{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:54:42Z","timestamp":1791060882590,"version":"4.1.0"},"reference-count":183,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["MANF-2018-19-BIH-93364"],"award-info":[{"award-number":["MANF-2018-19-BIH-93364"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["SR\/FST\/LSII\/2020\/782"],"award-info":[{"award-number":["SR\/FST\/LSII\/2020\/782"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021772","name":"Deanship of Scientific Research, University of Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021772","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018968","name":"Jamia Millia Islamia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbadis.2026.168190","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T17:18:49Z","timestamp":1770657529000},"page":"168190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the intersection of Alzheimer's disease and comorbidities: a review of the interplay between multiple chronic conditions"],"prefix":"10.1016","volume":"1872","author":[{"given":"Sumaiya","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunidhi","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Imtaiyaz","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fareeda","family":"Athar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asimul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbadis.2026.168190_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173974","article-title":"Role of natural products for the treatment of Alzheimer\u2019s disease","volume":"898","author":"Noori","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0010","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3390\/biom12071001","article-title":"Comparison of tau and amyloid-β targeted immunotherapy nanoparticles for alzheimer’s disease","volume":"12","author":"Mashal","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2026.168190_bb0015","first-page":"132","article-title":"An investigation into Alzheimer's disease, its current treatments, biomarkers, and risk factors","volume":"12","author":"Srivastav","year":"2023","journal-title":"Int. J. Enhanc. Res. Sci. Technol. Eng."},{"key":"10.1016\/j.bbadis.2026.168190_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41419-025-08186-8","article-title":"Amyloid-\u03b2 and Tau in Alzheimer\u2019s disease: pathogenesis, mechanisms, and interplay","volume":"17","author":"Abdulkhaliq","year":"2026","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0025","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/ijms27020884","article-title":"Glial cells as key mediators in the pathophysiology of neurodegenerative diseases","volume":"27","author":"Bogus","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0030","series-title":"BIO Web of Conferences","first-page":"03001","article-title":"Analysis of genetic mechanisms, clinical characteristics and pathological changes in familial Alzheimer's disease and sporadic Alzheimer's disease","volume":"vol. 111","author":"Deng","year":"2024"},{"key":"10.1016\/j.bbadis.2026.168190_bb0035","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3390\/ijms25031757","article-title":"Presenilin: a multi-functional molecule in the pathogenesis of Alzheimer\u2019s disease and other neurodegenerative diseases","volume":"25","author":"Sun","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0040","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.3390\/ijms26157328","article-title":"Are hippocampal hypoperfusion and ATP depletion prime movers in the genesis of Alzheimer\u2019s disease? A review of recent pertinent observations from molecular biology","volume":"26","author":"Walker","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0045","series-title":"Proteostasis: Investigating Molecular Dynamics in Neurodegenerative Disorders","first-page":"277","article-title":"Therapeutic strategies targeting amyloid-\u03b2 in Alzheimer\u2019s disease","author":"Tyagi","year":"2025"},{"key":"10.1016\/j.bbadis.2026.168190_bb0050","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/jnc.14256","article-title":"Shared pathological pathways of Alzheimer\u2019s disease with specific comorbidities: current perspectives and interventions","volume":"144","author":"Nday","year":"2018","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0055","doi-asserted-by":"crossref","first-page":"1708234","DOI":"10.3389\/fnagi.2025.1708234","article-title":"Are current etiological theories of Alzheimer\u2019s disease falsifiable? An epistemological assessment","volume":"17","author":"Costa","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0060","series-title":"An Integrated Assessment of Changes in Brain Structure and Function among Older Adults With Major Depressive Disorder or Mild Cognitive Impairment","author":"Rashidi-Ranjbar","year":"2022"},{"key":"10.1016\/j.bbadis.2026.168190_bb0065","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2183\/pjab.99.018","article-title":"Unraveling the mysteries of dendritic spine dynamics: five key principles shaping memory and cognition","volume":"99","author":"Kasai","year":"2023","journal-title":"Proc. Japan Acad. Ser. B"},{"key":"10.1016\/j.bbadis.2026.168190_bb0070","doi-asserted-by":"crossref","first-page":"1680349","DOI":"10.3389\/fnut.2025.1680349","article-title":"Targeting aging hallmarks in brain health within the framework of preventive medicine: mechanistic insights into naringenin\u2019s role in longevity, synaptic function, and cellular homeostasis","volume":"12","author":"Zhi","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbadis.2026.168190_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106897","article-title":"Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: whole-brain MRI analysis","volume":"209","author":"Morais","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0080","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-025-04673-z","article-title":"Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging","volume":"16","author":"Goel","year":"2026","journal-title":"3 Biotech"},{"key":"10.1016\/j.bbadis.2026.168190_bb0085","article-title":"Hypothalamic-pituitary-adrenal (HPA) axis: unveiling the potential mechanisms involved in stress-induced Alzheimer\u2019s disease and depression","volume":"16","author":"Sharan","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.bbadis.2026.168190_bb0090","first-page":"1217","article-title":"Sleep, neuroendocrine disorders, and the bidirectional relationship between the hypothalamic-pituitary-adrenal axis: a mini-review","volume":"29","author":"Udi","year":"2025","journal-title":"J. Appl. Sci. Environ. Manag."