{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:55:14Z","timestamp":1791060914950,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023 J05231"],"award-info":[{"award-number":["2023 J05231"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024 J011042"],"award-info":[{"award-number":["2024 J011042"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023 J011229"],"award-info":[{"award-number":["2023 J011229"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbadis.2026.168173","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T23:28:02Z","timestamp":1769470082000},"page":"168173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability"],"prefix":"10.1016","volume":"1872","author":[{"given":"Pengyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beihong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengmian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168173_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.001","article-title":"Metabolic dysfunction in polycystic ovary syndrome: pathogenic role of androgen excess and potential therapeutic strategies","volume":"35","author":"Sanchez-Garrido","year":"2020","journal-title":"Mol Metab"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12041454","article-title":"Polycystic ovary syndrome: etiology, current management, and future therapeutics","volume":"12","author":"Singh","year":"2023","journal-title":"J. Clin. Med."},{"issue":"8","key":"10.1016\/j.bbadis.2026.168173_bb0015","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1210\/js.2019-00078","article-title":"Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls","volume":"3","author":"Witchel","year":"2019","journal-title":"J Endocr Soc"},{"issue":"17","key":"10.1016\/j.bbadis.2026.168173_bb0020","doi-asserted-by":"crossref","first-page":"13123","DOI":"10.3390\/ijms241713123","article-title":"Mitochondrial dysfunction in PCOS: insights into reproductive organ pathophysiology","volume":"24","author":"Siemers","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168173_bb0025","article-title":"Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome","volume":"4","author":"Risal","year":"2023","journal-title":"Cell Rep Med"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0030","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41574-024-01057-w","article-title":"Polycystic ovary syndrome as a metabolic disease","volume":"21","author":"Helvaci","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3390\/endocrines5040040","article-title":"Granulosa cells: central regulators of female fertility","volume":"5","author":"Sch\u00fctz","year":"2024","journal-title":"Endocrines"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s13048-024-01484-3","article-title":"Granulosa cell insight: unraveling the potential of menstrual blood-derived stem cells and their exosomes on mitochondrial mechanisms in polycystic ovary syndrome (PCOS)","volume":"17","author":"Mansoori","year":"2024","journal-title":"J. Ovarian Res."},{"issue":"22","key":"10.1016\/j.bbadis.2026.168173_bb0045","doi-asserted-by":"crossref","first-page":"16247","DOI":"10.3390\/ijms242216247","article-title":"Essential role of granulosa cell glucose and lipid metabolism on oocytes and the potential metabolic imbalance in polycystic ovary syndrome","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168173_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107715","article-title":"Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers","volume":"220","author":"Saaoud","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0060","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ncrna.2023.12.005","article-title":"Circular RNA-mediated miRNA sponge & RNA binding protein in biological modulation of breast cancer","volume":"9","author":"Zhu","year":"2024","journal-title":"Noncoding RNA Res."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0065","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/s40001-024-02230-7","article-title":"Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology\/diseases","volume":"29","author":"Song","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"10","key":"10.1016\/j.bbadis.2026.168173_bb0070","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1002\/jcp.30376","article-title":"Circular RNAs: novel potential regulators in embryogenesis, female infertility, and pregnancy-related diseases","volume":"236","author":"Gao","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.bbadis.2026.168173_bb0075","doi-asserted-by":"crossref","first-page":"15537","DOI":"10.1002\/jcp.28201","article-title":"High throughput circRNAs sequencing profile of follicle fluid exosomes of polycystic ovary syndrome patients","volume":"234","author":"Wang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbadis.2026.168173_bb0080","first-page":"1","article-title":"Circ_0008927 promotes the progression of endometriosis via miR-608-\/PROM2-mediated Ferroptosis","volume":"23","author":"Shen","year":"2024","journal-title":"Gynecol. Obstet. Investig."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0085","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bbrc.2020.06.117","article-title":"Circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression","volume":"531","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbadis.2026.168173_bb0090","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.2147\/IJGM.S324126","article-title":"Identification of three potential circRNA biomarkers of polycystic ovary syndrome by bioinformatics analysis and validation","volume":"14","author":"Huang","year":"2021","journal-title":"Int J Gen Med"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0095","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.bbadis.2026.168173_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1071\/RD05051","article-title":"Purification of granulosa cells from human ovarian follicular fluid using granulosa cell aggregates","volume":"18","author":"Quinn","year":"2006","journal-title":"Reprod. Fertil. Dev."},{"issue":"13","key":"10.1016\/j.bbadis.2026.168173_bb0105","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE2 signaling cascade in inflammation: pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Mart\u00edn-V\u00e1zquez","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0110","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12974-020-1703-1","article-title":"Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception","volume":"17","author":"Jang","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0115","doi-asserted-by":"crossref","first-page":"bqab025","DOI":"10.1210\/endocr\/bqab025","article-title":"Prostaglandin-Endoperoxide synthase 2 (PTGS2) in the oviduct: roles in fertilization and early embryo development","volume":"162","author":"Anamthathmakula","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbadis.2026.168173_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.555414","article-title":"Molecules and prostaglandins related to embryo tolerance","volume":"11","author":"Mayoral Andrade","year":"2020","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.bbadis.2026.168173_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/biom14121533","article-title":"PTGS2\/GRP78 activation triggers endoplasmic reticulum stress leading to lipid metabolism disruption and cell apoptosis, exacerbating damage in bovine mastitis","volume":"14","author":"Chen","year":"2024","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.bbadis.2026.168173_bb0130","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/humrep\/deaa077","article-title":"Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK","volume":"35","author":"Jin","year":"2020","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0135","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqab025","article-title":"Prostaglandin-endoperoxide synthase 2 (PTGS2) in the oviduct: roles in fertilization and early embryo development","volume":"162","author":"Anamthathmakula","year":"2021","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.bbadis.2026.168173_bb0140","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.tem.2021.09.002","article-title":"Mechanisms of lipid metabolism in uterine receptivity and embryo development","volume":"32","author":"Ye","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2026.168173_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.animal.2023.100739","article-title":"Review: luteal prostaglandins: mechanisms regulating luteal survival and demise in ruminants","volume":"17","author":"Pate","year":"2023","journal-title":"Animal"},{"issue":"1","key":"10.1016\/j.bbadis.2026.168173_bb0150","doi-asserted-by":"crossref","first-page":"16596","DOI":"10.1038\/s41598-024-67461-4","article-title":"Transcriptome profiling reveals dysregulation of inflammatory and protein synthesis genes in PCOS","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbadis.2026.168173_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2022.100696","article-title":"LPS-induced PTGS2 manipulates the inflammatory response through trophoblast invasion in preeclampsia via NF-\u03baB pathway","volume":"22","author":"Li","year":"2022","journal-title":"Reprod. Biol."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:23:55Z","timestamp":1791059035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0925443926000219"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168173","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168173"}}