","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/ATVBAHA.113.301453","article-title":"Transcriptional control of macrophage polarization","volume":"33","author":"Tugal","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0425","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00011-016-1017-z","article-title":"The TLR4-NOS1-AP1 signaling axis regulates macrophage polarization","volume":"66","author":"Srivastava","year":"2017","journal-title":"Inflamm. Res."},{"issue":"5","key":"10.1016\/j.bbadis.2025.168136_bb0430","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1159\/000354525","article-title":"IL-17A induces pro-inflammatory cytokines production in macrophages via MAPKinases, NF-\u03baB and AP-1","volume":"32","author":"Chen","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"24","key":"10.1016\/j.bbadis.2025.168136_bb0435","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027228","article-title":"Global characteristics and dynamics of single immune cells after myocardial infarction","volume":"11","author":"Zhuang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"8","key":"10.1016\/j.bbadis.2025.168136_bb0440","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/CIRCRESAHA.119.315807","article-title":"Lgr4 governs a pro-inflammatory program in macrophages to antagonize post-infarction cardiac repair","volume":"127","author":"Huang","year":"2020","journal-title":"Circ. Res."},{"issue":"16","key":"10.1016\/j.bbadis.2025.168136_bb0445","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.7150\/thno.118369","article-title":"Single-cell RNA sequencing reveals that myeloid S100A8\/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload","volume":"15","author":"Yu","year":"2025","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.bbadis.2025.168136_bb0450","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01853-20","article-title":"Trypanosoma cruzi induces the PARP1\/AP-1 pathway for upregulation of metalloproteinases and transforming growth factor \u03b2 in macrophages: role in cardiac fibroblast differentiation and fibrosis in chagas disease","volume":"11","author":"Choudhuri","year":"2020","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.bbadis.2025.168136_bb0455","first-page":"540","article-title":"FOS+ macrophages promote chronic rejection of cardiac transplantation","volume":"22","author":"Chen","year":"2024","journal-title":"Exp. Clin. Transplant."},{"key":"10.1016\/j.bbadis.2025.168136_bb0460","article-title":"Elucidating the changes in the heterogeneity and function of radiation-induced cardiac macrophages using single-cell RNA sequencing","volume":"15","author":"Cao","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bbadis.2025.168136_bb0465","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1111\/jcmm.13201","article-title":"MiR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1\/c-Fos pathway","volume":"21","author":"Zhu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.bbadis.2025.168136_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142299","article-title":"The c-Fos\/AP-1 inhibitor inhibits sulfur mustard-induced chondrogenesis impairment in zebrafish larvae","volume":"359","author":"Wang","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbadis.2025.168136_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.775464","article-title":"A pivotal role for AP-1-mediated osteopontin expression in the increased migration of vascular smooth muscle cells stimulated with HMGB1","volume":"12","author":"Jeon","year":"2021","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0480","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/eurheartj\/ehad679","article-title":"On target inhibition of vascular smooth muscle cell phenotypic transition underpins TNF-OXPHOS-AP-1 as a promising avenue for anti-remodelling interventions in aortic dissection and rupture","volume":"45","author":"Miteva","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbadis.2025.168136_bb0485","article-title":"HSPA12A stimulates p38\/ERK-AP-1 signaling to promote angiogenesis and is required for functional recovery postmyocardial infarction","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041861","article-title":"The AP-1 transcription factor Fosl-2 regulates autophagy in cardiac fibroblasts during myocardial fibrogenesis","volume":"22","author":"Seidenberg","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.bbadis.2025.168136_bb0495","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/CIRCRESAHA.122.321725","article-title":"Targeting wnt-\u00df-catenin-FOSL signaling ameliorates right ventricular remodeling","volume":"132","author":"Nayakanti","year":"2023","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.bbadis.2025.168136_bb0500","doi-asserted-by":"crossref","first-page":"8890","DOI":"10.1073\/pnas.88.20.8890","article-title":"Overexpression of c-jun, junB, or junD affects cell growth differently","volume":"88","author":"Castellazzi","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0505","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ng790","article-title":"JunB can substitute for Jun in mouse development and cell proliferation","volume":"30","author":"Passegu\u00e9","year":"2002","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0510","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/hy0102.100783","article-title":"Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine","volume":"39","author":"Omura","year":"2002","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0515","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tcm.2003.11.002","article-title":"Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies","volume":"14","author":"Petrich","year":"2004","journal-title":"Trends Cardiovasc. Med."},{"issue":"22","key":"10.1016\/j.bbadis.2025.168136_bb0520","doi-asserted-by":"crossref","first-page":"14057","DOI":"10.1074\/jbc.272.22.14057","article-title":"The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy","volume":"272","author":"Ramirez","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"Pt 2","key":"10.1016\/j.bbadis.2025.168136_bb0525","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj3580489","article-title":"c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes","volume":"358","author":"Finn","year":"2001","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.bbadis.2025.168136_bb0530","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0092-8674(00)81999-6","article-title":"C-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions","volume":"87","author":"Kallunki","year":"1996","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbadis.2025.168136_bb0535","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras","volume":"76","author":"Pfarr","year":"1994","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.bbadis.2025.168136_bb0540","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/sj.onc.1200901","article-title":"Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts","volume":"14","author":"Lallemand","year":"1997","journal-title":"Oncogene"},{"issue":"19","key":"10.1016\/j.bbadis.2025.168136_bb0545","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1038\/sj.onc.1204389","article-title":"AP-1 in mouse development and tumorigenesis","volume":"20","author":"Jochum","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.bbadis.2025.168136_bb0550","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/dev.127.1.143","article-title":"Targeted disruption of the murine junD gene results in multiple defects in male reproductive function","volume":"127","author":"Th\u00e9pot","year":"2000","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.bbadis.2025.168136_bb0555","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1101\/gad.327005","article-title":"Distinct functions of junD in cardiac hypertrophy and heart failure","volume":"19","author":"Ricci","year":"2005","journal-title":"Genes Dev."},{"issue":"7933","key":"10.1016\/j.bbadis.2025.168136_bb0560","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-05354-0","article-title":"Clathrin-associated AP-1 controls termination of STING signalling","volume":"610","author":"Liu","year":"2022","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bbadis.2025.168136_bb0565","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s13238-021-00894-z","article-title":"Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis","volume":"13","author":"Wang","year":"2022","journal-title":"Protein Cell"},{"issue":"10","key":"10.1016\/j.bbadis.2025.168136_bb0570","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/s41401-022-00885-8","article-title":"Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1\/MAPK signaling","volume":"43","author":"Lin","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"9","key":"10.1016\/j.bbadis.2025.168136_bb0575","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.7150\/ijms.74533","article-title":"Targeting IRE1\u03b1-JNK-c-Jun\/AP-1-sEH signaling pathway improves myocardial and coronary endothelial function following global myocardial ischemia\/reperfusion","volume":"19","author":"Xue","year":"2022","journal-title":"Int. J. Med. Sci."},{"issue":"15","key":"10.1016\/j.bbadis.2025.168136_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.05.048","article-title":"TERT activation targets DNA methylation and multiple aging hallmarks","volume":"187","author":"Shim","year":"2024","journal-title":"Cell"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443925004867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:30:47Z","timestamp":1769506247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443925004867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0925443925004867"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168136","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of AP-1 in distinct cardiac cell types: Pathological repair and maladaptive remodeling","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2025.168136","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168136"}}