},{"key":"10.1016\/j.bbadis.2026.168190_bb0095","doi-asserted-by":"crossref","first-page":"39446","DOI":"10.31083\/JIN39446","article-title":"Brain insulin signaling pathway regulation of hippocampal neuroplasticity in neurocognitive disorders: mechanisms and therapeutic implications","volume":"24","author":"He","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0100","article-title":"Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0105","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/BST20220789","article-title":"Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance","volume":"51","author":"Duarte","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbadis.2026.168190_bb0110","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-021-02738-3","article-title":"Role of insulin receptor substance-1 modulating PI3K\/Akt insulin signaling pathway in Alzheimer\u2019s disease","volume":"11","author":"Zheng","year":"2021","journal-title":"3 Biotech"},{"key":"10.1016\/j.bbadis.2026.168190_bb0115","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/alz.12683","article-title":"The role of mitochondrial dysfunction in Alzheimer\u2019s disease pathogenesis","volume":"19","author":"Ashleigh","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.bbadis.2026.168190_bb0120","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.3390\/pharmaceutics14122657","article-title":"Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches","volume":"14","author":"Khan","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbadis.2026.168190_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/syn.21990","article-title":"Alzheimer's disease and metabolic syndrome: a link from oxidative stress and inflammation to neurodegeneration","volume":"71","author":"Rojas-Gutierrez","year":"2017","journal-title":"Synapse"},{"key":"10.1016\/j.bbadis.2026.168190_bb0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-021-00796-3","article-title":"Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms","volume":"37","author":"Wang","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0135","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1873-3468.13995","article-title":"Mitochondrial disorders of the OXPHOS system","volume":"595","author":"Fernandez-Vizarra","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbadis.2026.168190_bb0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","article-title":"Energy matters: presynaptic metabolism and the maintenance of synaptic transmission","volume":"23","author":"Li","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3390\/antiox8090392","article-title":"Mitochondrial genome (mtDNA) mutations that generate reactive oxygen species","volume":"8","author":"Hahn","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbadis.2026.168190_bb0150","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2174\/1566524023666230726145447","article-title":"Role of Nrf2 in oxidative stress, neuroinflammation and autophagy in Alzheimer\u2019s disease: regulation of Nrf2 by different signaling pathways","volume":"25","author":"Kaur","year":"2025","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbadis.2026.168190_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176057","article-title":"Review of PINK1-Parkin-mediated mitochondrial autophagy in Alzheimer\u2019s disease","volume":"959","author":"Zhou","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0165","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.3390\/ijms252312855","article-title":"Mitochondrial dynamics in brain cells during normal and pathological aging","volume":"25","author":"Sukhorukov","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0170","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/antiox11112167","article-title":"The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer\u2019s disease: therapeutic implications and future perspectives","volume":"11","author":"Jurc\u0103u","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbadis.2026.168190_bb0175","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14283\/jpad.2023.61","article-title":"Burden of illness in people with Alzheimer\u2019s disease: a systematic review of epidemiology, comorbidities and mortality","volume":"11","author":"Lanctot","year":"2024","journal-title":"J. Prev Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0180","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.14283\/jpad.2024.148","article-title":"Evaluating the causal effect of type 2 diabetes on Alzheimer\u2019s disease using large-scale genetic data","volume":"11","author":"Liu","year":"2024","journal-title":"J. Prev Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0185","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/biom13010183","article-title":"Type 2 diabetes and Alzheimer\u2019s disease: the emerging role of cellular lipotoxicity","volume":"13","author":"Marrano","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2026.168190_bb0190","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1007\/s12035-019-1475-8","article-title":"Mechanisms associated with type 2 diabetes as a risk factor for Alzheimer-related pathology","volume":"56","author":"Su","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.631770","article-title":"The impact of disease comorbidities in Alzheimer's disease","volume":"13","author":"Santiago","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0200","article-title":"Evaluation of the psychosocial status of patients with type 2 diabetes mellitus and their treating physicians using the Glycemic Happiness Scale: a multicentric, cross-sectional study","volume":"17","author":"Kalra","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.bbadis.2026.168190_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.547175","article-title":"Role of insulin in neurotrauma and neurodegeneration: a review","volume":"14","author":"Shaughness","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0210","doi-asserted-by":"crossref","first-page":"7489795","DOI":"10.1155\/2020\/7489795","article-title":"Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications","volume":"2020","author":"Papachristoforou","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0215","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3390\/biom12091228","article-title":"Role of reactive oxygen species in glucose metabolism disorder in diabetic pancreatic \u03b2-cells","volume":"12","author":"Mukai","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2026.168190_bb0220","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","article-title":"Advanced glycation end products and diabetes mellitus: mechanisms and perspectives","volume":"12","author":"Khalid","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbadis.2026.168190_bb0225","doi-asserted-by":"crossref","first-page":"1112363","DOI":"10.3389\/fendo.2023.1112363","article-title":"The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbadis.2026.168190_bb0230","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3390\/antiox14091044","article-title":"Oxidative stress, advanced glycation end products (AGEs), and neurodegeneration in Alzheimer\u2019s disease: a metabolic perspective","volume":"14","author":"Boccardi","year":"2025","journal-title":"Antioxidants"},{"issue":"10","key":"10.1016\/j.bbadis.2026.168190_bb0235","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2174\/1871527315666160803153459","article-title":"Every cloud has a silver lining: proneurogenic effects of A\u03b2 oligomers and HMGB-1 via activation of the RAGE-NF-\u03baB axis","volume":"16","author":"Bortolotto","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbadis.2026.168190_bb0240","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1134\/S002689332104004X","article-title":"Beta amyloid, tau protein, and neuroinflammation: an attempt to integrate different hypotheses of Alzheimer\u2019s disease pathogenesis","volume":"55","author":"Garbuz","year":"2021","journal-title":"Mol. Biol. (Mosk)"},{"key":"10.1016\/j.bbadis.2026.168190_bb0245","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2174\/1871527313666140806144831","article-title":"Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress","volume":"13","author":"T\u00f3bon-Velasco","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbadis.2026.168190_bb0250","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1007\/s12035-024-04457-1","article-title":"Insulin-like growth factor signaling in Alzheimer\u2019s disease: pathophysiology and therapeutic strategies","volume":"62","author":"Miao","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0255","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3390\/antiox11091845","article-title":"The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products","volume":"11","author":"Shiau","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbadis.2026.168190_bb0260","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/dneu.20506","article-title":"PI3K\/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation","volume":"67","author":"Peltier","year":"2007","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0265","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1017\/S1041610219000383","article-title":"Genome-wide RNA sequencing analysis reveals that IGF-2 attenuates memory decline, oxidative stress and amyloid plaques in an Alzheimer\u2019s disease mouse model (AD) by activating the PI3K\/AKT\/CREB signaling pathway","volume":"31","author":"Xia","year":"2019","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.bbadis.2026.168190_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26094209","article-title":"Peripheral inflammation and insulin resistance: their impact on blood\u2013brain barrier integrity and glia activation in Alzheimer\u2019s disease","volume":"26","author":"Ponce-Lopez","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0275","doi-asserted-by":"crossref","first-page":"16440","DOI":"10.3390\/ijms242216440","article-title":"The role of insulin-like growth factor I in mechanisms of resilience and vulnerability to sporadic Alzheimer\u2019s disease","volume":"24","author":"Zegarra-Valdivia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0280","doi-asserted-by":"crossref","first-page":"7392","DOI":"10.3390\/ijms26157392","article-title":"Human glucose transporters in health and selected neurodegenerative diseases","volume":"26","author":"Szablewski","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0285","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.3390\/ijms24043506","article-title":"How can insulin resistance cause Alzheimer\u2019s disease?","volume":"24","author":"Yoon","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0290","doi-asserted-by":"crossref","first-page":"9540","DOI":"10.3390\/ijms23179540","article-title":"Dysfunctional glucose metabolism in Alzheimer\u2019s disease onset and potential pharmacological interventions","volume":"23","author":"Kumar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0295","doi-asserted-by":"crossref","first-page":"779","DOI":"10.4103\/1673-5374.354515","article-title":"Altered O-GlcNAcylation and mitochondrial dysfunction, a molecular link between brain glucose dysregulation and sporadic Alzheimer\u2019s disease","volume":"18","author":"Huang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0300","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s43440-021-00293-5","article-title":"A review of the mechanisms underlying selected comorbidities in Alzheimer\u2019s disease","volume":"73","author":"Maciejewska","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbadis.2026.168190_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.873301","article-title":"Significance of brain glucose hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases","volume":"13","author":"Bl\u00e1zquez","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.bbadis.2026.168190_bb0310","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.2147\/DDDT.S173970","article-title":"Mechanism involved in insulin resistance via accumulation of \u03b2-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer\u2019s disease","volume":"12","author":"Rad","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0315","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00125-009-1323-x","article-title":"Uncontrolled diabetes increases the risk of Alzheimer\u2019s disease: a population-based cohort study","volume":"52","author":"Xu","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbadis.2026.168190_bb0320","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1111\/febs.16151","article-title":"AMPK in the brain: its roles in glucose and neural metabolism","volume":"289","author":"Muraleedharan","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.bbadis.2026.168190_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101924","article-title":"Nature\u2019s toolbox against tau aggregation: an updated review of current research","volume":"87","author":"Khan","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbadis.2026.168190_bb0330","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimer's Dement.: Transl. Res. Clin. Interv."},{"key":"10.1016\/j.bbadis.2026.168190_bb0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-39828-5","article-title":"Cross-disease analysis of Alzheimer\u2019s disease and type-2 diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases","volume":"9","author":"Caberlotto","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168190_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/cells11152262","article-title":"Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators","volume":"11","author":"G\u00f3mez-Virgilio","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168190_bb0345","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1038\/s41598-019-39828-5","article-title":"Cross-disease analysis of Alzheimer\u2019s disease and type-2 diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases","volume":"9","author":"Caberlotto","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168190_bb0350","series-title":"Autophagy - From Molecular Mechanisms to Flux Control in Health and Disease","first-page":"127","article-title":"Autophagy and neurodegenerative diseases","author":"Barbosa","year":"2025"},{"key":"10.1016\/j.bbadis.2026.168190_bb0355","series-title":"Emerging Concepts in Endocrine Structure and Functions","first-page":"349","article-title":"Adipose tissue as an endocrine organ and a glance on local hormones","author":"Al-Suhaimi","year":"2022"},{"key":"10.1016\/j.bbadis.2026.168190_bb0360","first-page":"104.100","article-title":"Some biochemical parameters secreted from the adipose tissues","volume":"32","author":"Abduljalal","year":"2023","journal-title":"J. Educ. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0365","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1113\/JP271691","article-title":"\u2018Adipaging\u2019: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue","volume":"594","author":"P\u00e9rez","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0370","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11154-021-09636-2","article-title":"Leptin, the brain and energy homeostasis: from an apparently simple to a highly complex neuronal system","volume":"23","author":"Maffei","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbadis.2026.168190_bb0375","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.3390\/ijms25137352","article-title":"Novel leptin-based therapeutic strategies to limit synaptic dysfunction in Alzheimer\u2019s disease","volume":"25","author":"Harvey","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0380","doi-asserted-by":"crossref","first-page":"18238","DOI":"10.1074\/jbc.M800053200","article-title":"Leptin increases adult hippocampal neurogenesis in vivo and in vitro","volume":"283","author":"Garza","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101098","article-title":"Regulation of hippocampal synaptic function by the metabolic hormone leptin: Implications for health and disease","volume":"82","author":"Irving","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0390","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3390\/nu15071767","article-title":"Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota","volume":"15","author":"Micheli","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbadis.2026.168190_bb0395","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/obr.12629","article-title":"Obesity as a risk factor for Alzheimer\u2019s disease: weighing the evidence","volume":"19","author":"Alford","year":"2018","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbadis.2026.168190_bb0400","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1021\/acschemneuro.1c00295","article-title":"APOE genotype and Alzheimer\u2019s disease: the influence of lifestyle and environmental factors","volume":"12","author":"Angelopoulou","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0405","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s13346-021-01026-0","article-title":"Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases","volume":"12","author":"Shetgaonkar","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0410","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1471-4159.2009.06408.x","article-title":"Cholesterol metabolism and transport in the pathogenesis of Alzheimer\u2019s disease","volume":"111","author":"Martins","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-019-0965-z","article-title":"Role of cholesterol and sphingolipids in brain development and neurological diseases","volume":"18","author":"Hussain","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0420","first-page":"1","article-title":"Cholesterol metabolism in CNS diseases: the potential of SREBP2 and LXR as therapeutic targets","author":"Wang","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0425","doi-asserted-by":"crossref","first-page":"30","DOI":"10.59556\/japi.73.1213","article-title":"Retrospective observational electronic medical records-based real world study to assess the prevalence and treatment of dyslipidemia in Indian patients","volume":"73","author":"Kanuru","year":"2025","journal-title":"J. Assoc. Physicians India"},{"key":"10.1016\/j.bbadis.2026.168190_bb0430","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5607\/en23010","article-title":"Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders","volume":"32","author":"Cheon","year":"2023","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0435","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3390\/biomedicines13071513","article-title":"The potential regulators of amyloidogenic pathway of APP processing in Alzheimer\u2019s disease","volume":"13","author":"Krawczuk","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbadis.2026.168190_bb0440","doi-asserted-by":"crossref","first-page":"9356","DOI":"10.3390\/ijms23169356","article-title":"HDL-like-mediated cell cholesterol trafficking in the central nervous system and Alzheimer\u2019s disease pathogenesis","volume":"23","author":"Borr\u00e0s","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0445","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"B\u00e4ck","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00011-025-02069-6","article-title":"Exploring the intersection of atherosclerosis and Alzheimer\u2019s disease: the role of inflammation and complement activation","volume":"74","author":"Vataja","year":"2025","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0455","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.3390\/ijms25094581","article-title":"The role of oxygen homeostasis and the HIF-1 factor in the development of neurodegeneration","volume":"25","author":"Mitroshina","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0460","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ng0194-29","article-title":"Genetic associations with human longevity at the APOE and ACE loci","volume":"6","author":"Sch\u00e4chter","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbadis.2026.168190_bb0465","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/07853890009011761","article-title":"Apolipoprotein E4: an allele associated with many diseases","volume":"32","author":"Smith","year":"2000","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbadis.2026.168190_bb0470","doi-asserted-by":"crossref","first-page":"1","DOI":"10.37349\/ent.2022.00015","article-title":"Balancing cholesterol in the brain: from synthesis to disposal","volume":"2","author":"Qian","year":"2022","journal-title":"Explor. Neuroprotective Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0475","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mcn.2014.10.006","article-title":"Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models","volume":"63","author":"Hohsfield","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0480","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/jnen\/60.8.778","article-title":"Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APPsw mice","volume":"60","author":"Mori","year":"2001","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0485","article-title":"Astrocytic functions and lipid metabolism: correlations and therapeutic targets in Alzheimer's disease and glioblastoma","volume":"4","author":"Zhang","year":"2024","journal-title":"Clin. Transl. Discov."},{"key":"10.1016\/j.bbadis.2026.168190_bb0490","doi-asserted-by":"crossref","first-page":"1096206","DOI":"10.3389\/fnagi.2023.1096206","article-title":"White matter injury, cholesterol dysmetabolism, and APP\/Abeta dysmetabolism interact to produce Alzheimer\u2019s disease (AD) neuropathology: a hypothesis and review","volume":"15","author":"Sharp","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0495","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1159\/000521650","article-title":"Thyroid disorders and development of cognitive impairment: a review study","volume":"112","author":"Khaleghzadeh-Ahangar","year":"2022","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbadis.2026.168190_bb0500","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1365-2265.2000.01146.x","article-title":"Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study","volume":"53","author":"Kalmijn","year":"2000","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0505","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12020-022-03190-w","article-title":"Thyroid hormone levels in Alzheimer disease: a systematic review and meta-analysis","volume":"79","author":"Dolatshahi","year":"2023","journal-title":"Endocrine"},{"key":"10.1016\/j.bbadis.2026.168190_bb0510","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1210\/clinem\/dgad447","article-title":"Association of thyroid hormone medication adherence with risk of dementia","volume":"109","author":"Han","year":"2024","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbadis.2026.168190_bb0515","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/qjmed\/hcr118","article-title":"Non-psychiatric comorbidity associated with Alzheimer\u2019s disease","volume":"104","author":"Duthie","year":"2011","journal-title":"QJM: Int. J. Med."},{"key":"10.1016\/j.bbadis.2026.168190_bb0520","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_684_24","article-title":"Clinical practice guidelines on addressing cognitive impairment in treatable dementias","volume":"67","author":"Siddiqui","year":"2025","journal-title":"Indian J. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0525","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12888-025-06532-w","article-title":"Depressive, anxiety, and sleep disturbance symptoms in patients with obstructive sleep apnea: a network analysis perspective","volume":"25","author":"Luo","year":"2025","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0530","article-title":"Exploring potential mechanisms of sleep disorders in Alzheimer\u2019s dementia: a scoping review","volume":"17","author":"Yusuff","year":"2025","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.bbadis.2026.168190_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2025.e41841","article-title":"Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer\u2019s disease: insights from cerebrospinal fluid analysis","volume":"11","author":"Artime-Naveda","year":"2025","journal-title":"Heliyon"},{"key":"10.1016\/j.bbadis.2026.168190_bb0540","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.sleep.2023.01.020","article-title":"Prevalence of sleep-related breathing disorders and associated risk factors among people with dementia: a meta-analysis","volume":"103","author":"Aini","year":"2023","journal-title":"Sleep Med."},{"key":"10.1016\/j.bbadis.2026.168190_bb0545","doi-asserted-by":"crossref","first-page":"e2125","DOI":"10.1212\/WNL.0000000000207220","article-title":"Association of bone mineral density and dementia: the Rotterdam study","volume":"100","author":"Xiao","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2026.168190_bb0550","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1186\/s12891-022-05580-7","article-title":"Potential association of bone mineral density loss with cognitive impairment and central and peripheral amyloid-\u03b2 changes: a cross-sectional study","volume":"23","author":"Zhang","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.bbadis.2026.168190_bb0555","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/genes14020338","article-title":"Genetic factors implicated in the investigation of possible connections between Alzheimer\u2019s disease and primary open angle glaucoma","volume":"14","author":"Kuang","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.bbadis.2026.168190_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101303","article-title":"The relationship between intraocular pressure and glaucoma: an evolving concept","volume":"103","author":"Asrani","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0565","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272811","article-title":"Glaucoma and Alzheimer: neurodegenerative disorders show an adrenergic dysbalance","volume":"17","author":"Hohberger","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbadis.2026.168190_bb0570","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2147\/EB.S401306","article-title":"Normal-tension glaucoma: a glymphopathy?","author":"Wostyn","year":"2023","journal-title":"Eye Brain"},{"key":"10.1016\/j.bbadis.2026.168190_bb0575","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5935\/1518-0557.20210047","article-title":"Trisomy 21 and assisted reproductive technologies: a review","volume":"26","author":"S\u00e1nchez-Pav\u00f3n","year":"2022","journal-title":"JBRA Assist. Reprod."},{"key":"10.1016\/j.bbadis.2026.168190_bb0580","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/jnnp.59.2.111","article-title":"Down\u2019s syndrome and the links with Alzheimer\u2019s disease","volume":"59","author":"Holland","year":"1995","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0585","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","article-title":"Neuroinflammation and proinflammatory cytokines in epileptogenesis","volume":"59","author":"Soltani Khaboushan","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0590","series-title":"Oxidants in Biology: A Question of Balance","first-page":"183","article-title":"The adventures of superoxide dismutase in health and disease: superoxide in the balance","author":"Powers","year":"2008"},{"key":"10.1016\/j.bbadis.2026.168190_bb0595","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1152\/physrev.00030.2022","article-title":"Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease","volume":"104","author":"Perluigi","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2026.168190_bb0600","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.3390\/biomedicines10123219","article-title":"Pediatric population with down syndrome: obesity and the risk of cardiovascular disease and their assessment using omics techniques","volume":"10","author":"Hetman","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbadis.2026.168190_bb0605","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41380-020-0760-2","article-title":"Cancer and Alzheimer\u2019s disease inverse relationship: an age-associated diverging derailment of shared pathways","volume":"26","author":"Lanni","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0610","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/microorganisms10091838","article-title":"Gut bacteria and neurotransmitters","volume":"10","author":"Dicks","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbadis.2026.168190_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110112","article-title":"Emerging role of gut microbiota in modulation of neuroinflammation and neurodegeneration with emphasis on Alzheimer\u2019s disease","volume":"106","author":"Goyal","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0620","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1007\/s00216-016-9868-2","article-title":"Influence of the amyloid dye Congo red on curli, cellulose, and the extracellular matrix in E. coli during growth and matrix purification","volume":"408","author":"Reichhardt","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0625","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1038\/s41598-024-54553-4","article-title":"A systematic review and meta-analysis of the effects of long-term antibiotic use on cognitive outcomes","volume":"14","author":"Ye","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbadis.2026.168190_bb0630","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00019442-200002000-00004","article-title":"Psychosis of Alzheimer\u2019s disease and related dementias: diagnostic criteria for a distinct syndrome","volume":"8","author":"Jeste","year":"2000","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0635","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.trci.2017.07.001","article-title":"Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms","volume":"3","author":"Lanct\u00f4t","year":"2017","journal-title":"Alzheimer's Dement.: Transl. Res. Clin. Interv."},{"key":"10.1016\/j.bbadis.2026.168190_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112958","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features","volume":"150","author":"Ribeiro","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbadis.2026.168190_bb0645","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/jgs.19411","article-title":"Long-term exposure to non-steroidal anti-inflammatory medication in relation to dementia risk","volume":"73","author":"Vom Hofe","year":"2025","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbadis.2026.168190_bb0650","article-title":"Dementia risk reduction: why haven\u2019t the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors","volume":"7","author":"Peters","year":"2021","journal-title":"Alzheimers Dement (N Y)."},{"key":"10.1016\/j.bbadis.2026.168190_bb0655","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3390\/ph15070827","article-title":"Selective COX-2 inhibitors: road from success to controversy and the quest for repurposing","volume":"15","author":"El-Malah","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbadis.2026.168190_bb0660","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12032-023-02256-7","article-title":"COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers","volume":"41","author":"Rodrigues","year":"2024","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0665","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1755-5949.2011.00251.x","article-title":"Seizures and epilepsy in Alzheimer\u2019s disease","volume":"18","author":"Friedman","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0670","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuroscience.2014.11.051","article-title":"Seizures in Alzheimer\u2019s disease","volume":"286","author":"Born","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbadis.2026.168190_bb0675","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.746381","article-title":"Similar profile and magnitude of cognitive impairments in focal and generalized epilepsy: a pilot study","volume":"12","author":"Gauffin","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0680","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.3390\/ijms22189689","article-title":"On the common journey of neural cells through ischemic brain injury and Alzheimer\u2019s disease","volume":"22","author":"Kriska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0685","first-page":"S21","article-title":"The cognitive syndrome of vascular dementia: implications for clinical trials","volume":"13","author":"Desmond","year":"1999","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.bbadis.2026.168190_bb0690","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/HYPERTENSIONAHA.121.17283","article-title":"Blood pressure levels and risks of dementia: a nationwide study of 4.5 million people","volume":"79","author":"Lee","year":"2022","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.bbadis.2026.168190_bb0695","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/CM9.0000000000003103","article-title":"Hypotension with neurovascular changes and cognitive dysfunction: An epidemiological, pathobiological, and treatment review","volume":"138","author":"Cheng","year":"2025","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbadis.2026.168190_bb0700","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.2174\/138161208786848748","article-title":"Ischemic neuronal damage","volume":"14","author":"Taoufik","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbadis.2026.168190_bb0705","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/ars.2013.5244","article-title":"Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress","volume":"20","author":"Lankhorst","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbadis.2026.168190_bb0710","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/antiox9080743","article-title":"ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease","volume":"9","author":"Simpson","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbadis.2026.168190_bb0715","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neulet.2014.10.016","article-title":"Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-\u03baB pathways","volume":"584","author":"Park","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbadis.2026.168190_bb0720","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbadis.2026.168190_bb0725","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12929-024-01090-x","article-title":"Role of glucagon-like peptide-1 receptor agonists in Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"31","author":"Hong","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbadis.2026.168190_bb0730","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1900\/RDS.2014.11.202","article-title":"Adverse effects of GLP-1 receptor agonists","volume":"11","author":"Filippatos","year":"2015","journal-title":"Rev. Diabetic Stud.: RDS"},{"key":"10.1016\/j.bbadis.2026.168190_bb0735","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.2174\/0929867327666200716113136","article-title":"Role of peroxisome proliferator-activated receptor gamma (PPAR\u03b3) in different disease states: recent updates","volume":"28","author":"Mal","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0740","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/JAD-170440","article-title":"Comorbidity analysis between Alzheimer\u2019s disease and type 2 diabetes mellitus (T2DM) based on shared pathways and the role of T2DM drugs","volume":"60","author":"Karki","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0745","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41419-022-05153-5","article-title":"ER stress and UPR in Alzheimer\u2019s disease: mechanisms, pathogenesis, treatments","volume":"13","author":"Ajoolabady","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108277","article-title":"Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives","volume":"239","author":"Ferrari","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0755","doi-asserted-by":"crossref","first-page":"841","DOI":"10.14336\/AD.2020.1111","article-title":"Effects of antihypertensive drugs on cognitive function in elderly patients with hypertension: a review","volume":"12","author":"Yang","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0760","doi-asserted-by":"crossref","first-page":"e2333353","DOI":"10.1001\/jamanetworkopen.2023.33353","article-title":"Use of antihypertensives, blood pressure, and estimated risk of dementia in late life: an individual participant data meta-analysis","volume":"6","author":"Lennon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbadis.2026.168190_bb0765","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.jacc.2024.01.030","article-title":"Risk of dementia during antihypertensive drug therapy in the elderly","volume":"83","author":"Rea","year":"2024","journal-title":"JACC"},{"key":"10.1016\/j.bbadis.2026.168190_bb0770","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/alz.12871","article-title":"Hypertension and hyperhomocysteinemia as modifiable risk factors for Alzheimer\u2019s disease and dementia: new evidence, potential therapeutic strategies, and biomarkers","volume":"19","author":"Carey","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.bbadis.2026.168190_bb0775","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/HYPERTENSIONAHA.119.12892","article-title":"Effects of nilvadipine on cerebral blood flow in patients with Alzheimer disease: a randomized trial","volume":"74","author":"de Jong","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.bbadis.2026.168190_bb0780","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.2174\/0929867327666200312114223","article-title":"Repurposing antihypertensive drugs for the management of Alzheimer\u2019s disease","volume":"28","author":"Law","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0785","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13195-021-00778-8","article-title":"The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer\u2019s disease: the importance of blood-brain barrier penetration and APOE \u03b54 carrier status","volume":"13","author":"Ouk","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbadis.2026.168190_bb0790","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s41983-024-00848-2","article-title":"The role of neurotransmitter receptors in antipsychotic medication efficacy for Alzheimer\u2019s-related psychosis","volume":"60","author":"Sharma","year":"2024","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"10.1016\/j.bbadis.2026.168190_bb0795","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12883-023-03191-w","article-title":"A systematic review and meta-analysis on the efficacy outcomes of selective serotonin reuptake inhibitors in depression in Alzheimer\u2019s disease","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0800","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3233\/JAD-2011-101113","article-title":"Antidepressants modulate intracellular amyloid peptide species in N2a neuroblastoma cells","volume":"24","author":"Aboukhatwa","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0805","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/1673-5374.264445","article-title":"Selective serotonin reuptake inhibitors and Alzheimer\u2019s disease","volume":"15","author":"Mdawar","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0810","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/cells10020255","article-title":"Lithium and therapeutic targeting of GSK-3","volume":"10","author":"Snitow","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbadis.2026.168190_bb0815","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1399-5618.2002.01150.x","article-title":"Regulation of tau phosphorylation and protection against \u03b2-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer\u2019s disease","volume":"4","author":"Alvarez","year":"2002","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.bbadis.2026.168190_bb0820","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s11064-021-03332-y","article-title":"Alzheimer\u2019s disease and epilepsy: a perspective on the opportunities for overlapping therapeutic innovation","volume":"46","author":"Lehmann","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0825","series-title":"Seminars in Neurology","first-page":"583","article-title":"Long-term effects of antiseizure medications","volume":"vol. 42","author":"LoPinto-Khoury","year":"2022"},{"key":"10.1016\/j.bbadis.2026.168190_bb0830","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamaneurol.2021.3310","article-title":"Effect of levetiracetam on cognition in patients with Alzheimer disease with and without epileptiform activity: a randomized clinical trial","volume":"78","author":"Vossel","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0835","doi-asserted-by":"crossref","DOI":"10.5812\/ijpr-128408","article-title":"Donepezil beyond Alzheimer\u2019s disease? A narrative review of therapeutic potentials of donepezil in different diseases","volume":"21","author":"Pooladgar","year":"2022","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0840","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.2174\/0929867329666220408102051","article-title":"Exploring the recent trends in management of dementia and frailty: focus on diagnosis and treatment","volume":"29","author":"Rahman","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbadis.2026.168190_bb0845","doi-asserted-by":"crossref","first-page":"6793803","DOI":"10.21037\/apm-21-1243","article-title":"A systematic review and meta-analysis on the efficacy of statins in the treatment of atherosclerosis","volume":"10","author":"Jia","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.bbadis.2026.168190_bb0850","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43044-023-00327-8","article-title":"Pleotropic effects of statins: the dilemma of wider utilization of statin","volume":"75","author":"Choudhary","year":"2023","journal-title":"Egypt. Heart J."},{"key":"10.1016\/j.bbadis.2026.168190_bb0855","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/ph14050458","article-title":"Some candidate drugs for pharmacotherapy of Alzheimer\u2019s disease","volume":"14","author":"Miziak","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbadis.2026.168190_bb0860","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/bcpt.14055","article-title":"Drugs targeting APOE4 that regulate beta-amyloid aggregation in the brain: therapeutic potential for Alzheimer\u2019s disease","volume":"135","author":"Poblano","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0865","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13208","article-title":"Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E \u025b4 allele","volume":"34","author":"Ji","year":"2024","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0870","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11481-015-9627-8","article-title":"ABCA1 is necessary for bexarotene-mediated clearance of soluble amyloid beta from the hippocampus of APP\/PS1 mice","volume":"11","author":"Corona","year":"2016","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0875","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3233\/JAD-150469","article-title":"Bexarotene promotes cholesterol efflux and restricts apical-to-basolateral transport of amyloid-\u03b2 peptides in an in vitro model of the human blood-brain barrier","volume":"48","author":"Kuntz","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbadis.2026.168190_bb0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102021","article-title":"The novel function of bexarotene for neurological diseases","volume":"90","author":"Liu","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbadis.2026.168190_bb0885","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146685","article-title":"ApoE mimetic improves pathology and memory in a model of Alzheimer\u2019s disease","volume":"1733","author":"Krishnamurthy","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.bbadis.2026.168190_bb0890","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114051","article-title":"Therapeutic potential of ApoE-mimetic peptides in CNS disorders: current perspective","volume":"353","author":"Ahmed","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0895","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ana.26043","article-title":"Apolipoprotein E4 reduction with antisense oligonucleotides decreases neurodegeneration in a tauopathy model","volume":"89","author":"Litvinchuk","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbadis.2026.168190_bb0900","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afae188","article-title":"Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial","volume":"53","author":"Sun","year":"2024","journal-title":"Age Ageing"},{"key":"10.1016\/j.bbadis.2026.168190_bb0905","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41380-022-01792-4","article-title":"Incretin and insulin signaling as novel therapeutic targets for Alzheimer\u2019s and Parkinson\u2019s disease","volume":"28","author":"Nowell","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbadis.2026.168190_bb0910","doi-asserted-by":"crossref","first-page":"e2666","DOI":"10.1212\/WNL.0000000000010733","article-title":"Effect of escitalopram on A\u03b2 levels and plaque load in an Alzheimer mouse model","volume":"95","author":"Cirrito","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.bbadis.2026.168190_bb0915","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/hmg\/ddab091","article-title":"Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer\u2019s disease","volume":"30","author":"Reddy","year":"2021","journal-title":"Hum. Mol. Genet."}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926000384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0925443926000384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:22:12Z","timestamp":1791058932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0925443926000384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":183,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0925443926000384"],"URL":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168190","relation":{},"ISSN":["0925-4439"],"issn-type":[{"value":"0925-4439","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the intersection of Alzheimer's disease and comorbidities: a review of the interplay between multiple chronic conditions","name":"articletitle","label":"Article Title"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbadis.2026.168190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"168190"}}